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Compile Data Set for Download or QSAR

Found 195 hits with Last Name = 'kadereit' and Initial = 'd'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174389
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-(5-hydroxy-2-metho...)
Show SMILES COc1ccc(O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C15H12ClFN2O4/c1-23-13-5-3-9(20)7-12(13)18-15(22)19-14(21)10-4-2-8(17)6-11(10)16/h2-7,20H,1H3,(H2,18,19,21,22)
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n/an/a 22.9n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174389
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-(5-hydroxy-2-metho...)
Show SMILES COc1ccc(O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C15H12ClFN2O4/c1-23-13-5-3-9(20)7-12(13)18-15(22)19-14(21)10-4-2-8(17)6-11(10)16/h2-7,20H,1H3,(H2,18,19,21,22)
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n/an/a 23n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM50275569
PNG
(CHEMBL4130148)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O |r|
Show InChI InChI=1S/C184H285N51O57/c1-20-94(10)144(174(285)211-114(55-60-141(252)253)159(270)217-121(74-102-78-196-106-43-28-27-42-104(102)106)163(274)215-118(71-93(8)9)171(282)231-183(16,17)180(291)204-95(11)148(259)198-80-136(246)197-83-139(249)232-64-34-47-129(232)172(283)224-127(87-239)170(281)222-125(85-237)152(263)200-81-137(247)202-97(13)177(288)234-66-36-49-131(234)179(290)235-67-37-50-132(235)178(289)233-65-35-48-130(233)173(284)221-124(84-236)147(191)258)228-166(277)119(72-100-38-23-21-24-39-100)216-160(271)115(68-90(2)3)212-155(266)107(44-29-31-61-185)205-149(260)96(12)203-153(264)109(46-33-63-195-182(192)193)206-156(267)111(52-57-134(189)244)209-157(268)113(54-59-140(250)251)210-164(275)122(76-142(254)255)218-161(272)116(69-91(4)5)213-158(269)112(53-58-135(190)245)208-154(265)108(45-30-32-62-186)207-168(279)126(86-238)223-162(273)117(70-92(6)7)214-165(276)123(77-143(256)257)219-169(280)128(88-240)225-176(287)146(99(15)242)229-167(278)120(73-101-40-25-22-26-41-101)220-175(286)145(98(14)241)227-138(248)82-199-151(262)110(51-56-133(188)243)226-181(292)184(18,19)230-150(261)105(187)75-103-79-194-89-201-103/h21-28,38-43,78-79,89-99,105,107-132,144-146,196,236-242H,20,29-37,44-77,80-88,185-187H2,1-19H3,(H2,188,243)(H2,189,244)(H2,190,245)(H2,191,258)(H,194,201)(H,197,246)(H,198,259)(H,199,262)(H,200,263)(H,202,247)(H,203,264)(H,204,291)(H,205,260)(H,206,267)(H,207,279)(H,208,265)(H,209,268)(H,210,275)(H,211,285)(H,212,266)(H,213,269)(H,214,276)(H,215,274)(H,216,271)(H,217,270)(H,218,272)(H,219,280)(H,220,286)(H,221,284)(H,222,281)(H,223,273)(H,224,283)(H,225,287)(H,226,292)(H,227,248)(H,228,277)(H,229,278)(H,230,261)(H,231,282)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,192,193,195)/t94-,95-,96-,97-,98+,99+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,144-,145-,146-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Displacement of [125I]GLP-1 from human GLP1R expressed in HEK293 cell membranes after 180 mins by microbeta counting method

J Med Chem 61: 5580-5593 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00292
BindingDB Entry DOI: 10.7270/Q2NP26XR
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174381
PNG
(4-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-2-hyd...)
Show SMILES COc1cc(C(O)=O)c(O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C16H11ClF2N2O6/c1-27-13-3-7(15(24)25)12(22)5-11(13)20-16(26)21-14(23)6-2-9(18)10(19)4-8(6)17/h2-5,22H,1H3,(H,24,25)(H2,20,21,23,26)
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n/an/a 50n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174381
PNG
(4-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-2-hyd...)
Show SMILES COc1cc(C(O)=O)c(O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C16H11ClF2N2O6/c1-27-13-3-7(15(24)25)12(22)5-11(13)20-16(26)21-14(23)6-2-9(18)10(19)4-8(6)17/h2-5,22H,1H3,(H,24,25)(H2,20,21,23,26)
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n/an/a 50.1n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174379
PNG
(1-{3-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-...)
Show SMILES CNC(=O)Nc1ccc(OC)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c1
Show InChI InChI=1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
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n/an/a 52.5n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174379
PNG
(1-{3-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-...)
Show SMILES CNC(=O)Nc1ccc(OC)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c1
Show InChI InChI=1S/C17H15ClF2N4O4/c1-21-16(26)22-8-3-4-14(28-2)13(5-8)23-17(27)24-15(25)9-6-11(19)12(20)7-10(9)18/h3-7H,1-2H3,(H2,21,22,26)(H2,23,24,25,27)
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n/an/a 53n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174397
PNG
(CHEMBL370848 | N-{4-Chloro-3-[3-(2-chloro-4,5-difl...)
Show SMILES CC(=O)Nc1ccc(Cl)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c1
Show InChI InChI=1S/C16H11Cl2F2N3O3/c1-7(24)21-8-2-3-10(17)14(4-8)22-16(26)23-15(25)9-5-12(19)13(20)6-11(9)18/h2-6H,1H3,(H,21,24)(H2,22,23,25,26)
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n/an/a 60n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174375
PNG
(CHEMBL381870 | N-{3-[3-(2-Chloro-4,5-difluoro-benz...)
Show SMILES COc1ccc(NC(C)=O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C17H14ClF2N3O4/c1-8(24)21-9-3-4-15(27-2)14(5-9)22-17(26)23-16(25)10-6-12(19)13(20)7-11(10)18/h3-7H,1-2H3,(H,21,24)(H2,22,23,25,26)
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n/an/a 60n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174397
PNG
(CHEMBL370848 | N-{4-Chloro-3-[3-(2-chloro-4,5-difl...)
Show SMILES CC(=O)Nc1ccc(Cl)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c1
Show InChI InChI=1S/C16H11Cl2F2N3O3/c1-7(24)21-8-2-3-10(17)14(4-8)22-16(26)23-15(25)9-5-12(19)13(20)6-11(9)18/h2-6H,1H3,(H,21,24)(H2,22,23,25,26)
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n/an/a 60.3n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174375
PNG
(CHEMBL381870 | N-{3-[3-(2-Chloro-4,5-difluoro-benz...)
Show SMILES COc1ccc(NC(C)=O)cc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl
Show InChI InChI=1S/C17H14ClF2N3O4/c1-8(24)21-9-3-4-15(27-2)14(5-9)22-17(26)23-16(25)10-6-12(19)13(20)7-11(10)18/h3-7H,1-2H3,(H,21,24)(H2,22,23,25,26)
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n/an/a 60.3n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174372
PNG
(1-(2-Chloro-benzoyl)-3-(5-hydroxy-2-methoxy-phenyl...)
Show SMILES COc1ccc(O)cc1NC(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13-7-6-9(19)8-12(13)17-15(21)18-14(20)10-4-2-3-5-11(10)16/h2-8,19H,1H3,(H2,17,18,20,21)
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n/an/a 64.6n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174372
PNG
(1-(2-Chloro-benzoyl)-3-(5-hydroxy-2-methoxy-phenyl...)
Show SMILES COc1ccc(O)cc1NC(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C15H13ClN2O4/c1-22-13-7-6-9(19)8-12(13)17-15(21)18-14(20)10-4-2-3-5-11(10)16/h2-8,19H,1H3,(H2,17,18,20,21)
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n/an/a 65n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174366
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-[4-(1H-tetrazol-5-...)
Show SMILES Fc1ccc(C(=O)NC(=O)Nc2ccc(cc2OC(F)(F)F)-c2nnn[nH]2)c(Cl)c1
Show InChI InChI=1S/C16H9ClF4N6O3/c17-10-6-8(18)2-3-9(10)14(28)23-15(29)22-11-4-1-7(13-24-26-27-25-13)5-12(11)30-16(19,20)21/h1-6H,(H2,22,23,28,29)(H,24,25,26,27)
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n/an/a 79.4n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174366
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-[4-(1H-tetrazol-5-...)
Show SMILES Fc1ccc(C(=O)NC(=O)Nc2ccc(cc2OC(F)(F)F)-c2nnn[nH]2)c(Cl)c1
Show InChI InChI=1S/C16H9ClF4N6O3/c17-10-6-8(18)2-3-9(10)14(28)23-15(29)22-11-4-1-7(13-24-26-27-25-13)5-12(11)30-16(19,20)21/h1-6H,(H2,22,23,28,29)(H,24,25,26,27)
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n/an/a 80n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174384
PNG
(5-Chloro-4-[3-(2-chloro-4,5-difluoro-benzoyl)-urei...)
Show SMILES OC(=O)c1cc(Cl)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)cc1O
Show InChI InChI=1S/C15H8Cl2F2N2O5/c16-7-3-10(19)9(18)2-5(7)13(23)21-15(26)20-11-4-12(22)6(14(24)25)1-8(11)17/h1-4,22H,(H,24,25)(H2,20,21,23,26)
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n/an/a 89.1n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174384
PNG
(5-Chloro-4-[3-(2-chloro-4,5-difluoro-benzoyl)-urei...)
Show SMILES OC(=O)c1cc(Cl)c(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)cc1O
Show InChI InChI=1S/C15H8Cl2F2N2O5/c16-7-3-10(19)9(18)2-5(7)13(23)21-15(26)20-11-4-12(22)6(14(24)25)1-8(11)17/h1-4,22H,(H,24,25)(H2,20,21,23,26)
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n/an/a 90n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174378
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-(3,4-dihydroxy-phe...)
Show SMILES Oc1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)cc1O
Show InChI InChI=1S/C14H10ClFN2O4/c15-10-5-7(16)1-3-9(10)13(21)18-14(22)17-8-2-4-11(19)12(20)6-8/h1-6,19-20H,(H2,17,18,21,22)
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n/an/a 120n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174378
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-(3,4-dihydroxy-phe...)
Show SMILES Oc1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)cc1O
Show InChI InChI=1S/C14H10ClFN2O4/c15-10-5-7(16)1-3-9(10)13(21)18-14(22)17-8-2-4-11(19)12(20)6-8/h1-6,19-20H,(H2,17,18,21,22)
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n/an/a 120n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174405
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-trifluo...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)c(OC(F)(F)F)c1
Show InChI InChI=1S/C16H9ClF4N2O5/c17-10-6-8(18)2-3-9(10)13(24)23-15(27)22-11-4-1-7(14(25)26)5-12(11)28-16(19,20)21/h1-6H,(H,25,26)(H2,22,23,24,27)
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n/an/a 150n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174373
PNG
(5-Chloro-4-[3-(2,4-dichloro-benzoyl)-ureido]-2-hyd...)
Show SMILES OC(=O)c1cc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)cc1O
Show InChI InChI=1S/C15H9Cl3N2O5/c16-6-1-2-7(9(17)3-6)13(22)20-15(25)19-11-5-12(21)8(14(23)24)4-10(11)18/h1-5,21H,(H,23,24)(H2,19,20,22,25)
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n/an/a 150n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174373
PNG
(5-Chloro-4-[3-(2,4-dichloro-benzoyl)-ureido]-2-hyd...)
Show SMILES OC(=O)c1cc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)cc1O
Show InChI InChI=1S/C15H9Cl3N2O5/c16-6-1-2-7(9(17)3-6)13(22)20-15(25)19-11-5-12(21)8(14(23)24)4-10(11)18/h1-5,21H,(H,23,24)(H2,19,20,22,25)
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n/an/a 151n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174405
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-trifluo...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)c(OC(F)(F)F)c1
Show InChI InChI=1S/C16H9ClF4N2O5/c17-10-6-8(18)2-3-9(10)13(24)23-15(27)22-11-4-1-7(14(25)26)5-12(11)28-16(19,20)21/h1-6H,(H,25,26)(H2,22,23,24,27)
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n/an/a 151n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174403
PNG
(1-{4-Chloro-3-[3-(2,4-dichloro-benzoyl)-ureido]-ph...)
Show SMILES CNC(=O)Nc1ccc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C16H13Cl3N4O3/c1-20-15(25)21-9-3-5-11(18)13(7-9)22-16(26)23-14(24)10-4-2-8(17)6-12(10)19/h2-7H,1H3,(H2,20,21,25)(H2,22,23,24,26)
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n/an/a 158n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174374
PNG
(3-Chloro-4-[3-(2-chloro-4-fluoro-benzoyl)-ureido]-...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C15H9Cl2FN2O4/c16-10-6-8(18)2-3-9(10)13(21)20-15(24)19-12-4-1-7(14(22)23)5-11(12)17/h1-6H,(H,22,23)(H2,19,20,21,24)
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n/an/a 158n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174362
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-2-hydroxy...)
Show SMILES COc1cc(C(O)=O)c(O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C16H12ClFN2O6/c1-26-13-5-9(15(23)24)12(21)6-11(13)19-16(25)20-14(22)8-3-2-7(18)4-10(8)17/h2-6,21H,1H3,(H,23,24)(H2,19,20,22,25)
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n/an/a 158n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174374
PNG
(3-Chloro-4-[3-(2-chloro-4-fluoro-benzoyl)-ureido]-...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C15H9Cl2FN2O4/c16-10-6-8(18)2-3-9(10)13(21)20-15(24)19-12-4-1-7(14(22)23)5-11(12)17/h1-6H,(H,22,23)(H2,19,20,21,24)
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n/an/a 160n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174403
PNG
(1-{4-Chloro-3-[3-(2,4-dichloro-benzoyl)-ureido]-ph...)
Show SMILES CNC(=O)Nc1ccc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C16H13Cl3N4O3/c1-20-15(25)21-9-3-5-11(18)13(7-9)22-16(26)23-14(24)10-4-2-8(17)6-12(10)19/h2-7H,1H3,(H2,20,21,25)(H2,22,23,24,26)
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n/an/a 160n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174362
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-2-hydroxy...)
Show SMILES COc1cc(C(O)=O)c(O)cc1NC(=O)NC(=O)c1ccc(F)cc1Cl
Show InChI InChI=1S/C16H12ClFN2O6/c1-26-13-5-9(15(23)24)12(21)6-11(13)19-16(25)20-14(22)8-3-2-7(18)4-10(8)17/h2-6,21H,1H3,(H,23,24)(H2,19,20,22,25)
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n/an/a 160n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174368
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-[2-chloro-4-(1H-te...)
Show SMILES Fc1ccc(C(=O)NC(=O)Nc2ccc(cc2Cl)-c2nnn[nH]2)c(Cl)c1
Show InChI InChI=1S/C15H9Cl2FN6O2/c16-10-6-8(18)2-3-9(10)14(25)20-15(26)19-12-4-1-7(5-11(12)17)13-21-23-24-22-13/h1-6H,(H2,19,20,25,26)(H,21,22,23,24)
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n/an/a 190n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174368
PNG
(1-(2-Chloro-4-fluoro-benzoyl)-3-[2-chloro-4-(1H-te...)
Show SMILES Fc1ccc(C(=O)NC(=O)Nc2ccc(cc2Cl)-c2nnn[nH]2)c(Cl)c1
Show InChI InChI=1S/C15H9Cl2FN6O2/c16-10-6-8(18)2-3-9(10)14(25)20-15(26)19-12-4-1-7(5-11(12)17)13-21-23-24-22-13/h1-6H,(H2,19,20,25,26)(H,21,22,23,24)
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n/an/a 191n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174380
PNG
(4-Chloro-3-[3-(2,4-dichloro-benzoyl)-ureido]-N-met...)
Show SMILES CNC(=O)c1ccc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C16H12Cl3N3O3/c1-20-14(23)8-2-5-11(18)13(6-8)21-16(25)22-15(24)10-4-3-9(17)7-12(10)19/h2-7H,1H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 200n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174380
PNG
(4-Chloro-3-[3-(2,4-dichloro-benzoyl)-ureido]-N-met...)
Show SMILES CNC(=O)c1ccc(Cl)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C16H12Cl3N3O3/c1-20-14(23)8-2-5-11(18)13(6-8)21-16(25)22-15(24)10-4-3-9(17)7-12(10)19/h2-7H,1H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 200n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174388
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-methoxy...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1ccc(F)cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClFN2O5/c1-25-13-6-8(15(22)23)2-5-12(13)19-16(24)20-14(21)10-4-3-9(18)7-11(10)17/h2-7H,1H3,(H,22,23)(H2,19,20,21,24)
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n/an/a 209n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174388
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-methoxy...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1ccc(F)cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12ClFN2O5/c1-25-13-6-8(15(22)23)2-5-12(13)19-16(24)20-14(21)10-4-3-9(18)7-11(10)17/h2-7H,1H3,(H,22,23)(H2,19,20,21,24)
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n/an/a 210n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174369
PNG
(1-(2-Chloro-4,5-difluoro-benzoyl)-3-[2-methoxy-4-(...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl)-c1nnc(C)[nH]1
Show InChI InChI=1S/C18H14ClF2N5O3/c1-8-22-16(26-25-8)9-3-4-14(15(5-9)29-2)23-18(28)24-17(27)10-6-12(20)13(21)7-11(10)19/h3-7H,1-2H3,(H,22,25,26)(H2,23,24,27,28)
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n/an/a 250n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174369
PNG
(1-(2-Chloro-4,5-difluoro-benzoyl)-3-[2-methoxy-4-(...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1cc(F)c(F)cc1Cl)-c1nnc(C)[nH]1
Show InChI InChI=1S/C18H14ClF2N5O3/c1-8-22-16(26-25-8)9-3-4-14(15(5-9)29-2)23-18(28)24-17(27)10-6-12(20)13(21)7-11(10)19/h3-7H,1-2H3,(H,22,25,26)(H2,23,24,27,28)
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n/an/a 251n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174385
PNG
(3-[3-(2,4-Dichloro-benzoyl)-ureido]-4-methoxy-N-me...)
Show SMILES CNC(=O)c1ccc(OC)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O4/c1-20-15(23)9-3-6-14(26-2)13(7-9)21-17(25)22-16(24)11-5-4-10(18)8-12(11)19/h3-8H,1-2H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 300n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174395
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-methoxy...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1ccc(F)cc1Cl)C(N)=O
Show InChI InChI=1S/C16H13ClFN3O4/c1-25-13-6-8(14(19)22)2-5-12(13)20-16(24)21-15(23)10-4-3-9(18)7-11(10)17/h2-7H,1H3,(H2,19,22)(H2,20,21,23,24)
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n/an/a 300n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174395
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-3-methoxy...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1ccc(F)cc1Cl)C(N)=O
Show InChI InChI=1S/C16H13ClFN3O4/c1-25-13-6-8(14(19)22)2-5-12(13)20-16(24)21-15(23)10-4-3-9(18)7-11(10)17/h2-7H,1H3,(H2,19,22)(H2,20,21,23,24)
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n/an/a 302n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174385
PNG
(3-[3-(2,4-Dichloro-benzoyl)-ureido]-4-methoxy-N-me...)
Show SMILES CNC(=O)c1ccc(OC)c(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C17H15Cl2N3O4/c1-20-15(23)9-3-6-14(26-2)13(7-9)21-17(25)22-16(24)11-5-4-10(18)8-12(11)19/h3-8H,1-2H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 302n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174365
PNG
(4-[3-(2,4-Dichloro-benzoyl)-ureido]-3-methoxy-N-me...)
Show SMILES CNC(=O)c1ccc(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c(OC)c1
Show InChI InChI=1S/C17H15Cl2N3O4/c1-20-15(23)9-3-6-13(14(7-9)26-2)21-17(25)22-16(24)11-5-4-10(18)8-12(11)19/h3-8H,1-2H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 407n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174365
PNG
(4-[3-(2,4-Dichloro-benzoyl)-ureido]-3-methoxy-N-me...)
Show SMILES CNC(=O)c1ccc(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c(OC)c1
Show InChI InChI=1S/C17H15Cl2N3O4/c1-20-15(23)9-3-6-13(14(7-9)26-2)21-17(25)22-16(24)11-5-4-10(18)8-12(11)19/h3-8H,1-2H3,(H,20,23)(H2,21,22,24,25)
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n/an/a 410n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174391
PNG
(3-Chloro-4-[3-(2,4-dichloro-benzoyl)-ureido]-benzo...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C15H9Cl3N2O4/c16-8-2-3-9(10(17)6-8)13(21)20-15(24)19-12-4-1-7(14(22)23)5-11(12)18/h1-6H,(H,22,23)(H2,19,20,21,24)
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n/an/a 417n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174391
PNG
(3-Chloro-4-[3-(2,4-dichloro-benzoyl)-ureido]-benzo...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(Cl)cc2Cl)c(Cl)c1
Show InChI InChI=1S/C15H9Cl3N2O4/c16-8-2-3-9(10(17)6-8)13(21)20-15(24)19-12-4-1-7(14(22)23)5-11(12)18/h1-6H,(H,22,23)(H2,19,20,21,24)
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n/an/a 420n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174396
PNG
(4-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-3-(2,...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C17H10ClF5N2O5/c18-9-5-11(20)10(19)4-8(9)14(26)25-16(29)24-12-2-1-7(15(27)28)3-13(12)30-6-17(21,22)23/h1-5H,6H2,(H,27,28)(H2,24,25,26,29)
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n/an/a 447n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174396
PNG
(4-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-3-(2,...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2cc(F)c(F)cc2Cl)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C17H10ClF5N2O5/c18-9-5-11(20)10(19)4-8(9)14(26)25-16(29)24-12-2-1-7(15(27)28)3-13(12)30-6-17(21,22)23/h1-5H,6H2,(H,27,28)(H2,24,25,26,29)
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n/an/a 450n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174404
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-2-hydroxy...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)cc1O
Show InChI InChI=1S/C15H10ClFN2O5/c16-11-5-7(17)1-3-9(11)13(21)19-15(24)18-8-2-4-10(14(22)23)12(20)6-8/h1-6,20H,(H,22,23)(H2,18,19,21,24)
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n/an/a 510n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174398
PNG
(4-[3-(2,4-Dichloro-benzoyl)-ureido]-3-methoxy-benz...)
Show SMILES COc1cc(ccc1NC(=O)NC(=O)c1ccc(Cl)cc1Cl)C(O)=O
Show InChI InChI=1S/C16H12Cl2N2O5/c1-25-13-6-8(15(22)23)2-5-12(13)19-16(24)20-14(21)10-4-3-9(17)7-11(10)18/h2-7H,1H3,(H,22,23)(H2,19,20,21,24)
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n/an/a 510n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate upon incubating for 40 min at 25 de...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50174404
PNG
(4-[3-(2-Chloro-4-fluoro-benzoyl)-ureido]-2-hydroxy...)
Show SMILES OC(=O)c1ccc(NC(=O)NC(=O)c2ccc(F)cc2Cl)cc1O
Show InChI InChI=1S/C15H10ClFN2O5/c16-11-5-7(17)1-3-9(11)13(21)19-15(24)18-8-2-4-10(14(22)23)12(20)6-8/h1-6,20H,(H,22,23)(H2,18,19,21,24)
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n/an/a 513n/an/an/an/a7.2n/a



Sanofi-Aventis Deutschland GmbH

Curated by ChEMBL


Assay Description
Logarithmic inhibitory concentration against human liver glycogen phosphorylase enzyme by the addition of glucose-1-phosphate and incubated for 40 mi...

J Med Chem 48: 6178-93 (2005)


Article DOI: 10.1021/jm049034y
BindingDB Entry DOI: 10.7270/Q2FT8KJ5
More data for this
Ligand-Target Pair
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