Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.0330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Feline coronavirus (strain FIPV WSU-79/1146) (FCoV...) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (PEDV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-NL63) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-HKU1) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (MHV-A59) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-229E) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496902![]() (CVD-0018409 | PF-07321332 | US11351149, Example 13...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem | 3.11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (IBV) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496900![]() (science.abl4784, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 7.93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496901![]() (science.abl4784, 5) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496896![]() (US11312704, Compound 101 | US11351149, Example 49 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496897![]() (science.abl4784, 3) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM496901![]() (science.abl4784, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 85 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM496900![]() (science.abl4784, 4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 909 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM496897![]() (science.abl4784, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 5.59E+3 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM496896![]() (US11312704, Compound 101 | US11351149, Example 49 ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM496902![]() (CVD-0018409 | PF-07321332 | US11351149, Example 13...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid PDB UniChem | n/a | n/a | n/a | n/a | 75 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme 2 (Homo sapiens (Human)) | BDBM420298![]() (CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PDB UniChem | n/a | n/a | n/a | n/a | 231 | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description VeroE6 cells were sorted for ACE2 expression by flow cytometry to generate clonal VeroE6 cells that are enriched for ACE2 surface expression. The ACE... | Science 374: 1-13 (2021) BindingDB Entry DOI: 10.7270/Q23T9MCM | |||||||||||
More data for this Ligand-Target Pair |