Found 37 hits with Last Name = 'clerc' and Initial = 'ff' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50058202
((S)-2-[(2-{(S)-2-[((R)-2-Amino-3-mercapto-propiony...)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](N)CS)C(O)=O Show InChI InChI=1S/C24H36N4O5S2/c1-14(2)20(27(3)22(30)17(25)13-34)23(31)28-12-16-8-6-5-7-15(16)11-19(28)21(29)26-18(24(32)33)9-10-35-4/h5-8,14,17-20,34H,9-13,25H2,1-4H3,(H,26,29)(H,32,33)/t17-,18-,19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of Human farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284949
((S)-2-{[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexa...)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(O)=O Show InChI InChI=1S/C29H46N6O6S2/c1-17(2)23(34(3)28(39)26(42)33-24(36)20(31)11-7-8-13-30)27(38)35-16-19-10-6-5-9-18(19)15-22(35)25(37)32-21(29(40)41)12-14-43-4/h5-6,9-10,17,20-23,26,42H,7-8,11-16,30-31H2,1-4H3,(H,32,37)(H,33,36)(H,40,41)/t20-,21+,22+,23+,26+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50403479
(CHEMBL2115457)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22-,26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50059852
((S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropyla...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibiion of bovine farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50284165
((S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propyl...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O Show InChI InChI=1S/C22H36N4O4S2/c1-14(2)19(24-12-16(23)13-31)21(28)26-18(11-15-7-5-4-6-8-15)20(27)25-17(22(29)30)9-10-32-3/h4-8,14,16-19,24,31H,9-13,23H2,1-3H3,(H,25,27)(H,26,28)(H,29,30)/t16-,17+,18+,19+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay under reducing (+DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284951
((S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexan...)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)(C)C)C(O)=O Show InChI InChI=1S/C29H46N6O6S2/c1-29(2,3)22(33-25(38)26(42)34-23(36)19(31)11-7-8-13-30)27(39)35-16-18-10-6-5-9-17(18)15-21(35)24(37)32-20(28(40)41)12-14-43-4/h5-6,9-10,19-22,26,42H,7-8,11-16,30-31H2,1-4H3,(H,32,37)(H,33,38)(H,34,36)(H,40,41)/t19-,20+,21+,22-,26+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285838
(CHEMBL89836 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(O)=O Show InChI InChI=1S/C38H52N6O8S4/c1-53-15-11-29(37(49)50)41-35(47)31-19-25-7-3-5-9-27(25)23-43(31)33(45)21-39-13-17-55-56-18-14-40-22-34(46)44-24-28-10-6-4-8-26(28)20-32(44)36(48)42-30(38(51)52)12-16-54-2/h3-10,29-32,39-40H,11-24H2,1-2H3,(H,41,47)(H,42,48)(H,49,50)(H,51,52)/t29-,30-,31-,32-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM13373
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O |r| Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibiion of bovine farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM13373
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O |r| Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
MMDB
PC cid
PC sid
UniChem
Patents
Similars
| MMDB
Article
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay in non-reducing (-DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285846
((S)-2-({(S)-2-[2-(2-Mercapto-ethylamino)-acetyl]-1...)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCS)C(O)=O Show InChI InChI=1S/C19H27N3O4S2/c1-28-9-6-15(19(25)26)21-18(24)16-10-13-4-2-3-5-14(13)12-22(16)17(23)11-20-7-8-27/h2-5,15-16,20,27H,6-12H2,1H3,(H,21,24)(H,25,26)/t15-,16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285842
(CHEMBL420801 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC Show InChI InChI=1S/C40H56N6O8S4/c1-53-39(51)31(13-17-55-3)43-37(49)33-21-27-9-5-7-11-29(27)25-45(33)35(47)23-41-15-19-57-58-20-16-42-24-36(48)46-26-30-12-8-6-10-28(30)22-34(46)38(50)44-32(14-18-56-4)40(52)54-2/h5-12,31-34,41-42H,13-26H2,1-4H3,(H,43,49)(H,44,50)/t31-,32-,33-,34-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285837
((S)-2-({(S)-2-[2-(2-Mercapto-ethylamino)-acetyl]-1...)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCS Show InChI InChI=1S/C20H29N3O4S2/c1-27-20(26)16(7-10-29-2)22-19(25)17-11-14-5-3-4-6-15(14)13-23(17)18(24)12-21-8-9-28/h3-6,16-17,21,28H,7-13H2,1-2H3,(H,22,25)/t16-,17-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284952
((S)-2-((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexano...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C27H44N6O6S2/c1-16(2)21(32-25(37)26(40)33-22(34)18(29)11-7-8-13-28)24(36)31-20(15-17-9-5-4-6-10-17)23(35)30-19(27(38)39)12-14-41-3/h4-6,9-10,16,18-21,26,40H,7-8,11-15,28-29H2,1-3H3,(H,30,35)(H,31,36)(H,32,37)(H,33,34)(H,38,39)/t18-,19+,20+,21+,26+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284950
((S)-2-((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexano...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(C)(C)C)c1ccccc1)C(O)=O Show InChI InChI=1S/C27H44N6O6S2/c1-27(2,3)20(32-24(37)25(40)33-21(34)17(29)12-8-9-14-28)23(36)31-19(16-10-6-5-7-11-16)22(35)30-18(26(38)39)13-15-41-4/h5-7,10-11,17-20,25,40H,8-9,12-15,28-29H2,1-4H3,(H,30,35)(H,31,36)(H,32,37)(H,33,34)(H,38,39)/t17-,18+,19+,20-,25+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284948
((S)-2-[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexan...)Show SMILES CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)c1ccccc1)C(O)=O Show InChI InChI=1S/C27H44N6O6S2/c1-16(2)21(33(3)26(37)25(40)32-22(34)18(29)12-8-9-14-28)24(36)31-20(17-10-6-5-7-11-17)23(35)30-19(27(38)39)13-15-41-4/h5-7,10-11,16,18-21,25,40H,8-9,12-15,28-29H2,1-4H3,(H,30,35)(H,31,36)(H,32,34)(H,38,39)/t18-,19+,20+,21+,25+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50284953
((S)-2-[(S)-2-((S)-2-{[(S)-2-((R)-2,6-Diamino-hexan...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](S)NC(=O)[C@H](N)CCCCN)C(O)=O Show InChI InChI=1S/C28H46N6O6S2/c1-17(2)22(34(3)27(38)26(41)33-23(35)19(30)12-8-9-14-29)25(37)32-21(16-18-10-6-5-7-11-18)24(36)31-20(28(39)40)13-15-42-4/h5-7,10-11,17,19-22,26,41H,8-9,12-16,29-30H2,1-4H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20+,21+,22+,26+/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM13373
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O |r| Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of Human farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285845
(2-({2-[(2-Mercapto-ethylcarbamoyl)-methyl]-1,2,3,4...)Show SMILES CSCCC(NC(=O)C1Cc2ccccc2CN1CC(=O)NCCS)C(O)=O Show InChI InChI=1S/C19H27N3O4S2/c1-28-9-6-15(19(25)26)21-18(24)16-10-13-4-2-3-5-14(13)11-22(16)12-17(23)20-7-8-27/h2-5,15-16,27H,6-12H2,1H3,(H,20,23)(H,21,24)(H,25,26) | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50403478
(CHEMBL2115458)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H]1CCCN1C(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(O)=O Show InChI InChI=1S/C28H42N6O6S2/c1-42-14-11-20(28(39)40)31-24(36)22-15-17-7-2-3-8-18(17)16-34(22)26(37)21-10-6-13-33(21)27(38)25(41)32-23(35)19(30)9-4-5-12-29/h2-3,7-8,19-22,25,41H,4-6,9-16,29-30H2,1H3,(H,31,36)(H,32,35)(H,39,40)/t19-,20-,21-,22-,25-/m0/s1 | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50403477
(CHEMBL2115025)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22+,26-/m0/s1 | PDB
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| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50403477
(CHEMBL2115025)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](S)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C28H44N6O6S2/c1-16(2)22(32-25(37)26(41)33-23(35)19(30)10-6-7-12-29)27(38)34-15-18-9-5-4-8-17(18)14-21(34)24(36)31-20(28(39)40)11-13-42-3/h4-5,8-9,16,19-22,26,41H,6-7,10-15,29-30H2,1-3H3,(H,31,36)(H,32,37)(H,33,35)(H,39,40)/t19-,20-,21-,22+,26-/m0/s1 | PDB
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| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM13373
((2S)-2-[(2S)-2-[(2S)-2-[(2R)-2-amino-3-sulfanylpro...)Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CS)C(C)C)C(O)=O |r| Show InChI InChI=1S/C22H34N4O5S2/c1-13(2)18(26-19(27)15(23)12-32)21(29)25-17(11-14-7-5-4-6-8-14)20(28)24-16(22(30)31)9-10-33-3/h4-8,13,15-18,32H,9-12,23H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)(H,30,31)/t15-,16-,17-,18-/m0/s1 | PDB
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| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50213274
(CHEMBL3350314)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C29H46N6O6S2/c1-17(2)24(34-26(37)22(16-42)33-25(36)20(31)10-6-7-12-30)28(39)35-15-19-9-5-4-8-18(19)14-23(35)27(38)32-21(29(40)41)11-13-43-3/h4-5,8-9,17,20-24,42H,6-7,10-16,30-31H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)(H,40,41)/t20-,21-,22-,23-,24+/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50213274
(CHEMBL3350314)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(C)C)C(O)=O Show InChI InChI=1S/C29H46N6O6S2/c1-17(2)24(34-26(37)22(16-42)33-25(36)20(31)10-6-7-12-30)28(39)35-15-19-9-5-4-8-18(19)14-23(35)27(38)32-21(29(40)41)11-13-43-3/h4-5,8-9,17,20-24,42H,6-7,10-16,30-31H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)(H,40,41)/t20-,21-,22-,23-,24+/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285840
(CHEMBL412576 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C50H72N6O12S4/c1-49(2,3)67-47(63)53(31-41(57)55-29-35-17-13-11-15-33(35)27-39(55)43(59)51-37(19-23-69-9)45(61)65-7)21-25-71-72-26-22-54(48(64)68-50(4,5)6)32-42(58)56-30-36-18-14-12-16-34(36)28-40(56)44(60)52-38(20-24-70-10)46(62)66-8/h11-18,37-40H,19-32H2,1-10H3,(H,51,59)(H,52,60)/t37-,38-,39-,40-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285842
(CHEMBL420801 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC Show InChI InChI=1S/C40H56N6O8S4/c1-53-39(51)31(13-17-55-3)43-37(49)33-21-27-9-5-7-11-29(27)25-45(33)35(47)23-41-15-19-57-58-20-16-42-24-36(48)46-26-30-12-8-6-10-28(30)22-34(46)38(50)44-32(14-18-56-4)40(52)54-2/h5-12,31-34,41-42H,13-26H2,1-4H3,(H,43,49)(H,44,50)/t31-,32-,33-,34-/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay under reducing (+DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285843
((S)-2-[((S)-2-{2-[tert-Butoxycarbonyl-(2-mercapto-...)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCS)C(=O)OC(C)(C)C)C(O)=O Show InChI InChI=1S/C24H35N3O6S2/c1-24(2,3)33-23(32)26(10-11-34)15-20(28)27-14-17-8-6-5-7-16(17)13-19(27)21(29)25-18(22(30)31)9-12-35-4/h5-8,18-19,34H,9-15H2,1-4H3,(H,25,29)(H,30,31)/t18-,19-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50213273
(CHEMBL3350692)Show SMILES CSCC[C@H](NC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)C(O)=O Show InChI InChI=1S/C29H44N6O6S2/c1-43-14-11-21(29(40)41)32-26(37)24-15-18-7-2-3-8-19(18)16-35(24)28(39)23-10-6-13-34(23)27(38)22(17-42)33-25(36)20(31)9-4-5-12-30/h2-3,7-8,20-24,42H,4-6,9-17,30-31H2,1H3,(H,32,37)(H,33,36)(H,40,41)/t20-,21-,22-,23+,24+/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase (FTase) of rat brain |
Bioorg Med Chem Lett 5: 1779-1784 (1995)
Article DOI: 10.1016/0960-894X(95)00314-J
BindingDB Entry DOI: 10.7270/Q2H41RDH |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285841
(CHEMBL262383 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(O)=O Show InChI InChI=1S/C48H68N6O12S4/c1-47(2,3)65-45(63)51(29-39(55)53-27-33-15-11-9-13-31(33)25-37(53)41(57)49-35(43(59)60)17-21-67-7)19-23-69-70-24-20-52(46(64)66-48(4,5)6)30-40(56)54-28-34-16-12-10-14-32(34)26-38(54)42(58)50-36(44(61)62)18-22-68-8/h9-16,35-38H,17-30H2,1-8H3,(H,49,57)(H,50,58)(H,59,60)(H,61,62)/t35-,36-,37-,38-/m0/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285842
(CHEMBL420801 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC Show InChI InChI=1S/C40H56N6O8S4/c1-53-39(51)31(13-17-55-3)43-37(49)33-21-27-9-5-7-11-29(27)25-45(33)35(47)23-41-15-19-57-58-20-16-42-24-36(48)46-26-30-12-8-6-10-28(30)22-34(46)38(50)44-32(14-18-56-4)40(52)54-2/h5-12,31-34,41-42H,13-26H2,1-4H3,(H,43,49)(H,44,50)/t31-,32-,33-,34-/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay in non-reducing (-DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50285839
((S)-2-[((S)-2-{2-[tert-Butoxycarbonyl-(2-mercapto-...)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCS)C(=O)OC(C)(C)C Show InChI InChI=1S/C25H37N3O6S2/c1-25(2,3)34-24(32)27(11-12-35)16-21(29)28-15-18-9-7-6-8-17(18)14-20(28)22(30)26-19(10-13-36-5)23(31)33-4/h6-9,19-20,35H,10-16H2,1-5H3,(H,26,30)/t19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285838
(CHEMBL89836 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(O)=O Show InChI InChI=1S/C38H52N6O8S4/c1-53-15-11-29(37(49)50)41-35(47)31-19-25-7-3-5-9-27(25)23-43(31)33(45)21-39-13-17-55-56-18-14-40-22-34(46)44-24-28-10-6-4-8-26(28)20-32(44)36(48)42-30(38(51)52)12-16-54-2/h3-10,29-32,39-40H,11-24H2,1-2H3,(H,41,47)(H,42,48)(H,49,50)(H,51,52)/t29-,30-,31-,32-/m0/s1 | PDB
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| Article
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay under reducing (+DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285841
(CHEMBL262383 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(O)=O Show InChI InChI=1S/C48H68N6O12S4/c1-47(2,3)65-45(63)51(29-39(55)53-27-33-15-11-9-13-31(33)25-37(53)41(57)49-35(43(59)60)17-21-67-7)19-23-69-70-24-20-52(46(64)66-48(4,5)6)30-40(56)54-28-34-16-12-10-14-32(34)26-38(54)42(58)50-36(44(61)62)18-22-68-8/h9-16,35-38H,17-30H2,1-8H3,(H,49,57)(H,50,58)(H,59,60)(H,61,62)/t35-,36-,37-,38-/m0/s1 | PDB
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay in non-reducing (-DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285838
(CHEMBL89836 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CNCCSSCCNCC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(O)=O Show InChI InChI=1S/C38H52N6O8S4/c1-53-15-11-29(37(49)50)41-35(47)31-19-25-7-3-5-9-27(25)23-43(31)33(45)21-39-13-17-55-56-18-14-40-22-34(46)44-24-28-10-6-4-8-26(28)20-32(44)36(48)42-30(38(51)52)12-16-54-2/h3-10,29-32,39-40H,11-24H2,1-2H3,(H,41,47)(H,42,48)(H,49,50)(H,51,52)/t29-,30-,31-,32-/m0/s1 | PDB
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibiion of bovine farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285840
(CHEMBL412576 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C50H72N6O12S4/c1-49(2,3)67-47(63)53(31-41(57)55-29-35-17-13-11-15-33(35)27-39(55)43(59)51-37(19-23-69-9)45(61)65-7)21-25-71-72-26-22-54(48(64)68-50(4,5)6)32-42(58)56-30-36-18-14-12-16-34(36)28-40(56)44(60)52-38(20-24-70-10)46(62)66-8/h11-18,37-40H,19-32H2,1-10H3,(H,51,59)(H,52,60)/t37-,38-,39-,40-/m0/s1 | PDB
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay under reducing (+DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285841
(CHEMBL262383 | Pseudopeptide derivative)Show SMILES CSCC[C@H](NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(O)=O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)C(O)=O Show InChI InChI=1S/C48H68N6O12S4/c1-47(2,3)65-45(63)51(29-39(55)53-27-33-15-11-9-13-31(33)25-37(53)41(57)49-35(43(59)60)17-21-67-7)19-23-69-70-24-20-52(46(64)66-48(4,5)6)30-40(56)54-28-34-16-12-10-14-32(34)26-38(54)42(58)50-36(44(61)62)18-22-68-8/h9-16,35-38H,17-30H2,1-8H3,(H,49,57)(H,50,58)(H,59,60)(H,61,62)/t35-,36-,37-,38-/m0/s1 | PDB
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Similars
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
In vitro inhibiion of bovine farnesyl transferase |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Mus musculus) | BDBM50285840
(CHEMBL412576 | Pseudopeptide derivative)Show SMILES COC(=O)[C@H](CCSC)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CN(CCSSCCN(CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCSC)C(=O)OC)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C Show InChI InChI=1S/C50H72N6O12S4/c1-49(2,3)67-47(63)53(31-41(57)55-29-35-17-13-11-15-33(35)27-39(55)43(59)51-37(19-23-69-9)45(61)65-7)21-25-71-72-26-22-54(48(64)68-50(4,5)6)32-42(58)56-30-36-18-14-12-16-34(36)28-40(56)44(60)52-38(20-24-70-10)46(62)66-8/h11-18,37-40H,19-32H2,1-10H3,(H,51,59)(H,52,60)/t37-,38-,39-,40-/m0/s1 | PDB
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Similars
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of farnesyl transferase in NIH3T3 cell based assay in non-reducing (-DTT) conditions |
Bioorg Med Chem Lett 5: 2677-2682 (1995)
Article DOI: 10.1016/0960-894X(95)00482-9
BindingDB Entry DOI: 10.7270/Q2QC03GF |
More data for this
Ligand-Target Pair | |
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