Found 106 hits with Last Name = 'wágner' and Initial = 'g' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323373
(1,2-dicyclohexyl-3-(pyridin-3-yl)propan-1-one O-3-...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2cccnc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C27H34ClN3O2/c28-23-14-7-15-24(18-23)30-27(32)33-31-26(22-12-5-2-6-13-22)25(21-10-3-1-4-11-21)17-20-9-8-16-29-19-20/h7-9,14-16,18-19,21-22,25H,1-6,10-13,17H2,(H,30,32)/b31-26+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM86716
(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)Show InChI InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGLUR1 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM86716
(CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...)Show InChI InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Binding affinity to human mGluR5 |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323380
((1,2-dicyclohexyl-3-(6-thioxocyclohexa-1,3-dienyl)...)Show SMILES Cc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C27H36N2O2S/c1-20-10-8-15-23(18-20)28-27(30)31-29-26(22-13-6-3-7-14-22)25(19-24-16-9-17-32-24)21-11-4-2-5-12-21/h8-10,15-18,21-22,25H,2-7,11-14,19H2,1H3,(H,28,30)/b29-26+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323371
((+)-1,2-dicyclohexyl-3-(1H-imidazol-1-yl)propan-1-...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cn2ccnc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C25H33ClN4O2/c26-21-12-7-13-22(16-21)28-25(31)32-29-24(20-10-5-2-6-11-20)23(17-30-15-14-27-18-30)19-8-3-1-4-9-19/h7,12-16,18-20,23H,1-6,8-11,17H2,(H,28,31)/b29-24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8.78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323378
((3-chlorophenylamino)(1,2-dicyclohexyl-3-(6-thioxo...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C26H33ClN2O2S/c27-21-13-7-14-22(17-21)28-26(30)31-29-25(20-11-5-2-6-12-20)24(18-23-15-8-16-32-23)19-9-3-1-4-10-19/h7-8,13-17,19-20,24H,1-6,9-12,18H2,(H,28,30)/b29-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397487
(US9994525, Example 3)Show InChI InChI=1S/C21H32N2O3/c1-18(24)23-15-10-21(11-16-23)26-20-8-6-19(7-9-20)25-17-5-14-22-12-3-2-4-13-22/h6-9,21H,2-5,10-17H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397490
(US9994525, Example 5)Show SMILES CC1(CC1)C(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C24H36N2O3/c1-24(12-13-24)23(27)26-17-10-22(11-18-26)29-21-8-6-20(7-9-21)28-19-5-16-25-14-3-2-4-15-25/h6-9,22H,2-5,10-19H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397495
(US9994525, Example 10)Show InChI InChI=1S/C19H30N2O2/c1-16-4-2-13-21(16)14-3-15-22-17-5-7-18(8-6-17)23-19-9-11-20-12-10-19/h5-8,16,19-20H,2-4,9-15H2,1H3/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397497
(US9994525, Example 12)Show SMILES C[C@@H]1CCCN1CCCOc1ccc(OC2CCN(CC2)C(=O)C2CCC2)cc1 |r| Show InChI InChI=1S/C24H36N2O3/c1-19-5-3-14-25(19)15-4-18-28-21-8-10-22(11-9-21)29-23-12-16-26(17-13-23)24(27)20-6-2-7-20/h8-11,19-20,23H,2-7,12-18H2,1H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397498
(US9994525, Example 13)Show SMILES C[C@@H]1CCCN1CCCOc1ccc(OC2CCN(CC2)C(=O)C2(C)CC2)cc1 |r| Show InChI InChI=1S/C24H36N2O3/c1-19-5-3-14-25(19)15-4-18-28-20-6-8-21(9-7-20)29-22-10-16-26(17-11-22)23(27)24(2)12-13-24/h6-9,19,22H,3-5,10-18H2,1-2H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397499
(US9994525, Example 14)Show SMILES CCOC(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H34N2O4/c1-3-26-22(25)24-15-11-21(12-16-24)28-20-9-7-19(8-10-20)27-17-5-14-23-13-4-6-18(23)2/h7-10,18,21H,3-6,11-17H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397500
(US9994525, Example 15)Show SMILES CCNC(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C22H35N3O3/c1-3-23-22(26)25-15-11-21(12-16-25)28-20-9-7-19(8-10-20)27-17-5-14-24-13-4-6-18(24)2/h7-10,18,21H,3-6,11-17H2,1-2H3,(H,23,26)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397501
(US9994525, Example 16)Show SMILES CCN(C)C(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCC[C@H]2C)cc1 |r| Show InChI InChI=1S/C23H37N3O3/c1-4-24(3)23(27)26-16-12-22(13-17-26)29-21-10-8-20(9-11-21)28-18-6-15-25-14-5-7-19(25)2/h8-11,19,22H,4-7,12-18H2,1-3H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323379
((1,2-dicyclohexyl-3-(6-thioxocyclohexa-1,3-dienyl)...)Show SMILES Fc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C26H33FN2O2S/c27-21-13-7-14-22(17-21)28-26(30)31-29-25(20-11-5-2-6-12-20)24(18-23-15-8-16-32-23)19-9-3-1-4-10-19/h7-8,13-17,19-20,24H,1-6,9-12,18H2,(H,28,30)/b29-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323377
((3-chlorophenylamino)(1,2-dicyclohexyl-3-(5-thioxo...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccsc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C26H33ClN2O2S/c27-22-12-7-13-23(17-22)28-26(30)31-29-25(21-10-5-2-6-11-21)24(16-19-14-15-32-18-19)20-8-3-1-4-9-20/h7,12-15,17-18,20-21,24H,1-6,8-11,16H2,(H,28,30)/b29-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323375
(CHEMBL1209400 | c1,2-dicyclohexyl-3-(1H-pyrrol-3-y...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2cc[nH]c2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C26H34ClN3O2/c27-22-12-7-13-23(17-22)29-26(31)32-30-25(21-10-5-2-6-11-21)24(16-19-14-15-28-18-19)20-8-3-1-4-9-20/h7,12-15,17-18,20-21,24,28H,1-6,8-11,16H2,(H,29,31)/b30-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323365
(1,2-dicyclohexyl-3-phenylpropan-1-one O-3-chloroph...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccccc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C28H35ClN2O2/c29-24-17-10-18-25(20-24)30-28(32)33-31-27(23-15-8-3-9-16-23)26(22-13-6-2-7-14-22)19-21-11-4-1-5-12-21/h1,4-5,10-12,17-18,20,22-23,26H,2-3,6-9,13-16,19H2,(H,30,32)/b31-27+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397493
(US9994525, Example 8)Show SMILES CCN(C)C(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C23H37N3O3/c1-3-24(2)23(27)26-17-12-22(13-18-26)29-21-10-8-20(9-11-21)28-19-7-16-25-14-5-4-6-15-25/h8-11,22H,3-7,12-19H2,1-2H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397494
(US9994525, Example 9)Show SMILES C[C@@H]1CCCN1CCCOc1ccc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc1 |r| Show InChI InChI=1S/C24H38N2O4/c1-19-7-5-14-25(19)15-6-18-28-20-8-10-21(11-9-20)29-22-12-16-26(17-13-22)23(27)30-24(2,3)4/h8-11,19,22H,5-7,12-18H2,1-4H3/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397496
(US9994525, Example 11)Show SMILES C[C@@H]1CCCN1CCCOc1ccc(OC2CCN(CC2)C(C)=O)cc1 |r| Show InChI InChI=1S/C21H32N2O3/c1-17-5-3-12-22(17)13-4-16-25-19-6-8-20(9-7-19)26-21-10-14-23(15-11-21)18(2)24/h6-9,17,21H,3-5,10-16H2,1-2H3/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397475
(US9994525, Example 1)Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)Oc1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C24H38N2O4/c1-24(2,3)30-23(27)26-17-12-22(13-18-26)29-21-10-8-20(9-11-21)28-19-7-16-25-14-5-4-6-15-25/h8-11,22H,4-7,12-19H2,1-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397476
(US9994525, Example 2)Show InChI InChI=1S/C19H30N2O2/c1-2-13-21(14-3-1)15-4-16-22-17-5-7-18(8-6-17)23-19-9-11-20-12-10-19/h5-8,19-20H,1-4,9-16H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397489
(US9994525, Example 4)Show SMILES O=C(C1CCC1)N1CCC(CC1)Oc1ccc(OCCCN2CCCCC2)cc1 Show InChI InChI=1S/C24H36N2O3/c27-24(20-6-4-7-20)26-17-12-23(13-18-26)29-22-10-8-21(9-11-22)28-19-5-16-25-14-2-1-3-15-25/h8-11,20,23H,1-7,12-19H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323363
(1,2-dicyclohexyl-3-phenylpropan-1-one O-m-tolylcar...)Show SMILES Cc1cccc(NC(=O)O\N=C(\C(Cc2ccccc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C29H38N2O2/c1-22-12-11-19-26(20-22)30-29(32)33-31-28(25-17-9-4-10-18-25)27(24-15-7-3-8-16-24)21-23-13-5-2-6-14-23/h2,5-6,11-14,19-20,24-25,27H,3-4,7-10,15-18,21H2,1H3,(H,30,32)/b31-28+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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PC sid
UniChem
Similars
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PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397491
(US9994525, Example 6)Show InChI InChI=1S/C22H34N2O4/c1-2-26-22(25)24-16-11-21(12-17-24)28-20-9-7-19(8-10-20)27-18-6-15-23-13-4-3-5-14-23/h7-10,21H,2-6,11-18H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM397492
(US9994525, Example 7)Show InChI InChI=1S/C22H35N3O3/c1-2-23-22(26)25-16-11-21(12-17-25)28-20-9-7-19(8-10-20)27-18-6-15-24-13-4-3-5-14-24/h7-10,21H,2-6,11-18H2,1H3,(H,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| US Patent
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University
| Assay Description
Receptor binding assays were performed in at least 5 concentrations, with two parallel samples in each concentrations, in at least two independent ex... |
Bioorg Med Chem 17: 2461-75 (2009)
BindingDB Entry DOI: 10.7270/Q2RN3B6Z |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323370
(1,2-dicyclohexyl-3-(1H-imidazol-1-yl)propan-1-one ...)Show SMILES Fc1cccc(NC(=O)O\N=C(\C(Cn2ccnc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C25H33FN4O2/c26-21-12-7-13-22(16-21)28-25(31)32-29-24(20-10-5-2-6-11-20)23(17-30-15-14-27-18-30)19-8-3-1-4-9-19/h7,12-16,18-20,23H,1-6,8-11,17H2,(H,28,31)/b29-24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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PC sid
UniChem
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PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50084137
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3 | PDB
UniProtKB/SwissProt
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PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at human mGLUR1 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50084137
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
MCE
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UniChem
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| Article
PubMed
| 36.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Binding affinity to human mGluR5 |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323369
(3-((1,2-dicyclohexyl-3-(1H-imidazol-1-yl)propylide...)Show SMILES O=C(Nc1cccc(c1)C#N)O\N=C(\C(Cn1ccnc1)C1CCCCC1)C1CCCCC1 Show InChI InChI=1S/C26H33N5O2/c27-17-20-8-7-13-23(16-20)29-26(32)33-30-25(22-11-5-2-6-12-22)24(18-31-15-14-28-19-31)21-9-3-1-4-10-21/h7-8,13-16,19,21-22,24H,1-6,9-12,18H2,(H,29,32)/b30-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323374
(1,2-dicyclohexyl-3-(pyridin-2-yl)propan-1-one O-3-...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccccn2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C27H34ClN3O2/c28-22-14-9-16-24(18-22)30-27(32)33-31-26(21-12-5-2-6-13-21)25(20-10-3-1-4-11-20)19-23-15-7-8-17-29-23/h7-9,14-18,20-21,25H,1-6,10-13,19H2,(H,30,32)/b31-26+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323366
(1,2-dicyclohexyl-3-(3-fluorophenyl)propan-1-one O-...)Show SMILES Fc1cccc(CC(C2CCCCC2)C(=N\OC(=O)Nc2cccc(Cl)c2)\C2CCCCC2)c1 Show InChI InChI=1S/C28H34ClFN2O2/c29-23-14-8-16-25(19-23)31-28(33)34-32-27(22-12-5-2-6-13-22)26(21-10-3-1-4-11-21)18-20-9-7-15-24(30)17-20/h7-9,14-17,19,21-22,26H,1-6,10-13,18H2,(H,31,33)/b32-27+ | PDB
MMDB
Reactome pathway
KEGG
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UniChem
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PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323372
(1,2-dicyclohexyl-3-(4-methyl-1H-imidazol-1-yl)prop...)Show SMILES Cc1cn(CC(C2CCCCC2)C(=N\OC(=O)Nc2cccc(Cl)c2)\C2CCCCC2)cn1 Show InChI InChI=1S/C26H35ClN4O2/c1-19-16-31(18-28-19)17-24(20-9-4-2-5-10-20)25(21-11-6-3-7-12-21)30-33-26(32)29-23-14-8-13-22(27)15-23/h8,13-16,18,20-21,24H,2-7,9-12,17H2,1H3,(H,29,32)/b30-25+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416269
(CHEMBL1082329)Show SMILES Clc1cccc(c1)-n1nnc(n1)C1CCCCN1C(=O)c1ccc(Br)o1 Show InChI InChI=1S/C17H15BrClN5O2/c18-15-8-7-14(26-15)17(25)23-9-2-1-6-13(23)16-20-22-24(21-16)12-5-3-4-11(19)10-12/h3-5,7-8,10,13H,1-2,6,9H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 49.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323364
(1,2-dicyclohexyl-3-(3-fluorophenyl)propan-1-one O-...)Show SMILES Cc1cccc(NC(=O)O\N=C(\C(Cc2cccc(F)c2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C29H37FN2O2/c1-21-10-8-17-26(18-21)31-29(33)34-32-28(24-14-6-3-7-15-24)27(23-12-4-2-5-13-23)20-22-11-9-16-25(30)19-22/h8-11,16-19,23-24,27H,2-7,12-15,20H2,1H3,(H,31,33)/b32-28+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416264
(CHEMBL1082987)Show SMILES Clc1cccc(c1)-n1nnc(n1)[C@H]1CCCCN1C(=O)C1CCC1 |r| Show InChI InChI=1S/C17H20ClN5O/c18-13-7-4-8-14(11-13)23-20-16(19-21-23)15-9-1-2-10-22(15)17(24)12-5-3-6-12/h4,7-8,11-12,15H,1-3,5-6,9-10H2/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 57.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416276
(CHEMBL1082975)Show InChI InChI=1S/C18H23N5O/c1-13-6-4-9-15(12-13)23-20-17(19-21-23)16-10-2-3-11-22(16)18(24)14-7-5-8-14/h4,6,9,12,14,16H,2-3,5,7-8,10-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 72.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416263
(CHEMBL1086591)Show SMILES Clc1cccc(c1)-n1nnc(n1)[C@@H]1CCCCN1C(=O)C1CCC1 |r| Show InChI InChI=1S/C17H20ClN5O/c18-13-7-4-8-14(11-13)23-20-16(19-21-23)15-9-1-2-10-22(15)17(24)12-5-3-6-12/h4,7-8,11-12,15H,1-3,5-6,9-10H2/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 77.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323368
(1,2-dicyclohexyl-3-(1H-imidazol-1-yl)propan-1-one ...)Show SMILES FC(F)(F)c1cccc(NC(=O)O\N=C(\C(Cn2ccnc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C26H33F3N4O2/c27-26(28,29)21-12-7-13-22(16-21)31-25(34)35-32-24(20-10-5-2-6-11-20)23(17-33-15-14-30-18-33)19-8-3-1-4-9-19/h7,12-16,18-20,23H,1-6,8-11,17H2,(H,31,34)/b32-24+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416265
(CHEMBL1083340)Show SMILES Cc1ccc(s1)C(=O)N1CSCC1c1nc(no1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H14ClN3O2S2/c1-10-5-6-14(25-10)17(22)21-9-24-8-13(21)16-19-15(20-23-16)11-3-2-4-12(18)7-11/h2-7,13H,8-9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 83.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416270
(CHEMBL1082976)Show InChI InChI=1S/C18H22ClN5O/c19-14-8-5-9-15(12-14)24-21-17(20-22-24)16-10-3-4-11-23(16)18(25)13-6-1-2-7-13/h5,8-9,12-13,16H,1-4,6-7,10-11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 87.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323381
((1,2-dicyclohexyl-3-(6-thioxocyclohexa-1,3-dienyl)...)Show SMILES COc1cccc(NC(=O)O\N=C(\C(Cc2cccs2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C27H36N2O3S/c1-31-23-15-8-14-22(18-23)28-27(30)32-29-26(21-12-6-3-7-13-21)25(19-24-16-9-17-33-24)20-10-4-2-5-11-20/h8-9,14-18,20-21,25H,2-7,10-13,19H2,1H3,(H,28,30)/b29-26+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416260
(CHEMBL1083598)Show SMILES Cc1ccc(s1)C(=O)N1CCCC1c1nnn(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H16ClN5OS/c1-11-7-8-15(25-11)17(24)22-9-3-6-14(22)16-19-21-23(20-16)13-5-2-4-12(18)10-13/h2,4-5,7-8,10,14H,3,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 89.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416271
(CHEMBL1084474)Show InChI InChI=1S/C19H25N5O/c1-14-7-6-10-16(13-14)24-21-18(20-22-24)17-11-4-5-12-23(17)19(25)15-8-2-3-9-15/h6-7,10,13,15,17H,2-5,8-9,11-12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 102 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323382
((E)-2-((1H-imidazol-1-yl)methyl)cyclohexanone O-ph...)Show InChI InChI=1S/C17H20N4O2/c22-17(19-15-7-2-1-3-8-15)23-20-16-9-5-4-6-14(16)12-21-11-10-18-13-21/h1-3,7-8,10-11,13-14H,4-6,9,12H2,(H,19,22)/b20-16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 104 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from rat mGLUR5 |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416272
(CHEMBL1084475)Show SMILES Cc1ccc(o1)C(=O)N1CCCC1c1nnn(n1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H16ClN5O2/c1-11-7-8-15(25-11)17(24)22-9-3-6-14(22)16-19-21-23(20-16)13-5-2-4-12(18)10-13/h2,4-5,7-8,10,14H,3,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50323387
(1,2-dicyclohexyl-3-(pyridin-4-yl)propan-1-one O-3-...)Show SMILES Clc1cccc(NC(=O)O\N=C(\C(Cc2ccncc2)C2CCCCC2)C2CCCCC2)c1 Show InChI InChI=1S/C27H34ClN3O2/c28-23-12-7-13-24(19-23)30-27(32)33-31-26(22-10-5-2-6-11-22)25(21-8-3-1-4-9-21)18-20-14-16-29-17-15-20/h7,12-17,19,21-22,25H,1-6,8-11,18H2,(H,30,32)/b31-26+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Antagonist activity at mGLUR5 in rat E17 cells assessed as calcium accumulation by fluorimetry |
Bioorg Med Chem Lett 20: 4371-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.075
BindingDB Entry DOI: 10.7270/Q2G1611F |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416275
(CHEMBL1083341)Show SMILES Cc1ccc(s1)C(=O)N1CCCC1c1nc(no1)-c1cccc(Cl)c1 Show InChI InChI=1S/C18H16ClN3O2S/c1-11-7-8-15(25-11)18(23)22-9-3-6-14(22)17-20-16(21-24-17)12-4-2-5-13(19)10-12/h2,4-5,7-8,10,14H,3,6,9H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 123 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50416279
(CHEMBL1084476)Show InChI InChI=1S/C17H16ClN5O2/c18-12-5-3-6-13(11-12)23-20-16(19-21-23)14-7-1-2-9-22(14)17(24)15-8-4-10-25-15/h3-6,8,10-11,14H,1-2,7,9H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gedeon Richter Plc
Curated by ChEMBL
| Assay Description
Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranes |
Bioorg Med Chem Lett 20: 3737-41 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.075
BindingDB Entry DOI: 10.7270/Q2FX7BPQ |
More data for this
Ligand-Target Pair | |
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