Found 8 hits with Last Name = 'savage' and Initial = 'gp' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50535485
(CHEMBL4594145)Show SMILES CC1(O)CC(c2c(O1)c1ccccc1oc2=O)/C1=C/C=C\C=C/C=C\1 |c:22,24,26,t:20| Show InChI InChI=1S/C21H18O4/c1-21(23)13-16(14-9-5-3-2-4-6-10-14)18-19(25-21)15-11-7-8-12-17(15)24-20(18)22/h2-12,16,23H,13H2,1H3/b3-2-,4-2-,5-3-,6-4-,9-5-,10-6-,14-9+,14-10+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50343352
(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)Show InChI InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50535487
(CHEMBL4530669)Show SMILES C[C@]1(O)C[C@H](/C2=C/C=C\C=C/C=C\2)[C@]2(COc3ccccc3C2=O)n2n1c(=O)n(-c1ccccc1)c2=O |r,c:7,9,11,t:5| Show InChI InChI=1S/C29H25N3O5/c1-28(36)18-23(20-12-6-3-2-4-7-13-20)29(19-37-24-17-11-10-16-22(24)25(29)33)32-27(35)30(26(34)31(28)32)21-14-8-5-9-15-21/h2-17,23,36H,18-19H2,1H3/b3-2-,4-2-,6-3-,7-4-,12-6-,13-7-,20-12+,20-13+/t23-,28+,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50535484
(CHEMBL4517532)Show InChI InChI=1S/C21H26O4/c1-14(22)13-17(15-9-5-3-2-4-6-10-15)19-20(23)16-11-7-8-12-18(16)25-21(19)24/h7-8,11-12,15,17,23H,2-6,9-10,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50535488
(CHEMBL4443961)Show InChI InChI=1S/C19H22O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h5-6,9-10,13,15,21H,2-4,7-8,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Vitamin K epoxide reductase complex subunit 1
(Homo sapiens (Human)) | BDBM50535486
(CHEMBL4463800)Show SMILES CC(=O)CC(c1c(O)c2ccccc2oc1=O)/C1=C/C=C(\C=C/C=C\1)/C(O)=O |c:21,23,25,t:19| Show InChI InChI=1S/C22H18O6/c1-13(23)12-17(14-6-2-3-7-15(11-10-14)21(25)26)19-20(24)16-8-4-5-9-18(16)28-22(19)27/h2-11,17,24H,12H2,1H3,(H,25,26)/b3-2-,6-2-,7-3-,11-10-,14-6+,14-10+,15-7+,15-11+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Queensland
Curated by ChEMBL
| Assay Description
Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA |
Bioorg Med Chem Lett 29: 1954-1956 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.039
BindingDB Entry DOI: 10.7270/Q2TQ652J |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50553414
(CHEMBL4777282)Show SMILES FC(F)Oc1ccc(cc1)-c1nnc2cncc(OCCC34C5C6C7C5C3C7C46)n12 |(27.46,-3.21,;27,-4.67,;28.03,-5.81,;25.5,-5,;25.03,-6.46,;23.53,-6.79,;23.06,-8.25,;24.1,-9.39,;25.6,-9.07,;26.06,-7.61,;23.62,-10.85,;24.53,-12.09,;23.62,-13.34,;22.15,-12.87,;20.82,-13.63,;19.49,-12.86,;19.49,-11.32,;20.82,-10.54,;20.82,-9.01,;19.49,-8.25,;19.49,-6.71,;18.17,-5.95,;16.95,-6.87,;17.13,-5.34,;16.2,-4.11,;16,-5.65,;17.24,-4.72,;17.43,-3.18,;18.36,-4.41,;22.15,-11.32,)| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ERG |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00746
BindingDB Entry DOI: 10.7270/Q2GB27QG |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50553415
(CHEMBL4780715)Show SMILES FC(F)Oc1ccc(cc1)-c1nnc2cncc(OCCc3ccccc3)n12 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ERG |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00746
BindingDB Entry DOI: 10.7270/Q2GB27QG |
More data for this
Ligand-Target Pair | |
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