Found 11 hits with Last Name = 'smith' and Initial = 'hd' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM82258
(CAS_114798-26-4 | Losartan | NSC_3961)Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470654
(CHEMBL141019)Show SMILES CCc1cc(Sc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c2ncccc2n1 Show InChI InChI=1S/C23H18N6S/c1-2-16-14-21(22-20(25-16)8-5-13-24-22)30-17-11-9-15(10-12-17)18-6-3-4-7-19(18)23-26-28-29-27-23/h3-14H,2H2,1H3,(H,26,27,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50003392
(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)Show SMILES Cc1cc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C24H19N5O/c1-16-14-23(21-8-4-5-9-22(21)25-16)30-15-17-10-12-18(13-11-17)19-6-2-3-7-20(19)24-26-28-29-27-24/h2-14H,15H2,1H3,(H,26,27,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50029659
(2-Methyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylsul...)Show SMILES Cc1cc(Sc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C23H17N5S/c1-15-14-22(20-8-4-5-9-21(20)24-15)29-17-12-10-16(11-13-17)18-6-2-3-7-19(18)23-25-27-28-26-23/h2-14H,1H3,(H,25,26,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50003391
(2-Methyl-4-{2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)Show SMILES Cc1cc(CCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C25H21N5/c1-17-16-20(22-7-4-5-9-24(22)26-17)15-12-18-10-13-19(14-11-18)21-6-2-3-8-23(21)25-27-29-30-28-25/h2-11,13-14,16H,12,15H2,1H3,(H,27,28,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470658
(CHEMBL142409)Show SMILES Cc1nc(Sc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c2ccccc2n1 Show InChI InChI=1S/C22H16N6S/c1-14-23-20-9-5-4-8-19(20)22(24-14)29-16-12-10-15(11-13-16)17-6-2-3-7-18(17)21-25-27-28-26-21/h2-13H,1H3,(H,25,26,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50003406
(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)Show SMILES Cc1cc(SCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C24H19N5S/c1-16-14-23(21-8-4-5-9-22(21)25-16)30-15-17-10-12-18(13-11-17)19-6-2-3-7-20(19)24-26-28-29-27-24/h2-14H,15H2,1H3,(H,26,27,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470655
(CHEMBL341724)Show InChI InChI=1S/C19H15N5S/c1-13-12-16(10-11-20-13)25-15-8-6-14(7-9-15)17-4-2-3-5-18(17)19-21-23-24-22-19/h2-12H,1H3,(H,21,22,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470656
(CHEMBL358791)Show SMILES Cc1cc(Sc2ccc(cc2)-c2ccccc2-c2nnn(n2)C(c2ccccc2)(c2ccccc2)c2ccccc2)c2ccccc2n1 Show InChI InChI=1S/C42H31N5S/c1-30-29-40(38-23-13-14-24-39(38)43-30)48-35-27-25-31(26-28-35)36-21-11-12-22-37(36)41-44-46-47(45-41)42(32-15-5-2-6-16-32,33-17-7-3-8-18-33)34-19-9-4-10-20-34/h2-29H,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470659
(CHEMBL358044)Show SMILES Cc1cc(c2ccccc2[n+]1[O-])S(=O)(=O)c1ccc(cc1)-c1ccccc1-c1nn[nH]n1 Show InChI InChI=1S/C23H17N5O3S/c1-15-14-22(20-8-4-5-9-21(20)28(15)29)32(30,31)17-12-10-16(11-13-17)18-6-2-3-7-19(18)23-24-26-27-25-23/h2-14H,1H3,(H,24,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor
(RAT) | BDBM50470657
(CHEMBL142300)Show SMILES Cc1nc(Sc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c2cc[nH]c2n1 Show InChI InChI=1S/C20H15N7S/c1-12-22-18-17(10-11-21-18)20(23-12)28-14-8-6-13(7-9-14)15-4-2-3-5-16(15)19-24-26-27-25-19/h2-11H,1H3,(H,21,22,23)(H,24,25,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co.
Curated by ChEMBL
| Assay Description
Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats |
J Med Chem 38: 4670-8 (1995)
Article DOI: 10.1021/jm00023a006
BindingDB Entry DOI: 10.7270/Q21J9DHJ |
More data for this
Ligand-Target Pair | |
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