Found 268 hits with Last Name = 'velter' and Initial = 'i' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547789
(CHEMBL4794209)Show SMILES C[C@@H]1CCN(C[C@H]1c1cc(nc2ncnn12)C(F)F)C(=O)c1ccc2occc2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547752
(CHEMBL4797113)Show SMILES CC1CCN(CC1c1cc(nc2ncnn12)C(F)F)C(=O)c1ccc2occc2c1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547793
(CHEMBL4741218)Show SMILES C[C@@H]1CCN(C[C@H]1c1cc(nc2ncnn12)C(F)F)c1cc(ccn1)-c1ccccc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547769
(CHEMBL4758144)Show SMILES CS(=O)(=O)n1ccc2cc(ccc12)C(=O)N1CCC[C@@H](C1)c1ccnc2ncnn12 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547790
(CHEMBL4754478)Show SMILES COc1ccc(cc1OC)C(=O)N1CC[C@@H](C)[C@@H](C1)c1cc(nc2ncnn12)C(F)F |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547765
(CHEMBL4783572)Show SMILES CC(=O)n1ccc2cc(ccc12)C(=O)N1CCCC(C1)c1ccnc2ncnn12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547766
(CHEMBL4788385)Show SMILES CS(=O)(=O)n1ccc2cc(ccc12)C(=O)N1CCCC(C1)c1ccnc2ncnn12 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547751
(CHEMBL4755779)Show SMILES FC(F)c1cc(C2CCCN(C2)C(=O)c2cc3CCCCc3s2)n2ncnc2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547775
(CHEMBL4742646)Show SMILES Cc1cc(C2CCCN(C2)C(=O)c2cc3CCCCc3s2)n2ncnc2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036330
(CHEMBL3353090)Show SMILES COc1cc(Nc2nc(nn2C)-c2ccc(c(OC)c2)-n2cnc(C)c2)cc(c1)C(F)(F)F Show InChI InChI=1S/C22H21F3N6O2/c1-13-11-31(12-26-13)18-6-5-14(7-19(18)33-4)20-28-21(30(2)29-20)27-16-8-15(22(23,24)25)9-17(10-16)32-3/h5-12H,1-4H3,(H,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036340
(CHEMBL3353100)Show SMILES COc1nc(ccc1-n1cnc(C)c1)-c1nc(Nc2cccc(c2)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C20H18F3N7O/c1-12-10-30(11-24-12)16-8-7-15(26-18(16)31-3)17-27-19(29(2)28-17)25-14-6-4-5-13(9-14)20(21,22)23/h4-11H,1-3H3,(H,25,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547778
(CHEMBL4761452)Show SMILES O=C(N1CCCC(C1)c1cc(nc2ncnn12)C#N)c1cc2CCCCc2s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547767
(CHEMBL4761967)Show SMILES O=C(N1CCC[C@@H](C1)c1ccnc2ncnn12)c1cc2CCCCc2s1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036336
(CHEMBL3352824)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(ccc2F)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C21H18F4N6O/c1-12-10-31(11-26-12)17-7-4-13(8-18(17)32-3)19-28-20(30(2)29-19)27-16-9-14(21(23,24)25)5-6-15(16)22/h4-11H,1-3H3,(H,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522626
(CHEMBL4451760)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1cccc(F)c1C)C#N |r| Show InChI InChI=1S/C23H19FN4O2/c1-13-15(4-3-5-17(13)24)22-23-27-20(12-28(23)8-9-30-22)19-10-16-18(26-19)7-6-14(11-25)21(16)29-2/h3-7,10,12,22,26H,8-9H2,1-2H3/t22-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036326
(CHEMBL3353086)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2cccc(c2)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C21H19F3N6O/c1-13-11-30(12-25-13)17-8-7-14(9-18(17)31-3)19-27-20(29(2)28-19)26-16-6-4-5-15(10-16)21(22,23)24/h4-12H,1-3H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522642
(CHEMBL4471286)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2C[C@H](C)C[C@H](c2n1)c1ccccc1Cl)C#N |r| Show InChI InChI=1S/C24H21ClN4O/c1-14-9-17(16-5-3-4-6-19(16)25)24-28-22(13-29(24)12-14)21-10-18-20(27-21)8-7-15(11-26)23(18)30-2/h3-8,10,13-14,17,27H,9,12H2,1-2H3/t14-,17+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522639
(CHEMBL4563162)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2C[C@@H](C)O[C@H](c2n1)c1ccccc1Cl)C#N |r| Show InChI InChI=1S/C23H19ClN4O2/c1-13-11-28-12-20(27-23(28)22(30-13)15-5-3-4-6-17(15)24)19-9-16-18(26-19)8-7-14(10-25)21(16)29-2/h3-9,12-13,22,26H,11H2,1-2H3/t13-,22+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522650
(CHEMBL4458813)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1ccccc1C(F)(F)F)C#N |r| Show InChI InChI=1S/C23H17F3N4O2/c1-31-20-13(11-27)6-7-17-15(20)10-18(28-17)19-12-30-8-9-32-21(22(30)29-19)14-4-2-3-5-16(14)23(24,25)26/h2-7,10,12,21,28H,8-9H2,1H3/t21-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036315
(CHEMBL3353099)Show SMILES COc1nc(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(ccc2F)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C20H17F4N7O/c1-11-9-31(10-25-11)16-7-6-14(26-18(16)32-3)17-28-19(30(2)29-17)27-15-8-12(20(22,23)24)4-5-13(15)21/h4-10H,1-3H3,(H,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522622
(CHEMBL4466805)Show SMILES COc1nc(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(F)cc(c2)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C20H17F4N7O/c1-11-9-31(10-25-11)16-5-4-15(27-18(16)32-3)17-28-19(30(2)29-17)26-14-7-12(20(22,23)24)6-13(21)8-14/h4-10H,1-3H3,(H,26,28,29) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522647
(CHEMBL4587055)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CC(C)(O)CC(c2n1)c1ccccc1Cl)C#N Show InChI InChI=1S/C24H21ClN4O2/c1-24(30)10-17(15-5-3-4-6-18(15)25)23-28-21(12-29(23)13-24)20-9-16-19(27-20)8-7-14(11-26)22(16)31-2/h3-9,12,17,27,30H,10,13H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036337
(CHEMBL3353096)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(ccc2F)N(C)C)n(C)n1 Show InChI InChI=1S/C22H24FN7O/c1-14-12-30(13-24-14)19-9-6-15(10-20(19)31-5)21-26-22(29(4)27-21)25-18-11-16(28(2)3)7-8-17(18)23/h6-13H,1-5H3,(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522633
(CHEMBL4521904)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1ccc(F)cc1C)C#N |r| Show InChI InChI=1S/C23H19FN4O2/c1-13-9-15(24)4-5-16(13)22-23-27-20(12-28(23)7-8-30-22)19-10-17-18(26-19)6-3-14(11-25)21(17)29-2/h3-6,9-10,12,22,26H,7-8H2,1-2H3/t22-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547764
(CHEMBL4740457) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547787
(CHEMBL4797527)Show SMILES Cc1cc(CN2CCC[C@@H](C2)c2cc(nc3ncnn23)C(F)F)cc(Cl)n1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036331
(CHEMBL3353091)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2cccc(OC(F)(F)F)c2)n(C)n1 Show InChI InChI=1S/C21H19F3N6O2/c1-13-11-30(12-25-13)17-8-7-14(9-18(17)31-3)19-27-20(29(2)28-19)26-15-5-4-6-16(10-15)32-21(22,23)24/h4-12H,1-3H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522624
(CHEMBL4536918)Show SMILES COc1c(ccc2[nH]c(cc12)-c1nc2C(CCCn2n1)c1ccc(F)cc1C)C#N Show InChI InChI=1S/C23H20FN5O/c1-13-10-15(24)6-7-16(13)17-4-3-9-29-23(17)27-22(28-29)20-11-18-19(26-20)8-5-14(12-25)21(18)30-2/h5-8,10-11,17,26H,3-4,9H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522648
(CHEMBL4549121)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1ccccc1Cl)C#N |r| Show InChI InChI=1S/C22H17ClN4O2/c1-28-20-13(11-24)6-7-17-15(20)10-18(25-17)19-12-27-8-9-29-21(22(27)26-19)14-4-2-3-5-16(14)23/h2-7,10,12,21,25H,8-9H2,1H3/t21-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036507
(CHEMBL3353560)Show SMILES CCn1nc(nc1Nc1cc(ccc1F)C(F)(F)F)-c1ccc(c(OC)c1)-n1cnc(C)c1 Show InChI InChI=1S/C22H20F4N6O/c1-4-32-21(28-17-10-15(22(24,25)26)6-7-16(17)23)29-20(30-32)14-5-8-18(19(9-14)33-3)31-11-13(2)27-12-31/h5-12H,4H2,1-3H3,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036332
(CHEMBL3353092)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2ccc(cc2)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C21H19F3N6O/c1-13-11-30(12-25-13)17-9-4-14(10-18(17)31-3)19-27-20(29(2)28-19)26-16-7-5-15(6-8-16)21(22,23)24/h4-12H,1-3H3,(H,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547780
(CHEMBL4751598)Show SMILES FC(F)c1cc(C2CCCN(C2)C(=O)c2cc3CCCCc3s2)n2nccc2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522645
(CHEMBL4520168)Show SMILES COc1c(ccc2[nH]c(cc12)-c1nc2[C@@H](OCCn2n1)c1cccc(F)c1C)C#N |r| Show InChI InChI=1S/C22H18FN5O2/c1-12-14(4-3-5-16(12)23)20-22-26-21(27-28(22)8-9-30-20)18-10-15-17(25-18)7-6-13(11-24)19(15)29-2/h3-7,10,20,25H,8-9H2,1-2H3/t20-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522632
(CHEMBL4544029)Show SMILES COc1c(ccc2[nH]c(cc12)-c1nc2[C@@H](OCCn2n1)c1ccc(F)cc1C)C#N |r| Show InChI InChI=1S/C22H18FN5O2/c1-12-9-14(23)4-5-15(12)20-22-26-21(27-28(22)7-8-30-20)18-10-16-17(25-18)6-3-13(11-24)19(16)29-2/h3-6,9-10,20,25H,7-8H2,1-2H3/t20-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036500
(CHEMBL3353556)Show SMILES Cc1cn(cn1)-c1ccc(cc1C#N)-c1nc(Nc2cc(ccc2F)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C21H15F4N7/c1-12-10-32(11-27-12)18-6-3-13(7-14(18)9-26)19-29-20(31(2)30-19)28-17-8-15(21(23,24)25)4-5-16(17)22/h3-8,10-11H,1-2H3,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522635
(CHEMBL4542879)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1c(F)cccc1C(F)(F)F)C#N |r| Show InChI InChI=1S/C23H16F4N4O2/c1-32-20-12(10-28)5-6-16-13(20)9-17(29-16)18-11-31-7-8-33-21(22(31)30-18)19-14(23(25,26)27)3-2-4-15(19)24/h2-6,9,11,21,29H,7-8H2,1H3/t21-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522623
(CHEMBL4539673)Show SMILES COc1c(ccc2[nH]c(cc12)-c1nc2C(CCCn2n1)c1ccccc1C(F)(F)F)C#N Show InChI InChI=1S/C23H18F3N5O/c1-32-20-13(12-27)8-9-18-16(20)11-19(28-18)21-29-22-15(6-4-10-31(22)30-21)14-5-2-3-7-17(14)23(24,25)26/h2-3,5,7-9,11,15,28H,4,6,10H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50547782
(CHEMBL4745282)Show SMILES O=C(N1CCCC(C1)c1ccnc2[nH]ccc12)c1cc2CCCCc2s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522637
(CHEMBL4535885)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CC(O)(CO)CC(c2n1)c1ccccc1Cl)C#N Show InChI InChI=1S/C24H21ClN4O3/c1-32-22-14(10-26)6-7-19-16(22)8-20(27-19)21-11-29-12-24(31,13-30)9-17(23(29)28-21)15-4-2-3-5-18(15)25/h2-8,11,17,27,30-31H,9,12-13H2,1H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036509
(CHEMBL3353562)Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(ccc2F)C(F)(F)F)n(CCC#N)n1 Show InChI InChI=1S/C23H19F4N7O/c1-14-12-33(13-29-14)19-7-4-15(10-20(19)35-2)21-31-22(34(32-21)9-3-8-28)30-18-11-16(23(25,26)27)5-6-17(18)24/h4-7,10-13H,3,9H2,1-2H3,(H,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522646
(CHEMBL4560947)Show SMILES COc1c(ccc2[nH]c(cc12)-c1cn2CCO[C@H](c2n1)c1cc(ccc1F)C(F)(F)F)C#N |r| Show InChI InChI=1S/C23H16F4N4O2/c1-32-20-12(10-28)2-5-17-15(20)9-18(29-17)19-11-31-6-7-33-21(22(31)30-19)14-8-13(23(25,26)27)3-4-16(14)24/h2-5,8-9,11,21,29H,6-7H2,1H3/t21-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Presenilin-1
(Homo sapiens (Human)) | BDBM50522628
(CHEMBL4446595)Show SMILES COc1c(ccc2[nH]c(cc12)-c1nc2[C@@H](OCCn2n1)c1ccccc1C(F)(F)F)C#N |r| Show InChI InChI=1S/C22H16F3N5O2/c1-31-18-12(11-26)6-7-16-14(18)10-17(27-16)20-28-21-19(32-9-8-30(21)29-20)13-4-2-3-5-15(13)22(23,24)25/h2-7,10,19,27H,8-9H2,1H3/t19-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development
Curated by ChEMBL
| Assay Description
Inhibition of gamma secretase in human SKNBE2 cells expressing human APP695 assessed as increase in Abeta38 levels incubated for 18 hrs by sandwich E... |
Bioorg Med Chem Lett 29: 1737-1745 (2019)
Article DOI: 10.1016/j.bmcl.2019.05.023
BindingDB Entry DOI: 10.7270/Q2765JQS |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036502
(CHEMBL3353557)Show SMILES COc1c(F)c(ccc1-n1cnc(C)c1)-c1nc(Nc2cc(ccc2F)C(F)(F)F)n(C)n1 Show InChI InChI=1S/C21H17F5N6O/c1-11-9-32(10-27-11)16-7-5-13(17(23)18(16)33-3)19-29-20(31(2)30-19)28-15-8-12(21(24,25)26)4-6-14(15)22/h4-10H,1-3H3,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547753
(CHEMBL4744076) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547763
(CHEMBL4793775)Show SMILES O=C(N1CCC[C@@H](C1)c1ccnc2ncnn12)c1ccc2OCCOc2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547779
(CHEMBL4793092)Show SMILES FC(F)(F)c1cc(C2CCCN(C2)C(=O)c2cc3CCCCc3s2)n2ncnc2n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50547760
(CHEMBL4763230)Show SMILES COc1ccc(cc1)C(=O)N1CCC[C@@H](C1)c1ccnc2ncnn12 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE2A expressed in Sf9 cells in presence of [3H]-cGMP and cGMP incubated for 40 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50036508
(CHEMBL3353561)Show SMILES COCCn1nc(nc1Nc1cc(ccc1F)C(F)(F)F)-c1ccc(c(OC)c1)-n1cnc(C)c1 Show InChI InChI=1S/C23H22F4N6O2/c1-14-12-32(13-28-14)19-7-4-15(10-20(19)35-3)21-30-22(33(31-21)8-9-34-2)29-18-11-16(23(25,26)27)5-6-17(18)24/h4-7,10-13H,8-9H2,1-3H3,(H,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human gamma secretase assessed as reduction in Abeta42 level |
Bioorg Med Chem Lett 24: 5805-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.024
BindingDB Entry DOI: 10.7270/Q22V2HRP |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Rattus norvegicus (rat)) | BDBM50547769
(CHEMBL4758144)Show SMILES CS(=O)(=O)n1ccc2cc(ccc12)C(=O)N1CCC[C@@H](C1)c1ccnc2ncnn12 |r| | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged rat recombinant PDE10A2 expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50547751
(CHEMBL4755779)Show SMILES FC(F)c1cc(C2CCCN(C2)C(=O)c2cc3CCCCc3s2)n2ncnc2n1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of 6xHis-tagged human recombinant PDE3A expressed in Sf9 cells in presence of [3H]-cAMP and cAMP incubated for 60 mins by scintillation co... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01272
BindingDB Entry DOI: 10.7270/Q22Z194S |
More data for this
Ligand-Target Pair | |
Search and Browse
