BindingDB PrimarySearch

Found 14 hits with Last Name = 'hines' and Initial = 'j'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Lysosomal alpha-glucosidase (Homo sapiens (Human))	BDBM50076963 ((3R,5R)-2-Hydroxymethyl-1-methyl-piperidine-3,4,5-...) Show SMILES CN1CC(O)C(O)C(O)C1CO Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	6.55	n/a
Ohio State University Curated by ChEMBL					Assay Description Inhibitory potency for brewer's yeast alpha-glucosidase in 0.1 M sodium phosphate buffer at pH 6.55.				Bioorg Med Chem Lett 9: 1255-60 (1999) BindingDB Entry DOI: 10.7270/Q2MK6C2S
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Lysosomal alpha-glucosidase (Homo sapiens (Human))	BDBM50076963 ((3R,5R)-2-Hydroxymethyl-1-methyl-piperidine-3,4,5-...) Show SMILES CN1CC(O)C(O)C(O)C1CO Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	3.69E+5	n/a	n/a	n/a	n/a	n/a	n/a	6.5	n/a
Ohio State University Curated by ChEMBL					Assay Description Inhibitory potency for brewer's yeast alpha-glucosidase in 0.01 mM EDTA, 0.01 mM PIPES and 0.2 M NaOAc at pH 6.5.				Bioorg Med Chem Lett 9: 1255-60 (1999) BindingDB Entry DOI: 10.7270/Q2MK6C2S
Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50357312 (IBRUTINIB \| PCI-32765 \| US10124003, Ref. Ex. Compo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of BTK (unknown origin)				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126877 BindingDB Entry DOI: 10.7270/Q2TH8R7H
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7262 (14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM7262 (14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50571206 (CHEMBL4861930) Show SMILES OC1(CSC(=S)N1Cc1ccncc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50571206 (CHEMBL4861930) Show SMILES OC1(CSC(=S)N1Cc1ccncc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50571206 (CHEMBL4861930) Show SMILES OC1(CSC(=S)N1Cc1ccncc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human wild type GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50129131 (CHEBI:83275 \| Hypothemycin \| US10434085, Compound ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	663	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM50357312 (IBRUTINIB \| PCI-32765 \| US10124003, Ref. Ex. Compo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of BTK C481S mutant (unknown origin)				Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2019.126877 BindingDB Entry DOI: 10.7270/Q2TH8R7H
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50166940 (NP-031112 \| NP-12 \| Tideglusib \| US20230414581, Co...) Show SMILES O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50129131 (CHEBI:83275 \| Hypothemycin \| US10434085, Compound ...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50571206 (CHEMBL4861930) Show SMILES OC1(CSC(=S)N1Cc1ccncc1)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSK-3beta C199A mutant incubated with substrate in presence of ATP measured by serial dilution assay				Citation and Details Article DOI: 10.1016/j.bmc.2021.116179 BindingDB Entry DOI: 10.7270/Q2H70KMS
TBA					More data for this Ligand-Target Pair