Compile Data Set for Download or QSAR

Found 78 hits with Last Name = 'miyata' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50149871 ((R)-2-((3-(biphenyl-4-yloxy)-3-(4-fluorophenyl)pro...) Show SMILES CN(CC[C@@H](Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O |r| Show InChI InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50102692 (4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-...) Show SMILES COc1cc(cc(OC)c1OCc1ccccc1)C(=O)NCC1(CCCC1)N(C)C Show InChI InChI=1S/C24H32N2O4/c1-26(2)24(12-8-9-13-24)17-25-23(27)19-14-20(28-3)22(21(15-19)29-4)30-16-18-10-6-5-7-11-18/h5-7,10-11,14-15H,8-9,12-13,16-17H2,1-4H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439754 (CHEMBL2419440) Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1cccc(C#N)c1C |(17.73,-47.68,;16.46,-48.55,;15.07,-47.89,;14.59,-46.43,;13.05,-46.43,;12.58,-47.9,;11.25,-48.66,;9.92,-47.87,;8.58,-48.63,;8.57,-50.17,;9.91,-50.95,;11.24,-50.19,;7.24,-50.94,;5.91,-50.15,;4.57,-50.92,;4.56,-52.46,;5.9,-53.23,;7.23,-52.47,;13.83,-48.8,;13.83,-50.34,;12.5,-51.11,;12.5,-52.65,;13.84,-53.42,;15.17,-52.65,;16.51,-53.42,;17.84,-54.17,;15.17,-51.1,;16.5,-50.33,)| Show InChI InChI=1S/C23H19N5/c1-3-22-26-27-23(28(22)21-11-7-10-18(14-24)16(21)2)19-12-13-20(25-15-19)17-8-5-4-6-9-17/h4-13,15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439750 (CHEMBL2419441) Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1ccccc1F |(35.66,-25.77,;34.52,-26.8,;33.06,-26.33,;32.58,-24.87,;31.04,-24.87,;30.56,-26.34,;29.23,-27.1,;27.9,-26.32,;26.57,-27.08,;26.56,-28.62,;27.89,-29.4,;29.23,-28.63,;25.22,-29.38,;23.89,-28.6,;22.55,-29.36,;22.55,-30.9,;23.88,-31.68,;25.22,-30.91,;31.81,-27.24,;31.82,-28.78,;30.49,-29.55,;30.49,-31.09,;31.82,-31.86,;33.16,-31.09,;33.15,-29.54,;34.48,-28.77,)| Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)16-12-13-18(23-14-16)15-8-4-3-5-9-15/h3-14H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50335001 (3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(14.8,-4.75,;13.34,-4.27,;12.87,-2.81,;11.33,-2.81,;10.85,-4.27,;9.53,-5.05,;9.53,-6.59,;8.2,-7.36,;6.86,-6.59,;6.86,-5.06,;8.18,-4.28,;5.54,-7.37,;4.2,-6.6,;2.88,-7.37,;2.87,-8.92,;4.21,-9.69,;5.54,-8.92,;12.09,-5.18,;12.09,-6.71,;10.76,-7.47,;10.75,-9.01,;12.09,-9.79,;13.43,-9.01,;13.42,-7.47,;14.75,-6.7,)| Show InChI InChI=1S/C21H16FN3/c1-15-23-24-21(25(15)20-10-6-5-9-19(20)22)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50335010 (3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(31.78,4.31,;30.63,3.28,;29.17,3.76,;28.69,5.23,;27.15,5.23,;26.68,3.77,;25.35,2.99,;25.36,1.45,;24.03,.67,;22.69,1.44,;22.68,2.97,;24.01,3.75,;21.37,.67,;20.03,1.43,;18.7,.66,;18.7,-.88,;20.04,-1.65,;21.37,-.88,;27.92,2.86,;27.92,1.33,;26.58,.56,;26.58,-.98,;27.91,-1.75,;29.25,-.98,;29.25,.56,;30.58,1.33,)| Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50335010 (3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(31.78,4.31,;30.63,3.28,;29.17,3.76,;28.69,5.23,;27.15,5.23,;26.68,3.77,;25.35,2.99,;25.36,1.45,;24.03,.67,;22.69,1.44,;22.68,2.97,;24.01,3.75,;21.37,.67,;20.03,1.43,;18.7,.66,;18.7,-.88,;20.04,-1.65,;21.37,-.88,;27.92,2.86,;27.92,1.33,;26.58,.56,;26.58,-.98,;27.91,-1.75,;29.25,-.98,;29.25,.56,;30.58,1.33,)| Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50335010 (3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(31.78,4.31,;30.63,3.28,;29.17,3.76,;28.69,5.23,;27.15,5.23,;26.68,3.77,;25.35,2.99,;25.36,1.45,;24.03,.67,;22.69,1.44,;22.68,2.97,;24.01,3.75,;21.37,.67,;20.03,1.43,;18.7,.66,;18.7,-.88,;20.04,-1.65,;21.37,-.88,;27.92,2.86,;27.92,1.33,;26.58,.56,;26.58,-.98,;27.91,-1.75,;29.25,-.98,;29.25,.56,;30.58,1.33,)| Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50335010 (3-Biphenyl-4-yl-5-ethyl-4-(2-fluorophenyl)-1,2,4-t...) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(31.78,4.31,;30.63,3.28,;29.17,3.76,;28.69,5.23,;27.15,5.23,;26.68,3.77,;25.35,2.99,;25.36,1.45,;24.03,.67,;22.69,1.44,;22.68,2.97,;24.01,3.75,;21.37,.67,;20.03,1.43,;18.7,.66,;18.7,-.88,;20.04,-1.65,;21.37,-.88,;27.92,2.86,;27.92,1.33,;26.58,.56,;26.58,-.98,;27.91,-1.75,;29.25,-.98,;29.25,.56,;30.58,1.33,)| Show InChI InChI=1S/C22H18FN3/c1-2-21-24-25-22(26(21)20-11-7-6-10-19(20)23)18-14-12-17(13-15-18)16-8-4-3-5-9-16/h3-15H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439740 (CHEMBL2419428) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(CO)c1C |(14.92,-39.34,;13.65,-40.21,;12.26,-39.55,;11.78,-38.08,;10.24,-38.09,;9.77,-39.55,;8.44,-40.31,;7.11,-39.53,;5.78,-40.29,;5.76,-41.83,;7.1,-42.61,;8.44,-41.85,;4.43,-42.59,;3.1,-41.81,;1.76,-42.57,;1.75,-44.11,;3.09,-44.89,;4.42,-44.13,;11.02,-40.45,;11.03,-41.99,;9.7,-42.76,;9.69,-44.31,;11.03,-45.08,;12.37,-44.31,;13.7,-45.08,;13.7,-46.62,;12.36,-42.76,;13.69,-41.98,)| Show InChI InChI=1S/C24H23N3O/c1-3-23-25-26-24(27(23)22-11-7-10-21(16-28)17(22)2)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15,28H,3,16H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360102 (CHEMBL1928735) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2cccnc12 |(49.41,-6.17,;48.68,-7.53,;47.14,-7.57,;46.66,-6.11,;45.12,-6.11,;44.65,-7.58,;43.32,-8.34,;41.99,-7.56,;40.65,-8.32,;40.64,-9.86,;41.98,-10.64,;43.31,-9.87,;39.31,-10.62,;37.98,-9.84,;36.64,-10.61,;36.64,-12.15,;37.98,-12.92,;39.31,-12.15,;45.89,-8.48,;45.9,-10.02,;44.56,-10.79,;44.56,-12.33,;45.89,-13.1,;47.24,-12.32,;48.58,-13.08,;49.91,-12.29,;49.89,-10.74,;48.55,-9.99,;47.23,-10.77,)| Show InChI InChI=1S/C25H20N4/c1-2-23-27-28-25(21-15-13-19(14-16-21)18-8-4-3-5-9-18)29(23)22-12-6-10-20-11-7-17-26-24(20)22/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439745 (CHEMBL2419423) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C |(36.18,-5.89,;34.91,-6.76,;33.52,-6.09,;33.04,-4.63,;31.5,-4.63,;31.03,-6.1,;29.7,-6.86,;28.37,-6.08,;27.03,-6.84,;27.02,-8.38,;28.36,-9.16,;29.69,-8.39,;25.69,-9.14,;24.36,-8.36,;23.02,-9.12,;23.01,-10.66,;24.35,-11.44,;25.68,-10.67,;32.28,-7,;32.28,-8.54,;30.95,-9.31,;30.95,-10.85,;32.29,-11.63,;33.62,-10.85,;33.62,-9.3,;34.95,-8.53,)| Show InChI InChI=1S/C23H21N3/c1-3-22-24-25-23(26(22)21-12-8-7-9-17(21)2)20-15-13-19(14-16-20)18-10-5-4-6-11-18/h4-16H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439743 (CHEMBL2419425) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(N)c1C |(37.67,-16.43,;36.4,-17.3,;35.01,-16.63,;34.53,-15.17,;32.99,-15.17,;32.52,-16.64,;31.19,-17.4,;29.86,-16.61,;28.53,-17.37,;28.51,-18.92,;29.85,-19.69,;31.18,-18.93,;27.18,-19.68,;25.85,-18.9,;24.51,-19.66,;24.5,-21.2,;25.84,-21.98,;27.17,-21.21,;33.77,-17.54,;33.77,-19.08,;32.45,-19.85,;32.44,-21.39,;33.78,-22.16,;35.12,-21.39,;36.45,-22.16,;35.11,-19.84,;36.44,-19.07,)| Show InChI InChI=1S/C23H22N4/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3,24H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50335001 (3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-methyl-4H-1,2...) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(14.8,-4.75,;13.34,-4.27,;12.87,-2.81,;11.33,-2.81,;10.85,-4.27,;9.53,-5.05,;9.53,-6.59,;8.2,-7.36,;6.86,-6.59,;6.86,-5.06,;8.18,-4.28,;5.54,-7.37,;4.2,-6.6,;2.88,-7.37,;2.87,-8.92,;4.21,-9.69,;5.54,-8.92,;12.09,-5.18,;12.09,-6.71,;10.76,-7.47,;10.75,-9.01,;12.09,-9.79,;13.43,-9.01,;13.42,-7.47,;14.75,-6.7,)| Show InChI InChI=1S/C21H16FN3/c1-15-23-24-21(25(15)20-10-6-5-9-19(20)22)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-14H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439741 (CHEMBL2419427) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(O)c1C |(34.05,-28.9,;32.78,-29.77,;31.39,-29.11,;30.91,-27.64,;29.37,-27.65,;28.9,-29.11,;27.57,-29.87,;26.24,-29.09,;24.9,-29.85,;24.89,-31.39,;26.23,-32.17,;27.56,-31.41,;23.56,-32.15,;22.23,-31.37,;20.89,-32.13,;20.88,-33.67,;22.22,-34.45,;23.55,-33.69,;30.15,-30.01,;30.15,-31.55,;28.82,-32.32,;28.82,-33.87,;30.15,-34.64,;31.49,-33.87,;32.83,-34.64,;31.49,-32.32,;32.82,-31.54,)| Show InChI InChI=1S/C23H21N3O/c1-3-22-24-25-23(26(22)20-10-7-11-21(27)16(20)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15,27H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439743 (CHEMBL2419425) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(N)c1C |(37.67,-16.43,;36.4,-17.3,;35.01,-16.63,;34.53,-15.17,;32.99,-15.17,;32.52,-16.64,;31.19,-17.4,;29.86,-16.61,;28.53,-17.37,;28.51,-18.92,;29.85,-19.69,;31.18,-18.93,;27.18,-19.68,;25.85,-18.9,;24.51,-19.66,;24.5,-21.2,;25.84,-21.98,;27.17,-21.21,;33.77,-17.54,;33.77,-19.08,;32.45,-19.85,;32.44,-21.39,;33.78,-22.16,;35.12,-21.39,;36.45,-22.16,;35.11,-19.84,;36.44,-19.07,)| Show InChI InChI=1S/C23H22N4/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3,24H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360093 (CHEMBL1928737) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2cnccc12 |(18.08,-15.77,;17.35,-17.13,;15.81,-17.17,;15.34,-15.71,;13.8,-15.71,;13.32,-17.17,;11.99,-17.94,;10.66,-17.16,;9.32,-17.92,;9.32,-19.46,;10.65,-20.24,;11.99,-19.47,;7.98,-20.22,;6.65,-19.44,;5.32,-20.21,;5.31,-21.75,;6.65,-22.52,;7.98,-21.75,;14.57,-18.08,;14.57,-19.62,;13.23,-20.39,;13.23,-21.92,;14.57,-22.7,;15.91,-21.92,;17.26,-22.68,;18.59,-21.89,;18.57,-20.34,;17.23,-19.59,;15.9,-20.37,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-13-11-19(12-14-20)18-7-4-3-5-8-18)29(24)23-10-6-9-21-17-26-16-15-22(21)23/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50335011 (3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...) Show SMILES CC(C)c1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(2.67,-3.47,;1.87,-4.79,;2.6,-6.14,;.33,-4.75,;-.15,-3.28,;-1.69,-3.28,;-2.16,-4.74,;-3.49,-5.52,;-3.48,-7.06,;-4.81,-7.84,;-6.15,-7.07,;-6.16,-5.53,;-4.83,-4.76,;-7.47,-7.84,;-8.81,-7.08,;-10.14,-7.85,;-10.14,-9.39,;-8.8,-10.16,;-7.47,-9.39,;-.92,-5.65,;-.92,-7.18,;-2.26,-7.95,;-2.26,-9.49,;-.93,-10.26,;.41,-9.48,;.41,-7.95,;1.74,-7.18,)| Show InChI InChI=1S/C23H20FN3/c1-16(2)22-25-26-23(27(22)21-11-7-6-10-20(21)24)19-14-12-18(13-15-19)17-8-4-3-5-9-17/h3-16H,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360093 (CHEMBL1928737) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2cnccc12 |(18.08,-15.77,;17.35,-17.13,;15.81,-17.17,;15.34,-15.71,;13.8,-15.71,;13.32,-17.17,;11.99,-17.94,;10.66,-17.16,;9.32,-17.92,;9.32,-19.46,;10.65,-20.24,;11.99,-19.47,;7.98,-20.22,;6.65,-19.44,;5.32,-20.21,;5.31,-21.75,;6.65,-22.52,;7.98,-21.75,;14.57,-18.08,;14.57,-19.62,;13.23,-20.39,;13.23,-21.92,;14.57,-22.7,;15.91,-21.92,;17.26,-22.68,;18.59,-21.89,;18.57,-20.34,;17.23,-19.59,;15.9,-20.37,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-13-11-19(12-14-20)18-7-4-3-5-8-18)29(24)23-10-6-9-21-17-26-16-15-22(21)23/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50360102 (CHEMBL1928735) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2cccnc12 |(49.41,-6.17,;48.68,-7.53,;47.14,-7.57,;46.66,-6.11,;45.12,-6.11,;44.65,-7.58,;43.32,-8.34,;41.99,-7.56,;40.65,-8.32,;40.64,-9.86,;41.98,-10.64,;43.31,-9.87,;39.31,-10.62,;37.98,-9.84,;36.64,-10.61,;36.64,-12.15,;37.98,-12.92,;39.31,-12.15,;45.89,-8.48,;45.9,-10.02,;44.56,-10.79,;44.56,-12.33,;45.89,-13.1,;47.24,-12.32,;48.58,-13.08,;49.91,-12.29,;49.89,-10.74,;48.55,-9.99,;47.23,-10.77,)| Show InChI InChI=1S/C25H20N4/c1-2-23-27-28-25(21-15-13-19(14-16-21)18-8-4-3-5-9-18)29(23)22-12-6-10-20-11-7-17-26-24(20)22/h3-17H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439731 (CHEMBL2419437) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(C#N)c1C |(17.02,-34.76,;15.75,-35.63,;14.36,-34.96,;13.88,-33.5,;12.34,-33.5,;11.87,-34.97,;10.54,-35.73,;9.21,-34.95,;7.88,-35.71,;7.86,-37.25,;9.2,-38.03,;10.53,-37.26,;6.53,-38.01,;5.2,-37.23,;3.86,-37.99,;3.85,-39.53,;5.19,-40.31,;6.52,-39.54,;13.12,-35.87,;13.12,-37.41,;11.8,-38.18,;11.79,-39.73,;13.13,-40.5,;14.47,-39.72,;15.8,-40.49,;17.13,-41.26,;14.46,-38.17,;15.79,-37.4,)| Show InChI InChI=1S/C24H20N4/c1-3-23-26-27-24(28(23)22-11-7-10-21(16-25)17(22)2)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (Homo sapiens (Human))	BDBM50439754 (CHEMBL2419440) Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1cccc(C#N)c1C |(17.73,-47.68,;16.46,-48.55,;15.07,-47.89,;14.59,-46.43,;13.05,-46.43,;12.58,-47.9,;11.25,-48.66,;9.92,-47.87,;8.58,-48.63,;8.57,-50.17,;9.91,-50.95,;11.24,-50.19,;7.24,-50.94,;5.91,-50.15,;4.57,-50.92,;4.56,-52.46,;5.9,-53.23,;7.23,-52.47,;13.83,-48.8,;13.83,-50.34,;12.5,-51.11,;12.5,-52.65,;13.84,-53.42,;15.17,-52.65,;16.51,-53.42,;17.84,-54.17,;15.17,-51.1,;16.5,-50.33,)| Show InChI InChI=1S/C23H19N5/c1-3-22-26-27-23(28(22)21-11-7-10-18(14-24)16(21)2)19-12-13-20(25-15-19)17-8-5-4-6-9-17/h4-13,15H,3H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Inhibition of GlyT1 in human SK-N-MC cells				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439737 (CHEMBL2419431) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(F)c1C |(33.17,-50.76,;31.9,-51.63,;30.52,-50.96,;30.04,-49.5,;28.5,-49.51,;28.02,-50.97,;26.69,-51.73,;25.37,-50.95,;24.03,-51.71,;24.02,-53.25,;25.35,-54.03,;26.69,-53.26,;22.68,-54.01,;21.35,-53.23,;20.02,-53.99,;20.01,-55.53,;21.34,-56.31,;22.68,-55.54,;29.27,-51.87,;29.28,-53.41,;27.95,-54.18,;27.95,-55.73,;29.28,-56.5,;30.62,-55.73,;31.95,-56.49,;30.61,-54.18,;31.94,-53.4,)| Show InChI InChI=1S/C23H20FN3/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439737 (CHEMBL2419431) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(F)c1C |(33.17,-50.76,;31.9,-51.63,;30.52,-50.96,;30.04,-49.5,;28.5,-49.51,;28.02,-50.97,;26.69,-51.73,;25.37,-50.95,;24.03,-51.71,;24.02,-53.25,;25.35,-54.03,;26.69,-53.26,;22.68,-54.01,;21.35,-53.23,;20.02,-53.99,;20.01,-55.53,;21.34,-56.31,;22.68,-55.54,;29.27,-51.87,;29.28,-53.41,;27.95,-54.18,;27.95,-55.73,;29.28,-56.5,;30.62,-55.73,;31.95,-56.49,;30.61,-54.18,;31.94,-53.4,)| Show InChI InChI=1S/C23H20FN3/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439749 (CHEMBL2417571) Show SMILES CCc1nnc(-c2ccc(cn2)-c2ccccc2)n1-c1ccccc1F |(17.93,-34.77,;16.62,-35.57,;15.27,-34.84,;14.79,-33.37,;13.25,-33.38,;12.77,-34.84,;11.44,-35.6,;10.12,-34.82,;8.78,-35.58,;8.77,-37.12,;10.1,-37.9,;11.44,-37.14,;7.43,-37.88,;6.1,-37.1,;4.76,-37.86,;4.76,-39.41,;6.09,-40.18,;7.43,-39.42,;14.02,-35.75,;14.03,-37.29,;12.7,-38.06,;12.7,-39.6,;14.03,-40.37,;15.37,-39.6,;15.36,-38.05,;16.69,-37.27,)| Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)18-13-12-16(14-23-18)15-8-4-3-5-9-15/h3-14H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439745 (CHEMBL2419423) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1C |(36.18,-5.89,;34.91,-6.76,;33.52,-6.09,;33.04,-4.63,;31.5,-4.63,;31.03,-6.1,;29.7,-6.86,;28.37,-6.08,;27.03,-6.84,;27.02,-8.38,;28.36,-9.16,;29.69,-8.39,;25.69,-9.14,;24.36,-8.36,;23.02,-9.12,;23.01,-10.66,;24.35,-11.44,;25.68,-10.67,;32.28,-7,;32.28,-8.54,;30.95,-9.31,;30.95,-10.85,;32.29,-11.63,;33.62,-10.85,;33.62,-9.3,;34.95,-8.53,)| Show InChI InChI=1S/C23H21N3/c1-3-22-24-25-23(26(22)21-12-8-7-9-17(21)2)20-15-13-19(14-16-20)18-10-5-4-6-11-18/h4-16H,3H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439750 (CHEMBL2419441) Show SMILES CCc1nnc(-c2ccc(nc2)-c2ccccc2)n1-c1ccccc1F |(35.66,-25.77,;34.52,-26.8,;33.06,-26.33,;32.58,-24.87,;31.04,-24.87,;30.56,-26.34,;29.23,-27.1,;27.9,-26.32,;26.57,-27.08,;26.56,-28.62,;27.89,-29.4,;29.23,-28.63,;25.22,-29.38,;23.89,-28.6,;22.55,-29.36,;22.55,-30.9,;23.88,-31.68,;25.22,-30.91,;31.81,-27.24,;31.82,-28.78,;30.49,-29.55,;30.49,-31.09,;31.82,-31.86,;33.16,-31.09,;33.15,-29.54,;34.48,-28.77,)| Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)16-12-13-18(23-14-16)15-8-4-3-5-9-15/h3-14H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439755 (CHEMBL2419438) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(c1C)[N+]([O-])=O |(33.7,-35.11,;32.43,-35.98,;31.05,-35.32,;30.57,-33.85,;29.03,-33.86,;28.55,-35.32,;27.22,-36.08,;25.89,-35.3,;24.56,-36.06,;24.55,-37.6,;25.88,-38.38,;27.22,-37.62,;23.21,-38.36,;21.88,-37.58,;20.54,-38.35,;20.54,-39.89,;21.87,-40.66,;23.21,-39.9,;29.8,-36.23,;29.81,-37.77,;28.48,-38.54,;28.48,-40.08,;29.81,-40.85,;31.15,-40.08,;31.14,-38.53,;32.47,-37.75,;32.48,-40.84,;32.49,-42.38,;33.81,-40.08,)| Show InChI InChI=1S/C23H20N4O2/c1-3-22-24-25-23(26(22)20-10-7-11-21(16(20)2)27(28)29)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360092 (CHEMBL1928736) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ccncc12 |(2.75,-17.23,;2.02,-18.59,;.48,-18.63,;.01,-17.17,;-1.53,-17.17,;-2.01,-18.64,;-3.34,-19.4,;-4.67,-18.62,;-6.01,-19.38,;-6.01,-20.92,;-4.68,-21.7,;-3.34,-20.93,;-7.35,-21.68,;-8.68,-20.9,;-10.01,-21.67,;-10.02,-23.21,;-8.68,-23.98,;-7.35,-23.22,;-.76,-19.54,;-.76,-21.08,;-2.1,-21.85,;-2.1,-23.39,;-.76,-24.16,;.58,-23.38,;1.93,-24.14,;3.26,-23.35,;3.24,-21.8,;1.9,-21.05,;.57,-21.83,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(21-13-11-19(12-14-21)18-7-4-3-5-8-18)29(24)23-10-6-9-20-15-16-26-17-22(20)23/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360091 (CHEMBL1928738) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ncccc12 |(33.75,-15.3,;33.02,-16.65,;31.48,-16.7,;31,-15.24,;29.46,-15.24,;28.99,-16.7,;27.66,-17.46,;26.32,-16.68,;24.99,-17.44,;24.98,-18.99,;26.32,-19.76,;27.65,-19,;23.65,-19.75,;22.32,-18.97,;20.98,-19.73,;20.97,-21.27,;22.31,-22.05,;23.64,-21.28,;30.23,-17.61,;30.23,-19.14,;28.9,-19.91,;28.9,-21.45,;30.23,-22.22,;31.58,-21.44,;32.92,-22.2,;34.25,-21.42,;34.23,-19.87,;32.89,-19.11,;31.57,-19.9,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-15-13-19(14-16-20)18-8-4-3-5-9-18)29(24)23-12-6-11-22-21(23)10-7-17-26-22/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439751 (CHEMBL2419444) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F |(16.51,-26.63,;15.04,-26.16,;14.56,-24.69,;13.02,-24.7,;12.55,-26.16,;11.22,-26.92,;9.89,-26.14,;8.55,-26.9,;8.54,-28.44,;9.88,-29.22,;11.21,-28.46,;7.21,-29.2,;5.88,-28.42,;4.54,-29.18,;4.53,-30.73,;5.87,-31.5,;7.2,-30.74,;13.8,-27.07,;13.8,-28.6,;12.47,-29.38,;12.47,-30.92,;13.8,-31.69,;15.14,-30.92,;15.14,-29.37,;16.47,-28.59,)| Show InChI InChI=1S/C20H15FN4/c1-14-23-24-20(25(14)19-8-3-2-6-17(19)21)16-11-9-15(10-12-16)18-7-4-5-13-22-18/h2-13H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439749 (CHEMBL2417571) Show SMILES CCc1nnc(-c2ccc(cn2)-c2ccccc2)n1-c1ccccc1F |(17.93,-34.77,;16.62,-35.57,;15.27,-34.84,;14.79,-33.37,;13.25,-33.38,;12.77,-34.84,;11.44,-35.6,;10.12,-34.82,;8.78,-35.58,;8.77,-37.12,;10.1,-37.9,;11.44,-37.14,;7.43,-37.88,;6.1,-37.1,;4.76,-37.86,;4.76,-39.41,;6.09,-40.18,;7.43,-39.42,;14.02,-35.75,;14.03,-37.29,;12.7,-38.06,;12.7,-39.6,;14.03,-40.37,;15.37,-39.6,;15.36,-38.05,;16.69,-37.27,)| Show InChI InChI=1S/C21H17FN4/c1-2-20-24-25-21(26(20)19-11-7-6-10-17(19)22)18-13-12-16(14-23-18)15-8-4-3-5-9-15/h3-14H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439744 (CHEMBL2419424) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(C)c1C |(17.93,-17.5,;16.66,-18.37,;15.27,-17.7,;14.79,-16.24,;13.25,-16.24,;12.77,-17.71,;11.44,-18.47,;10.12,-17.69,;8.78,-18.45,;8.77,-19.99,;10.1,-20.77,;11.44,-20,;7.43,-20.75,;6.1,-19.97,;4.77,-20.73,;4.76,-22.27,;6.09,-23.05,;7.43,-22.28,;14.02,-18.61,;14.03,-20.15,;12.7,-20.92,;12.7,-22.47,;14.03,-23.24,;15.37,-22.47,;16.7,-23.23,;15.36,-20.92,;16.69,-20.14,)| Show InChI InChI=1S/C24H23N3/c1-4-23-25-26-24(27(23)22-12-8-9-17(2)18(22)3)21-15-13-20(14-16-21)19-10-6-5-7-11-19/h5-16H,4H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439744 (CHEMBL2419424) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(C)c1C |(17.93,-17.5,;16.66,-18.37,;15.27,-17.7,;14.79,-16.24,;13.25,-16.24,;12.77,-17.71,;11.44,-18.47,;10.12,-17.69,;8.78,-18.45,;8.77,-19.99,;10.1,-20.77,;11.44,-20,;7.43,-20.75,;6.1,-19.97,;4.77,-20.73,;4.76,-22.27,;6.09,-23.05,;7.43,-22.28,;14.02,-18.61,;14.03,-20.15,;12.7,-20.92,;12.7,-22.47,;14.03,-23.24,;15.37,-22.47,;16.7,-23.23,;15.36,-20.92,;16.69,-20.14,)| Show InChI InChI=1S/C24H23N3/c1-4-23-25-26-24(27(23)22-12-8-9-17(2)18(22)3)21-15-13-20(14-16-21)19-10-6-5-7-11-19/h5-16H,4H2,1-3H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439741 (CHEMBL2419427) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(O)c1C |(34.05,-28.9,;32.78,-29.77,;31.39,-29.11,;30.91,-27.64,;29.37,-27.65,;28.9,-29.11,;27.57,-29.87,;26.24,-29.09,;24.9,-29.85,;24.89,-31.39,;26.23,-32.17,;27.56,-31.41,;23.56,-32.15,;22.23,-31.37,;20.89,-32.13,;20.88,-33.67,;22.22,-34.45,;23.55,-33.69,;30.15,-30.01,;30.15,-31.55,;28.82,-32.32,;28.82,-33.87,;30.15,-34.64,;31.49,-33.87,;32.83,-34.64,;31.49,-32.32,;32.82,-31.54,)| Show InChI InChI=1S/C23H21N3O/c1-3-22-24-25-23(26(22)20-10-7-11-21(27)16(20)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15,27H,3H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360096 (CHEMBL1928741) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1nccc2ccccc12 |(19.56,-25.35,;18.83,-26.71,;17.29,-26.75,;16.81,-25.29,;15.27,-25.29,;14.8,-26.76,;13.47,-27.52,;12.14,-26.74,;10.8,-27.5,;10.79,-29.04,;12.13,-29.82,;13.46,-29.05,;9.46,-29.8,;8.13,-29.02,;6.79,-29.79,;6.79,-31.33,;8.13,-32.1,;9.46,-31.34,;16.04,-27.66,;16.05,-29.2,;14.71,-29.97,;14.71,-31.51,;16.05,-32.28,;17.39,-31.5,;18.73,-32.26,;20.07,-31.47,;20.05,-29.92,;18.7,-29.17,;17.38,-29.95,)| Show InChI InChI=1S/C25H20N4/c1-2-23-27-28-24(21-14-12-19(13-15-21)18-8-4-3-5-9-18)29(23)25-22-11-7-6-10-20(22)16-17-26-25/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439751 (CHEMBL2419444) Show SMILES Cc1nnc(-c2ccc(cc2)-c2ccccn2)n1-c1ccccc1F |(16.51,-26.63,;15.04,-26.16,;14.56,-24.69,;13.02,-24.7,;12.55,-26.16,;11.22,-26.92,;9.89,-26.14,;8.55,-26.9,;8.54,-28.44,;9.88,-29.22,;11.21,-28.46,;7.21,-29.2,;5.88,-28.42,;4.54,-29.18,;4.53,-30.73,;5.87,-31.5,;7.2,-30.74,;13.8,-27.07,;13.8,-28.6,;12.47,-29.38,;12.47,-30.92,;13.8,-31.69,;15.14,-30.92,;15.14,-29.37,;16.47,-28.59,)| Show InChI InChI=1S/C20H15FN4/c1-14-23-24-20(25(14)19-8-3-2-6-17(19)21)16-11-9-15(10-12-16)18-7-4-5-13-22-18/h2-13H,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360094 (CHEMBL1928739) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccnc2ccccc12 |(49.46,-16.1,;48.73,-17.46,;47.2,-17.51,;46.72,-16.05,;45.18,-16.05,;44.7,-17.51,;43.37,-18.27,;42.04,-17.49,;40.71,-18.25,;40.7,-19.79,;42.04,-20.57,;43.37,-19.8,;39.37,-20.55,;38.03,-19.78,;36.7,-20.54,;36.69,-22.08,;38.03,-22.86,;39.36,-22.09,;45.95,-18.42,;45.95,-19.95,;44.62,-20.72,;44.62,-22.26,;45.95,-23.03,;47.3,-22.25,;48.64,-23.01,;49.97,-22.23,;49.95,-20.67,;48.61,-19.92,;47.29,-20.7,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-14-12-19(13-15-20)18-8-4-3-5-9-18)29(24)23-16-17-26-22-11-7-6-10-21(22)23/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439736 (CHEMBL2419432) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(Cl)c1C |(49.15,-50.86,;47.88,-51.73,;46.49,-51.06,;46.01,-49.6,;44.47,-49.6,;43.99,-51.07,;42.66,-51.83,;41.34,-51.05,;40,-51.81,;39.99,-53.35,;41.32,-54.13,;42.66,-53.36,;38.65,-54.11,;37.32,-53.33,;35.98,-54.09,;35.98,-55.63,;37.31,-56.41,;38.65,-55.64,;45.24,-51.97,;45.25,-53.51,;43.92,-54.28,;43.92,-55.83,;45.25,-56.6,;46.59,-55.82,;47.92,-56.59,;46.58,-54.27,;47.91,-53.5,)| Show InChI InChI=1S/C23H20ClN3/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439735 (CHEMBL2419433) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(Br)c1C |(20.35,-7.11,;19.08,-7.98,;17.69,-7.31,;17.21,-5.85,;15.67,-5.85,;15.2,-7.32,;13.87,-8.08,;12.54,-7.3,;11.2,-8.06,;11.19,-9.6,;12.53,-10.38,;13.86,-9.61,;9.86,-10.36,;8.53,-9.58,;7.19,-10.34,;7.18,-11.88,;8.52,-12.66,;9.85,-11.89,;16.45,-8.22,;16.45,-9.76,;15.13,-10.53,;15.12,-12.08,;16.46,-12.85,;17.79,-12.07,;19.13,-12.84,;17.79,-10.52,;19.12,-9.75,)| Show InChI InChI=1S/C23H20BrN3/c1-3-22-25-26-23(27(22)21-11-7-10-20(24)16(21)2)19-14-12-18(13-15-19)17-8-5-4-6-9-17/h4-15H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439739 (CHEMBL2419429) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(COC)c1C |(33.47,-40.28,;32.2,-41.15,;30.81,-40.48,;30.33,-39.02,;28.79,-39.02,;28.32,-40.49,;26.99,-41.25,;25.66,-40.47,;24.32,-41.23,;24.31,-42.77,;25.65,-43.55,;26.98,-42.78,;22.98,-43.53,;21.65,-42.75,;20.31,-43.51,;20.3,-45.05,;21.64,-45.83,;22.97,-45.06,;29.57,-41.39,;29.57,-42.93,;28.24,-43.7,;28.24,-45.24,;29.58,-46.02,;30.91,-45.24,;32.25,-46.01,;32.25,-47.55,;33.59,-48.32,;30.91,-43.69,;32.24,-42.92,)| Show InChI InChI=1S/C25H25N3O/c1-4-24-26-27-25(28(24)23-12-8-11-22(17-29-3)18(23)2)21-15-13-20(14-16-21)19-9-6-5-7-10-19/h5-16H,4,17H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439746 (CHEMBL2419422) Show SMILES CCc1nnc(N2CCN(CC2)c2ccccc2)n1-c1ccccc1F |(36.3,-46.33,;35.01,-47.16,;33.64,-46.45,;33.16,-44.99,;31.62,-44.99,;31.15,-46.46,;29.82,-47.22,;28.49,-46.43,;27.15,-47.19,;27.14,-48.74,;28.48,-49.51,;29.81,-48.75,;25.8,-49.5,;24.47,-48.72,;23.14,-49.48,;23.13,-51.02,;24.47,-51.8,;25.8,-51.03,;32.39,-47.36,;32.4,-48.9,;31.07,-49.67,;31.07,-51.21,;32.4,-51.98,;33.74,-51.21,;33.73,-49.66,;35.06,-48.89,)| Show InChI InChI=1S/C20H22FN5/c1-2-19-22-23-20(26(19)18-11-7-6-10-17(18)21)25-14-12-24(13-15-25)16-8-4-3-5-9-16/h3-11H,2,12-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50360091 (CHEMBL1928738) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ncccc12 |(33.75,-15.3,;33.02,-16.65,;31.48,-16.7,;31,-15.24,;29.46,-15.24,;28.99,-16.7,;27.66,-17.46,;26.32,-16.68,;24.99,-17.44,;24.98,-18.99,;26.32,-19.76,;27.65,-19,;23.65,-19.75,;22.32,-18.97,;20.98,-19.73,;20.97,-21.27,;22.31,-22.05,;23.64,-21.28,;30.23,-17.61,;30.23,-19.14,;28.9,-19.91,;28.9,-21.45,;30.23,-22.22,;31.58,-21.44,;32.92,-22.2,;34.25,-21.42,;34.23,-19.87,;32.89,-19.11,;31.57,-19.9,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-15-13-19(14-16-20)18-8-4-3-5-9-18)29(24)23-12-6-11-22-21(23)10-7-17-26-22/h3-17H,2H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439756 (CHEMBL2419439) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(CC#N)c1C |(17.37,-45.76,;16.1,-46.63,;14.71,-45.97,;14.23,-44.5,;12.69,-44.51,;12.22,-45.97,;10.89,-46.73,;9.56,-45.95,;8.23,-46.71,;8.21,-48.25,;9.55,-49.03,;10.88,-48.27,;6.88,-49.01,;5.55,-48.23,;4.21,-48.99,;4.2,-50.54,;5.54,-51.31,;6.87,-50.55,;13.47,-46.88,;13.47,-48.42,;12.15,-49.19,;12.14,-50.73,;13.48,-51.5,;14.82,-50.73,;16.15,-51.49,;16.15,-53.03,;16.16,-54.57,;14.81,-49.18,;16.14,-48.4,)| Show InChI InChI=1S/C25H22N4/c1-3-24-27-28-25(29(24)23-11-7-10-19(16-17-26)18(23)2)22-14-12-21(13-15-22)20-8-5-4-6-9-20/h4-15H,3,16H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360106 (CHEMBL1928733) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2[nH]ncc12 |(17.39,-6.43,;16.66,-7.78,;15.12,-7.83,;14.64,-6.37,;13.1,-6.37,;12.62,-7.83,;11.29,-8.59,;9.96,-7.81,;8.62,-8.58,;8.62,-10.12,;9.96,-10.9,;11.29,-10.13,;7.28,-10.88,;5.95,-10.1,;4.61,-10.87,;4.61,-12.41,;5.95,-13.18,;7.28,-12.42,;13.87,-8.74,;13.87,-10.28,;12.54,-11.05,;12.54,-12.59,;13.87,-13.36,;15.22,-12.58,;16.69,-13.04,;17.58,-11.79,;16.67,-10.55,;15.21,-11.04,)| Show InChI InChI=1S/C23H19N5/c1-2-22-26-27-23(28(22)21-10-6-9-20-19(21)15-24-25-20)18-13-11-17(12-14-18)16-7-4-3-5-8-16/h3-15H,2H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360104 (CHEMBL1928731) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc2ccn(C)c12 |(51.49,3.11,;50.76,1.75,;49.22,1.71,;48.74,3.17,;47.2,3.17,;46.73,1.7,;45.39,.94,;44.06,1.72,;42.72,.96,;42.72,-.58,;44.06,-1.36,;45.39,-.59,;41.38,-1.34,;40.05,-.57,;38.71,-1.33,;38.71,-2.87,;40.05,-3.65,;41.38,-2.88,;47.97,.8,;47.98,-.74,;46.64,-1.51,;46.64,-3.05,;47.97,-3.82,;49.32,-3.04,;50.79,-3.5,;51.68,-2.25,;50.76,-1.02,;51.23,.45,;49.31,-1.51,)| Show InChI InChI=1S/C25H22N4/c1-3-23-26-27-25(21-14-12-19(13-15-21)18-8-5-4-6-9-18)29(23)22-11-7-10-20-16-17-28(2)24(20)22/h4-17H,3H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50439742 (CHEMBL2419426) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(N(C)C)c1C |(16.04,-28.67,;14.77,-29.54,;13.38,-28.87,;12.9,-27.41,;11.36,-27.41,;10.88,-28.88,;9.55,-29.64,;8.23,-28.86,;6.89,-29.62,;6.88,-31.16,;8.21,-31.94,;9.55,-31.17,;5.54,-31.92,;4.21,-31.14,;2.88,-31.9,;2.87,-33.44,;4.2,-34.22,;5.54,-33.45,;12.13,-29.78,;12.14,-31.32,;10.81,-32.09,;10.81,-33.64,;12.14,-34.41,;13.48,-33.63,;14.81,-34.4,;14.82,-35.94,;16.15,-33.63,;13.47,-32.08,;14.8,-31.31,)| Show InChI InChI=1S/C25H26N4/c1-5-24-26-27-25(29(24)23-13-9-12-22(18(23)2)28(3)4)21-16-14-20(15-17-21)19-10-7-6-8-11-19/h6-17H,5H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT1 in rat C6 glioma cells incubated for 30 mins prior to substrate addition measured after 10 mins by scintillati...				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50439740 (CHEMBL2419428) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cccc(CO)c1C |(14.92,-39.34,;13.65,-40.21,;12.26,-39.55,;11.78,-38.08,;10.24,-38.09,;9.77,-39.55,;8.44,-40.31,;7.11,-39.53,;5.78,-40.29,;5.76,-41.83,;7.1,-42.61,;8.44,-41.85,;4.43,-42.59,;3.1,-41.81,;1.76,-42.57,;1.75,-44.11,;3.09,-44.89,;4.42,-44.13,;11.02,-40.45,;11.03,-41.99,;9.7,-42.76,;9.69,-44.31,;11.03,-45.08,;12.37,-44.31,;13.7,-45.08,;13.7,-46.62,;12.36,-42.76,;13.69,-41.98,)| Show InChI InChI=1S/C24H23N3O/c1-3-23-25-26-24(27(23)22-11-7-10-21(16-28)17(22)2)20-14-12-19(13-15-20)18-8-5-4-6-9-18/h4-15,28H,3,16H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from GlyT2 in Wistar rat brainstem cells after 10 mins by scintillation counting analysis				J Med Chem 56: 5744-56 (2014) Article DOI: 10.1021/jm400383w BindingDB Entry DOI: 10.7270/Q2D79CVX
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 2 (Rattus norvegicus)	BDBM50335011 (3-Biphenyl-4-yl-4-(2-fluorophenyl)-5-isopropyl-4H-...) Show SMILES CC(C)c1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1ccccc1F |(2.67,-3.47,;1.87,-4.79,;2.6,-6.14,;.33,-4.75,;-.15,-3.28,;-1.69,-3.28,;-2.16,-4.74,;-3.49,-5.52,;-3.48,-7.06,;-4.81,-7.84,;-6.15,-7.07,;-6.16,-5.53,;-4.83,-4.76,;-7.47,-7.84,;-8.81,-7.08,;-10.14,-7.85,;-10.14,-9.39,;-8.8,-10.16,;-7.47,-9.39,;-.92,-5.65,;-.92,-7.18,;-2.26,-7.95,;-2.26,-9.49,;-.93,-10.26,;.41,-9.48,;.41,-7.95,;1.74,-7.18,)| Show InChI InChI=1S/C23H20FN3/c1-16(2)22-25-26-23(27(22)21-11-7-6-10-20(21)24)19-14-12-18(13-15-19)17-8-4-3-5-9-17/h3-16H,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from Wistar rat brain GlyT2 after 10 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair
Sodium- and chloride-dependent glycine transporter 1 (attus norvegicus (Rat))	BDBM50360095 (CHEMBL1928740) Show SMILES CCc1nnc(-c2ccc(cc2)-c2ccccc2)n1-c1cncc2ccccc12 |(2.85,-26.54,;2.12,-27.9,;.58,-27.94,;.11,-26.48,;-1.43,-26.48,;-1.91,-27.95,;-3.24,-28.71,;-4.57,-27.93,;-5.91,-28.69,;-5.91,-30.23,;-4.57,-31.01,;-3.24,-30.24,;-7.25,-30.99,;-8.58,-30.21,;-9.91,-30.98,;-9.92,-32.52,;-8.58,-33.29,;-7.25,-32.53,;-.66,-28.85,;-.66,-30.39,;-1.99,-31.16,;-2,-32.7,;-.66,-33.47,;.69,-32.69,;2.03,-33.45,;3.36,-32.66,;3.34,-31.11,;2,-30.36,;.67,-31.14,)| Show InChI InChI=1S/C25H20N4/c1-2-24-27-28-25(20-14-12-19(13-15-20)18-8-4-3-5-9-18)29(24)23-17-26-16-21-10-6-7-11-22(21)23/h3-17H,2H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc. Curated by ChEMBL					Assay Description Displacement of [3H]glycine from rat GlyT1 expressed in rat C6 cells after 30 mins by scintillation counting				Bioorg Med Chem 20: 34-41 (2011) Article DOI: 10.1016/j.bmc.2011.11.038 BindingDB Entry DOI: 10.7270/Q2WM1DVF
					More data for this Ligand-Target Pair

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