Compile Data Set for Download or QSAR

Found 170 hits with Last Name = 'sankara warrier' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412768 (N-(3-fluoropyridin-4-yl)-5-methyl-2-(6-methylpyrid...) Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(C)n1 Show InChI InChI=1S/C18H15FN6/c1-10-8-21-17-15(10)18(23-13-6-7-20-9-12(13)19)25-16(24-17)14-5-3-4-11(2)22-14/h3-9H,1-2H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412735 (2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...) Show SMILES FC(F)c1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H11F3N6/c18-10-8-21-6-5-11(10)24-16-9-4-7-22-15(9)25-17(26-16)13-3-1-2-12(23-13)14(19)20/h1-8,14H,(H2,21,22,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412743 (N-(3-fluoropyridin-4-yl)-2-(pyridin-2-yl)-7H-pyrro...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccccn1 Show InChI InChI=1S/C16H11FN6/c17-11-9-18-7-5-12(11)21-15-10-4-8-20-14(10)22-16(23-15)13-3-1-2-6-19-13/h1-9H,(H2,18,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412766 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...) Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c1F Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-19-14(20)11(6-8-24-19)27-17-10-5-7-23-16(10)28-18(29-17)13-4-2-3-12(26-13)15(21)22/h2-8,15H,1H3,(H3,23,24,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412738 (2-(pyrrolidin-1-yl)-N-(4-((2-(6-(trifluoromethyl)p...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCCC3)c2)c2cc[nH]c2n1 Show InChI InChI=1S/C23H21F3N8O/c24-23(25,26)17-5-3-4-16(30-17)22-32-20-15(7-9-28-20)21(33-22)29-14-6-8-27-18(12-14)31-19(35)13-34-10-1-2-11-34/h3-9,12H,1-2,10-11,13H2,(H3,27,28,29,31,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412739 (2-(4-methylpiperazin-1-yl)-N-(4-((2-(6-(trifluorom...) Show SMILES CN1CCN(CC(=O)Nc2cc(Nc3nc(nc4[nH]ccc34)-c3cccc(n3)C(F)(F)F)ccn2)CC1 Show InChI InChI=1S/C24H24F3N9O/c1-35-9-11-36(12-10-35)14-20(37)32-19-13-15(5-7-28-19)30-22-16-6-8-29-21(16)33-23(34-22)17-3-2-4-18(31-17)24(25,26)27/h2-8,13H,9-12,14H2,1H3,(H3,28,29,30,32,33,34,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412745 (N-(3-fluoropyridin-4-yl)-2-(6-(trifluoromethyl)pyr...) Show SMILES Fc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C17H10F4N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PDB UniChem	PDB US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair				3D Structure (crystal)
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412773 (N-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...) Show SMILES CN(c1ccncc1)c1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F3N6/c1-27(11-5-8-22-9-6-11)17-12-7-10-23-15(12)25-16(26-17)13-3-2-4-14(24-13)18(19,20)21/h2-10H,1H3,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412775 (3-chloro-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1 Show InChI InChI=1S/C17H10ClF3N6/c18-10-8-22-6-5-11(10)25-15-9-4-7-23-14(9)26-16(27-15)12-2-1-3-13(24-12)17(19,20)21/h1-8H,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412746 (2-(5-fluoro-6-methylpyridin-2-yl)-N-(3-fluoropyrid...) Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H12F2N6/c1-9-11(18)2-3-14(22-9)17-24-15-10(4-7-21-15)16(25-17)23-13-5-6-20-8-12(13)19/h2-8H,1H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412747 (2-(6-(difluoromethyl)pyridin-2-yl)-4-(1H-pyrrolo[3...) Show SMILES FC(F)c1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cc[nH]c2n1 Show InChI InChI=1S/C19H12F2N6/c20-16(21)13-2-1-3-14(24-13)18-25-17-12(4-8-23-17)19(26-18)27-9-6-11-10-22-7-5-15(11)27/h1-10,16H,(H,23,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412774 (3-(trifluoromethyl)-N-{2-[6-(trifluoromethyl)pyrid...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccncc2C(F)(F)F)c2cc[nH]c2n1 Show InChI InChI=1S/C18H10F6N6/c19-17(20,21)10-8-25-6-5-11(10)28-15-9-4-7-26-14(9)29-16(30-15)12-2-1-3-13(27-12)18(22,23)24/h1-8H,(H2,25,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412755 (N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C19H14F3N7O/c1-10(30)25-15-9-11(5-7-23-15)26-17-12-6-8-24-16(12)28-18(29-17)13-3-2-4-14(27-13)19(20,21)22/h2-9H,1H3,(H3,23,24,25,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412734 (N-(3-fluoropyridin-4-yl)-2-(6-methylpyridin-2-yl)-...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C17H13FN6/c1-10-3-2-4-14(21-10)17-23-15-11(5-8-20-15)16(24-17)22-13-6-7-19-9-12(13)18/h2-9H,1H3,(H2,19,20,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412751 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)c(F)cn1 Show InChI InChI=1S/C19H14F3N7O/c1-9(30)25-15-7-14(11(20)8-24-15)27-18-10-5-6-23-17(10)28-19(29-18)13-4-2-3-12(26-13)16(21)22/h2-8,16H,1H3,(H3,23,24,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412759 (N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrr...) Show SMILES CCC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C20H16F3N7O/c1-2-16(31)28-15-10-11(6-8-24-15)26-18-12-7-9-25-17(12)29-19(30-18)13-4-3-5-14(27-13)20(21,22)23/h3-10H,2H2,1H3,(H3,24,25,26,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412778 (N-[4-({2-[6-(difluoromethyl)pyridin-2-yl]-5-{[(2-h...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(CNCC(C)(C)O)c23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C24H26F2N8O2/c1-13(35)30-18-9-15(7-8-28-18)31-23-19-14(10-27-12-24(2,3)36)11-29-22(19)33-21(34-23)17-6-4-5-16(32-17)20(25)26/h4-9,11,20,27,36H,10,12H2,1-3H3,(H3,28,29,30,31,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.75	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412741 (2-(6-(difluoromethyl)pyridin-2-yl)-N-(3-fluoropyri...) Show SMILES Cc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F Show InChI InChI=1S/C18H13F3N6/c1-9-7-23-17-14(9)18(25-11-5-6-22-8-10(11)19)27-16(26-17)13-4-2-3-12(24-13)15(20)21/h2-8,15H,1H3,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412752 (US10399987, Example 17 | methyl (4-((2-(6-(difluor...) Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C19H15F2N7O2/c1-30-19(29)26-14-9-10(5-7-22-14)24-17-11-6-8-23-16(11)27-18(28-17)13-4-2-3-12(25-13)15(20)21/h2-9,15H,1H3,(H3,22,23,24,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412764 (N-(4-((2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(C)n2)ccn1 Show InChI InChI=1S/C19H16FN7O/c1-10-14(20)3-4-15(23-10)19-26-17-13(6-8-22-17)18(27-19)25-12-5-7-21-16(9-12)24-11(2)28/h3-9H,1-2H3,(H3,21,22,24,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412767 (2-morpholino-N-(4-((2-(6-(trifluoromethyl)pyridin-...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)CN3CCOCC3)c2)c2cc[nH]c2n1 Show InChI InChI=1S/C23H21F3N8O2/c24-23(25,26)17-3-1-2-16(30-17)22-32-20-15(5-7-28-20)21(33-22)29-14-4-6-27-18(12-14)31-19(35)13-34-8-10-36-11-9-34/h1-7,12H,8-11,13H2,(H3,27,28,29,31,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412736 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-7H-pyrro...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C19H15F2N7O/c1-10(29)24-15-9-11(5-7-22-15)25-18-12-6-8-23-17(12)27-19(28-18)14-4-2-3-13(26-14)16(20)21/h2-9,16H,1H3,(H3,22,23,24,25,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412781 (N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...) Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C18H15FN6O/c1-10-12(19)3-4-14(22-10)18-24-16-11(5-8-21-16)17(25-18)23-13-6-7-20-9-15(13)26-2/h3-9H,1-2H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.790	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412762 (3-methyl-N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl...) Show SMILES CC(C)CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C22H20F3N7O/c1-12(2)10-18(33)30-17-11-13(6-8-26-17)28-20-14-7-9-27-19(14)31-21(32-20)15-4-3-5-16(29-15)22(23,24)25/h3-9,11-12H,10H2,1-2H3,(H3,26,27,28,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.850	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412772 (3-methyl-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7H...) Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F3N6/c1-10-9-22-7-6-12(10)25-16-11-5-8-23-15(11)26-17(27-16)13-3-2-4-14(24-13)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412776 (N-[4-({2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrr...) Show SMILES FC(F)(F)c1cccc(n1)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1 Show InChI InChI=1S/C21H16F3N7O/c22-21(23,24)15-3-1-2-14(28-15)19-30-17-13(7-9-26-17)18(31-19)27-12-6-8-25-16(10-12)29-20(32)11-4-5-11/h1-3,6-11H,4-5H2,(H3,25,26,27,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.870	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412756 (N-(4-((2-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccccn2)ccn1 Show InChI InChI=1S/C18H15N7O/c1-11(26)22-15-10-12(5-8-20-15)23-17-13-6-9-21-16(13)24-18(25-17)14-4-2-3-7-19-14/h2-10H,1H3,(H3,20,21,22,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412749 (2-(5-fluoropyridin-2-yl)-N-(3-fluoropyridin-4-yl)-...) Show SMILES Fc1ccc(nc1)-c1nc(Nc2ccncc2F)c2cc[nH]c2n1 Show InChI InChI=1S/C16H10F2N6/c17-9-1-2-13(21-7-9)16-23-14-10(3-6-20-14)15(24-16)22-12-4-5-19-8-11(12)18/h1-8H,(H2,19,20,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387321 (2-methyl-6-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}pyrro...) Show SMILES Cc1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C19H14N6/c1-13-4-2-5-15(21-13)18-22-19(17-6-3-10-25(17)23-18)24-11-8-14-12-20-9-7-16(14)24/h2-12H,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412780 (N-[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrolo[2,...) Show SMILES Cc1cnccc1Nc1nc(nc2[nH]ccc12)-c1ccc(F)c(C)n1 Show InChI InChI=1S/C18H15FN6/c1-10-9-20-7-6-14(10)23-17-12-5-8-21-16(12)24-18(25-17)15-4-3-13(19)11(2)22-15/h3-9H,1-2H3,(H2,20,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412757 (N-(4-((2-(6-methylpyridin-2-yl)-7H-pyrrolo[2,3-d]p...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(C)n2)ccn1 Show InChI InChI=1S/C19H17N7O/c1-11-4-3-5-15(22-11)19-25-17-14(7-9-21-17)18(26-19)24-13-6-8-20-16(10-13)23-12(2)27/h3-10H,1-2H3,(H3,20,21,23,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387324 (2-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}pyrrolo[2,1-f]...) Show SMILES c1cc2c(nc(nn2c1)-c1ccccn1)-n1ccc2cnccc12 Show InChI InChI=1S/C18H12N6/c1-2-8-20-14(4-1)17-21-18(16-5-3-10-24(16)22-17)23-11-7-13-12-19-9-6-15(13)23/h1-12H	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387329 (7-methoxy-N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f...) Show SMILES COc1ccc2c(Nc3nc(nn4cccc34)-c3cccc(C)n3)ccnc2c1 Show InChI InChI=1S/C22H18N6O/c1-14-5-3-6-18(24-14)21-26-22(20-7-4-12-28(20)27-21)25-17-10-11-23-19-13-15(29-2)8-9-16(17)19/h3-13H,1-2H3,(H,23,25,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387344 (2-ethyl-6-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}pyrrol...) Show SMILES CCc1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C20H16N6/c1-2-15-5-3-6-16(22-15)19-23-20(18-7-4-11-26(18)24-19)25-12-9-14-13-21-10-8-17(14)25/h3-13H,2H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412744 (2-(pyridin-2-yl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)...) Show SMILES c1cc2c(nc(nc2[nH]1)-c1ccccn1)-n1ccc2cnccc12 Show InChI InChI=1S/C18H12N6/c1-2-7-20-14(3-1)17-22-16-13(4-9-21-16)18(23-17)24-10-6-12-11-19-8-5-15(12)24/h1-11H,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387345 (2-cyclopropyl-6-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}...) Show SMILES C1CC1c1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C21H16N6/c1-3-16(14-6-7-14)23-17(4-1)20-24-21(19-5-2-11-27(19)25-20)26-12-9-15-13-22-10-8-18(15)26/h1-5,8-14H,6-7H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412753 (N-(5-fluoro-4-((2-(5-fluoro-6-methylpyridin-2-yl)-...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2ccc(F)c(n2)C(F)F)c(F)cn1 Show InChI InChI=1S/C19H13F4N7O/c1-8(31)26-14-6-13(11(21)7-25-14)28-18-9-4-5-24-17(9)29-19(30-18)12-3-2-10(20)15(27-12)16(22)23/h2-7,16H,1H3,(H3,24,25,26,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387340 (3-fluoro-2-methyl-6-(4-{1H-pyrrolo[3,2-c]pyridin-1...) Show SMILES Cc1nc(ccc1F)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C19H13FN6/c1-12-14(20)4-5-15(22-12)18-23-19(17-3-2-9-26(17)24-18)25-10-7-13-11-21-8-6-16(13)25/h2-11H,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387322 (2-fluoro-6-(4-{1H-pyrrolo[3,2-c]pyridin-1-yl}pyrro...) Show SMILES Fc1cccc(n1)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C18H11FN6/c19-16-5-1-3-13(21-16)17-22-18(15-4-2-9-25(15)23-17)24-10-7-12-11-20-8-6-14(12)24/h1-11H	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412782 (N-(4-{[2-(5-fluoro-6-methylpyridin-2-yl)-7H-pyrrol...) Show SMILES Cc1nc(ccc1F)-c1nc(Nc2ccnc(NC(=O)C3CC3)c2)c2cc[nH]c2n1 Show InChI InChI=1S/C21H18FN7O/c1-11-15(22)4-5-16(25-11)20-28-18-14(7-9-24-18)19(29-20)26-13-6-8-23-17(10-13)27-21(30)12-2-3-12/h4-10,12H,2-3H2,1H3,(H3,23,24,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412770 (1-(((2-(6-(difluoromethyl)pyridin-2-yl)-4-((3-fluo...) Show SMILES CC(C)(O)CNCc1c[nH]c2nc(nc(Nc3ccncc3F)c12)-c1cccc(n1)C(F)F Show InChI InChI=1S/C22H22F3N7O/c1-22(2,33)11-27-8-12-9-28-20-17(12)21(30-14-6-7-26-10-13(14)23)32-19(31-20)16-5-3-4-15(29-16)18(24)25/h3-7,9-10,18,27,33H,8,11H2,1-2H3,(H2,26,28,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387333 (N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]tr...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccnc3cc(ccc23)C(F)(F)F)c2cccn2n1 Show InChI InChI=1S/C22H15F3N6/c1-13-4-2-5-17(27-13)20-29-21(19-6-3-11-31(19)30-20)28-16-9-10-26-18-12-14(22(23,24)25)7-8-15(16)18/h2-12H,1H3,(H,26,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412760 (N-(4-((2-(6-(difluoromethyl)pyridin-2-yl)-5-methyl...) Show SMILES CC(=O)Nc1cc(Nc2nc(nc3[nH]cc(C)c23)-c2cccc(n2)C(F)F)ccn1 Show InChI InChI=1S/C20H17F2N7O/c1-10-9-24-19-16(10)20(26-12-6-7-23-15(8-12)25-11(2)30)29-18(28-19)14-5-3-4-13(27-14)17(21)22/h3-9,17H,1-2H3,(H3,23,24,25,26,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387354 (N-[2-(6-methylpyridin-2-yl)pyrrolo[2,1-f][1,2,4]tr...) Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3[nH]ncc3c2)c2cccn2n1 Show InChI InChI=1S/C19H15N7/c1-12-4-2-5-16(21-12)18-23-19(17-6-3-9-26(17)25-18)22-14-7-8-15-13(10-14)11-20-24-15/h2-11H,1H3,(H,20,24)(H,22,23,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412777 (3-methoxy-N-{2-[6-(trifluoromethyl)pyridin-2-yl]-7...) Show SMILES COc1cnccc1Nc1nc(nc2[nH]ccc12)-c1cccc(n1)C(F)(F)F Show InChI InChI=1S/C18H13F3N6O/c1-28-13-9-22-7-6-11(13)25-16-10-5-8-23-15(10)26-17(27-16)12-3-2-4-14(24-12)18(19,20)21/h2-9H,1H3,(H2,22,23,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412771 (N-[3-fluoro-4-({2-[6-(trifluoromethyl)pyridin-2-yl...) Show SMILES CC(=O)Nc1nccc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)c1F Show InChI InChI=1S/C19H13F4N7O/c1-9(31)26-18-14(20)11(6-8-25-18)28-16-10-5-7-24-15(10)29-17(30-16)12-3-2-4-13(27-12)19(21,22)23/h2-8H,1H3,(H3,24,25,26,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387338 (N-{2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f...) Show SMILES COc1ccc2c(Nc3nc(nn4cccc34)-c3cccc(n3)C(F)F)ccnc2c1 Show InChI InChI=1S/C22H16F2N6O/c1-31-13-7-8-14-15(9-10-25-18(14)12-13)27-22-19-6-3-11-30(19)29-21(28-22)17-5-2-4-16(26-17)20(23)24/h2-12,20H,1H3,(H,25,27,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412784 (N-(6-{4-[(3-chloropyridin-4-yl)amino]-7H-pyrrolo[2...) Show SMILES CS(=O)(=O)Nc1cccc(n1)-c1nc(Nc2ccncc2Cl)c2cc[nH]c2n1 Show InChI InChI=1S/C17H14ClN7O2S/c1-28(26,27)25-14-4-2-3-13(21-14)17-23-15-10(5-8-20-15)16(24-17)22-12-6-7-19-9-11(12)18/h2-9H,1H3,(H,21,25)(H2,19,20,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387353 (2-(methylsulfanyl)-4-(4-{1H-pyrrolo[3,2-c]pyridin-...) Show SMILES CSc1nccc(n1)-c1nc(-n2ccc3cnccc23)c2cccn2n1 Show InChI InChI=1S/C18H13N7S/c1-26-18-20-8-4-13(21-18)16-22-17(15-3-2-9-25(15)23-16)24-10-6-12-11-19-7-5-14(12)24/h2-11H,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 [4-503,T204D] (Homo sapiens (Human))	BDBM412765 (US10399987, Example 30 | methyl (4-((2-(6-(trifluo...) Show SMILES COC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 Show InChI InChI=1S/C19H14F3N7O2/c1-31-18(30)27-14-9-10(5-7-23-14)25-16-11-6-8-24-15(11)28-17(29-16)12-3-2-4-13(26-12)19(20,21)22/h2-9H,1H3,(H3,23,24,25,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myer Squibb Company US Patent					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				US Patent US10399987 (2019) BindingDB Entry DOI: 10.7270/Q2222X4N
					More data for this Ligand-Target Pair

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