Compile Data Set for Download or QSAR

Found 226 hits with Last Name = 'schoellerman' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409484 (1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C19H18FN3O/c1-13-9-14(3-4-16(13)20)15-10-18-17(21-11-15)5-8-23(18)12-19(24)22-6-2-7-22/h3-5,8-11H,2,6-7,12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409560 (2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]py...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(C)c(Cl)s1 Show InChI InChI=1S/C16H16ClN3OS/c1-10-6-14(22-16(10)17)11-7-13-12(18-8-11)4-5-20(13)9-15(21)19(2)3/h4-8H,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50509848 (CHEMBL4547576) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C18H16F3N3O/c1-23(2)17(25)10-24-6-5-15-16(24)8-12(9-22-15)11-3-4-14(19)13(7-11)18(20)21/h3-9,18H,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409128 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCCC3)c2c1 Show InChI InChI=1S/C20H20FN3O/c1-14-10-15(4-5-17(14)21)16-11-19-18(22-12-16)6-9-24(19)13-20(25)23-7-2-3-8-23/h4-6,9-12H,2-3,7-8,13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409482 (1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CC(F)C3)c2c1 Show InChI InChI=1S/C19H17F2N3O/c1-12-6-13(2-3-16(12)21)14-7-18-17(22-8-14)4-5-23(18)11-19(25)24-9-15(20)10-24/h2-8,15H,9-11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409275 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C18H18FN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409568 (N,N-Dimethyl-2-[6-(m-tolyl)pyrrolo[3,2-b]pyridin-1...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(C)c1 Show InChI InChI=1S/C18H19N3O/c1-13-5-4-6-14(9-13)15-10-17-16(19-11-15)7-8-21(17)12-18(22)20(2)3/h4-11H,12H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM436689 (N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC3)c2c1 Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)12-3-1-2-10(6-12)11-7-14-16(22-8-11)24-17(27)25(14)9-15(26)23-13-4-5-13/h1-3,6-8,13H,4-5,9H2,(H,23,26)(H,22,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from rat GluN2B receptor				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409569 (N,N-Dimethyl-2-[6-[3-(trifluoromethyl)phenyl]pyrro...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C18H16F3N3O/c1-23(2)17(25)11-24-7-6-15-16(24)9-13(10-22-15)12-4-3-5-14(8-12)18(19,20)21/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409264 (1-(Azetidin-1-yl)-2-[6-[3-(trifluoromethyl)phenyl]...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)15-4-1-3-13(9-15)14-10-17-16(23-11-14)5-8-25(17)12-18(26)24-6-2-7-24/h1,3-5,8-11H,2,6-7,12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409572 (N,N-Dimethyl-2-[6-[5-(trifluoromethyl)-2-thienyl]p...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(s1)C(F)(F)F Show InChI InChI=1S/C16H14F3N3OS/c1-21(2)15(23)9-22-6-5-11-12(22)7-10(8-20-11)13-3-4-14(24-13)16(17,18)19/h3-8H,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409602 (2-[6-(3-Chloro-4-fluoro-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C17H15ClFN3O/c1-21(2)17(23)10-22-6-5-15-16(22)8-12(9-20-15)11-3-4-14(19)13(18)7-11/h3-9H,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409513 (2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H14ClN3OS/c1-18(2)15(20)9-19-6-5-11-12(19)7-10(8-17-11)13-3-4-14(16)21-13/h3-8H,9H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	27	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409301 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCCCC3)c2c1 Show InChI InChI=1S/C21H22FN3O/c1-15-11-16(5-6-18(15)22)17-12-20-19(23-13-17)7-10-25(20)14-21(26)24-8-3-2-4-9-24/h5-7,10-13H,2-4,8-9,14H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409521 (N,N-Dimethyl-2-[6-(5-methyl-2-thienyl)pyrrolo[3,2-...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(C)s1 Show InChI InChI=1S/C16H17N3OS/c1-11-4-5-15(21-11)12-8-14-13(17-9-12)6-7-19(14)10-16(20)18(2)3/h4-9H,10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409563 (2-[6-(3-Chlorophenyl)pyrrolo[3,2-b]pyridin-1-yl]-N...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H16ClN3O/c1-20(2)17(22)11-21-7-6-15-16(21)9-13(10-19-15)12-4-3-5-14(18)8-12/h3-10H,11H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50509850 (CHEMBL4451514) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C18H18ClN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50509851 (CHEMBL4529810) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(C)cs1 Show InChI InChI=1S/C16H17N3OS/c1-11-6-15(21-10-11)12-7-14-13(17-8-12)4-5-19(14)9-16(20)18(2)3/h4-8,10H,9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409514 (2-[6-(3,4-Difluorophenyl)pyrrolo[3,2-b]pyridin-1-y...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C17H15F2N3O/c1-21(2)17(23)10-22-6-5-15-16(22)8-12(9-20-15)11-3-4-13(18)14(19)7-11/h3-9H,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409279 (6-(4-Fluoro-3-methyl-phenyl)-1-(2-pyridylmethyl)py...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(Cc3ccccn3)c2c1 Show InChI InChI=1S/C20H16FN3/c1-14-10-15(5-6-18(14)21)16-11-20-19(23-12-16)7-9-24(20)13-17-4-2-3-8-22-17/h2-12H,13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	66	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409280 ((R/S)-6-(4-Fluoro-3-methyl-phenyl)-1-(tetrahydrofu...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC3CCOC3)c2c1 Show InChI InChI=1S/C19H19FN2O/c1-13-8-15(2-3-17(13)20)16-9-19-18(21-10-16)4-6-22(19)11-14-5-7-23-12-14/h2-4,6,8-10,14H,5,7,11-12H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409352 (5-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...) Show SMILES Cc1noc(Cn2ccc3ncc(cc23)-c2ccc(F)c(C)c2)n1 Show InChI InChI=1S/C18H15FN4O/c1-11-7-13(3-4-15(11)19)14-8-17-16(20-9-14)5-6-23(17)10-18-21-12(2)22-24-18/h3-9H,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50509847 (CHEMBL4467491) Show SMILES FC(F)c1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C19H16F3N3O/c20-15-3-2-12(8-14(15)19(21)22)13-9-17-16(23-10-13)4-7-25(17)11-18(26)24-5-1-6-24/h2-4,7-10,19H,1,5-6,11H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50509849 (CHEMBL4590530) Show SMILES Cc1nnc(Cn2ccc3ncc(cc23)-c2ccc(F)c(C)c2)o1 Show InChI InChI=1S/C18H15FN4O/c1-11-7-13(3-4-15(11)19)14-8-17-16(20-9-14)5-6-23(17)10-18-22-21-12(2)24-18/h3-9H,10H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409486 (N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccn(CC(=O)NC3CC3)c2c1 Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)14-3-1-2-12(8-14)13-9-17-16(23-10-13)6-7-25(17)11-18(26)24-15-4-5-15/h1-3,6-10,15H,4-5,11H2,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409399 ((R/S)-1-Cyclopropyl-2-[6-(4-fluoro-3-methyl-phenyl...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(O)C3CC3)c2c1 Show InChI InChI=1S/C19H19FN2O/c1-12-8-14(4-5-16(12)20)15-9-18-17(21-10-15)6-7-22(18)11-19(23)13-2-3-13/h4-10,13,19,23H,2-3,11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM409375 (2-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(Cc3ncco3)c2c1 Show InChI InChI=1S/C18H14FN3O/c1-12-8-13(2-3-15(12)19)14-9-17-16(21-10-14)4-6-22(17)11-18-20-5-7-23-18/h2-10H,11H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	117	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor me...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409375 (2-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(Cc3ncco3)c2c1 Show InChI InChI=1S/C18H14FN3O/c1-12-8-13(2-3-15(12)19)14-9-17-16(21-10-14)4-6-22(17)11-18-20-5-7-23-18/h2-10H,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409271 (1-(Cyclobutylmethyl)-6-(4-fluoro-3-methyl-phenyl)p...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC3CCC3)c2c1 Show InChI InChI=1S/C19H19FN2/c1-13-9-15(5-6-17(13)20)16-10-19-18(21-11-16)7-8-22(19)12-14-3-2-4-14/h5-11,14H,2-4,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409279 (6-(4-Fluoro-3-methyl-phenyl)-1-(2-pyridylmethyl)py...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(Cc3ccccn3)c2c1 Show InChI InChI=1S/C20H16FN3/c1-14-10-15(5-6-18(14)21)16-11-20-19(23-12-16)7-9-24(20)13-17-4-2-3-8-22-17/h2-12H,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409280 ((R/S)-6-(4-Fluoro-3-methyl-phenyl)-1-(tetrahydrofu...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC3CCOC3)c2c1 Show InChI InChI=1S/C19H19FN2O/c1-13-8-15(2-3-17(13)20)16-9-19-18(21-10-16)4-6-22(19)11-14-5-7-23-12-14/h2-4,6,8-10,14H,5,7,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409484 (1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C19H18FN3O/c1-13-9-14(3-4-16(13)20)15-10-18-17(21-11-15)5-8-23(18)12-19(24)22-6-2-7-22/h3-5,8-11H,2,6-7,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409482 (1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CC(F)C3)c2c1 Show InChI InChI=1S/C19H17F2N3O/c1-12-6-13(2-3-16(12)21)14-7-18-17(22-8-14)4-5-23(18)11-19(25)24-9-15(20)10-24/h2-8,15H,9-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409486 (N-Cyclopropyl-2-[6-[3-(trifluoromethyl)phenyl]pyrr...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2ccn(CC(=O)NC3CC3)c2c1 Show InChI InChI=1S/C19H16F3N3O/c20-19(21,22)14-3-1-2-12(8-14)13-9-17-16(23-10-13)6-7-25(17)11-18(26)24-15-4-5-15/h1-3,6-10,15H,4-5,11H2,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409275 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C18H18FN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50509849 (CHEMBL4590530) Show SMILES Cc1nnc(Cn2ccc3ncc(cc23)-c2ccc(F)c(C)c2)o1 Show InChI InChI=1S/C18H15FN4O/c1-11-7-13(3-4-15(11)19)14-8-17-16(20-9-14)5-6-23(17)10-18-22-21-12(2)24-18/h3-9H,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409352 (5-[[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyri...) Show SMILES Cc1noc(Cn2ccc3ncc(cc23)-c2ccc(F)c(C)c2)n1 Show InChI InChI=1S/C18H15FN4O/c1-11-7-13(3-4-15(11)19)14-8-17-16(20-9-14)5-6-23(17)10-18-21-12(2)22-24-18/h3-9H,10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM409128 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCCC3)c2c1 Show InChI InChI=1S/C20H20FN3O/c1-14-10-15(4-5-17(14)21)16-11-19-18(22-12-16)6-9-24(19)13-20(25)23-7-2-3-8-23/h4-6,9-12H,2-3,7-8,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysi...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409514 (2-[6-(3,4-Difluorophenyl)pyrrolo[3,2-b]pyridin-1-y...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(F)c1 Show InChI InChI=1S/C17H15F2N3O/c1-21(2)17(23)10-22-6-5-15-16(22)8-12(9-20-15)11-3-4-13(18)14(19)7-11/h3-9H,10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409484 (1-(Azetidin-1-yl)-2-[6-(4-fluoro-3-methyl-phenyl)p...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CCC3)c2c1 Show InChI InChI=1S/C19H18FN3O/c1-13-9-14(3-4-16(13)20)15-10-18-17(21-11-15)5-8-23(18)12-19(24)22-6-2-7-22/h3-5,8-11H,2,6-7,12H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409602 (2-[6-(3-Chloro-4-fluoro-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C17H15ClFN3O/c1-21(2)17(23)10-22-6-5-15-16(22)8-12(9-20-15)11-3-4-14(19)13(18)7-11/h3-9H,10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM50509848 (CHEMBL4547576) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(c1)C(F)F Show InChI InChI=1S/C18H16F3N3O/c1-23(2)17(25)10-24-6-5-15-16(24)8-12(9-22-15)11-3-4-14(19)13(7-11)18(20)21/h3-9,18H,10H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409560 (2-[6-(5-Chloro-4-methyl-2-thienyl)pyrrolo[3,2-b]py...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(C)c(Cl)s1 Show InChI InChI=1S/C16H16ClN3OS/c1-10-6-14(22-16(10)17)11-7-13-12(18-8-11)4-5-20(13)9-15(21)19(2)3/h4-8H,9H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM436689 (N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...) Show SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC3)c2c1 Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)12-3-1-2-10(6-12)11-7-14-16(22-8-11)24-17(27)25(14)9-15(26)23-13-4-5-13/h1-3,6-8,13H,4-5,9H2,(H,23,26)(H,22,24,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM50509850 (CHEMBL4451514) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C18H18ClN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409275 (2-[6-(4-Fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyrid...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C18H18FN3O/c1-12-8-13(4-5-15(12)19)14-9-17-16(20-10-14)6-7-22(17)11-18(23)21(2)3/h4-10H,11H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM50509851 (CHEMBL4529810) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cc(C)cs1 Show InChI InChI=1S/C16H17N3OS/c1-11-6-15(21-10-11)12-7-14-13(17-8-12)4-5-19(14)9-16(20)18(2)3/h4-8,10H,9H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409482 (1-(3-Fluoroazetidin-1-yl)-2-[6-(4-fluoro-3-methyl-...) Show SMILES Cc1cc(ccc1F)-c1cnc2ccn(CC(=O)N3CC(F)C3)c2c1 Show InChI InChI=1S/C19H17F2N3O/c1-12-6-13(2-3-16(12)21)14-7-18-17(22-8-14)4-5-23(18)11-19(25)24-9-15(20)10-24/h2-8,15H,9-11H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409513 (2-[6-(5-Chloro-2-thienyl)pyrrolo[3,2-b]pyridin-1-y...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1ccc(Cl)s1 Show InChI InChI=1S/C15H14ClN3OS/c1-18(2)15(20)9-19-6-5-11-12(19)7-10(8-17-11)13-3-4-14(16)21-13/h3-8H,9H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1/2B (Homo sapiens (Human))	BDBM409568 (N,N-Dimethyl-2-[6-(m-tolyl)pyrrolo[3,2-b]pyridin-1...) Show SMILES CN(C)C(=O)Cn1ccc2ncc(cc12)-c1cccc(C)c1 Show InChI InChI=1S/C18H19N3O/c1-13-5-4-6-14(9-13)15-10-17-16(19-11-15)7-8-21(17)12-18(22)20(2)3/h4-11H,12H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research & Development, LLC Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...				ACS Med Chem Lett 10: 261-266 (2019) Article DOI: 10.1021/acsmedchemlett.8b00542 BindingDB Entry DOI: 10.7270/Q2B85CG6
					More data for this Ligand-Target Pair

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