Compile Data Set for Download or QSAR

Found 202 hits with Last Name = 'clapper' and Initial = 'jr'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50419129 (CHEMBL1830441) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCCCCc2ccccc2)c1 Show InChI InChI=1S/C24H24N2O3/c25-23(27)21-13-6-11-19(16-21)20-12-7-14-22(17-20)29-24(28)26-15-5-4-10-18-8-2-1-3-9-18/h1-3,6-9,11-14,16-17H,4-5,10,15H2,(H2,25,27)(H,26,28)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.331	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50271030 (3'-carbamoylbiphenyl-3-yl naphthalen-2-ylmethylcar...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C25H20N2O3/c26-24(28)22-9-3-7-20(14-22)21-8-4-10-23(15-21)30-25(29)27-16-17-11-12-18-5-1-2-6-19(18)13-17/h1-15H,16H2,(H2,26,28)(H,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50271030 (3'-carbamoylbiphenyl-3-yl naphthalen-2-ylmethylcar...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C25H20N2O3/c26-24(28)22-9-3-7-20(14-22)21-8-4-10-23(15-21)30-25(29)27-16-17-11-12-18-5-1-2-6-19(18)13-17/h1-15H,16H2,(H2,26,28)(H,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.631	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503340 (CHEMBL4468636) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CC3COCC3C2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C22H24F9N3O3/c23-20(24,25)16-2-1-13(17(7-16)34-9-14-11-36-12-15(14)10-34)8-32-3-5-33(6-4-32)19(35)37-18(21(26,27)28)22(29,30)31/h1-2,7,14-15,18H,3-6,8-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503331 (CHEMBL4522687) Show SMILES O[C@H]1CCN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H22F9N3O3/c21-18(22,23)13-2-1-12(15(9-13)32-4-3-14(33)11-32)10-30-5-7-31(8-6-30)17(34)35-16(19(24,25)26)20(27,28)29/h1-2,9,14,16,33H,3-8,10-11H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503336 (CHEMBL4437377) Show SMILES O[C@@H]1CCN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H22F9N3O3/c21-18(22,23)13-2-1-12(15(9-13)32-4-3-14(33)11-32)10-30-5-7-31(8-6-30)17(34)35-16(19(24,25)26)20(27,28)29/h1-2,9,14,16,33H,3-8,10-11H2/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180052 (US9133148, 9aq) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL in human intact PC3 cells preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM179948 (US9133148, 2l) Show SMILES FC(F)(F)C(OC(=O)N1CCN(CC1)C(c1cccnc1)c1cccnc1)C(F)(F)F Show InChI InChI=1S/C19H18F6N4O2/c20-18(21,22)16(19(23,24)25)31-17(30)29-9-7-28(8-10-29)15(13-3-1-5-26-11-13)14-4-2-6-27-12-14/h1-6,11-12,15-16H,7-10H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180039 (US9133148, 9ad) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2cccc(Cl)c2N2CCOCC2)CC1)C(F)(F)F Show InChI InChI=1S/C19H22ClF6N3O3/c20-14-3-1-2-13(15(14)28-8-10-31-11-9-28)12-27-4-6-29(7-5-27)17(30)32-16(18(21,22)23)19(24,25)26/h1-3,16H,4-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503334 (CHEMBL4468639) Show SMILES FCCN1CCN(CC1)c1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C21H26ClF7N4O2/c22-16-2-1-15(17(13-16)32-9-5-30(4-3-23)6-10-32)14-31-7-11-33(12-8-31)19(34)35-18(20(24,25)26)21(27,28)29/h1-2,13,18H,3-12,14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503335 (CHEMBL4450649) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCC3(C2)CCOCC3)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C24H28F9N3O3/c25-22(26,27)17-2-1-16(18(13-17)36-6-3-21(15-36)4-11-38-12-5-21)14-34-7-9-35(10-8-34)20(37)39-19(23(28,29)30)24(31,32)33/h1-2,13,19H,3-12,14-15H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM26739 (3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.57	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM26739 (3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180078 (US9133148, 10g) Show SMILES Cn1cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(n1)-c1ccccc1Cl Show InChI InChI=1S/C19H19ClF6N4O2/c1-28-10-12(15(27-28)13-4-2-3-5-14(13)20)11-29-6-8-30(9-7-29)17(31)32-16(18(21,22)23)19(24,25)26/h2-5,10,16H,6-9,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50271029 (CHEMBL520890 | Naphthalen-2-ylmethylcarbamic Acid ...) Show SMILES CC(=O)c1cccc(c1)-c1cccc(OC(=O)NCc2ccc3ccccc3c2)c1 Show InChI InChI=1S/C26H21NO3/c1-18(28)21-8-4-9-23(15-21)24-10-5-11-25(16-24)30-26(29)27-17-19-12-13-20-6-2-3-7-22(20)14-19/h2-16H,17H2,1H3,(H,27,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270860 (CHEMBL521228 | Naphthalen-2-ylmethylcarbamic Acid ...) Show SMILES O=C(NCc1ccc2ccccc2c1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C24H19NO2/c26-24(25-17-18-13-14-20-9-4-5-10-21(20)15-18)27-23-12-6-11-22(16-23)19-7-2-1-3-8-19/h1-16H,17H2,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270860 (CHEMBL521228 | Naphthalen-2-ylmethylcarbamic Acid ...) Show SMILES O=C(NCc1ccc2ccccc2c1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C24H19NO2/c26-24(25-17-18-13-14-20-9-4-5-10-21(20)15-18)27-23-12-6-11-22(16-23)19-7-2-1-3-8-19/h1-16H,17H2,(H,25,26)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.37	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270864 (8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester | C...) Show SMILES O=C(NCCCCCCCCc1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C27H31NO2/c29-27(30-26-20-13-19-25(22-26)24-17-10-6-11-18-24)28-21-12-4-2-1-3-7-14-23-15-8-5-9-16-23/h5-6,8-11,13,15-20,22H,1-4,7,12,14,21H2,(H,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503339 (CHEMBL4469632) Show SMILES Cn1ncc2cc(ccc12)C(N1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)c1ccc2n(C)ncc2c1 Show InChI InChI=1S/C25H24F6N6O2/c1-34-19-5-3-15(11-17(19)13-32-34)21(16-4-6-20-18(12-16)14-33-35(20)2)36-7-9-37(10-8-36)23(38)39-22(24(26,27)28)25(29,30)31/h3-6,11-14,21-22H,7-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM26739 (3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...) Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of California; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino US Patent					Assay Description The assays for compounds described herein are amenable to high throughput screening. Preferred assays thus detect binding of the inhibitor to FAAH or...				US Patent US9187413 (2015) BindingDB Entry DOI: 10.7270/Q2FQ9VD1
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50271026 (4'-Phenyl-4-phenylbutylcarbamic Acid Biphenyl-3-yl...) Show SMILES O=C(NCCCCc1ccc(cc1)-c1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C29H27NO2/c31-29(32-28-16-9-15-27(22-28)25-13-5-2-6-14-25)30-21-8-7-10-23-17-19-26(20-18-23)24-11-3-1-4-12-24/h1-6,9,11-20,22H,7-8,10,21H2,(H,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503336 (CHEMBL4437377) Show SMILES O[C@@H]1CCN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H22F9N3O3/c21-18(22,23)13-2-1-12(15(9-13)32-4-3-14(33)11-32)10-30-5-7-31(8-6-30)17(34)35-16(19(24,25)26)20(27,28)29/h1-2,9,14,16,33H,3-8,10-11H2/t14-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503333 (CHEMBL4539731) Show SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F)O2 |r| Show InChI InChI=1S/C22H24F9N3O3/c23-20(24,25)14-2-1-13(17(9-14)34-11-15-3-4-16(12-34)36-15)10-32-5-7-33(8-6-32)19(35)37-18(21(26,27)28)22(29,30)31/h1-2,9,15-16,18H,3-8,10-12H2/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270861 (4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester | C...) Show SMILES O=C(NCCCCc1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C23H23NO2/c25-23(24-17-8-7-12-19-10-3-1-4-11-19)26-22-16-9-15-21(18-22)20-13-5-2-6-14-20/h1-6,9-11,13-16,18H,7-8,12,17H2,(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.33	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270861 (4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester | C...) Show SMILES O=C(NCCCCc1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C23H23NO2/c25-23(24-17-8-7-12-19-10-3-1-4-11-19)26-22-16-9-15-21(18-22)20-13-5-2-6-14-20/h1-6,9-11,13-16,18H,7-8,12,17H2,(H,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503327 (CHEMBL4435014) Show SMILES [H][C@]12CCCN1CN(CC2)c1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C22H27ClF6N4O2/c23-16-4-3-15(18(12-16)33-7-5-17-2-1-6-32(17)14-33)13-30-8-10-31(11-9-30)20(34)35-19(21(24,25)26)22(27,28)29/h3-4,12,17,19H,1-2,5-11,13-14H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503342 (CHEMBL4436074) Show SMILES CS(=O)(=O)c1ccc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(c1)N1CCCC1 Show InChI InChI=1S/C20H25F6N3O4S/c1-34(31,32)15-5-4-14(16(12-15)28-6-2-3-7-28)13-27-8-10-29(11-9-27)18(30)33-17(19(21,22)23)20(24,25)26/h4-5,12,17H,2-3,6-11,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM179938 (US9133148, 2b) Show SMILES FC(F)(F)C(OC(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C21H18Cl2F6N2O2/c22-15-5-1-13(2-6-15)17(14-3-7-16(23)8-4-14)30-9-11-31(12-10-30)19(32)33-18(20(24,25)26)21(27,28)29/h1-8,17-18H,9-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503344 (CHEMBL4439400) Show SMILES [H][C@]12CC[C@]([H])(COC1)N2c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C22H24F9N3O3/c23-20(24,25)14-2-1-13(17(9-14)34-15-3-4-16(34)12-36-11-15)10-32-5-7-33(8-6-32)19(35)37-18(21(26,27)28)22(29,30)31/h1-2,9,15-16,18H,3-8,10-12H2/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270862 (6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester | C...) Show SMILES O=C(NCCCCCCc1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C25H27NO2/c27-25(26-19-10-2-1-5-12-21-13-6-3-7-14-21)28-24-18-11-17-23(20-24)22-15-8-4-9-16-22/h3-4,6-9,11,13-18,20H,1-2,5,10,12,19H2,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Parma Curated by ChEMBL					Assay Description Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation counting				Eur J Med Chem 46: 4466-73 (2011) Article DOI: 10.1016/j.ejmech.2011.07.021 BindingDB Entry DOI: 10.7270/Q2FB546B
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50270862 (6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester | C...) Show SMILES O=C(NCCCCCCc1ccccc1)Oc1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C25H27NO2/c27-25(26-19-10-2-1-5-12-21-13-6-3-7-14-21)28-24-18-11-17-23(20-24)22-15-8-4-9-16-22/h3-4,6-9,11,13-18,20H,1-2,5,10,12,19H2,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Parma Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis				J Med Chem 51: 3487-98 (2008) Article DOI: 10.1021/jm701631z BindingDB Entry DOI: 10.7270/Q2TM79W9
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503333 (CHEMBL4539731) Show SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F)O2 |r| Show InChI InChI=1S/C22H24F9N3O3/c23-20(24,25)14-2-1-13(17(9-14)34-11-15-3-4-16(12-34)36-15)10-32-5-7-33(8-6-32)19(35)37-18(21(26,27)28)22(29,30)31/h1-2,9,15-16,18H,3-8,10-12H2/t15-,16+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180052 (US9133148, 9aq) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503331 (CHEMBL4522687) Show SMILES O[C@H]1CCN(C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r| Show InChI InChI=1S/C20H22F9N3O3/c21-18(22,23)13-2-1-12(15(9-13)32-4-3-14(33)11-32)10-30-5-7-31(8-6-30)17(34)35-16(19(24,25)26)20(27,28)29/h1-2,9,14,16,33H,3-8,10-11H2/t14-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503337 (CHEMBL4517565) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(Cl)cc2N2CC3CCC(C2)O3)CC1)C(F)(F)F Show InChI InChI=1S/C21H24ClF6N3O3/c22-14-2-1-13(17(9-14)31-11-15-3-4-16(12-31)33-15)10-29-5-7-30(8-6-29)19(32)34-18(20(23,24)25)21(26,27)28/h1-2,9,15-16,18H,3-8,10-12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503334 (CHEMBL4468639) Show SMILES FCCN1CCN(CC1)c1cc(Cl)ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C21H26ClF7N4O2/c22-16-2-1-15(17(13-16)32-9-5-30(4-3-23)6-10-32)14-31-7-11-33(12-8-31)19(34)35-18(20(24,25)26)21(27,28)29/h1-2,13,18H,3-12,14H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503345 (CHEMBL4550205) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCCCC2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C21H24F9N3O2/c22-19(23,24)15-5-4-14(16(12-15)32-6-2-1-3-7-32)13-31-8-10-33(11-9-31)18(34)35-17(20(25,26)27)21(28,29)30/h4-5,12,17H,1-3,6-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180033 (US9133148, 9x) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(Br)cc2N2CCCC2)CC1)C(F)(F)F Show InChI InChI=1S/C19H22BrF6N3O2/c20-14-4-3-13(15(11-14)28-5-1-2-6-28)12-27-7-9-29(10-8-27)17(30)31-16(18(21,22)23)19(24,25)26/h3-4,11,16H,1-2,5-10,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503340 (CHEMBL4468636) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CC3COCC3C2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C22H24F9N3O3/c23-20(24,25)16-2-1-13(17(7-16)34-9-14-11-36-12-15(14)10-34)8-32-3-5-33(6-4-32)19(35)37-18(21(26,27)28)22(29,30)31/h1-2,7,14-15,18H,3-6,8-12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180029 (US9133148, 9t) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(Cl)cc2N2CCOCC2)CC1)C(F)(F)F Show InChI InChI=1S/C19H22ClF6N3O3/c20-14-2-1-13(15(11-14)28-7-9-31-10-8-28)12-27-3-5-29(6-4-27)17(30)32-16(18(21,22)23)19(24,25)26/h1-2,11,16H,3-10,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM180076 (US9133148, 10e) Show SMILES Cn1cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(n1)-c1ccccc1 Show InChI InChI=1S/C19H20F6N4O2/c1-27-11-14(15(26-27)13-5-3-2-4-6-13)12-28-7-9-29(10-8-28)17(30)31-16(18(20,21)22)19(23,24)25/h2-6,11,16H,7-10,12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM108250 (3‐(3‐carbamoylphenyl)‐4‐me...) Show SMILES Cc1ccc(OC(=O)NC2CCCCC2)cc1-c1cccc(c1)C(N)=O Show InChI InChI=1S/C21H24N2O3/c1-14-10-11-18(26-21(25)23-17-8-3-2-4-9-17)13-19(14)15-6-5-7-16(12-15)20(22)24/h5-7,10-13,17H,2-4,8-9H2,1H3,(H2,22,24)(H,23,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.5	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of California; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino US Patent					Assay Description The assays for compounds described herein are amenable to high throughput screening. Preferred assays thus detect binding of the inhibitor to FAAH or...				US Patent US9187413 (2015) BindingDB Entry DOI: 10.7270/Q2FQ9VD1
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM50503335 (CHEMBL4450649) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCC3(C2)CCOCC3)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C24H28F9N3O3/c25-22(26,27)17-2-1-16(18(13-17)36-6-3-21(15-36)4-11-38-12-5-21)14-34-7-9-35(10-8-34)20(37)39-19(23(28,29)30)24(31,32)33/h1-2,13,19H,3-12,14-15H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503338 (CHEMBL4584757) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(Cl)cc2)CC1)C(F)(F)F Show InChI InChI=1S/C15H15ClF6N2O2/c16-11-3-1-10(2-4-11)9-23-5-7-24(8-6-23)13(25)26-12(14(17,18)19)15(20,21)22/h1-4,12H,5-9H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM180012 (US9133148, 9c) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCOCC2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C20H22F9N3O3/c21-18(22,23)14-2-1-13(15(11-14)31-7-9-34-10-8-31)12-30-3-5-32(6-4-30)17(33)35-16(19(24,25)26)20(27,28)29/h1-2,11,16H,3-10,12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50503329 (CHEMBL4546592) Show SMILES CN1CC2CN(CC2C1)c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C23H27F9N4O2/c1-33-9-15-12-36(13-16(15)10-33)18-8-17(21(24,25)26)3-2-14(18)11-34-4-6-35(7-5-34)20(37)38-19(22(27,28)29)23(30,31)32/h2-3,8,15-16,19H,4-7,9-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM179948 (US9133148, 2l) Show SMILES FC(F)(F)C(OC(=O)N1CCN(CC1)C(c1cccnc1)c1cccnc1)C(F)(F)F Show InChI InChI=1S/C19H18F6N4O2/c20-18(21,22)16(19(23,24)25)31-17(30)29-9-7-28(8-10-29)15(13-3-1-5-26-11-13)14-4-2-6-27-12-14/h1-6,11-12,15-16H,7-10H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579] (Rattus norvegicus (rat))	BDBM50437227 (CHEMBL2402927 | US9187413, 1b (URB937)) Show SMILES NC(=O)c1cccc(c1)-c1cc(OC(=O)NC2CCCCC2)ccc1O Show InChI InChI=1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26.8	n/a	n/a	n/a	n/a	n/a	n/a
The Regents of the University of California; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino US Patent					Assay Description The assays for compounds described herein are amenable to high throughput screening. Preferred assays thus detect binding of the inhibitor to FAAH or...				US Patent US9187413 (2015) BindingDB Entry DOI: 10.7270/Q2FQ9VD1
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM180035 (US9133148, 9z) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(Cl)cc2N2CCCC2)CC1)C(F)(F)F Show InChI InChI=1S/C19H22ClF6N3O2/c20-14-4-3-13(15(11-14)28-5-1-2-6-28)12-27-7-9-29(10-8-27)17(30)31-16(18(21,22)23)19(24,25)26/h3-4,11,16H,1-2,5-10,12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair
Monoglyceride lipase (Mus musculus (mouse))	BDBM180052 (US9133148, 9aq) Show SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2ccc(cc2N2CCCC2)C(F)(F)F)CC1)C(F)(F)F Show InChI InChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Abide Therapeutics Curated by ChEMBL					Assay Description Inhibition of MGLL derived from mouse brain homogenates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay				J Med Chem 61: 9062-9084 (2018) Article DOI: 10.1021/acs.jmedchem.8b00951 BindingDB Entry DOI: 10.7270/Q2TH8QZH
					More data for this Ligand-Target Pair

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