Found 362 hits with Last Name = 'bender' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328523
(2-Amino-N-{(2S,3S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-18(19-11-13-21(14-12-19)20-8-5-4-6-9-20)27(37-30(40)31(2,3)34)29(39)38-15-7-10-26(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h4-6,8-9,11-14,16-18,26-27H,7,10,15,34H2,1-3H3,(H,35,36)(H,37,40)/t18-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328523
(2-Amino-N-{(2S,3S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-18(19-11-13-21(14-12-19)20-8-5-4-6-9-20)27(37-30(40)31(2,3)34)29(39)38-15-7-10-26(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h4-6,8-9,11-14,16-18,26-27H,7,10,15,34H2,1-3H3,(H,35,36)(H,37,40)/t18-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328527
(CHEMBL1259208 | N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H31Cl2FN4O3/c1-17(18-6-8-19(9-7-18)20-10-12-21(34)13-11-20)27(37-30(40)31(2,3)41)29(39)38-14-4-5-26(38)28-35-24-15-22(32)23(33)16-25(24)36-28/h6-13,15-17,26-27,41H,4-5,14H2,1-3H3,(H,35,36)(H,37,40)/t17-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328539
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5-ter...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)N |r| Show InChI InChI=1S/C30H39N5O2/c1-29(2,3)25-19-32-26(34-25)24-12-9-17-35(24)27(36)23(33-28(37)30(4,5)31)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24H,9,12,17-18,31H2,1-5H3,(H,32,34)(H,33,37)/t23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328527
(CHEMBL1259208 | N-[(2S,3S)-1-[(2S)-2-(5,6-Dichloro...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H31Cl2FN4O3/c1-17(18-6-8-19(9-7-18)20-10-12-21(34)13-11-20)27(37-30(40)31(2,3)41)29(39)38-14-4-5-26(38)28-35-24-15-22(32)23(33)16-25(24)36-28/h6-13,15-17,26-27,41H,4-5,14H2,1-3H3,(H,35,36)(H,37,40)/t17-,26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328523
(2-Amino-N-{(2S,3S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-18(19-11-13-21(14-12-19)20-8-5-4-6-9-20)27(37-30(40)31(2,3)34)29(39)38-15-7-10-26(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h4-6,8-9,11-14,16-18,26-27H,7,10,15,34H2,1-3H3,(H,35,36)(H,37,40)/t18-,26-,27-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328537
(3-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(CN)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-31(2,18-34)30(40)37-26(15-19-10-12-21(13-11-19)20-7-4-3-5-8-20)29(39)38-14-6-9-27(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h3-5,7-8,10-13,16-17,26-27H,6,9,14-15,18,34H2,1-2H3,(H,35,36)(H,37,40)/t26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328534
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C30H31Cl2N5O2/c1-30(2,33)29(39)36-25(15-18-10-12-20(13-11-18)19-7-4-3-5-8-19)28(38)37-14-6-9-26(37)27-34-23-16-21(31)22(32)17-24(23)35-27/h3-5,7-8,10-13,16-17,25-26H,6,9,14-15,33H2,1-2H3,(H,34,35)(H,36,39)/t25-,26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328522
(CHEMBL1259179 | N-{(2S)-3-(Biphenyl-4-yl)-1-[(2S)-...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N4O3/c1-29(2,3)25-19-31-26(33-25)24-12-9-17-34(24)27(35)23(32-28(36)30(4,5)37)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24,37H,9,12,17-18H2,1-5H3,(H,31,33)(H,32,36)/t23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328522
(CHEMBL1259179 | N-{(2S)-3-(Biphenyl-4-yl)-1-[(2S)-...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N4O3/c1-29(2,3)25-19-31-26(33-25)24-12-9-17-34(24)27(35)23(32-28(36)30(4,5)37)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24,37H,9,12,17-18H2,1-5H3,(H,31,33)(H,32,36)/t23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328524
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H29Cl2N5O2/c1-14(15-8-5-4-6-9-15)21(31-24(34)25(2,3)28)23(33)32-11-7-10-20(32)22-29-18-12-16(26)17(27)13-19(18)30-22/h4-6,8-9,12-14,20-21H,7,10-11,28H2,1-3H3,(H,29,30)(H,31,34)/t14-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328528
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-4-(1-methyl...)Show SMILES Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)C(C)(C)N)C(=O)N2CCC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 |r| Show InChI InChI=1S/C30H32Cl2N6O3/c1-30(2,33)29(41)36-24(13-17-6-8-18(9-7-17)19-10-11-26(39)37(3)16-19)28(40)38-12-4-5-25(38)27-34-22-14-20(31)21(32)15-23(22)35-27/h6-11,14-16,24-25H,4-5,12-13,33H2,1-3H3,(H,34,35)(H,36,41)/t24-,25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328538
(3-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(N)CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-31(2,34)18-28(39)35-26(15-19-10-12-21(13-11-19)20-7-4-3-5-8-20)30(40)38-14-6-9-27(38)29-36-24-16-22(32)23(33)17-25(24)37-29/h3-5,7-8,10-13,16-17,26-27H,6,9,14-15,18,34H2,1-2H3,(H,35,39)(H,36,37)/t26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328539
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5-ter...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)N |r| Show InChI InChI=1S/C30H39N5O2/c1-29(2,3)25-19-32-26(34-25)24-12-9-17-35(24)27(36)23(33-28(37)30(4,5)31)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24H,9,12,17-18,31H2,1-5H3,(H,32,34)(H,33,37)/t23-,24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328528
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-4-(1-methyl...)Show SMILES Cn1cc(ccc1=O)-c1ccc(C[C@H](NC(=O)C(C)(C)N)C(=O)N2CCC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 |r| Show InChI InChI=1S/C30H32Cl2N6O3/c1-30(2,33)29(41)36-24(13-17-6-8-18(9-7-17)19-10-11-26(39)37(3)16-19)28(40)38-12-4-5-25(38)27-34-22-14-20(31)21(32)15-23(22)35-27/h6-11,14-16,24-25H,4-5,12-13,33H2,1-3H3,(H,34,35)(H,36,41)/t24-,25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328523
(2-Amino-N-{(2S,3S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc(cc1)-c1ccccc1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-18(19-11-13-21(14-12-19)20-8-5-4-6-9-20)27(37-30(40)31(2,3)34)29(39)38-15-7-10-26(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h4-6,8-9,11-14,16-18,26-27H,7,10,15,34H2,1-3H3,(H,35,36)(H,37,40)/t18-,26-,27-/m0/s1 | Reactome pathway
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328536
(5,6-Dichloro-2-[(2S)-1-(2-methylalanyl-O-methyl-L-...)Show SMILES COc1ccc(C[C@H](NC(=O)C(C)(C)N)C(=O)N2CC[C@H]2c2nc3cc(Cl)c(Cl)cc3[nH]2)cc1 |r| Show InChI InChI=1S/C24H27Cl2N5O3/c1-24(2,27)23(33)30-19(10-13-4-6-14(34-3)7-5-13)22(32)31-9-8-20(31)21-28-17-11-15(25)16(26)12-18(17)29-21/h4-7,11-12,19-20H,8-10,27H2,1-3H3,(H,28,29)(H,30,33)/t19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328524
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H29Cl2N5O2/c1-14(15-8-5-4-6-9-15)21(31-24(34)25(2,3)28)23(33)32-11-7-10-20(32)22-29-18-12-16(26)17(27)13-19(18)30-22/h4-6,8-9,12-14,20-21H,7,10-11,28H2,1-3H3,(H,29,30)(H,31,34)/t14-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328529
(5,6-Dichloro-2-[(2S)-1-(2-methylalanyl-beta,beta-d...)Show SMILES CC(C)(N)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)C(C)(C)c1ccccc1 |r| Show InChI InChI=1S/C26H31Cl2N5O2/c1-25(2,15-9-6-5-7-10-15)21(32-24(35)26(3,4)29)23(34)33-12-8-11-20(33)22-30-18-13-16(27)17(28)14-19(18)31-22/h5-7,9-10,13-14,20-21H,8,11-12,29H2,1-4H3,(H,30,31)(H,32,35)/t20-,21+/m0/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328522
(CHEMBL1259179 | N-{(2S)-3-(Biphenyl-4-yl)-1-[(2S)-...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N4O3/c1-29(2,3)25-19-31-26(33-25)24-12-9-17-34(24)27(35)23(32-28(36)30(4,5)37)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24,37H,9,12,17-18H2,1-5H3,(H,31,33)(H,32,36)/t23-,24-/m0/s1 | Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328534
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C30H31Cl2N5O2/c1-30(2,33)29(39)36-25(15-18-10-12-20(13-11-18)19-7-4-3-5-8-19)28(38)37-14-6-9-26(37)27-34-23-16-21(31)22(32)17-24(23)35-27/h3-5,7-8,10-13,16-17,25-26H,6,9,14-15,33H2,1-2H3,(H,34,35)(H,36,39)/t25-,26-/m0/s1 | Reactome pathway
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328522
(CHEMBL1259179 | N-{(2S)-3-(Biphenyl-4-yl)-1-[(2S)-...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)O |r| Show InChI InChI=1S/C30H38N4O3/c1-29(2,3)25-19-31-26(33-25)24-12-9-17-34(24)27(35)23(32-28(36)30(4,5)37)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24,37H,9,12,17-18H2,1-5H3,(H,31,33)(H,32,36)/t23-,24-/m0/s1 | Reactome pathway
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328539
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5-ter...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)N |r| Show InChI InChI=1S/C30H39N5O2/c1-29(2,3)25-19-32-26(34-25)24-12-9-17-35(24)27(36)23(33-28(37)30(4,5)31)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24H,9,12,17-18,31H2,1-5H3,(H,32,34)(H,33,37)/t23-,24-/m0/s1 | Reactome pathway
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328583
(CHEMBL1259135 | N-{(2S)-3-(Biphenyl-4-yl)-1-[(2S)-...)Show SMILES CC(C)(O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(F)c(F)cc2[nH]1 |r| Show InChI InChI=1S/C30H30F2N4O3/c1-30(2,39)29(38)35-25(15-18-10-12-20(13-11-18)19-7-4-3-5-8-19)28(37)36-14-6-9-26(36)27-33-23-16-21(31)22(32)17-24(23)34-27/h3-5,7-8,10-13,16-17,25-26,39H,6,9,14-15H2,1-2H3,(H,33,34)(H,35,38)/t25-,26-/m0/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328525
(CHEMBL1259221 | N-{(2S,3S)-1-[(2S)-2-(5,6-Dichloro...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H28Cl2N4O3/c1-14(15-8-5-4-6-9-15)21(30-24(33)25(2,3)34)23(32)31-11-7-10-20(31)22-28-18-12-16(26)17(27)13-19(18)29-22/h4-6,8-9,12-14,20-21,34H,7,10-11H2,1-3H3,(H,28,29)(H,30,33)/t14-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
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PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328532
((S)-1-(2-(5-(3-bromophenyl)-1H-imidazol-2-yl)-4,4-...)Show SMILES CC(C)(Cc1ccc(cc1)-c1cccc(Cl)c1Cl)C(=O)N1CC(F)(F)C[C@H]1c1nc(c[nH]1)-c1cccc(Br)c1 |r| Show InChI InChI=1S/C30H26BrCl2F2N3O/c1-29(2,14-18-9-11-19(12-10-18)22-7-4-8-23(32)26(22)33)28(39)38-17-30(34,35)15-25(38)27-36-16-24(37-27)20-5-3-6-21(31)13-20/h3-13,16,25H,14-15,17H2,1-2H3,(H,36,37)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328582
(4'-(3-{(2S,4R)-2-[5-(3-Chlorophenyl)-1H-imidazol-2...)Show SMILES O[C@@H]1C[C@H](N(C1)C(=O)CCc1ccc(cc1)-c1cccc(c1)C#N)c1nc(c[nH]1)-c1cccc(Cl)c1 |r| Show InChI InChI=1S/C29H25ClN4O2/c30-24-6-2-5-23(14-24)26-17-32-29(33-26)27-15-25(35)18-34(27)28(36)12-9-19-7-10-21(11-8-19)22-4-1-3-20(13-22)16-31/h1-8,10-11,13-14,17,25,27,35H,9,12,15,18H2,(H,32,33)/t25-,27+/m1/s1 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328525
(CHEMBL1259221 | N-{(2S,3S)-1-[(2S)-2-(5,6-Dichloro...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H28Cl2N4O3/c1-14(15-8-5-4-6-9-15)21(30-24(33)25(2,3)34)23(32)31-11-7-10-20(31)22-28-18-12-16(26)17(27)13-19(18)29-22/h4-6,8-9,12-14,20-21,34H,7,10-11H2,1-3H3,(H,28,29)(H,30,33)/t14-,20-,21-/m0/s1 | Reactome pathway
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| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328524
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H29Cl2N5O2/c1-14(15-8-5-4-6-9-15)21(31-24(34)25(2,3)28)23(33)32-11-7-10-20(32)22-29-18-12-16(26)17(27)13-19(18)30-22/h4-6,8-9,12-14,20-21H,7,10-11,28H2,1-3H3,(H,29,30)(H,31,34)/t14-,20-,21-/m0/s1 | Reactome pathway
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PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558172
(CHEMBL4750179)Show SMILES Cc1cc(ccn1)-c1ccc2OCCn3c(Nc4cccc(Cl)c4)nnc3-c2c1 | KEGG
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328526
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C24H27Cl2N5O2/c1-13(14-7-5-4-6-8-14)20(30-23(33)24(2,3)27)22(32)31-10-9-19(31)21-28-17-11-15(25)16(26)12-18(17)29-21/h4-8,11-13,19-20H,9-10,27H2,1-3H3,(H,28,29)(H,30,33)/t13-,19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328529
(5,6-Dichloro-2-[(2S)-1-(2-methylalanyl-beta,beta-d...)Show SMILES CC(C)(N)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)C(C)(C)c1ccccc1 |r| Show InChI InChI=1S/C26H31Cl2N5O2/c1-25(2,15-9-6-5-7-10-15)21(32-24(35)26(3,4)29)23(34)33-12-8-11-20(33)22-30-18-13-16(27)17(28)14-19(18)31-22/h5-7,9-10,13-14,20-21H,8,11-12,29H2,1-4H3,(H,30,31)(H,32,35)/t20-,21+/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328539
(2-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5-ter...)Show SMILES CC(C)(C)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)C(C)(C)N |r| Show InChI InChI=1S/C30H39N5O2/c1-29(2,3)25-19-32-26(34-25)24-12-9-17-35(24)27(36)23(33-28(37)30(4,5)31)18-20-13-15-22(16-14-20)21-10-7-6-8-11-21/h6-8,10-11,13-16,19,23-24H,9,12,17-18,31H2,1-5H3,(H,32,34)(H,33,37)/t23-,24-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328537
(3-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(CN)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-31(2,18-34)30(40)37-26(15-19-10-12-21(13-11-19)20-7-4-3-5-8-20)29(39)38-14-6-9-27(38)28-35-24-16-22(32)23(33)17-25(24)36-28/h3-5,7-8,10-13,16-17,26-27H,6,9,14-15,18,34H2,1-2H3,(H,35,36)(H,37,40)/t26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558167
(CHEMBL4798957)Show SMILES Cc1cc(ccn1)-c1ccc2OCCn3c(Nc4cccc(OC(F)(F)F)c4)nnc3-c2c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558171
(CHEMBL4790150)Show SMILES FC(F)(F)c1cccc(Nc2nnc3-c4cc(ccc4OCCn23)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328559
(3-(4'-Chlorobiphenyl-4-yl)-1-[(2S)-2-(4-phenyl-1H-...)Show SMILES Clc1ccc(cc1)-c1ccc(CCC(=O)N2CCC[C@H]2c2nc(c[nH]2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C28H26ClN3O/c29-24-15-13-22(14-16-24)21-11-8-20(9-12-21)10-17-27(33)32-18-4-7-26(32)28-30-19-25(31-28)23-5-2-1-3-6-23/h1-3,5-6,8-9,11-16,19,26H,4,7,10,17-18H2,(H,30,31)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328535
(5,6-Dichloro-2-[(2S)-1-(2-methylalanyl-4-chloro-L-...)Show SMILES CC(C)(N)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C24H26Cl3N5O2/c1-24(2,28)23(34)31-19(10-13-5-7-14(25)8-6-13)22(33)32-9-3-4-20(32)21-29-17-11-15(26)16(27)12-18(17)30-21/h5-8,11-12,19-20H,3-4,9-10,28H2,1-2H3,(H,29,30)(H,31,34)/t19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328557
(3-(4'-Methylbiphenyl-4-yl)-1-[(2S)-2-(4-phenyl-1H-...)Show SMILES Cc1ccc(cc1)-c1ccc(CCC(=O)N2CCC[C@H]2c2nc(c[nH]2)-c2ccccc2)cc1 |r| Show InChI InChI=1S/C29H29N3O/c1-21-9-14-23(15-10-21)24-16-11-22(12-17-24)13-18-28(33)32-19-5-8-27(32)29-30-20-26(31-29)25-6-3-2-4-7-25/h2-4,6-7,9-12,14-17,20,27H,5,8,13,18-19H2,1H3,(H,30,31)/t27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558161
(CHEMBL4746135)Show SMILES Cc1cc(ccn1)-c1ccc2OCCn3c(Oc4cccc(Cl)c4F)nnc3-c2c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558165
(CHEMBL4761139)Show SMILES Cc1cc(ccn1)-c1ccc2OCCn3c(Oc4cccc(Cl)c4)nnc3-c2c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558195
(CHEMBL4800653)Show SMILES Fc1c(Cl)cccc1NC(=O)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328525
(CHEMBL1259221 | N-{(2S,3S)-1-[(2S)-2-(5,6-Dichloro...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)O)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H28Cl2N4O3/c1-14(15-8-5-4-6-9-15)21(30-24(33)25(2,3)34)23(32)31-11-7-10-20(31)22-28-18-12-16(26)17(27)13-19(18)29-22/h4-6,8-9,12-14,20-21,34H,7,10-11H2,1-3H3,(H,28,29)(H,30,33)/t14-,20-,21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Mus musculus) | BDBM50328524
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C25H29Cl2N5O2/c1-14(15-8-5-4-6-9-15)21(31-24(34)25(2,3)28)23(33)32-11-7-10-20(32)22-29-18-12-16(26)17(27)13-19(18)30-22/h4-6,8-9,12-14,20-21H,7,10-11,28H2,1-3H3,(H,29,30)(H,31,34)/t14-,20-,21-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of mouse PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Mus musculus) | BDBM50558200
(CHEMBL4785678)Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)N1CCOc2ccc(cc2C1)-c1ccncc1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at mouse GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558170
(CHEMBL4788072)Show SMILES Cc1cc(ccn1)-c1ccc2OCCn3c(Nc4cccc(c4)C(F)(F)F)nnc3-c2c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Probable G-protein coupled receptor 142
(Homo sapiens (Human)) | BDBM50558168
(CHEMBL4755454)Show SMILES FC(F)(F)Oc1cccc(Nc2nnc3-c4cc(ccc4OCCn23)-c2ccncc2)c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2016.04.018
BindingDB Entry DOI: 10.7270/Q2HM5D44 |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328526
(5,6-Dichloro-2-{(2S)-1-[2-methylalanyl-(betaS)-bet...)Show SMILES C[C@H]([C@H](NC(=O)C(C)(C)N)C(=O)N1CC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccccc1 |r| Show InChI InChI=1S/C24H27Cl2N5O2/c1-13(14-7-5-4-6-8-14)20(30-23(33)24(2,3)27)22(32)31-10-9-19(31)21-28-17-11-15(25)16(26)12-18(17)29-21/h4-8,11-13,19-20H,9-10,27H2,1-3H3,(H,28,29)(H,30,33)/t13-,19-,20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328550
(CHEMBL1259218 | tert-Butyl{(2S)-3-(Biphenyl-4-yl)-...)Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1C(=O)c1nc2ccccc2[nH]1 |r| Show InChI InChI=1S/C32H34N4O4/c1-32(2,3)40-31(39)35-26(20-21-15-17-23(18-16-21)22-10-5-4-6-11-22)30(38)36-19-9-14-27(36)28(37)29-33-24-12-7-8-13-25(24)34-29/h4-8,10-13,15-18,26-27H,9,14,19-20H2,1-3H3,(H,33,34)(H,35,39)/t26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
Lysosomal Pro-X carboxypeptidase
(Homo sapiens (Human)) | BDBM50328538
(3-Amino-N-{(2S)-3-(biphenyl-4-yl)-1-[(2S)-2-(5,6-d...)Show SMILES CC(C)(N)CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1CCC[C@H]1c1nc2cc(Cl)c(Cl)cc2[nH]1 |r| Show InChI InChI=1S/C31H33Cl2N5O2/c1-31(2,34)18-28(39)35-26(15-19-10-12-21(13-11-19)20-7-4-3-5-8-20)30(40)38-14-6-9-27(38)29-36-24-16-22(32)23(33)17-25(24)37-29/h3-5,7-8,10-13,16-17,26-27H,6,9,14-15,18,34H2,1-2H3,(H,35,39)(H,36,37)/t26-,27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human PrCP by FRET in presence of 1% mouse serum albumin |
J Med Chem 53: 7251-63 (2010)
Article DOI: 10.1021/jm101013m
BindingDB Entry DOI: 10.7270/Q2QV3MQR |
More data for this
Ligand-Target Pair | |
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