Compile Data Set for Download or QSAR

Found 361 hits with Last Name = 'mallow' and Initial = 'k'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445676 (Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...) Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H18N6O2S/c1-2-25-17-16(18(27)23-19(25)28)26(11-13-6-4-3-5-7-13)15(22-17)10-14-12-24-8-9-29-20(24)21-14/h3-9,12H,2,10-11H2,1H3,(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445676 (Ex. 14/KM-06-64/(I-14) | US10683309, Example 14 | ...) Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H18N6O2S/c1-2-25-17-16(18(27)23-19(25)28)26(11-13-6-4-3-5-7-13)15(22-17)10-14-12-24-8-9-29-20(24)21-14/h3-9,12H,2,10-11H2,1H3,(H,23,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445677 (Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...) Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N8O2S/c1-3-31-21-20(22(33)27-23(31)34)32(19(26-21)12-17-14-30-10-11-35-24(30)25-17)13-15-4-6-16(7-5-15)18-8-9-29(2)28-18/h4-11,14H,3,12-13H2,1-2H3,(H,27,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357737 (KM-05-166/(I-206) | US10214530, Example 24) Show SMILES CCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H20N6O4/c1-2-28-21-20(22(30)27-23(28)31)29(11-13-6-4-3-5-7-13)19(26-21)10-18-24-14-8-16-17(33-12-32-16)9-15(14)25-18/h3-9H,2,10-12H2,1H3,(H,24,25)(H,27,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445677 (Ex. 15/KM-06-96/(I-15) | US10683309, Example 15 | ...) Show SMILES CCn1c2nc(Cc3cn4ccsc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N8O2S/c1-3-31-21-20(22(33)27-23(31)34)32(19(26-21)12-17-14-30-10-11-35-24(30)25-17)13-15-4-6-16(7-5-15)18-8-9-29(2)28-18/h4-11,14H,3,12-13H2,1-2H3,(H,27,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357735 (KM-05-193/(I-209) | US10214530, Example 27) Show SMILES CCCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N6O4/c1-2-8-29-22-21(23(31)28-24(29)32)30(12-14-6-4-3-5-7-14)20(27-22)11-19-25-15-9-17-18(34-13-33-17)10-16(15)26-19/h3-7,9-10H,2,8,11-13H2,1H3,(H,25,26)(H,28,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357737 (KM-05-166/(I-206) | US10214530, Example 24) Show SMILES CCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H20N6O4/c1-2-28-21-20(22(30)27-23(28)31)29(11-13-6-4-3-5-7-13)19(26-21)10-18-24-14-8-16-17(33-12-32-16)9-15(14)25-18/h3-9H,2,10-12H2,1H3,(H,24,25)(H,27,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357735 (KM-05-193/(I-209) | US10214530, Example 27) Show SMILES CCCn1c2nc(Cc3nc4cc5OCOc5cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N6O4/c1-2-8-29-22-21(23(31)28-24(29)32)30(12-14-6-4-3-5-7-14)20(27-22)11-19-25-15-9-17-18(34-13-33-17)10-16(15)26-19/h3-7,9-10H,2,8,11-13H2,1H3,(H,25,26)(H,28,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445685 (Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H17ClN6O2S/c1-2-26-17-16(18(28)24-19(26)29)27(9-12-6-4-3-5-7-12)15(23-17)8-13-10-25-11-14(21)30-20(25)22-13/h3-7,10-11H,2,8-9H2,1H3,(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445685 (Ex. 21/KM-06-108/(I-21) | US10683309, Example 21 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H17ClN6O2S/c1-2-26-17-16(18(28)24-19(26)29)27(9-12-6-4-3-5-7-12)15(23-17)8-13-10-25-11-14(21)30-20(25)22-13/h3-7,10-11H,2,8-9H2,1H3,(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445680 (Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H20N6O2S/c1-3-26-18-17(19(28)24-20(26)29)27(11-14-7-5-4-6-8-14)16(23-18)9-15-12-25-10-13(2)30-21(25)22-15/h4-8,10,12H,3,9,11H2,1-2H3,(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445694 (Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H23N7O3S/c1-4-29-20-19(21(32)27-22(29)33)30(11-15-5-7-16(8-6-15)24-14(3)31)18(26-20)9-17-12-28-10-13(2)34-23(28)25-17/h5-8,10,12H,4,9,11H2,1-3H3,(H,24,31)(H,27,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445680 (Ex. 16/KM-06-97/(I-16) | US10683309, Example 16 | ...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C21H20N6O2S/c1-3-26-18-17(19(28)24-20(26)29)27(11-14-7-5-4-6-8-14)16(23-18)9-15-12-25-10-13(2)30-21(25)22-15/h4-8,10,12H,3,9,11H2,1-2H3,(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445694 (Ex. 30/KM-06-150/(I-30) | US10683309, Example 30 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H23N7O3S/c1-4-29-20-19(21(32)27-22(29)33)30(11-15-5-7-16(8-6-15)24-14(3)31)18(26-20)9-17-12-28-10-13(2)34-23(28)25-17/h5-8,10,12H,4,9,11H2,1-3H3,(H,24,31)(H,27,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445669 (Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C26H24N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h4-13,16H,3,14-15H2,1-2H3,(H,29,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445672 (Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nccs3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H21N7O2S/c1-2-31-22-21(23(33)29-25(31)34)32(14-16-6-8-17(9-7-16)24-26-10-12-35-24)20(28-22)13-18-15-30-11-4-3-5-19(30)27-18/h3-12,15H,2,13-14H2,1H3,(H,29,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445692 (Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H20ClN7O3S/c1-3-29-19-18(20(32)27-21(29)33)30(9-13-4-6-14(7-5-13)24-12(2)31)17(26-19)8-15-10-28-11-16(23)34-22(28)25-15/h4-7,10-11H,3,8-9H2,1-2H3,(H,24,31)(H,27,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445696 (Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H25N7O3S/c1-3-30-22-21(23(34)28-24(30)35)32(13-16-6-8-18(9-7-16)31-10-4-5-20(31)33)19(27-22)11-17-14-29-12-15(2)36-25(29)26-17/h6-9,12,14H,3-5,10-11,13H2,1-2H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445669 (Ex. 7/KM-06-81/(I-7) | US10683309, Example 7 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C26H24N8O2/c1-3-33-24-23(25(35)29-26(33)36)34(15-17-7-9-18(10-8-17)20-11-13-31(2)30-20)22(28-24)14-19-16-32-12-5-4-6-21(32)27-19/h4-13,16H,3,14-15H2,1-2H3,(H,29,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445672 (Ex. 10/KM-06-90/(I-10) | US10683309, Example 10 | ...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nccs3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H21N7O2S/c1-2-31-22-21(23(33)29-25(31)34)32(14-16-6-8-17(9-7-16)24-26-10-12-35-24)20(28-22)13-18-15-30-11-4-3-5-19(30)27-18/h3-12,15H,2,13-14H2,1H3,(H,29,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445692 (Ex. 28/KM-06-148/(I-28) | US10683309, Example 28 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(NC(C)=O)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H20ClN7O3S/c1-3-29-19-18(20(32)27-21(29)33)30(9-13-4-6-14(7-5-13)24-12(2)31)17(26-19)8-15-10-28-11-16(23)34-22(28)25-15/h4-7,10-11H,3,8-9H2,1-2H3,(H,24,31)(H,27,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445696 (Ex. 32/KM-06-153/(I-32) | US10683309, Example 32 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)N3CCCC3=O)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H25N7O3S/c1-3-30-22-21(23(34)28-24(30)35)32(13-16-6-8-18(9-7-16)31-10-4-5-20(31)33)19(27-22)11-17-14-29-12-15(2)36-25(29)26-17/h6-9,12,14H,3-5,10-11,13H2,1-2H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445670 (Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H22N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445675 (Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...) Show SMILES CCn1c2nc(Cc3cn4nc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H19N7O2S/c1-3-25-17-16(18(28)23-19(25)29)26(10-13-7-5-4-6-8-13)15(22-17)9-14-11-27-20(21-14)30-12(2)24-27/h4-8,11H,3,9-10H2,1-2H3,(H,23,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445670 (Ex. 8/KM-06-82/(I-8) | US10683309, Example 8 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H22N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445675 (Ex. 13/KM-06-66/(I-13) | US10683309, Example 13 | ...) Show SMILES CCn1c2nc(Cc3cn4nc(C)sc4n3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C20H19N7O2S/c1-3-25-17-16(18(28)23-19(25)29)26(10-13-7-5-4-6-8-13)15(22-17)9-14-11-27-20(21-14)30-12(2)24-27/h4-8,11H,3,9-10H2,1-2H3,(H,23,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357739 (AG-01-128/(I-202) | US10214530, Example 18) Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H20N6O2/c1-2-27-20-19(21(29)26-22(27)30)28(13-14-8-4-3-5-9-14)18(25-20)12-17-23-15-10-6-7-11-16(15)24-17/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445666 (Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)C(=O)OC)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N6O4/c1-3-29-21-20(22(31)27-24(29)33)30(13-15-7-9-16(10-8-15)23(32)34-2)19(26-21)12-17-14-28-11-5-4-6-18(28)25-17/h4-11,14H,3,12-13H2,1-2H3,(H,27,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445671 (Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ncccn3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C26H22N8O2/c1-2-33-24-22(25(35)31-26(33)36)34(15-17-7-9-18(10-8-17)23-27-11-5-12-28-23)21(30-24)14-19-16-32-13-4-3-6-20(32)29-19/h3-13,16H,2,14-15H2,1H3,(H,31,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445674 (Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nc(C)no3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H22N8O3/c1-3-32-22-21(23(34)29-25(32)35)33(13-16-7-9-17(10-8-16)24-26-15(2)30-36-24)20(28-22)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357736 (MW-01-157/(I-207) | US10214530, Example 25) Show SMILES CCCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H22N6O2/c1-2-12-28-21-20(22(30)27-23(28)31)29(14-15-8-4-3-5-9-15)19(26-21)13-18-24-16-10-6-7-11-17(16)25-18/h3-11H,2,12-14H2,1H3,(H,24,25)(H,27,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM50598894 (CHEMBL5197055) Show SMILES CCCn1c2nc(Cc3nc4cc(O)ccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445674 (Ex. 12/KM-06-93/(I-12) | US10683309, Example 12 | ...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3nc(C)no3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H22N8O3/c1-3-32-22-21(23(34)29-25(32)35)33(13-16-7-9-17(10-8-16)24-26-15(2)30-36-24)20(28-22)12-18-14-31-11-5-4-6-19(31)27-18/h4-11,14H,3,12-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357739 (AG-01-128/(I-202) | US10214530, Example 18) Show SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H20N6O2/c1-2-27-20-19(21(29)26-22(27)30)28(13-14-8-4-3-5-9-14)18(25-20)12-17-23-15-10-6-7-11-16(15)24-17/h3-11H,2,12-13H2,1H3,(H,23,24)(H,26,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357734 (KM-05-185/(I-204) | US10214530, Example 21) Show SMILES CCCn1c2nc(Cc3nc4ccc(O)cc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H22N6O3/c1-2-10-28-21-20(22(31)27-23(28)32)29(13-14-6-4-3-5-7-14)19(26-21)12-18-24-16-9-8-15(30)11-17(16)25-18/h3-9,11,30H,2,10,12-13H2,1H3,(H,24,25)(H,27,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM357736 (MW-01-157/(I-207) | US10214530, Example 25) Show SMILES CCCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C23H22N6O2/c1-2-12-28-21-20(22(30)27-23(28)31)29(14-15-8-4-3-5-9-15)19(26-21)13-18-24-16-10-6-7-11-17(16)25-18/h3-11H,2,12-14H2,1H3,(H,24,25)(H,27,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN US Patent					Assay Description These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...				US Patent US10214530 (2019) BindingDB Entry DOI: 10.7270/Q25B04SK
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445666 (Ex. 4/KM-06-78/(I-4) | US10683309, Example 4 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)C(=O)OC)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H22N6O4/c1-3-29-21-20(22(31)27-24(29)33)30(13-15-7-9-16(10-8-15)23(32)34-2)19(26-21)12-17-14-28-11-5-4-6-18(28)25-17/h4-11,14H,3,12-13H2,1-2H3,(H,27,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445671 (Ex. 9/KM-06-89/(I-9) | US10683309, Example 9 | US1...) Show SMILES CCn1c2nc(Cc3cn4ccccc4n3)n(Cc3ccc(cc3)-c3ncccn3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C26H22N8O2/c1-2-33-24-22(25(35)31-26(33)36)34(15-17-7-9-18(10-8-17)23-27-11-5-12-28-23)21(30-24)14-19-16-32-13-4-3-6-20(32)29-19/h3-13,16H,2,14-15H2,1H3,(H,31,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM50598895 (CHEMBL5172829) Show SMILES CCOc1ccc2[nH]c(Cc3nc4n(CC)c(=O)[nH]c(=O)c4n3Cc3ccccc3)nc2c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00598 BindingDB Entry DOI: 10.7270/Q2G164VF
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445681 (Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H24N8O2S/c1-4-32-22-21(23(34)28-24(32)35)33(13-16-5-7-17(8-6-16)19-9-10-30(3)29-19)20(27-22)11-18-14-31-12-15(2)36-25(31)26-18/h5-10,12,14H,4,11,13H2,1-3H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445681 (Ex. 17/KM-06-98/(I-17) | US10683309, Example 17 | ...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H24N8O2S/c1-4-32-22-21(23(34)28-24(32)35)33(13-16-5-7-17(8-6-16)19-9-10-30(3)29-19)20(27-22)11-18-14-31-12-15(2)36-25(31)26-18/h5-10,12,14H,4,11,13H2,1-3H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445693 (Ex. 29/KM-06-149/(I-29) | US10683309, Example 29 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-n3cncn3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H18ClN9O2S/c1-2-30-19-18(20(33)28-21(30)34)31(8-13-3-5-15(6-4-13)32-12-24-11-25-32)17(27-19)7-14-9-29-10-16(23)35-22(29)26-14/h3-6,9-12H,2,7-8H2,1H3,(H,28,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445693 (Ex. 29/KM-06-149/(I-29) | US10683309, Example 29 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-n3cncn3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H18ClN9O2S/c1-2-30-19-18(20(33)28-21(30)34)31(8-13-3-5-15(6-4-13)32-12-24-11-25-32)17(27-19)7-14-9-29-10-16(23)35-22(29)26-14/h3-6,9-12H,2,7-8H2,1H3,(H,28,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445684 (Ex. 20/KM-06-107/(I-20) | US10683309, Example 20 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H21ClN8O2S/c1-3-32-21-20(22(34)28-23(32)35)33(11-14-4-6-15(7-5-14)17-8-9-30(2)29-17)19(27-21)10-16-12-31-13-18(25)36-24(31)26-16/h4-9,12-13H,3,10-11H2,1-2H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445684 (Ex. 20/KM-06-107/(I-20) | US10683309, Example 20 |...) Show SMILES CCn1c2nc(Cc3cn4cc(Cl)sc4n3)n(Cc3ccc(cc3)-c3ccn(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C24H21ClN8O2S/c1-3-32-21-20(22(34)28-23(32)35)33(11-14-4-6-15(7-5-14)17-8-9-30(2)29-17)19(27-21)10-16-12-31-13-18(25)36-24(31)26-16/h4-9,12-13H,3,10-11H2,1-2H3,(H,28,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445691 (Ex. 27/KM-06-115/(I-27) | US10683309, Example 27 |...) Show SMILES CCn1c2nc(Cc3cn4cc(C)sc4n3)n(Cc3ccc(OC)cc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C22H22N6O3S/c1-4-27-19-18(20(29)25-21(27)30)28(11-14-5-7-16(31-3)8-6-14)17(24-19)9-15-12-26-10-13(2)32-22(26)23-15/h5-8,10,12H,4,9,11H2,1-3H3,(H,25,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445703 (Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...) Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H26N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h7-10,14H,3-6,11-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445703 (Ex. 39/KM-06-180/(I-39) | US10683309, Example 39 |...) Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-c3noc(C)n3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H26N8O3/c1-3-32-23-21(24(34)29-25(32)35)33(13-16-7-9-17(10-8-16)22-26-15(2)36-30-22)20(28-23)12-18-14-31-11-5-4-6-19(31)27-18/h7-10,14H,3-6,11-13H2,1-2H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US11028104 (2021) BindingDB Entry DOI: 10.7270/Q2JM2DRC
					More data for this Ligand-Target Pair
Tryptophan 5-hydroxylase 2 (Homo sapiens (Human))	BDBM445697 (Ex. 33/KM-06-156/(I-33) | US10683309, Example 33 |...) Show SMILES CCn1c2nc(Cc3cn4CCCCc4n3)n(Cc3ccc(cc3)-n3ccnc3)c2c(=O)[nH]c1=O Show InChI InChI=1S/C25H26N8O2/c1-2-32-23-22(24(34)29-25(32)35)33(14-17-6-8-19(9-7-17)31-12-10-26-16-31)21(28-23)13-18-15-30-11-4-3-5-20(30)27-18/h6-10,12,15-16H,2-5,11,13-14H2,1H3,(H,29,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN; FORSCHUNGSVERBUND BERLIN E.V. US Patent					Assay Description The full-length coding sequences of human TPH1 and TPH2 were PCR amplified, ligated into a MBP fusion vector (pMalc2x, New England Biolabs, MA, USA) ...				US Patent US10683309 (2020) BindingDB Entry DOI: 10.7270/Q2NG4TQ6
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 361 total )  |  Next  |  Last  >>

Jump to: