Found 13 hits with Last Name = 'nagaoka' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183267
(CHEMBL3817920)Show SMILES C[C@H]1O[C@H]([C@H](OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n4c(C)nc5c(N)ncnc45)[C@@H]3O)n3cnc4c(N)ncnc34)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H]1O)n1cc(F)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C40H49FN17O23P3/c1-12-21(59)26(37(75-12)55-3-14(41)35(64)54-40(55)65)79-82(66,67)73-5-16-23(61)28(39(77-16)57-11-52-19-30(43)46-8-49-33(19)57)81-84(70,71)74-6-17-24(62)27(38(78-17)56-10-51-18-29(42)45-7-48-32(18)56)80-83(68,69)72-4-15-22(60)25(63)36(76-15)58-13(2)53-20-31(44)47-9-50-34(20)58/h3,7-12,15-17,21-28,36-39,59-63H,4-6H2,1-2H3,(H,66,67)(H,68,69)(H,70,71)(H2,42,45,48)(H2,43,46,49)(H2,44,47,50)(H,54,64,65)/t12-,15-,16-,17-,21-,22-,23-,24-,25-,26-,27-,28-,36-,37-,38-,39-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183268
(CHEMBL3818137)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](CO)O[C@H]([C@@H]4O)n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H50N17O24P3/c1-13-52-21-32(43)46-10-49-35(21)57(13)37-25(63)22(60)15(76-37)5-72-83(68,69)80-28-24(62)17(78-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-74-84(70,71)81-29-23(61)16(77-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-73-82(66,67)79-27-14(4-58)75-36(26(27)64)54-3-2-18(59)53-40(54)65/h2-3,8-12,14-17,22-29,36-39,58,60-64H,4-7H2,1H3,(H,66,67)(H,68,69)(H,70,71)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,59,65)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 134 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183269
(CHEMBL3818726)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@@H](CO)O[C@H]([C@@H]4O)n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)39-25(66)22(63)15(78-39)3-74-85(70,71)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-23(64)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-84(68,69)81-27-14(2-62)77-38(26(27)67)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183270
(CHEMBL3818262)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H50N17O24P3/c1-13-52-21-32(43)46-10-49-35(21)57(13)36-26(64)22(60)15(76-36)5-72-82(66,67)80-28-24(62)17(78-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-74-84(70,71)81-29-25(63)16(77-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-73-83(68,69)79-27-23(61)14(4-58)75-37(27)54-3-2-18(59)53-40(54)65/h2-3,8-12,14-17,22-29,36-39,58,60-64H,4-7H2,1H3,(H,66,67)(H,68,69)(H,70,71)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,59,65)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183271
(CHEMBL3819183)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H51N17O27P4/c1-13-52-21-32(43)46-10-49-35(21)57(13)36-26(63)22(59)14(78-36)5-75-86(68,69)83-28-24(61)17(81-38(28)55-11-50-19-30(41)44-8-47-33(19)55)7-77-88(72,73)84-29-25(62)16(80-39(29)56-12-51-20-31(42)45-9-48-34(20)56)6-76-87(70,71)82-27-23(60)15(4-74-85(65,66)67)79-37(27)54-3-2-18(58)53-40(54)64/h2-3,8-12,14-17,22-29,36-39,59-63H,4-7H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,41,44,47)(H2,42,45,48)(H2,43,46,49)(H,53,58,64)(H2,65,66,67)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,36-,37-,38-,39-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183278
(CHEMBL3819262)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4ccc(=O)[nH]c4=O)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C39H49N17O27P4/c40-29-18-32(46-7-43-29)54(10-49-18)35-25(62)21(58)13(77-35)4-74-85(67,68)82-27-23(60)16(80-37(27)55-11-50-19-30(41)44-8-47-33(19)55)6-76-87(71,72)83-28-24(61)15(79-38(28)56-12-51-20-31(42)45-9-48-34(20)56)5-75-86(69,70)81-26-22(59)14(3-73-84(64,65)66)78-36(26)53-2-1-17(57)52-39(53)63/h1-2,7-16,21-28,35-38,58-62H,3-6H2,(H,67,68)(H,69,70)(H,71,72)(H2,40,43,46)(H2,41,44,47)(H2,42,45,48)(H,52,57,63)(H2,64,65,66)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,35-,36-,37-,38-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 84 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50309130
(CHEMBL591446 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C41H52N20O25P4/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(66)22(62)14(80-38)3-77-88(70,71)85-28-24(64)16(82-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-79-90(74,75)86-29-25(65)17(83-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-78-89(72,73)84-27-23(63)15(2-76-87(67,68)69)81-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-66H,2-5H2,1H3,(H,70,71)(H,72,73)(H,74,75)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)(H2,67,68,69)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage |
Bioorg Med Chem Lett 20: 1186-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50183322
(CHEMBL601940)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50152834
(2''-5--oligoadenylate derivative | [(2R,3R,4R,5R)-...)Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)O[C@@H]2[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]3[C@H](O)[C@@H](COP([O-])(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)([O-])=O)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O Show InChI InChI=1S/C40H50N20O25P4/c41-29-17-33(49-5-45-29)57(9-53-17)37-25(65)21(61)13(79-37)2-76-87(69,70)84-27-23(63)15(81-39(27)59-11-55-19-31(43)47-7-51-35(19)59)4-78-89(73,74)85-28-24(64)16(82-40(28)60-12-56-20-32(44)48-8-52-36(20)60)3-77-88(71,72)83-26-22(62)14(1-75-86(66,67)68)80-38(26)58-10-54-18-30(42)46-6-50-34(18)58/h5-16,21-28,37-40,61-65H,1-4H2,(H,69,70)(H,71,72)(H,73,74)(H2,41,45,49)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,66,67,68)/p-4/t13-,14-,15-,16-,21-,22-,23-,24-,25-,26-,27-,28-,37-,38-,39-,40-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage |
Bioorg Med Chem Lett 20: 1186-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50309127
(CHEMBL601939 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)41-29(83-86(72,73)74-3-15-22(63)26(67)38(78-15)58-10-54-18-30(42)46-6-50-34(18)58)25(66)17(80-41)5-76-85(70,71)82-28-24(65)16(79-40(28)60-12-56-20-32(44)48-8-52-36(20)60)4-75-84(68,69)81-27-23(64)14(2-62)77-39(27)59-11-55-19-31(43)47-7-51-35(19)59/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >50 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage |
Bioorg Med Chem Lett 20: 1186-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50309128
(CHEMBL591445 | {[(2R,3R,4R,5R)-4-[({[(2R,3S,4R,5R)...)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](CO)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C31H39N15O16P2/c1-10-43-16-25(34)37-7-40-28(16)46(10)29-20(51)17(48)12(59-29)3-56-63(52,53)62-22-19(50)13(60-31(22)45-9-42-15-24(33)36-6-39-27(15)45)4-57-64(54,55)61-21-18(49)11(2-47)58-30(21)44-8-41-14-23(32)35-5-38-26(14)44/h5-9,11-13,17-22,29-31,47-51H,2-4H2,1H3,(H,52,53)(H,54,55)(H2,32,35,38)(H2,33,36,39)(H2,34,37,40)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >50 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage |
Bioorg Med Chem Lett 20: 1186-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50309129
(CHEMBL601938 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(67)22(63)15(78-38)3-74-84(68,69)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-25(66)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-85(70,71)81-27-23(64)14(2-62)77-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Inhibition of human RNaseL ANK domain expressed in Escherichia coli assessed as 5' flurescein-r(C11U2C7)-3' RNA cleavage |
Bioorg Med Chem Lett 20: 1186-8 (2010)
Article DOI: 10.1016/j.bmcl.2009.12.005
BindingDB Entry DOI: 10.7270/Q2G73DVP |
More data for this
Ligand-Target Pair | |
2-5A-dependent ribonuclease
(Homo sapiens (Human)) | BDBM50309129
(CHEMBL601938 | {[(2R,3R,4R,5R)-4-[({[(2R,3R,4R,5R)...)Show SMILES Cc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)O[C@@H]2[C@H](O)[C@@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](CO)O[C@H]4n4cnc5c(N)ncnc45)O[C@H]3n3cnc4c(N)ncnc34)O[C@H]2n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C41H51N20O22P3/c1-13-57-21-33(45)49-9-53-37(21)61(13)38-26(67)22(63)15(78-38)3-74-84(68,69)82-28-24(65)17(80-40(28)59-11-55-19-31(43)47-7-51-35(19)59)5-76-86(72,73)83-29-25(66)16(79-41(29)60-12-56-20-32(44)48-8-52-36(20)60)4-75-85(70,71)81-27-23(64)14(2-62)77-39(27)58-10-54-18-30(42)46-6-50-34(18)58/h6-12,14-17,22-29,38-41,62-67H,2-5H2,1H3,(H,68,69)(H,70,71)(H,72,73)(H2,42,46,50)(H2,43,47,51)(H2,44,48,52)(H2,45,49,53)/t14-,15-,16-,17-,22-,23-,24-,25-,26-,27-,28-,29-,38-,39-,40-,41-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a |
Gifu University
Curated by ChEMBL
| Assay Description
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophor... |
Bioorg Med Chem 24: 3870-4 (2016)
Article DOI: 10.1016/j.bmc.2016.06.033
BindingDB Entry DOI: 10.7270/Q2RF5WZ4 |
More data for this
Ligand-Target Pair | |
Search and Browse
