Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human)) | BDBM50127140![]() ((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentration | J Med Chem 45: 5564-75 (2002) Article DOI: 10.1021/jm010057b BindingDB Entry DOI: 10.7270/Q2XS5Z46 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human)) | BDBM50473977![]() (CHEMBL538994) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >4.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentration | J Med Chem 45: 5564-75 (2002) Article DOI: 10.1021/jm010057b BindingDB Entry DOI: 10.7270/Q2XS5Z46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human)) | BDBM50045698![]() (1-Cyclopropyl-7-(2,6-dimethyl-pyridin-4-yl)-6,8-di...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity in a DNA cleavage assay using HeLa DNA topoisomerase II yielding its effective concentration | J Med Chem 45: 5564-75 (2002) Article DOI: 10.1021/jm010057b BindingDB Entry DOI: 10.7270/Q2XS5Z46 | |||||||||||
More data for this Ligand-Target Pair |