Found 10 hits with Last Name = 'najafnia' and Initial = 'l' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50221108
(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)thi...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1SCC(=O)N1c1ccc(F)cc1 |w:10.10| Show InChI InChI=1S/C16H14FNO3S2/c1-23(20,21)14-8-2-11(3-9-14)16-18(15(19)10-22-16)13-6-4-12(17)5-7-13/h2-9,16H,10H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50221106
(2-(4-(methylsulfonyl)phenyl)-3-p-tolylthiazolidin-...)Show SMILES Cc1ccc(cc1)N1C(SCC1=O)c1ccc(cc1)S(C)(=O)=O |w:8.14| Show InChI InChI=1S/C17H17NO3S2/c1-12-3-7-14(8-4-12)18-16(19)11-22-17(18)13-5-9-15(10-6-13)23(2,20)21/h3-10,17H,11H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50221107
(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)th...)Show SMILES COc1ccc(cc1)N1C(SCC1=O)c1ccc(cc1)S(C)(=O)=O |w:9.15| Show InChI InChI=1S/C17H17NO4S2/c1-22-14-7-5-13(6-8-14)18-16(19)11-23-17(18)12-3-9-15(10-4-12)24(2,20)21/h3-10,17H,11H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50221105
(2-(4-(methylsulfonyl)phenyl)-3-phenylthiazolidin-4...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1SCC(=O)N1c1ccccc1 |w:10.10| Show InChI InChI=1S/C16H15NO3S2/c1-22(19,20)14-9-7-12(8-10-14)16-17(15(18)11-21-16)13-5-3-2-4-6-13/h2-10,16H,11H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Homo sapiens (Human)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX1 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Homo sapiens (Human)) | BDBM50221106
(2-(4-(methylsulfonyl)phenyl)-3-p-tolylthiazolidin-...)Show SMILES Cc1ccc(cc1)N1C(SCC1=O)c1ccc(cc1)S(C)(=O)=O |w:8.14| Show InChI InChI=1S/C17H17NO3S2/c1-12-3-7-14(8-4-12)18-16(19)11-22-17(18)13-5-9-15(10-6-13)23(2,20)21/h3-10,17H,11H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX1 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Homo sapiens (Human)) | BDBM50221105
(2-(4-(methylsulfonyl)phenyl)-3-phenylthiazolidin-4...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1SCC(=O)N1c1ccccc1 |w:10.10| Show InChI InChI=1S/C16H15NO3S2/c1-22(19,20)14-9-7-12(8-10-14)16-17(15(18)11-21-16)13-5-3-2-4-6-13/h2-10,16H,11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX1 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Homo sapiens (Human)) | BDBM50221107
(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)th...)Show SMILES COc1ccc(cc1)N1C(SCC1=O)c1ccc(cc1)S(C)(=O)=O |w:9.15| Show InChI InChI=1S/C17H17NO4S2/c1-22-14-7-5-13(6-8-14)18-16(19)11-23-17(18)12-3-9-15(10-4-12)24(2,20)21/h3-10,17H,11H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX1 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Homo sapiens (Human)) | BDBM50221108
(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)thi...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1SCC(=O)N1c1ccc(F)cc1 |w:10.10| Show InChI InChI=1S/C16H14FNO3S2/c1-23(20,21)14-8-2-11(3-9-14)16-18(15(19)10-22-16)13-6-4-12(17)5-7-13/h2-9,16H,10H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX1 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair | |
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