Compile Data Set for Download or QSAR

Found 31 hits with Last Name = 'winneroski, jr.' and Initial = 'll'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458383 (1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ccc2CN(Cc2n1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-6-18(30-23-5-4-16-9-28(15(3)29)12-21(16)26-23)11-27(13)10-17-7-20-22(8-19(17)24)31-14(2)25-20/h4-5,7-8,13,18H,6,9-12H2,1-3H3/t13-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.214	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458383 (1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ccc2CN(Cc2n1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-6-18(30-23-5-4-16-9-28(15(3)29)12-21(16)26-23)11-27(13)10-17-7-20-22(8-19(17)24)31-14(2)25-20/h4-5,7-8,13,18H,6,9-12H2,1-3H3/t13-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.214	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150692 (US8987254, 7) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F |r,t:1| Show InChI InChI=1S/C23H18F2N8OS/c1-27-16-3-5-19(28-9-16)20(34)31-15-2-4-18(25)17(6-15)23-12-33(22-29-7-14(24)8-30-22)10-13(23)11-35-21(26)32-23/h2-9,13H,10-12H2,(H2,26,32)(H,31,34)/t13-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.358	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458387 (1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...) Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ccc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F |r| Show InChI InChI=1S/C24H27FN4O2S/c1-13-7-18(31-24-6-5-17-10-28(16(4)30)12-22(17)27-24)11-29(13)14(2)19-8-21-23(9-20(19)25)32-15(3)26-21/h5-6,8-9,13-14,18H,7,10-12H2,1-4H3/t13-,14-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.385	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458387 (1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...) Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ccc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F |r| Show InChI InChI=1S/C24H27FN4O2S/c1-13-7-18(31-24-6-5-17-10-28(16(4)30)12-22(17)27-24)11-29(13)14(2)19-8-21-23(9-20(19)25)32-15(3)26-21/h5-6,8-9,13-14,18H,7,10-12H2,1-4H3/t13-,14-,18+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.385	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150690 (US8987254, 5) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cccc(NC(=O)c2ccc(cn2)[N+]#[C-])c1 |r,t:1| Show InChI InChI=1S/C23H19FN8OS/c1-26-18-5-6-19(27-10-18)20(33)30-17-4-2-3-14(7-17)23-13-32(22-28-8-16(24)9-29-22)11-15(23)12-34-21(25)31-23/h2-10,15H,11-13H2,(H2,25,31)(H,30,33)/t15-,23+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458382 (1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ncc2CN(Cc2n1)C(C)=O |r| Show InChI InChI=1S/C22H24FN5O2S/c1-12-4-17(30-22-24-7-16-9-28(14(3)29)11-20(16)26-22)10-27(12)8-15-5-19-21(6-18(15)23)31-13(2)25-19/h5-7,12,17H,4,8-11H2,1-3H3/t12-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.465	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458382 (1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ncc2CN(Cc2n1)C(C)=O |r| Show InChI InChI=1S/C22H24FN5O2S/c1-12-4-17(30-22-24-7-16-9-28(14(3)29)11-20(16)26-22)10-27(12)8-15-5-19-21(6-18(15)23)31-13(2)25-19/h5-7,12,17H,4,8-11H2,1-3H3/t12-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.465	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150687 (US8987254, 2) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cccc(NC(=O)c2cnc(CO)cn2)c1 |r,t:1| Show InChI InChI=1S/C22H21FN8O2S/c23-15-5-27-21(28-6-15)31-9-14-11-34-20(24)30-22(14,12-31)13-2-1-3-16(4-13)29-19(33)18-8-25-17(10-32)7-26-18/h1-8,14,32H,9-12H2,(H2,24,30)(H,29,33)/t14-,22+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.482	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458386 (1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...) Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ncc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F |r| Show InChI InChI=1S/C23H26FN5O2S/c1-12-5-17(31-23-25-8-16-9-28(15(4)30)11-21(16)27-23)10-29(12)13(2)18-6-20-22(7-19(18)24)32-14(3)26-20/h6-8,12-13,17H,5,9-11H2,1-4H3/t12-,13-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.495	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458386 (1-[2-[(3R,5S)-1-[(1S)-1-(6-fluoro-2-methyl-1,3-ben...) Show SMILES C[C@H](N1C[C@@H](C[C@@H]1C)Oc1ncc2CN(Cc2n1)C(C)=O)c1cc2nc(C)sc2cc1F |r| Show InChI InChI=1S/C23H26FN5O2S/c1-12-5-17(31-23-25-8-16-9-28(15(4)30)11-21(16)27-23)10-29(12)13(2)18-6-20-22(7-19(18)24)32-14(3)26-20/h6-8,12-13,17H,5,9-11H2,1-4H3/t12-,13-,17+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.495	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150688 (US8987254, 3 | US9999624, 3) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,t:1| Show InChI InChI=1S/C22H18F3N7OS/c23-13-1-4-18(27-6-13)19(33)30-15-2-3-17(25)16(5-15)22-11-32(21-28-7-14(24)8-29-21)9-12(22)10-34-20(26)31-22/h1-8,12H,9-11H2,(H2,26,31)(H,30,33)/t12-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.554	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150689 (US8987254, 4) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(NC(=O)c2cnc(CO)cn2)ccc1F |r,t:1| Show InChI InChI=1S/C22H20F2N8O2S/c23-13-4-28-21(29-5-13)32-8-12-10-35-20(25)31-22(12,11-32)16-3-14(1-2-17(16)24)30-19(34)18-7-26-15(9-33)6-27-18/h1-7,12,33H,8-11H2,(H2,25,31)(H,30,34)/t12-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.569	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458385 (1-[3-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cnc2CN(Cc2c1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-18-5-17-10-28(15(3)29)12-22(17)25-8-18)11-27(13)9-16-6-21-23(7-20(16)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.592	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458385 (1-[3-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cnc2CN(Cc2c1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-18-5-17-10-28(15(3)29)12-22(17)25-8-18)11-27(13)9-16-6-21-23(7-20(16)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.592	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150686 (US8987254, 1 | US9999624, 1) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cccc(NC(=O)c2ccc(F)cn2)c1 |r,t:1| Show InChI InChI=1S/C22H19F2N7OS/c23-15-4-5-18(26-7-15)19(32)29-17-3-1-2-13(6-17)22-12-31(21-27-8-16(24)9-28-21)10-14(22)11-33-20(25)30-22/h1-9,14H,10-12H2,(H2,25,30)(H,29,32)/t14-,22+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.610	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150693 (US8987254, 8 | US9999624, 9) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cc(NC(=O)c2ncc(F)cc2F)ccc1F |r,t:1| Show InChI InChI=1S/C22H17F4N7OS/c23-12-3-17(26)18(28-5-12)19(34)31-14-1-2-16(25)15(4-14)22-10-33(21-29-6-13(24)7-30-21)8-11(22)9-35-20(27)32-22/h1-7,11H,8-10H2,(H2,27,32)(H,31,34)/t11-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM150691 (US8987254, 6 | US9999624, 7) Show SMILES NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cccc(NC(=O)c2ncc(F)cc2F)c1 |r,t:1| Show InChI InChI=1S/C22H18F3N7OS/c23-14-5-17(25)18(27-6-14)19(33)30-16-3-1-2-12(4-16)22-11-32(21-28-7-15(24)8-29-21)9-13(22)10-34-20(26)31-22/h1-8,13H,9-11H2,(H2,26,31)(H,30,33)/t13-,22+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.739	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US8987254 (2015) BindingDB Entry DOI: 10.7270/Q2FX786M
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458384 (1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cc2CN(Cc2cn1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-23-6-16-9-28(15(3)29)11-18(16)8-25-23)12-27(13)10-17-5-21-22(7-20(17)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.782	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10752632 (2020) BindingDB Entry DOI: 10.7270/Q2T72MHD
					More data for this Ligand-Target Pair
Protein O-GlcNAcase (Homo sapiens (Human))	BDBM458384 (1-[6-[(3R,5S)-1-[(6-fluoro-2-methyl-1,3-benzothiaz...) Show SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1cc2CN(Cc2cn1)C(C)=O |r| Show InChI InChI=1S/C23H25FN4O2S/c1-13-4-19(30-23-6-16-9-28(15(3)29)11-18(16)8-25-23)12-27(13)10-17-5-21-22(7-20(17)24)31-14(2)26-21/h5-8,13,19H,4,9-12H2,1-3H3/t13-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.782	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...				US Patent US10836773 (2020) BindingDB Entry DOI: 10.7270/Q2PG1VVK
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM158179 (US9029367, 3) Show SMILES NC1=N[C@]2(COC[C@@]2(F)CS1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F |r,t:1| Show InChI InChI=1S/C19H15F2N5O2S/c1-23-12-3-5-15(24-7-12)16(27)25-11-2-4-14(20)13(6-11)19-9-28-8-18(19,21)10-29-17(22)26-19/h2-7H,8-10H2,(H2,22,26)(H,25,27)/t18-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.66	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US9029367 (2015) BindingDB Entry DOI: 10.7270/Q21Z4344
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM158178 (US9029367, 2) Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]12COC[C@@]1(F)CSC(N)=N2 |r,c:30| Show InChI InChI=1S/C18H17F2N5O3S/c1-27-14-6-22-13(5-23-14)15(26)24-10-2-3-12(19)11(4-10)18-8-28-7-17(18,20)9-29-16(21)25-18/h2-6H,7-9H2,1H3,(H2,21,25)(H,24,26)/t17-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.2	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US9029367 (2015) BindingDB Entry DOI: 10.7270/Q21Z4344
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM158177 (US9029367, 1) Show SMILES NC1=N[C@]2(COC[C@@]2(F)CS1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,t:1| Show InChI InChI=1S/C18H15F3N4O2S/c19-10-1-4-14(23-6-10)15(26)24-11-2-3-13(20)12(5-11)18-8-27-7-17(18,21)9-28-16(22)25-18/h1-6H,7-9H2,(H2,22,25)(H,24,26)/t17-,18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.6	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US9029367 (2015) BindingDB Entry DOI: 10.7270/Q21Z4344
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM158181 (US9029367, 57) Show SMILES NC1=N[C@]2(COC[C@@]2(F)CO1)c1cc(NC(=O)c2cnc(OCC3(F)CC3)cn2)ccc1F |r,t:1| Show InChI InChI=1S/C21H20F3N5O4/c22-14-2-1-12(5-13(14)21-11-31-9-20(21,24)10-33-18(25)29-21)28-17(30)15-6-27-16(7-26-15)32-8-19(23)3-4-19/h1-2,5-7H,3-4,8-11H2,(H2,25,29)(H,28,30)/t20-,21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25.7	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US9029367 (2015) BindingDB Entry DOI: 10.7270/Q21Z4344
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM158180 (US9029367, 34) Show SMILES NC1=N[C@]2(COC[C@@]2(F)CO1)c1cc(NC(=O)c2ccc(cn2)[N+]#[C-])ccc1F |r,t:1| Show InChI InChI=1S/C19H15F2N5O3/c1-23-12-3-5-15(24-7-12)16(27)25-11-2-4-14(20)13(6-11)19-10-28-8-18(19,21)9-29-17(22)26-19/h2-7H,8-10H2,(H2,22,26)(H,25,27)/t18-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten uL of each dilution is ad...				US Patent US9029367 (2015) BindingDB Entry DOI: 10.7270/Q21Z4344
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126005 (US8772282, 1 | US8772282, 203) Show SMILES Cl.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1ccccc1 |r,t:1| Show InChI InChI=1S/C16H16FN5S.ClH/c17-13-6-19-15(20-7-13)22-8-12-9-23-14(18)21-16(12,10-22)11-4-2-1-3-5-11;/h1-7,12H,8-10H2,(H2,18,21);1H/t12-,16+;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	64.4	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126007 (US8772282, 16) Show SMILES CI.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1cccs1 |r,t:2| Show InChI InChI=1S/C14H14FN5S2.CH3I/c15-10-4-17-13(18-5-10)20-6-9-7-22-12(16)19-14(9,8-20)11-2-1-3-21-11;1-2/h1-5,9H,6-8H2,(H2,16,19);1H3/t9-,14-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	77.3	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126012 (US8772282, 32) Show SMILES Cl.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1ccc(F)s1 |r,t:1| Show InChI InChI=1S/C14H13F2N5S2.ClH/c15-9-3-18-13(19-4-9)21-5-8-6-22-12(17)20-14(8,7-21)10-1-2-11(16)23-10;/h1-4,8H,5-7H2,(H2,17,20);1H/t8-,14-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	91.2	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126011 (US8772282, 31) Show SMILES Cl.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1ccc(s1)C#N |r,t:1| Show InChI InChI=1S/C15H13FN6S2.ClH/c16-10-4-19-14(20-5-10)22-6-9-7-23-13(18)21-15(9,8-22)12-2-1-11(3-17)24-12;/h1-2,4-5,9H,6-8H2,(H2,18,21);1H/t9-,15-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126010 (US8772282, 30) Show SMILES Cl.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncccn1)c1ccc(F)s1 |r,t:1| Show InChI InChI=1S/C14H14FN5S2.ClH/c15-11-3-2-10(22-11)14-8-20(13-17-4-1-5-18-13)6-9(14)7-21-12(16)19-14;/h1-5,9H,6-8H2,(H2,16,19);1H/t9-,14-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	166	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair
Beta-secretase 1 (Homo sapiens (Human))	BDBM126009 (US8772282, 23) Show SMILES Cl.NC1=N[C@]2(CN(C[C@H]2CS1)c1ncc(F)cn1)c1ccns1 |r,t:1| Show InChI InChI=1S/C13H13FN6S2.ClH/c14-9-3-16-12(17-4-9)20-5-8-6-21-11(15)19-13(8,7-20)10-1-2-18-22-10;/h1-4,8H,5-7H2,(H2,15,19);1H/t8-,13-;/m0./s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	4.6	25
Eli Lilly and Company US Patent					Assay Description Serial dilutions of test compounds are prepared as described above. Compounds are further diluted 20x in KH2PO4 buffer. Ten μL of each dilution ...				US Patent US8772282 (2014) BindingDB Entry DOI: 10.7270/Q2JH3JVQ
					More data for this Ligand-Target Pair