Compile Data Set for Download or QSAR

Found 9 hits with Last Name = 'hegazy' and Initial = 'ls'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50465712 (CHEMBL4284414) Show SMILES CCOC(=O)c1ccc(CN(Cc2ccc(cc2)-c2cccc(c2)S(C)(=O)=O)S(=O)(=O)c2c(C)cc(C)cc2C)o1 Show InChI InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Inverse agonist activity at LXRbeta (unknown origin) expressed in HEK293 cells 24 hrs by Dual-Glo luciferase assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50465712 (CHEMBL4284414) Show SMILES CCOC(=O)c1ccc(CN(Cc2ccc(cc2)-c2cccc(c2)S(C)(=O)=O)S(=O)(=O)c2c(C)cc(C)cc2C)o1 Show InChI InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Inverse agonist activity at LXRalpha (unknown origin) expressed in HEK293 cells 24 hrs by Dual-Glo luciferase assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50396601 (CHEMBL2171902) Show SMILES CN1c2ccc(O)cc2C(=C)c2ccccc2C1=O Show InChI InChI=1S/C16H13NO2/c1-10-12-5-3-4-6-13(12)16(19)17(2)15-8-7-11(18)9-14(10)15/h3-9,18H,1H2,2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Antagonist activity at human LXRalpha expressed in HEK293T cells by luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50465711 (CHEMBL1316881) Show SMILES CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1ccc2OCCOc2c1 Show InChI InChI=1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha-LBD (182 to 447 amino acids) expressed in HEK293T cells by luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50465713 (CHEMBL4277633 | US20230340011, Example 94.) Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)N1CCC(CC1)OC |r,t:9| Show InChI InChI=1S/C30H49NO3/c1-20(5-10-28(33)31-17-13-23(34-4)14-18-31)25-8-9-26-24-7-6-21-19-22(32)11-15-29(21,2)27(24)12-16-30(25,26)3/h6,20,22-27,32H,5,7-19H2,1-4H3/t20-,22+,24+,25-,26+,27+,29+,30-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha expressed in HEK293 cells after 24 hrs by One-Glo luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50465711 (CHEMBL1316881) Show SMILES CN(CC(=O)Nc1ccc(F)c(F)c1F)C(=O)c1ccc2OCCOc2c1 Show InChI InChI=1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	530	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human LXRbeta-LBD (196 to 461 amino acids) expressed in HEK293T cells by luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50034786 (CHEMBL3360964) Show SMILES CS(=O)(=O)c1cccc(c1)-c1ccc(s1)-c1cc(nn1-c1ccccc1Cl)C(F)(F)F Show InChI InChI=1S/C21H14ClF3N2O2S2/c1-31(28,29)14-6-4-5-13(11-14)18-9-10-19(30-18)17-12-20(21(23,24)25)26-27(17)16-8-3-2-7-15(16)22/h2-12H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	108	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human full length LXRbeta expressed in African green monkey CV-1 cells co-expressing human pCMX/RXRalpha after 20 hrs by lucifera...				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50465710 (CHEMBL4289727) Show SMILES CC(OC(=O)c1oc2cc(F)ccc2c1C)C(=O)N1CCNC1=O Show InChI InChI=1S/C16H15FN2O5/c1-8-11-4-3-10(17)7-12(11)24-13(8)15(21)23-9(2)14(20)19-6-5-18-16(19)22/h3-4,7,9H,5-6H2,1-2H3,(H,18,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	720	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at GAL4-tagged human LXRbeta LBD expressed in HEK293T cells after 12 hrs by luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20186 ((4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-...) Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@]([H])(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC(=O)N(C)C |r,t:9| Show InChI InChI=1S/C26H43NO2/c1-17(6-11-24(29)27(4)5)21-9-10-22-20-8-7-18-16-19(28)12-14-25(18,2)23(20)13-15-26(21,22)3/h7,17,19-23,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,25+,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	422	n/a	n/a	n/a	n/a
Saint Louis University School of Medicine Curated by ChEMBL					Assay Description Agonist activity at human LXRalpha expressed in HEK293 cells after 24 hrs by One-Glo luciferase reporter gene assay				J Med Chem 61: 10935-10956 (2018) Article DOI: 10.1021/acs.jmedchem.8b00045 BindingDB Entry DOI: 10.7270/Q2SX6GX7
					More data for this Ligand-Target Pair