BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 96 hits with Last Name = 'geballe' and Initial = 'm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253203
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-bromob...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2Br)cc1 |r|
Show InChI InChI=1S/C25H27BrCl2N2O4S/c1-35(32,33)29-20-7-9-22(10-8-20)34-17-21(31)16-30(15-19-4-2-3-5-23(19)26)13-12-18-6-11-24(27)25(28)14-18/h2-11,14,21,29,31H,12-13,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252672
PNG
((S)-1-(4-Methanesulfonamidephenoxy)-3-(3,4-dichlor...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H22Cl2N2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253241
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,3,4-tr...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccc(F)c(F)c2F)cc1 |r|
Show InChI InChI=1S/C25H25Cl2F3N2O4S/c1-37(34,35)31-18-4-6-20(7-5-18)36-15-19(33)14-32(11-10-16-2-8-21(26)22(27)12-16)13-17-3-9-23(28)25(30)24(17)29/h2-9,12,19,31,33H,10-11,13-15H2,1H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 51n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252889
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(3-fluoro-4-...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(F)c2)cc1 |r|
Show InChI InChI=1S/C18H22ClFN2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50253032
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-butyl-3,4...)
Show SMILES CCCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C22H30Cl2N2O4S/c1-3-4-12-26(13-11-17-5-10-21(23)22(24)14-17)15-19(27)16-30-20-8-6-18(7-9-20)25-31(2,28)29/h5-10,14,19,25,27H,3-4,11-13,15-16H2,1-2H3/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252673
PNG
((S)-1-(4-Methanesulfonamido-2-fluorophenoxy)-3-(3,...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)c(F)c1 |r|
Show InChI InChI=1S/C18H21Cl2FN2O4S/c1-28(25,26)23-13-3-5-18(17(21)9-13)27-11-14(24)10-22-7-6-12-2-4-15(19)16(20)8-12/h2-5,8-9,14,22-24H,6-7,10-11H2,1H3/t14-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 72n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50007674
PNG
((+)-erythro 4-[2-(4-Benzyl-piperidin-1-yl)-1-hydro...)
Show SMILES C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3/t16-,21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 73n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253204
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-fluoro...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2F)cc1 |r|
Show InChI InChI=1S/C25H27Cl2FN2O4S/c1-35(32,33)29-20-7-9-22(10-8-20)34-17-21(31)16-30(15-19-4-2-3-5-25(19)28)13-12-18-6-11-23(26)24(27)14-18/h2-11,14,21,29,31H,12-13,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253003
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-ethyl-3,4...)
Show SMILES CCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C20H26Cl2N2O4S/c1-3-24(11-10-15-4-9-19(21)20(22)12-15)13-17(25)14-28-18-7-5-16(6-8-18)23-29(2,26)27/h4-9,12,17,23,25H,3,10-11,13-14H2,1-2H3/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 96n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252886
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(4-chlorophe...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C18H23ClN2O4S/c1-26(23,24)21-16-6-8-18(9-7-16)25-13-17(22)12-20-11-10-14-2-4-15(19)5-3-14/h2-9,17,20-22H,10-13H2,1H3/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 101n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253078
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(4-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccc(O)cc2)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O5S/c1-35(32,33)28-20-5-9-23(10-6-20)34-17-22(31)16-29(15-19-2-7-21(30)8-3-19)13-12-18-4-11-24(26)25(27)14-18/h2-11,14,22,28,30-31H,12-13,15-17H2,1H3/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 113n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253030
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCO)CCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C20H26Cl2N2O5S/c1-30(27,28)23-16-3-5-18(6-4-16)29-14-17(26)13-24(10-11-25)9-8-15-2-7-19(21)20(22)12-15/h2-7,12,17,23,25-26H,8-11,13-14H2,1H3/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 122n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50253031
PNG
((S)-1-(4-Methanesulfonamidophenoxy)3-(N-propyl-3,4...)
Show SMILES CCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C21H28Cl2N2O4S/c1-3-11-25(12-10-16-4-9-20(22)21(23)13-16)14-18(26)15-29-19-7-5-17(6-8-19)24-30(2,27)28/h4-9,13,18,24,26H,3,10-12,14-15H2,1-2H3/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253002
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,...)
Show SMILES CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H24Cl2N2O4S/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253120
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,4-dihy...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccc(O)cc2O)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O6S/c1-36(33,34)28-19-4-7-22(8-5-19)35-16-21(31)15-29(14-18-3-6-20(30)13-25(18)32)11-10-17-2-9-23(26)24(27)12-17/h2-9,12-13,21,28,30-32H,10-11,14-16H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 146n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50253003
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-ethyl-3,4...)
Show SMILES CCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C20H26Cl2N2O4S/c1-3-24(11-10-15-4-9-19(21)20(22)12-15)13-17(25)14-28-18-7-5-16(6-8-18)23-29(2,26)27/h4-9,12,17,23,25H,3,10-11,13-14H2,1-2H3/t17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252846
PNG
((R)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@H](O)CN(CCO)CCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C20H26Cl2N2O5S/c1-30(27,28)23-16-3-5-18(6-4-16)29-14-17(26)13-24(10-11-25)9-8-15-2-7-19(21)20(22)12-15/h2-7,12,17,23,25-26H,8-11,13-14H2,1H3/t17-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 173n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253057
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-benzyl-3,...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O4S/c1-34(31,32)28-21-8-10-23(11-9-21)33-18-22(30)17-29(16-20-5-3-2-4-6-20)14-13-19-7-12-24(26)25(27)15-19/h2-12,15,22,28,30H,13-14,16-18H2,1H3/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 177n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252812
PNG
((R)-1-(4-Methanesulfonamidophenoxy)-3-(3,4-dichlor...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H22Cl2N2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 188n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252999
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(3,4-dimethy...)
Show SMILES Cc1ccc(CCNC[C@H](O)COc2ccc(NS(C)(=O)=O)cc2)cc1C |r|
Show InChI InChI=1S/C20H28N2O4S/c1-15-4-5-17(12-16(15)2)10-11-21-13-19(23)14-26-20-8-6-18(7-9-20)22-27(3,24)25/h4-9,12,19,21-23H,10-11,13-14H2,1-3H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 207n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253077
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(3-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2cccc(O)c2)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O5S/c1-35(32,33)28-20-6-8-23(9-7-20)34-17-22(31)16-29(15-19-3-2-4-21(30)13-19)12-11-18-5-10-24(26)25(27)14-18/h2-10,13-14,22,28,30-31H,11-12,15-17H2,1H3/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 238n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253238
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(3-fluoro...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2cccc(F)c2)cc1 |r|
Show InChI InChI=1S/C25H27Cl2FN2O4S/c1-35(32,33)29-21-6-8-23(9-7-21)34-17-22(31)16-30(15-19-3-2-4-20(28)13-19)12-11-18-5-10-24(26)25(27)14-18/h2-10,13-14,22,29,31H,11-12,15-17H2,1H3/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 249n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252813
PNG
((R)-1-(4-Methanesulfonamidophenoxy)3-(N-methyl-3,4...)
Show SMILES CN(CCc1ccc(Cl)c(Cl)c1)C[C@@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H24Cl2N2O4S/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3/t16-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 253n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253239
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(4-fluoro...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccc(F)cc2)cc1 |r|
Show InChI InChI=1S/C25H27Cl2FN2O4S/c1-35(32,33)29-21-7-9-23(10-8-21)34-17-22(31)16-30(15-19-2-5-20(28)6-3-19)13-12-18-4-11-24(26)25(27)14-18/h2-11,14,22,29,31H,12-13,15-17H2,1H3/t22-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 275n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252680
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(3-pridyl...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2cccnc2)cc1 |r|
Show InChI InChI=1S/C24H27Cl2N3O4S/c1-34(31,32)28-20-5-7-22(8-6-20)33-17-21(30)16-29(15-19-3-2-11-27-14-19)12-10-18-4-9-23(25)24(26)13-18/h2-9,11,13-14,21,28,30H,10,12,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 278n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253240
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,6-difl...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2c(F)cccc2F)cc1 |r|
Show InChI InChI=1S/C25H26Cl2F2N2O4S/c1-36(33,34)30-18-6-8-20(9-7-18)35-16-19(32)14-31(15-21-24(28)3-2-4-25(21)29)12-11-17-5-10-22(26)23(27)13-17/h2-10,13,19,30,32H,11-12,14-16H2,1H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 281n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252936
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(3,4-difluor...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(F)c(F)c2)cc1 |r|
Show InChI InChI=1S/C18H22F2N2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 357n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50253002
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,...)
Show SMILES CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C19H24Cl2N2O4S/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253054
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-isobutyl-...)
Show SMILES CC(C)CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C22H30Cl2N2O4S/c1-16(2)13-26(11-10-17-4-9-21(23)22(24)12-17)14-19(27)15-30-20-7-5-18(6-8-20)25-31(3,28)29/h4-9,12,16,19,25,27H,10-11,13-15H2,1-3H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252888
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(3-chloro-4-...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(F)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H22ClFN2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-18(20)17(19)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 397n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252849
PNG
((R)-1-(4-Methanesulfonamidophenoxy)-3-(N-(3-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2cccc(O)c2)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O5S/c1-35(32,33)28-20-6-8-23(9-7-20)34-17-22(31)16-29(15-19-3-2-4-21(30)13-19)12-11-18-5-10-24(26)25(27)14-18/h2-10,13-14,22,28,30-31H,11-12,15-17H2,1H3/t22-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 409n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253032
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-butyl-3,4...)
Show SMILES CCCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C22H30Cl2N2O4S/c1-3-4-12-26(13-11-17-5-10-21(23)22(24)14-17)15-19(27)16-30-20-8-6-18(7-9-20)25-31(2,28)29/h5-10,14,19,25,27H,3-4,11-13,15-16H2,1-2H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 421n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252674
PNG
((S)-1-(4-Methanesulfonamido-3-fluorophenoxy)-3-(3,...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1F |r|
Show InChI InChI=1S/C18H21Cl2FN2O4S/c1-28(25,26)23-18-5-3-14(9-17(18)21)27-11-13(24)10-22-7-6-12-2-4-15(19)16(20)8-12/h2-5,8-9,13,22-24H,6-7,10-11H2,1H3/t13-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 427n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252845
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(2-chlorophe...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccccc2Cl)cc1 |r|
Show InChI InChI=1S/C18H23ClN2O4S/c1-26(23,24)21-15-6-8-17(9-7-15)25-13-16(22)12-20-11-10-14-4-2-3-5-18(14)19/h2-9,16,20-22H,10-13H2,1H3/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 429n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50253057
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-benzyl-3,...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O4S/c1-34(31,32)28-21-8-10-23(11-9-21)33-18-22(30)17-29(16-20-5-3-2-4-6-20)14-13-19-7-12-24(26)25(27)15-19/h2-12,15,22,28,30H,13-14,16-18H2,1H3/t22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252848
PNG
((R)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2O)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O5S/c1-35(32,33)28-20-7-9-22(10-8-20)34-17-21(30)16-29(15-19-4-2-3-5-25(19)31)13-12-18-6-11-23(26)24(27)14-18/h2-11,14,21,28,30-31H,12-13,15-17H2,1H3/t21-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 433n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253202
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-chloro...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2Cl)cc1 |r|
Show InChI InChI=1S/C25H27Cl3N2O4S/c1-35(32,33)29-20-7-9-22(10-8-20)34-17-21(31)16-30(15-19-4-2-3-5-23(19)26)13-12-18-6-11-24(27)25(28)14-18/h2-11,14,21,29,31H,12-13,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 479n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252678
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-acetyl...)
Show SMILES CC(=O)Oc1ccccc1CN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C27H30Cl2N2O6S/c1-19(32)37-27-6-4-3-5-21(27)16-31(14-13-20-7-12-25(28)26(29)15-20)17-23(33)18-36-24-10-8-22(9-11-24)30-38(2,34)35/h3-12,15,23,30,33H,13-14,16-18H2,1-2H3/t23-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50252672
PNG
((S)-1-(4-Methanesulfonamidephenoxy)-3-(3,4-dichlor...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H22Cl2N2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Binding affinity to dopamine transporter

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50252672
PNG
((S)-1-(4-Methanesulfonamidephenoxy)-3-(3,4-dichlor...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H22Cl2N2O4S/c1-27(24,25)22-14-3-5-16(6-4-14)26-12-15(23)11-21-9-8-13-2-7-17(19)18(20)10-13/h2-7,10,15,21-23H,8-9,11-12H2,1H3/t15-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Binding affinity to norepinephrine transporter

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253277
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2,3,4,5,...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2c(F)c(F)c(F)c(F)c2F)cc1 |r|
Show InChI InChI=1S/C25H23Cl2F5N2O4S/c1-39(36,37)33-15-3-5-17(6-4-15)38-13-16(35)11-34(9-8-14-2-7-19(26)20(27)10-14)12-18-21(28)23(30)25(32)24(31)22(18)29/h2-7,10,16,33,35H,8-9,11-13H2,1H3/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 524n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252676
PNG
((S)-1-(3-Methanesulfonamidophenoxy)-3-(3,4-dichlor...)
Show SMILES CS(=O)(=O)Nc1cccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)c1 |r|
Show InChI InChI=1S/C18H22Cl2N2O4S/c1-27(24,25)22-14-3-2-4-16(10-14)26-12-15(23)11-21-8-7-13-5-6-17(19)18(20)9-13/h2-6,9-10,15,21-23H,7-8,11-12H2,1H3/t15-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252933
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(2-fluorophe...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccccc2F)cc1 |r|
Show InChI InChI=1S/C18H23FN2O4S/c1-26(23,24)21-15-6-8-17(9-7-15)25-13-16(22)12-20-11-10-14-4-2-3-5-18(14)19/h2-9,16,20-22H,10-13H2,1H3/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 573n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252805
PNG
((S)-1-(4-ethylsulphonamidophenoxy)-3-(3,4-dichloro...)
Show SMILES CCS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C19H24Cl2N2O4S/c1-2-28(25,26)23-15-4-6-17(7-5-15)27-13-16(24)12-22-10-9-14-3-8-18(20)19(21)11-14/h3-8,11,16,22-24H,2,9-10,12-13H2,1H3/t16-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 587n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252677
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-nitrob...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2[N+]([O-])=O)cc1 |r|
Show InChI InChI=1S/C25H27Cl2N3O6S/c1-37(34,35)28-20-7-9-22(10-8-20)36-17-21(31)16-29(13-12-18-6-11-23(26)24(27)14-18)15-19-4-2-3-5-25(19)30(32)33/h2-11,14,21,28,31H,12-13,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 589n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253056
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-isopropyl...)
Show SMILES CC(C)N(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C21H28Cl2N2O4S/c1-15(2)25(11-10-16-4-9-20(22)21(23)12-16)13-18(26)14-29-19-7-5-17(6-8-19)24-30(3,27)28/h4-9,12,15,18,24,26H,10-11,13-14H2,1-3H3/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 603n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50252885
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(3-chlorophe...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CNCCc2cccc(Cl)c2)cc1 |r|
Show InChI InChI=1S/C18H23ClN2O4S/c1-26(23,24)21-16-5-7-18(8-6-16)25-13-17(22)12-20-10-9-14-3-2-4-15(19)11-14/h2-8,11,17,20-22H,9-10,12-13H2,1H3/t17-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 628n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253031
PNG
((S)-1-(4-Methanesulfonamidophenoxy)3-(N-propyl-3,4...)
Show SMILES CCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C21H28Cl2N2O4S/c1-3-11-25(12-10-16-4-9-20(22)21(23)13-16)14-18(26)15-29-19-7-5-17(6-8-19)24-30(2,27)28/h4-9,13,18,24,26H,3,10-12,14-15H2,1-2H3/t18-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
UniChem

Similars
Article
PubMed
n/an/a 635n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253033
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-pentyl-3,...)
Show SMILES CCCCCN(CCc1ccc(Cl)c(Cl)c1)C[C@H](O)COc1ccc(NS(C)(=O)=O)cc1 |r|
Show InChI InChI=1S/C23H32Cl2N2O4S/c1-3-4-5-13-27(14-12-18-6-11-22(24)23(25)15-18)16-20(28)17-31-21-9-7-19(8-10-21)26-32(2,29)30/h6-11,15,20,26,28H,3-5,12-14,16-17H2,1-2H3/t20-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 659n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1


(RAT)		BDBM50253076
PNG
((S)-1-(4-Methanesulfonamidophenoxy)-3-(N-(2-hydrox...)
Show SMILES CS(=O)(=O)Nc1ccc(OC[C@@H](O)CN(CCc2ccc(Cl)c(Cl)c2)Cc2ccccc2O)cc1 |r|
Show InChI InChI=1S/C25H28Cl2N2O5S/c1-35(32,33)28-20-7-9-22(10-8-20)34-17-21(30)16-29(15-19-4-2-3-5-25(19)31)13-12-18-6-11-23(26)24(27)14-18/h2-11,14,21,28,30-31H,12-13,15-17H2,1H3/t21-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 662n/an/an/an/an/an/a



Emory University

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current b...

J Med Chem 51: 5506-21 (2008)


Article DOI: 10.1021/jm8002153
BindingDB Entry DOI: 10.7270/Q2PZ59QH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 96 total )  |  Next  |  Last  >>
Jump to: