Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557765 (CHEMBL4791414) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557761 (CHEMBL4758580) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557764 (CHEMBL4787891) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557766 (CHEMBL4751832) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557760 (CHEMBL4749011) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557742 (CHEMBL4752199) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109863 (US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557753 (CHEMBL4748097) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557756 (CHEMBL4779273) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 4 (Homo sapiens (Human)) | BDBM50167609 ((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-fused human JAK2 (880 to end residues) expressed in baculovirus infected Sf21 cells using TK-substrate-biotin as substra... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM50341824 ((1S,2R,3R)-2-Methyl-1-[5-(4-methylpyrazol-1-yl)thi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557755 (CHEMBL4782729) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM50341816 ((1S,2R,3R)-1-[5-(4-Methoxypyrazol-1-yl)thiophene-2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human)) | BDBM50167609 ((2R,5R)-1-[4-(2,4-Dichloro-benzyloxy)-benzenesulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557744 (CHEMBL4741185) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557763 (CHEMBL4744618) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109863 (US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109866 (US8609647, 26 | US8609647, 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109867 (US8609647, 27 | US8609647, 37 | US8609647, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557767 (CHEMBL4764221) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109868 (US8609647, 19 | US8609647, 21 | US8609647, 6) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109865 (US8609647, 25 | US8609647, 3 | US8609647, 59) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-fused human JAK2 (880 to end residues) expressed in baculovirus infected Sf21 cells using TK-substrate-biotin as substra... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM50545650 (Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-fused human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substrat... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human)) | BDBM50341819 ((1S,2R,3R)-1-(6-Chloro-4H-thieno[3,2-b]indole-2-su...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant aggrecanase 2 after 150 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557746 (CHEMBL4779579) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM50193995 (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-fused human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substrat... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557759 (CHEMBL4763627) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557745 (CHEMBL4741913) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557757 (CHEMBL4792464) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | <3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 4 (Homo sapiens (Human)) | BDBM50104963 ((2S,3R)-2-(cyclopropylmethylamino)-N1-hydroxy-N4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109867 (US8609647, 27 | US8609647, 37 | US8609647, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557754 (CHEMBL4764416) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109863 (US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM50311088 (CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP14 after 60 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM50311088 (CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant MMP13 after 60 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557758 (CHEMBL4749061) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557743 (CHEMBL4744988) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557747 (CHEMBL4795223) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
A disintegrin and metalloproteinase with thrombospondin motifs 4 (Homo sapiens (Human)) | BDBM50311088 (CHEMBL1078281 | cis-rac-1-(5-(4-chloro-1H-pyrazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibition of human recombinant aggrecanase 1 after 150 mins by fluorescence plate reader | J Med Chem 54: 2839-63 (2011) Article DOI: 10.1021/jm101609j BindingDB Entry DOI: 10.7270/Q2N87B3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109867 (US8609647, 27 | US8609647, 37 | US8609647, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109863 (US8609647, 1 | US8609647, 15 | US8609647, 2 | US86...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM109869 (US8609647, 7 | US8609647, 84) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-2 (Homo sapiens (Human)) | BDBM50557739 (CHEMBL4798505) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TGFbeta receptor 2 (unknown origin) using biotin-labelled TTLKDLIYDMTTSGSGSGLPLLVQRTIARTsubstrate in presence of [gamma33P] ATP measure... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00679 BindingDB Entry DOI: 10.7270/Q2PG1WD5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109866 (US8609647, 26 | US8609647, 4) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109869 (US8609647, 7 | US8609647, 84) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109909 (US8609647, 54 | US8609647, 66) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. US Patent | Assay Description In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT... | US Patent US8609647 (2013) BindingDB Entry DOI: 10.7270/Q29C6W24 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM109867 (US8609647, 27 | US8609647, 37 | US8609647, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Japan Tobacco Inc. Curated by ChEMBL | Assay Description Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi... | J Med Chem 63: 7163-7185 (2020) Article DOI: 10.1021/acs.jmedchem.0c00450 BindingDB Entry DOI: 10.7270/Q2FX7F2W | |||||||||||
More data for this Ligand-Target Pair |
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