Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50469275 (CHEMBL4290673) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 1 hr | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50469275 (CHEMBL4290673) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His6-tagged human COX-2 expressed in Baculovirus infected Sf21 cells using arachidonic acid as substrate preincu... | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His6-tagged human COX-2 expressed in Baculovirus infected Sf21 cells using arachidonic acid as substrate preincu... | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cruzipain (Trypanosoma cruzi) | BDBM50282986 (CHEMBL3786939) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco - UFPE Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma cruzi cruzain preincubated for 10 mins followed by Z-FR-AMC substrate addition measured for 5 mins at 12 secs t... | Eur J Med Chem 141: 346-361 (2017) Article DOI: 10.1016/j.ejmech.2017.09.047 BindingDB Entry DOI: 10.7270/Q2F1927C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50469276 (CHEMBL4282782) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of recombinant N-terminal His6-tagged human COX-2 expressed in Baculovirus infected Sf21 cells using arachidonic acid as substrate preincu... | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50469276 (CHEMBL4282782) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 1 hr | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco (UFPE) Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 1 hr | Bioorg Med Chem 26: 5388-5396 (2018) Article DOI: 10.1016/j.bmc.2018.07.024 BindingDB Entry DOI: 10.7270/Q26T0QCC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cruzipain (Trypanosoma cruzi) | BDBM50516805 (CHEMBL3785388) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Pernambuco Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured for 5 mins b... | Eur J Med Chem 180: 191-203 (2019) Article DOI: 10.1016/j.ejmech.2019.07.018 BindingDB Entry DOI: 10.7270/Q2M90D1Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cruzipain (Trypanosoma cruzi) | BDBM50282987 (CHEMBL4165151) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal de Pernambuco - UFPE Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma cruzi cruzain preincubated for 10 mins followed by Z-FR-AMC substrate addition measured for 5 mins at 12 secs t... | Eur J Med Chem 141: 346-361 (2017) Article DOI: 10.1016/j.ejmech.2017.09.047 BindingDB Entry DOI: 10.7270/Q2F1927C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cruzipain (Trypanosoma cruzi) | BDBM50516806 (CHEMBL3787052) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de Pernambuco Curated by ChEMBL | Assay Description Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition and measured for 5 mins b... | Eur J Med Chem 180: 191-203 (2019) Article DOI: 10.1016/j.ejmech.2019.07.018 BindingDB Entry DOI: 10.7270/Q2M90D1Q | |||||||||||
More data for this Ligand-Target Pair |