Found 13 hits with Last Name = 'khalifa' and Initial = 'mm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549123
(CHEMBL4779272)Show SMILES C\C(=N/NC(=O)c1cc(ccc1Cl)[N+]([O-])=O)c1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2-c2ccc(C)cc2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 452 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549119
(CHEMBL4763393)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 684 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549115
(CHEMBL4784161)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nc(C)cc(C)n2)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 707 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549116
(CHEMBL4781567)Show SMILES CC(=O)NS(=O)(=O)c1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2-c2ccc(C)cc2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 721 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549122
(CHEMBL4794044)Show SMILES C\C(=N/NC(N)=S)c1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2-c2ccc(C)cc2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549124
(CHEMBL4777885)Show SMILES C\C(=N/NC(=O)c1ccccc1O)c1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2-c2ccc(C)cc2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549117
(CHEMBL4749461)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)C(=O)NNC(=O)c2ccccc2O)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549118
(CHEMBL4753486)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)C(=O)NNc2ccccc2)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM16673
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549120
(CHEMBL4760160)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549121
(CHEMBL4749856)Show SMILES Cc1ccc(cc1)-n1c(SCC(=O)Nc2ccc(cc2)C(=O)NCc2ccccc2)nc2ccccc2c1=O | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50549125
(CHEMBL4755652)Show SMILES CC(=O)c1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2-c2ccc(C)cc2)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human VEGFR2 incubated for 2.5 hrs by ELISA |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115872 BindingDB Entry DOI: 10.7270/Q2KH0RZQ |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085045
(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)Show SMILES Cc1c(C)c2OC(C)(COc3ccc(Cc4sc(=O)[nH]c4O)cc3)CCc2c(C)c1O Show InChI InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,26-27H,9-12H2,1-4H3,(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Kyoto Pharmaceutical University
Curated by ChEMBL
| Assay Description Agonist activity at PPARgamma (unknown origin) by nuclear receptor cofactor assay |
Bioorg Med Chem Lett 23: 4813-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.101 BindingDB Entry DOI: 10.7270/Q2PV6P91 |
More data for this Ligand-Target Pair | |