Found 28 hits with Last Name = 'raffaele' and Initial = 'nb' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451395
(US10709718, Compound 20)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)c1ccsc1 |r,wU:19.21,wD:22.28,c:12,(-2.62,-5.39,;-3.96,-4.62,;-2.62,-3.85,;-5.29,-5.39,;-6.62,-4.62,;-7.96,-5.39,;-9.29,-4.62,;-9.29,-3.08,;-7.96,-2.31,;-7.96,-.77,;-6.62,-3.08,;-5.29,-2.31,;-3.96,-3.08,;-2.62,-2.31,;-1.29,-3.08,;.05,-2.31,;.05,-.77,;-1.29,,;-2.62,-.77,;1.38,,;1.38,1.54,;2.71,2.31,;4.05,1.54,;4.05,,;2.71,-.77,;5.38,2.31,;5.38,3.85,;5.38,5.39,;3.84,3.85,;6.92,3.85,;7.83,2.6,;9.29,3.08,;9.29,4.62,;7.83,5.1,)| Show InChI InChI=1S/C24H27N4O4PS/c1-24(2)21(28-20-22(25)26-14-27-23(20)31-24)17-5-3-15(4-6-17)16-7-9-18(10-8-16)32-33(29,30)19-11-12-34-13-19/h3-6,11-14,16,18H,7-10H2,1-2H3,(H,29,30)(H2,25,26,27)/t16-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451394
(US10709718, Compound 19)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)c1cccs1 |r,wU:19.21,wD:22.28,c:12,(-2.62,-5.39,;-3.96,-4.62,;-2.62,-3.85,;-5.29,-5.39,;-6.62,-4.62,;-7.96,-5.39,;-9.29,-4.62,;-9.29,-3.08,;-7.96,-2.31,;-7.96,-.77,;-6.62,-3.08,;-5.29,-2.31,;-3.96,-3.08,;-2.62,-2.31,;-1.29,-3.08,;.05,-2.31,;.05,-.77,;-1.29,,;-2.62,-.77,;1.38,,;1.38,1.54,;2.71,2.31,;4.05,1.54,;4.05,,;2.71,-.77,;5.38,2.31,;5.38,3.85,;5.38,5.39,;3.84,3.85,;6.92,3.85,;7.83,2.6,;9.29,3.08,;9.29,4.62,;7.83,5.1,)| Show InChI InChI=1S/C24H27N4O4PS/c1-24(2)21(28-20-22(25)26-14-27-23(20)31-24)17-7-5-15(6-8-17)16-9-11-18(12-10-16)32-33(29,30)19-4-3-13-34-19/h3-8,13-14,16,18H,9-12H2,1-2H3,(H,29,30)(H2,25,26,27)/t16-,18- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451264
(US10709718, Compound 3)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(O)=O |r,wU:19.21,wD:22.28,c:12,(-2,-4.13,;-3.33,-3.36,;-2,-2.59,;-4.67,-4.13,;-6,-3.36,;-7.34,-4.13,;-8.67,-3.36,;-8.67,-1.82,;-7.34,-1.05,;-7.34,.49,;-6,-1.82,;-4.67,-1.05,;-3.33,-1.82,;-2,-1.05,;-.67,-1.82,;.67,-1.05,;.67,.49,;-.67,1.26,;-2,.49,;2,1.26,;2,2.8,;3.33,3.57,;4.67,2.8,;4.67,1.26,;3.33,.49,;6,3.57,;7.34,2.8,;8.67,3.57,;7.34,1.26,;6.57,4.13,)| Show InChI InChI=1S/C20H25N4O5P/c1-20(2)17(24-16-18(21)22-11-23-19(16)28-20)14-5-3-12(4-6-14)13-7-9-15(10-8-13)29-30(25,26)27/h3-6,11,13,15H,7-10H2,1-2H3,(H2,21,22,23)(H2,25,26,27)/t13-,15- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451327
(US10709718, Compound 5)Show SMILES CP(O)(=O)C[C@H]1CC[C@@H](CC1)c1ccc(NC(=O)c2nnc(Nc3ccc(F)c(F)c3)o2)cc1 |r,wU:8.11,wD:5.4,(10.71,2,;10.71,3.54,;12.04,2.77,;12.04,4.31,;9.37,4.31,;8.04,3.54,;6.7,4.31,;5.37,3.54,;5.37,2,;6.7,1.23,;8.04,2,;4.04,1.23,;4.04,-.31,;2.7,-1.08,;1.37,-.31,;.04,-1.08,;-1.3,-.31,;-1.3,1.23,;-2.63,-1.08,;-3.54,.17,;-5,-.31,;-5,-1.85,;-6.09,-2.93,;-7.58,-2.54,;-7.98,-1.05,;-9.46,-.65,;-10.55,-1.74,;-12.04,-1.34,;-10.15,-3.23,;-11.24,-4.31,;-8.67,-3.62,;-3.54,-2.32,;1.37,1.23,;2.7,2,)| Show InChI InChI=1S/C23H25F2N4O4P/c1-34(31,32)13-14-2-4-15(5-3-14)16-6-8-17(9-7-16)26-21(30)22-28-29-23(33-22)27-18-10-11-19(24)20(25)12-18/h6-12,14-15H,2-5,13H2,1H3,(H,26,30)(H,27,29)(H,31,32)/t14-,15- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451398
(US10709718, Compound 23)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(O)(=O)C2CC2)CC1 |r,wU:19.21,wD:22.25,c:12,(-2,-4.24,;-3.33,-3.47,;-2,-2.7,;-4.67,-4.24,;-6,-3.47,;-7.34,-4.24,;-8.67,-3.47,;-8.67,-1.93,;-7.34,-1.16,;-7.34,.38,;-6,-1.93,;-4.67,-1.16,;-3.33,-1.93,;-2,-1.16,;-.67,-1.93,;.67,-1.16,;.67,.38,;-.67,1.16,;-2,.38,;2,1.15,;2,2.69,;3.33,3.46,;4.67,2.69,;6,3.46,;7.34,2.7,;8.67,3.47,;7.34,4.24,;7.34,1.16,;6.57,-.18,;8.11,-.18,;4.67,1.15,;3.33,.38,)| Show InChI InChI=1S/C24H31N4O3P/c1-24(2)21(28-20-22(25)26-14-27-23(20)31-24)18-9-7-17(8-10-18)16-5-3-15(4-6-16)13-32(29,30)19-11-12-19/h7-10,14-16,19H,3-6,11-13H2,1-2H3,(H,29,30)(H2,25,26,27)/t15-,16- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451396
(US10709718, Compound 21)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(O)(=O)c2ccccc2)CC1 |r,wU:19.21,wD:22.25,c:12,(-2,-4.24,;-3.33,-3.47,;-2,-2.7,;-4.67,-4.24,;-6,-3.47,;-7.34,-4.24,;-8.67,-3.47,;-8.67,-1.93,;-7.34,-1.16,;-7.34,.38,;-6,-1.93,;-4.67,-1.16,;-3.33,-1.93,;-2,-1.16,;-.67,-1.93,;.67,-1.16,;.67,.38,;-.67,1.16,;-2,.38,;2,1.15,;2,2.69,;3.33,3.46,;4.67,2.69,;6,3.46,;7.34,2.7,;8.67,3.47,;7.34,4.24,;7.34,1.16,;6,.39,;6,-1.15,;7.34,-1.92,;8.67,-1.15,;8.67,.39,;4.67,1.15,;3.33,.38,)| Show InChI InChI=1S/C27H31N4O3P/c1-27(2)24(31-23-25(28)29-17-30-26(23)34-27)21-14-12-20(13-15-21)19-10-8-18(9-11-19)16-35(32,33)22-6-4-3-5-7-22/h3-7,12-15,17-19H,8-11,16H2,1-2H3,(H,32,33)(H2,28,29,30)/t18-,19- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451392
(US10709718, Compound 17)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)Cc1ccc(cc1)C(O)=O |r,wU:19.21,wD:22.28,c:12,(-3.75,-7.95,;-5.08,-7.18,;-3.75,-6.41,;-6.41,-7.95,;-7.75,-7.18,;-9.08,-7.95,;-10.42,-7.18,;-10.42,-5.64,;-9.08,-4.87,;-9.08,-3.33,;-7.75,-5.64,;-6.41,-4.87,;-5.08,-5.64,;-3.75,-4.87,;-2.41,-5.64,;-1.08,-4.87,;-1.08,-3.33,;-2.41,-2.56,;-3.75,-3.33,;.25,-2.56,;.25,-1.02,;1.59,-.25,;2.92,-1.02,;2.92,-2.56,;1.59,-3.33,;4.26,-.25,;4.26,1.29,;4.26,2.83,;2.72,1.29,;5.8,1.29,;6.57,2.62,;8.11,2.62,;8.88,3.95,;8.11,5.29,;6.57,5.29,;5.8,3.95,;8.88,6.62,;10.42,6.62,;8.11,7.95,)| Show InChI InChI=1S/C28H31N4O6P/c1-28(2)24(32-23-25(29)30-16-31-26(23)37-28)20-9-7-18(8-10-20)19-11-13-22(14-12-19)38-39(35,36)15-17-3-5-21(6-4-17)27(33)34/h3-10,16,19,22H,11-15H2,1-2H3,(H,33,34)(H,35,36)(H2,29,30,31)/t19-,22- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451382
(US10709718, Compound 9)Show SMILES CCOP(O)(=O)O[C@H]1CCC(CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wD:7.6,t:21,(5.23,6.54,;5.23,5,;6.57,4.23,;6.57,2.69,;8.11,2.69,;5.03,2.69,;6.57,1.15,;5.23,.38,;3.9,1.15,;2.56,.38,;2.56,-1.15,;3.9,-1.93,;5.23,-1.15,;1.23,-1.93,;1.23,-3.47,;-.1,-4.23,;-1.44,-3.47,;-1.44,-1.93,;-.1,-1.15,;-2.77,-4.23,;-4.1,-3.47,;-5.44,-4.23,;-6.77,-3.47,;-6.77,-1.93,;-8.11,-4.23,;-8.11,-5.78,;-6.77,-6.54,;-5.44,-5.78,;-4.1,-6.54,;-2.77,-5.78,;-1.44,-6.54,;-1.44,-5,)| Show InChI InChI=1S/C22H29N4O5P/c1-4-29-32(27,28)31-17-11-9-15(10-12-17)14-5-7-16(8-6-14)19-22(2,3)30-21-18(26-19)20(23)24-13-25-21/h5-8,13,15,17H,4,9-12H2,1-3H3,(H,27,28)(H2,23,24,25)/t15?,17- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451387
(US10709718, Compound 10)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CC[C@@H](CC1)OP(O)(=O)OC1CCCC1 |r,wD:22.28,c:12,(-1.44,-6.51,;-2.77,-5.74,;-1.44,-4.97,;-4.1,-6.51,;-5.44,-5.74,;-6.77,-6.51,;-8.11,-5.74,;-8.11,-4.2,;-6.77,-3.43,;-6.77,-1.89,;-5.44,-4.2,;-4.1,-3.43,;-2.77,-4.2,;-1.44,-3.43,;-.1,-4.2,;1.23,-3.43,;1.23,-1.89,;-.1,-1.12,;-1.44,-1.89,;2.56,-1.12,;2.56,.42,;3.9,1.19,;5.23,.42,;5.23,-1.12,;3.9,-1.89,;6.57,1.19,;6.57,2.73,;8.11,2.73,;5.03,2.73,;6.57,4.27,;5.23,5.04,;4.76,6.51,;3.22,6.51,;2.74,5.04,;3.99,4.14,)| Show InChI InChI=1S/C25H33N4O5P/c1-25(2)22(29-21-23(26)27-15-28-24(21)32-25)18-9-7-16(8-10-18)17-11-13-20(14-12-17)34-35(30,31)33-19-5-3-4-6-19/h7-10,15,17,19-20H,3-6,11-14H2,1-2H3,(H,30,31)(H2,26,27,28)/t17?,20- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451388
(US10709718, Compound 11)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)C1CC[C@@H](CC1)OP(O)(=O)Cc1ccccc1 |r,wD:22.28,c:12,(-2.98,-6.62,;-4.31,-5.85,;-2.98,-5.08,;-5.64,-6.62,;-6.98,-5.85,;-8.31,-6.62,;-9.65,-5.85,;-9.65,-4.31,;-8.31,-3.54,;-8.31,-2,;-6.98,-4.31,;-5.64,-3.54,;-4.31,-4.31,;-2.98,-3.54,;-1.64,-4.31,;-.31,-3.54,;-.31,-2,;-1.64,-1.23,;-2.98,-2,;1.02,-1.23,;1.02,.31,;2.36,1.08,;3.69,.31,;3.69,-1.23,;2.36,-2,;5.03,1.08,;5.03,2.62,;5.03,4.16,;3.49,2.62,;6.57,2.62,;7.34,3.95,;8.88,3.95,;9.65,5.29,;8.88,6.62,;7.34,6.62,;6.57,5.29,)| Show InChI InChI=1S/C27H31N4O4P/c1-27(2)24(31-23-25(28)29-17-30-26(23)34-27)21-10-8-19(9-11-21)20-12-14-22(15-13-20)35-36(32,33)16-18-6-4-3-5-7-18/h3-11,17,20,22H,12-16H2,1-2H3,(H,32,33)(H2,28,29,30)/t20?,22- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451262
(US10709718, Compound 1)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(C)(O)=O)CC1 |r,wU:19.21,wD:22.25,c:12,(-1.44,-5.39,;-2.77,-4.62,;-1.44,-3.85,;-4.1,-5.39,;-5.44,-4.62,;-6.77,-5.39,;-8.11,-4.62,;-8.11,-3.08,;-6.77,-2.31,;-6.77,-.77,;-5.44,-3.08,;-4.1,-2.31,;-2.77,-3.08,;-1.44,-2.31,;-.1,-3.08,;1.23,-2.31,;1.23,-.77,;-.1,,;-1.44,-.77,;2.56,,;2.56,1.54,;3.9,2.31,;5.23,1.54,;6.57,2.31,;6.57,3.85,;8.11,3.85,;6.57,5.39,;5.03,3.85,;5.23,,;3.9,-.77,)| Show InChI InChI=1S/C22H29N4O3P/c1-22(2)19(26-18-20(23)24-13-25-21(18)29-22)17-10-8-16(9-11-17)15-6-4-14(5-7-15)12-30(3,27)28/h8-11,13-15H,4-7,12H2,1-3H3,(H,27,28)(H2,23,24,25)/t14-,15- | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451390
(US10709718, Compound 13)Show SMILES CCP(O)(=O)O[C@H]1CC[C@@H](CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wU:9.12,wD:6.5,t:20,(8.49,5.18,;7.72,3.85,;6.18,3.85,;6.18,5.39,;4.64,3.85,;6.18,2.31,;4.85,1.54,;3.51,2.31,;2.18,1.54,;2.18,,;3.51,-.77,;4.85,,;.85,-.77,;.85,-2.31,;-.49,-3.08,;-1.82,-2.31,;-1.82,-.77,;-.49,,;-3.16,-3.08,;-4.49,-2.31,;-5.82,-3.08,;-7.16,-2.31,;-7.16,-.77,;-8.49,-3.08,;-8.49,-4.62,;-7.16,-5.39,;-5.82,-4.62,;-4.49,-5.39,;-3.16,-4.62,;-1.82,-5.39,;-1.82,-3.85,)| Show InChI InChI=1S/C22H29N4O4P/c1-4-31(27,28)30-17-11-9-15(10-12-17)14-5-7-16(8-6-14)19-22(2,3)29-21-18(26-19)20(23)24-13-25-21/h5-8,13,15,17H,4,9-12H2,1-3H3,(H,27,28)(H2,23,24,25)/t15-,17- | PDB
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| US Patent
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451391
(US10709718, Compound 14)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)c1ccccc1 |r,wU:19.21,wD:22.28,c:12,(-2.98,-5.39,;-4.31,-4.62,;-2.98,-3.85,;-5.64,-5.39,;-6.98,-4.62,;-8.31,-5.39,;-9.65,-4.62,;-9.65,-3.08,;-8.31,-2.31,;-8.31,-.77,;-6.98,-3.08,;-5.64,-2.31,;-4.31,-3.08,;-2.98,-2.31,;-1.64,-3.08,;-.31,-2.31,;-.31,-.77,;-1.64,,;-2.98,-.77,;1.02,,;1.02,1.54,;2.36,2.31,;3.69,1.54,;3.69,,;2.36,-.77,;5.03,2.31,;5.03,3.85,;5.03,5.39,;3.49,3.85,;6.57,3.85,;7.34,2.52,;8.88,2.52,;9.65,3.85,;8.88,5.18,;7.34,5.18,)| Show InChI InChI=1S/C26H29N4O4P/c1-26(2)23(30-22-24(27)28-16-29-25(22)33-26)19-10-8-17(9-11-19)18-12-14-20(15-13-18)34-35(31,32)21-6-4-3-5-7-21/h3-11,16,18,20H,12-15H2,1-2H3,(H,31,32)(H2,27,28,29)/t18-,20- | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451381
(US10709718, Compound 8)Show SMILES CC(C)COP(O)(=O)O[C@H]1CC[C@@H](CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wU:12.15,wD:9.8,t:23,(9.65,5.95,;8.88,4.62,;9.65,3.29,;7.34,4.62,;6.57,3.29,;5.03,3.29,;5.03,4.83,;3.49,3.29,;5.03,1.75,;3.69,.98,;2.36,1.75,;1.02,.98,;1.02,-.56,;2.36,-1.33,;3.69,-.56,;-.31,-1.33,;-.31,-2.87,;-1.64,-3.64,;-2.98,-2.87,;-2.98,-1.33,;-1.64,-.56,;-4.31,-3.64,;-5.64,-2.87,;-6.98,-3.64,;-8.31,-2.87,;-8.31,-1.33,;-9.65,-3.64,;-9.65,-5.18,;-8.31,-5.95,;-6.98,-5.18,;-5.64,-5.95,;-4.31,-5.18,;-2.98,-5.95,;-2.98,-4.41,)| Show InChI InChI=1S/C24H33N4O5P/c1-15(2)13-31-34(29,30)33-19-11-9-17(10-12-19)16-5-7-18(8-6-16)21-24(3,4)32-23-20(28-21)22(25)26-14-27-23/h5-8,14-15,17,19H,9-13H2,1-4H3,(H,29,30)(H2,25,26,27)/t17-,19- | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451393
(US10709718, Compound 18)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP([O-])(=O)Cc1cccc(c1)C([O-])=O |r,wU:19.21,wD:22.28,c:12,(-2.98,-7.95,;-4.31,-7.18,;-2.98,-6.41,;-5.64,-7.95,;-6.98,-7.18,;-8.31,-7.95,;-9.65,-7.18,;-9.65,-5.64,;-8.31,-4.87,;-8.31,-3.33,;-6.98,-5.64,;-5.64,-4.87,;-4.31,-5.64,;-2.98,-4.87,;-1.64,-5.64,;-.31,-4.87,;-.31,-3.33,;-1.64,-2.56,;-2.98,-3.33,;1.02,-2.56,;1.02,-1.02,;2.36,-.25,;3.69,-1.02,;3.69,-2.56,;2.36,-3.33,;5.03,-.25,;5.03,1.29,;5.03,2.83,;3.49,1.29,;6.57,1.29,;7.34,2.62,;8.88,2.62,;9.65,3.95,;8.88,5.29,;7.34,5.29,;6.57,3.95,;6.57,6.62,;7.34,7.95,;5.03,6.62,)| Show InChI InChI=1S/C28H31N4O6P/c1-28(2)24(32-23-25(29)30-16-31-26(23)37-28)20-8-6-18(7-9-20)19-10-12-22(13-11-19)38-39(35,36)15-17-4-3-5-21(14-17)27(33)34/h3-9,14,16,19,22H,10-13,15H2,1-2H3,(H,33,34)(H,35,36)(H2,29,30,31)/p-2/t19-,22- | PDB
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| PC cid
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451389
(US10709718, Compound 12)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)OCCc1ccccc1 |r,wU:19.21,wD:22.28,c:12,(-4.13,-7.29,;-5.47,-6.52,;-4.13,-5.75,;-6.8,-7.29,;-8.13,-6.52,;-9.47,-7.29,;-10.8,-6.52,;-10.8,-4.98,;-9.47,-4.21,;-9.47,-2.67,;-8.13,-4.98,;-6.8,-4.21,;-5.47,-4.98,;-4.13,-4.21,;-2.8,-4.98,;-1.46,-4.21,;-1.46,-2.67,;-2.8,-1.9,;-4.13,-2.67,;-.13,-1.9,;-.13,-.36,;1.2,.41,;2.54,-.36,;2.54,-1.9,;1.2,-2.67,;3.87,.41,;3.87,1.95,;3.87,3.49,;2.33,1.95,;5.41,1.95,;6.18,3.29,;7.72,3.29,;8.49,4.62,;10.03,4.62,;10.8,5.95,;10.03,7.29,;8.49,7.29,;7.72,5.95,)| Show InChI InChI=1S/C28H33N4O5P/c1-28(2)25(32-24-26(29)30-18-31-27(24)36-28)22-10-8-20(9-11-22)21-12-14-23(15-13-21)37-38(33,34)35-17-16-19-6-4-3-5-7-19/h3-11,18,21,23H,12-17H2,1-2H3,(H,33,34)(H2,29,30,31)/t21-,23- | PDB
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| US Patent
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451406
(US10709718, Compound 34)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(O)(=O)c2cccc(Cl)c2)CC1 |r,wU:19.21,wD:22.25,c:12,(-2.67,-4.24,;-4,-3.47,;-2.67,-2.7,;-5.33,-4.24,;-6.67,-3.47,;-8,-4.24,;-9.34,-3.47,;-9.34,-1.93,;-8,-1.16,;-8,.38,;-6.67,-1.93,;-5.33,-1.16,;-4,-1.93,;-2.67,-1.16,;-1.33,-1.93,;,-1.16,;,.38,;-1.33,1.15,;-2.67,.38,;1.33,1.15,;1.33,2.69,;2.67,3.46,;4,2.69,;5.33,3.46,;6.67,2.7,;8,3.47,;6.67,4.24,;6.67,1.16,;5.33,.39,;5.33,-1.15,;6.67,-1.92,;8,-1.15,;9.34,-1.92,;8,.39,;4,1.15,;2.67,.38,)| Show InChI InChI=1S/C27H30ClN4O3P/c1-27(2)24(32-23-25(29)30-16-31-26(23)35-27)20-12-10-19(11-13-20)18-8-6-17(7-9-18)15-36(33,34)22-5-3-4-21(28)14-22/h3-5,10-14,16-18H,6-9,15H2,1-2H3,(H,33,34)(H2,29,30,31)/t17-,18- | PDB
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| PC cid
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UniChem
| US Patent
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451263
(US10709718, Compound 2)Show SMILES CP(O)(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccccc2)cc1 |r| Show InChI InChI=1S/C26H27N2O4P/c1-33(31,32)24-9-5-8-23(24)25(29)20-12-10-18(11-13-20)19-14-16-22(17-15-19)28-26(30)27-21-6-3-2-4-7-21/h2-4,6-7,10-17,23-24H,5,8-9H2,1H3,(H,31,32)(H2,27,28,30)/t23-,24-/m1/s1 | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451405
(US10709718, Compound 33)Show SMILES CC(C)P(O)(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wU:10.13,wD:7.6,t:21,(8.67,.39,;7.34,1.16,;6,.39,;7.34,2.7,;8.67,3.47,;7.34,4.24,;6,3.46,;4.67,2.69,;3.33,3.46,;2,2.69,;2,1.15,;3.33,.38,;4.67,1.15,;.67,.38,;.67,-1.16,;-.67,-1.93,;-2,-1.16,;-2,.38,;-.67,1.15,;-3.33,-1.93,;-4.67,-1.16,;-6,-1.93,;-7.34,-1.16,;-7.34,.38,;-8.67,-1.93,;-8.67,-3.47,;-7.34,-4.24,;-6,-3.47,;-4.67,-4.24,;-3.33,-3.47,;-2,-4.24,;-2,-2.7,)| Show InChI InChI=1S/C24H33N4O3P/c1-15(2)32(29,30)13-16-5-7-17(8-6-16)18-9-11-19(12-10-18)21-24(3,4)31-23-20(28-21)22(25)26-14-27-23/h9-12,14-17H,5-8,13H2,1-4H3,(H,29,30)(H2,25,26,27)/t16-,17- | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451404
(US10709718, Compound 32)Show SMILES CCCCP(O)(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wU:11.14,wD:8.7,t:22,(9.34,-1.92,;8,-1.15,;8,.39,;6.67,1.16,;6.67,2.7,;8,3.47,;6.67,4.24,;5.33,3.46,;4,2.69,;2.67,3.46,;1.33,2.69,;1.33,1.15,;2.67,.38,;4,1.15,;,.38,;,-1.16,;-1.33,-1.93,;-2.67,-1.16,;-2.67,.38,;-1.33,1.15,;-4,-1.93,;-5.33,-1.16,;-6.67,-1.93,;-8,-1.16,;-8,.38,;-9.34,-1.93,;-9.34,-3.47,;-8,-4.24,;-6.67,-3.47,;-5.33,-4.24,;-4,-3.47,;-2.67,-4.24,;-2.67,-2.7,)| Show InChI InChI=1S/C25H35N4O3P/c1-4-5-14-33(30,31)15-17-6-8-18(9-7-17)19-10-12-20(13-11-19)22-25(2,3)32-24-21(29-22)23(26)27-16-28-24/h10-13,16-18H,4-9,14-15H2,1-3H3,(H,30,31)(H2,26,27,28)/t17-,18- | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451397
(US10709718, Compound 22)Show SMILES CCP(O)(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C1=Nc2c(N)ncnc2OC1(C)C |r,wU:9.12,wD:6.5,t:20,(8.67,.39,;7.34,1.16,;7.34,2.7,;8.67,3.47,;7.34,4.24,;6,3.46,;4.67,2.69,;3.33,3.46,;2,2.69,;2,1.15,;3.33,.38,;4.67,1.15,;.67,.38,;.67,-1.16,;-.67,-1.93,;-2,-1.16,;-2,.38,;-.67,1.16,;-3.33,-1.93,;-4.67,-1.16,;-6,-1.93,;-7.34,-1.16,;-7.34,.38,;-8.67,-1.93,;-8.67,-3.47,;-7.34,-4.24,;-6,-3.47,;-4.67,-4.24,;-3.33,-3.47,;-2,-4.24,;-2,-2.7,)| Show InChI InChI=1S/C23H31N4O3P/c1-4-31(28,29)13-15-5-7-16(8-6-15)17-9-11-18(12-10-17)20-23(2,3)30-22-19(27-20)21(24)25-14-26-22/h9-12,14-16H,4-8,13H2,1-3H3,(H,28,29)(H2,24,25,26)/t15-,16- | PDB
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UniChem
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451400
(US10709718, Compound 25)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(O)(=O)c2cccs2)CC1 |r,wU:19.21,wD:22.25,c:12,(-2,-4.23,;-3.33,-3.47,;-2,-2.69,;-4.67,-4.23,;-6,-3.47,;-7.34,-4.23,;-8.67,-3.47,;-8.67,-1.93,;-7.34,-1.15,;-7.34,.38,;-6,-1.93,;-4.67,-1.15,;-3.33,-1.93,;-2,-1.15,;-.67,-1.93,;.67,-1.15,;.67,.38,;-.67,1.15,;-2,.38,;2,1.15,;2,2.69,;3.33,3.47,;4.67,2.69,;6,3.47,;7.34,2.69,;8.67,3.47,;7.34,4.23,;7.34,1.15,;6.09,.25,;6.57,-1.21,;8.11,-1.21,;8.58,.25,;4.67,1.15,;3.33,.38,)| Show InChI InChI=1S/C25H29N4O3PS/c1-25(2)22(29-21-23(26)27-15-28-24(21)32-25)19-11-9-18(10-12-19)17-7-5-16(6-8-17)14-33(30,31)20-4-3-13-34-20/h3-4,9-13,15-17H,5-8,14H2,1-2H3,(H,30,31)(H2,26,27,28)/t16-,17- | PDB
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Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451401
(US10709718, Compound 26)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CP(O)(=O)c2ccsc2)CC1 |r,wU:19.21,wD:22.25,c:12,(-2,-4.23,;-3.33,-3.47,;-2,-2.69,;-4.67,-4.23,;-6,-3.47,;-7.34,-4.23,;-8.67,-3.47,;-8.67,-1.93,;-7.34,-1.15,;-7.34,.38,;-6,-1.93,;-4.67,-1.15,;-3.33,-1.93,;-2,-1.15,;-.67,-1.93,;.67,-1.15,;.67,.38,;-.67,1.15,;-2,.38,;2,1.15,;2,2.69,;3.33,3.47,;4.67,2.69,;6,3.47,;7.34,2.69,;8.67,3.47,;7.34,4.23,;7.34,1.15,;6.09,.25,;6.57,-1.21,;8.11,-1.21,;8.58,.25,;4.67,1.15,;3.33,.38,)| Show InChI InChI=1S/C25H29N4O3PS/c1-25(2)22(29-21-23(26)27-15-28-24(21)32-25)19-9-7-18(8-10-19)17-5-3-16(4-6-17)13-33(30,31)20-11-12-34-14-20/h7-12,14-17H,3-6,13H2,1-2H3,(H,30,31)(H2,26,27,28)/t16-,17- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451402
(US10709718, Compound 30)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)OCc1cccnc1 |r,wU:19.21,wD:22.28,c:12,(-4.13,-5.39,;-5.47,-4.62,;-4.13,-3.85,;-6.8,-5.39,;-8.13,-4.62,;-9.47,-5.39,;-10.8,-4.62,;-10.8,-3.08,;-9.47,-2.31,;-9.47,-.77,;-8.13,-3.08,;-6.8,-2.31,;-5.47,-3.08,;-4.13,-2.31,;-2.8,-3.08,;-1.46,-2.31,;-1.46,-.77,;-2.8,,;-4.13,-.77,;-.13,,;-.13,1.54,;1.2,2.31,;2.54,1.54,;2.54,,;1.2,-.77,;3.87,2.31,;3.87,3.85,;3.87,5.39,;2.33,3.85,;5.41,3.85,;6.18,2.52,;7.72,2.52,;8.49,1.18,;10.03,1.18,;10.8,2.52,;10.03,3.85,;8.49,3.85,)| Show InChI InChI=1S/C26H30N5O5P/c1-26(2)23(31-22-24(27)29-16-30-25(22)35-26)20-7-5-18(6-8-20)19-9-11-21(12-10-19)36-37(32,33)34-15-17-4-3-13-28-14-17/h3-8,13-14,16,19,21H,9-12,15H2,1-2H3,(H,32,33)(H2,27,29,30)/t19-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451403
(US10709718, Compound 31)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@@H](CC1)OP(O)(=O)OCc1ccncc1 |r,wU:19.21,wD:22.28,c:12,(-4.13,-5.39,;-5.47,-4.62,;-4.13,-3.85,;-6.8,-5.39,;-8.13,-4.62,;-9.47,-5.39,;-10.8,-4.62,;-10.8,-3.08,;-9.47,-2.31,;-9.47,-.77,;-8.13,-3.08,;-6.8,-2.31,;-5.47,-3.08,;-4.13,-2.31,;-2.8,-3.08,;-1.46,-2.31,;-1.46,-.77,;-2.8,,;-4.13,-.77,;-.13,,;-.13,1.54,;1.2,2.31,;2.54,1.54,;2.54,,;1.2,-.77,;3.87,2.31,;3.87,3.85,;3.87,5.39,;2.33,3.85,;5.41,3.85,;6.18,2.52,;7.72,2.52,;8.49,1.18,;10.03,1.18,;10.8,2.52,;10.03,3.85,;8.49,3.85,)| Show InChI InChI=1S/C26H30N5O5P/c1-26(2)23(31-22-24(27)29-16-30-25(22)35-26)20-5-3-18(4-6-20)19-7-9-21(10-8-19)36-37(32,33)34-15-17-11-13-28-14-12-17/h3-6,11-14,16,19,21H,7-10,15H2,1-2H3,(H,32,33)(H2,27,29,30)/t19-,21- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451368
(US10709718, Compound 6)Show SMILES OP(O)(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-n1cnc2c(Cl)ncnc12 |r,wU:8.11,wD:5.4,(8.61,2.93,;7.07,2.93,;7.07,1.39,;7.07,4.47,;5.53,2.93,;4.2,2.16,;2.86,2.93,;1.53,2.16,;1.53,.62,;2.86,-.15,;4.2,.62,;.2,-.15,;.2,-1.69,;-1.14,-2.46,;-2.47,-1.69,;-2.47,-.15,;-1.14,.62,;-3.8,-2.46,;-3.8,-4,;-5.27,-4.47,;-6.17,-3.23,;-7.71,-3.07,;-8.61,-4.31,;-8.33,-1.66,;-7.43,-.41,;-5.9,-.57,;-5.27,-1.98,)| Show InChI InChI=1S/C18H20ClN4O3P/c19-17-16-18(21-10-20-17)23(11-22-16)15-7-5-14(6-8-15)13-3-1-12(2-4-13)9-27(24,25)26/h5-8,10-13H,1-4,9H2,(H2,24,25,26)/t12-,13- | PDB
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antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451399
(US10709718, Compound 24)Show SMILES [O-]P1(=O)OCCC(O1)c1ccc(cc1)-c1ccc(NC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C22H21N2O5P/c25-22(23-19-4-2-1-3-5-19)24-20-12-10-17(11-13-20)16-6-8-18(9-7-16)21-14-15-28-30(26,27)29-21/h1-13,21H,14-15H2,(H,26,27)(H2,23,24,25)/p-1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM451370
(US10709718, Compound 7)Show SMILES CC(C)(CO)COP(O)(=O)c1ccc(NC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C18H23N2O5P/c1-18(2,12-21)13-25-26(23,24)16-10-8-15(9-11-16)20-17(22)19-14-6-4-3-5-7-14/h3-11,21H,12-13H2,1-2H3,(H,23,24)(H2,19,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Metabasis Therapeutics, Inc.
US Patent
| Assay Description
The inhibition of DGAT-1 activity can be assessed in intestinal microsome preparations by monitoring the incorporation of radiolabeled fatty acyl-CoA... |
US Patent US10709718 (2020)
BindingDB Entry DOI: 10.7270/Q2XG9V68 |
More data for this
Ligand-Target Pair | |
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