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Compile Data Set for Download or QSAR

Found 585 hits with Last Name = 'hauff' and Initial = 'p'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520924
PNG
(US11149018, Example 205)
Show SMILES CC[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2ccccc2OC(F)(F)F)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.410n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520771
PNG
(US11149018, Example 58)
Show SMILES CC[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2ccccc2Cl)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.520n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520911
PNG
(US11149018, Example 193)
Show SMILES CC[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2ccccc2C(F)(F)F)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.620n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520868
PNG
(US11149018, Example 152)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520929
PNG
(US11149018, Example 210)
Show SMILES C[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2ccccc2OC(F)(F)F)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.680n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520869
PNG
(US11149018, Example 153 | US11149018, Example 274)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.730n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520939
PNG
(US11149018, Example 220)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.760n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520843
PNG
(US11149018, Example 127)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.790n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520774
PNG
(US11149018, Example 61)
Show SMILES CC[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@@H](CCC(O)=O)c2ccccc2Cl)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.830n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520770
PNG
((+/−)-5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]...)
Show SMILES CCC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2ccccc2Cl)c1C
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.840n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520844
PNG
(US11149018, Example 128 | US11149018, Example 272)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.850n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523442
PNG
(US11136296, Example 173 | US11136296, Example 222 ...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)-c1ccccc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.960n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520944
PNG
(5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylqui...)
Show SMILES CC[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2cc(F)ccc2F)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523442
PNG
(US11136296, Example 173 | US11136296, Example 222 ...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)-c1ccccc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520852
PNG
(US11149018, Example 136)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520761
PNG
(US11149018, Example 48)
Show SMILES C[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@@H](CCC(O)=O)c2ccccc2Cl)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520937
PNG
(US11149018, Example 218)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCC(F)(F)C1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523470
PNG
(US11136296, Example 201)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(Cl)ccc(F)c1F)-c1ccccc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM395298
PNG
(6-(Difluoromethyl)-N-[2-(3-hydroxy-3-methylbutyl)-...)
Show SMILES CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)F)c(cc2n1)C(C)(C)O
Show InChI InChI=1S/C22H26F2N4O3/c1-21(2,30)8-9-28-12-13-10-18(14(22(3,4)31)11-17(13)27-28)26-20(29)16-7-5-6-15(25-16)19(23)24/h5-7,10-12,19,30-31H,8-9H2,1-4H3,(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...


US Patent US10793545 (2020)


BindingDB Entry DOI: 10.7270/Q29S1V3D
More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM395298
PNG
(6-(Difluoromethyl)-N-[2-(3-hydroxy-3-methylbutyl)-...)
Show SMILES CC(C)(O)CCn1cc2cc(NC(=O)c3cccc(n3)C(F)F)c(cc2n1)C(C)(C)O
Show InChI InChI=1S/C22H26F2N4O3/c1-21(2,30)8-9-28-12-13-10-18(14(22(3,4)31)11-17(13)27-28)26-20(29)16-7-5-6-15(25-16)19(23)24/h5-7,10-12,19,30-31H,8-9H2,1-4H3,(H,26,29)
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
antibodypedia
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UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a



Amgen



Assay Description
For the assay, 11 different concentrations in the range from 20 μM to 0.073 nM were prepared from a 2 mM DMSO solution of the test substance. 50...


Bioorg Med Chem Lett 19: 3550-4 (2009)


BindingDB Entry DOI: 10.7270/Q2J67K7G
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520867
PNG
((+/−)-5-({[6-Bromo-3-methyl-2-(piperidin-1-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCCC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520759
PNG
(US11149018, Example 46)
Show SMILES C[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2ccccc2Cl)c1C |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520927
PNG
(US11149018, Example 208)
Show SMILES CC[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@@H](CCC(O)=O)c2ccccc2OC(F)(F)F)c1C |r|
PDB

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antibodypedia
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US Patent
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520877
PNG
(US11149018, Example 161)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(F)cccc1C(F)(F)F)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520954
PNG
((+)-5-({[6-Bromo-3-methyl-2-(piperidin-1-yl)quinol...)
Show SMILES COc1ccccc1[C@@H](CCC(O)=O)CNC(=O)c1c(C)c(nc2ccc(Br)cc12)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520958
PNG
((+)-5-({[2-(Azepan-1-yl)-6-bromo-3-methylquinolin-...)
Show SMILES COc1ccccc1[C@@H](CCC(O)=O)CNC(=O)c1c(C)c(nc2ccc(Br)cc12)N1CCCCCC1 |r|
PDB

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US Patent
n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520855
PNG
(5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylqui...)
Show SMILES CCC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2ccccc2OC(F)(F)F)c1C
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520861
PNG
(US11149018, Example 145)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(Cl)ccc(F)c1F)N1CCCCC1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
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US Patent
n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520874
PNG
(5-[({6-Bromo-2-[3-ethylpiperidin-1-yl]-3-methylqui...)
Show SMILES CCC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2c(F)ccc(F)c2Cl)c1C
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523496
PNG
(US11136296, Example 227)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(F)cccc1C(F)(F)F)-c1ccccc1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520918
PNG
(US11149018, Example 199)
Show SMILES C[C@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@@H](CCC(O)=O)c2ccccc2C(F)(F)F)c1C |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520901
PNG
(US11149018, Example 183)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1c(F)cccc1OC(F)F)N1CCCCC1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523480
PNG
(US11136296, Example 211)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1ccccc1OC(F)(F)F)-c1ccccc1 |r|
PDB

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n/an/a 1.70n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520873
PNG
(5-[({6-Bromo-3-methyl-2-[3-methylpiperidin-1-yl]qu...)
Show SMILES CC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2c(F)ccc(F)c2Cl)c1C
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520921
PNG
(US11149018, Example 202)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCC[C@@H](F)C1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520842
PNG
((+/−)-5-({[6-Bromo-3-methyl-2-(piperidin-1-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCCC1
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520945
PNG
(US11149018, Example 226)
Show SMILES CC[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@H](CCC(O)=O)c2cc(F)ccc2F)c1C |r|
PDB

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n/an/a 1.80n/an/an/an/an/an/a


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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523478
PNG
((+/-)-5-{[(6-Bromo-3-methyl-2-phenylquinolin-4-yl)...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1ccccc1OC(F)(F)F)-c1ccccc1
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520935
PNG
(US11149018, Example 216 | US11149018, Example 282)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCC1 |r|
PDB

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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520931
PNG
(US11149018, Example 212)
Show SMILES C[C@@H]1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NC[C@@H](CCC(O)=O)c2ccccc2OC(F)(F)F)c1C |r|
PDB

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n/an/a 1.90n/an/an/an/an/an/a


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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM523505
PNG
(US11136296, Example 236)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(Cl)ccc(Cl)c1Cl)-c1ccccc1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520849
PNG
(US11149018, Example 133)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCC(F)(F)C1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520889
PNG
(US11149018, Example 173)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(Cl)ccc(Cl)c1Cl)N1CCCCC1 |r|
PDB

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n/an/a 2.20n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520860
PNG
((+/−)-5-({[6-Bromo-3-methyl-2-(piperidin-1-y...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1c(Cl)ccc(F)c1F)N1CCCCC1
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520856
PNG
(5-[({6-Bromo-3-methyl-2-[3-methylpiperidin-1-yl]qu...)
Show SMILES CC1CCCN(C1)c1nc2ccc(Br)cc2c(C(=O)NCC(CCC(O)=O)c2ccccc2OC(F)(F)F)c1C
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520895
PNG
(US11149018, Example 179)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1c(Cl)ccc(Cl)c1Cl)N1CCCC(F)(F)C1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM50547377
PNG
(CHEMBL4749767)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1c(F)ccc(F)c1Cl)-c1ccccc1
PDB

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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q2NS0Z2X
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520847
PNG
(US11149018, Example 131 | US11149018, Example 280)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(O)=O)c1ccccc1OC(F)(F)F)N1CCCC1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM521009
PNG
((+)-5-({[6-Bromo-2-(3,3-difluoropiperidin-1-yl)-3-...)
Show SMILES COc1ccccc1[C@@H](CCC(O)=O)CNC(=O)c1c(C)c(nc2ccc(Br)cc12)N1CCCC(F)(F)C1 |r|
PDB

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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
Prostaglandin F2-alpha receptor


(Homo sapiens (Human))
BDBM520872
PNG
(5-[({6-Bromo-2-[3-fluoropiperidin-1-yl]-3-methylqu...)
Show SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCC(F)C1
PDB

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n/an/a 2.5n/an/an/an/an/an/a


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Assay Description
For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...


Citation and Details

BindingDB Entry DOI: 10.7270/Q25X2D3J
More data for this
Ligand-Target Pair
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