Found 370 hits with Last Name = 'roche' and Initial = 'p' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50388144
(CHEMBL2058177)Show SMILES CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC |r| Show InChI InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
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UniChem
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| Article
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description
Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 72 hr by scintillation cou... |
J Med Chem 55: 558-62 (2012)
Article DOI: 10.1021/jm201263k
BindingDB Entry DOI: 10.7270/Q2MS3TTZ |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586222
(CHEMBL5082786)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccnc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50388144
(CHEMBL2058177)Show SMILES CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC |r| Show InChI InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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CHEMBL
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PC sid
UniChem
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| Article
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description
Inhibition of eIF4A1-mediated protein synthesis in human BJAB cells assessed as inhibition of [35S]Met incorporation after 1 hr by scintillation coun... |
J Med Chem 55: 558-62 (2012)
Article DOI: 10.1021/jm201263k
BindingDB Entry DOI: 10.7270/Q2MS3TTZ |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB
MMDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326574
(6-phenylpyridazin-3-yl thiophene-2-carboxylate | C...)Show InChI InChI=1S/C15H10N2O2S/c18-15(13-7-4-10-20-13)19-14-9-8-12(16-17-14)11-5-2-1-3-6-11/h1-10H | PDB
MMDB
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| Article
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492703
(CHEMBL2408158)Show InChI InChI=1S/C15H14N4O/c16-9-11-4-5-12(17-10-11)7-15(20)14-8-13-3-1-2-6-19(13)18-14/h4-5,8,10H,1-3,6-7H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492718
(CHEMBL2408008)Show InChI InChI=1S/C13H13FN4O/c14-9-4-5-12(15-8-9)16-13(19)11-7-10-3-1-2-6-18(10)17-11/h4-5,7-8H,1-3,6H2,(H,15,16,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50051408
(CHEMBL3337527 | US11071729, Compound 2)Show InChI InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3 | PDB
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| PDB
Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description
Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cells |
J Med Chem 57: 6495-512 (2014)
Article DOI: 10.1021/jm500496m
BindingDB Entry DOI: 10.7270/Q2DJ5H8J |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM50586222
(CHEMBL5082786)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccnc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
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| PC cid
PC sid
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UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD2-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50543359
(GSK620)Show InChI InChI=1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22) | PDB
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UniChem
| Article
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| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by TR-FRET method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586230
(CHEMBL5081350)Show SMILES COc1ccccc1NC(=O)CSc1nc2sc3CN(CCc3c2c(=O)n1Cc1ccco1)C(C)=O | PDB
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492724
(CHEMBL2408176)Show InChI InChI=1S/C13H13ClN2/c14-11-5-3-4-10(8-11)13-9-12-6-1-2-7-16(12)15-13/h3-5,8-9H,1-2,6-7H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB
MMDB
KEGG
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PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586215
(CHEMBL5080392)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cc(Cl)ccc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492705
(CHEMBL2408007)Show InChI InChI=1S/C14H13N5O/c15-8-10-4-5-13(16-9-10)17-14(20)12-7-11-3-1-2-6-19(11)18-12/h4-5,7,9H,1-3,6H2,(H,16,17,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50544300
(GSK046)Show SMILES C[C@H](Oc1cc(cc(F)c1NC(C)=O)C(=O)N[C@H]1CC[C@H](O)CC1)c1ccccc1 |wU:20.21,1.0,wD:17.17,(8.38,-8.55,;8.38,-7.03,;9.68,-6.27,;11.08,-7.03,;11.08,-8.55,;12.38,-9.42,;13.78,-8.55,;13.78,-7.03,;15.08,-6.27,;12.38,-6.27,;12.38,-4.64,;13.78,-3.88,;15.08,-4.64,;13.78,-2.36,;12.38,-10.94,;11.08,-11.7,;13.78,-11.7,;15.08,-10.94,;16.48,-11.7,;17.78,-10.94,;17.78,-9.42,;19.07,-8.55,;16.48,-8.55,;15.08,-9.42,;6.98,-6.27,;6.98,-4.64,;5.69,-3.88,;4.28,-4.64,;4.28,-6.27,;5.69,-7.03,)| Show InChI InChI=1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18-,19-/m0/s1 | PDB
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PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 98 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by TR-FRET method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586228
(CHEMBL5077541)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccccc3Cl)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492726
(CHEMBL2408161)Show InChI InChI=1S/C15H13ClN4O/c16-14-12-3-1-2-6-20(12)19-15(14)13(21)7-11-5-4-10(8-17)9-18-11/h4-5,9H,1-3,6-7H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 2
(Homo sapiens (Human)) | BDBM50586215
(CHEMBL5080392)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cc(Cl)ccc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD2-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50586222
(CHEMBL5082786)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccnc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD4-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586226
(CHEMBL5069987)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccccc3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
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antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM33627
((1,3-benzoxazol-2-ylthio)formic acid butyl ester |...)Show InChI InChI=1S/C12H13NO3S/c1-2-3-8-15-12(14)17-11-13-9-6-4-5-7-10(9)16-11/h4-7H,2-3,8H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586236
(CHEMBL5083228)Show SMILES CCOc1ccccc1NC(=O)CSc1nc2sc3CN(CCc3c2c(=O)n1Cc1ccco1)C(C)=O | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586242
(CHEMBL5074953)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cc(F)ccc3F)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586243
(CHEMBL5072385)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccc(c3)C(C)=O)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586239
(CHEMBL5094390)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccc(C)c(F)c3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586238
(CHEMBL5089658)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccccc3F)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586233
(CHEMBL5077199)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccccc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465543
(CHEMBL4278778)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc5NC(=O)CCCc5c4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C25H26N6O5S/c1-2-30-15-26-23-22(30)24(33)29-25(34)31(23)14-17-8-6-16(7-9-17)13-27-37(35,36)19-10-11-20-18(12-19)4-3-5-21(32)28-20/h6-12,15,27H,2-5,13-14H2,1H3,(H,28,32)(H,29,33,34) | PDB
KEGG
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B.MOAD
antibodypedia
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| PC cid
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PDB
UniChem
| Article
PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465543
(CHEMBL4278778)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc5NC(=O)CCCc5c4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C25H26N6O5S/c1-2-30-15-26-23-22(30)24(33)29-25(34)31(23)14-17-8-6-16(7-9-17)13-27-37(35,36)19-10-11-20-18(12-19)4-3-5-21(32)28-20/h6-12,15,27H,2-5,13-14H2,1H3,(H,28,32)(H,29,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492704
(CHEMBL2408152)Show InChI InChI=1S/C13H13ClN4O/c14-9-4-5-12(15-8-9)16-13(19)11-7-10-3-1-2-6-18(10)17-11/h4-5,7-8H,1-3,6H2,(H,15,16,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 262 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586227
(CHEMBL5079297)Show SMILES COc1cccc(NC(=O)CSc2nc3sc4CN(CCc4c3c(=O)n2Cc2ccco2)C(C)=O)c1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492721
(CHEMBL2408183)Show InChI InChI=1S/C14H14N4O/c15-8-11-4-5-12(16-9-11)10-19-14-7-13-3-1-2-6-18(13)17-14/h4-5,7,9H,1-3,6,10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465544
(CHEMBL4285802)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc(Oc5ccccc5)cc4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C27H25N5O5S/c1-2-31-18-28-25-24(31)26(33)30-27(34)32(25)17-20-10-8-19(9-11-20)16-29-38(35,36)23-14-12-22(13-15-23)37-21-6-4-3-5-7-21/h3-15,18,29H,2,16-17H2,1H3,(H,30,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586244
(CHEMBL5086321)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccc(cc3)C(C)=O)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586215
(CHEMBL5080392)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cc(Cl)ccc3C)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 325 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity to human partial length BRD3-BD2 (G306 to P416) expressed in bacterial system assessed as dissociation constant by BROMOscan method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492733
(CHEMBL2408193)Show InChI InChI=1S/C13H14N4O/c18-13(15-12-6-1-3-7-14-12)11-9-10-5-2-4-8-17(10)16-11/h1,3,6-7,9H,2,4-5,8H2,(H,14,15,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 364 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586237
(CHEMBL5075819)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccc(F)cc3F)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Rattus norvegicus (Rat)) | BDBM50492720
(CHEMBL2408157)Show InChI InChI=1S/C14H15N3O/c18-14(9-11-5-1-3-7-15-11)13-10-12-6-2-4-8-17(12)16-13/h1,3,5,7,10H,2,4,6,8-9H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Addex Therapeutics
Curated by ChEMBL
| Assay Description
Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass... |
Bioorg Med Chem Lett 23: 4523-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.044
BindingDB Entry DOI: 10.7270/Q29S1V02 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465534
(CHEMBL4288560)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc(cc4)-c4ccccc4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C27H25N5O4S/c1-2-31-18-28-25-24(31)26(33)30-27(34)32(25)17-20-10-8-19(9-11-20)16-29-37(35,36)23-14-12-22(13-15-23)21-6-4-3-5-7-21/h3-15,18,29H,2,16-17H2,1H3,(H,30,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465540
(CHEMBL4282396)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4ccc5NC(=O)CCc5c4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C24H24N6O5S/c1-2-29-14-25-22-21(29)23(32)28-24(33)30(22)13-16-5-3-15(4-6-16)12-26-36(34,35)18-8-9-19-17(11-18)7-10-20(31)27-19/h3-6,8-9,11,14,26H,2,7,10,12-13H2,1H3,(H,27,31)(H,28,32,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586240
(CHEMBL5076502)Show SMILES CSc1cccc(NC(=O)CSc2nc3sc4CN(CCc4c3c(=O)n2Cc2ccco2)C(C)=O)c1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586224
(CHEMBL5085041)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cc(Cl)ccc3C)n(-c3ccc(C)o3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50326573
(1-Phenyl-3-(2-thiazolyl)-2-thiourea | 1-phenyl-3-(...)Show InChI InChI=1S/C9H8N4S2/c14-8(12-9-13-10-6-15-9)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Brain Mind Institute
Curated by ChEMBL
| Assay Description
Inhibition of human MIF tautomerase activity in presence of Triton X-100 as detergent |
Bioorg Med Chem 18: 5425-40 (2010)
Article DOI: 10.1016/j.bmc.2010.05.010
BindingDB Entry DOI: 10.7270/Q2KH0P9C |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586232
(CHEMBL5089846)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccc(F)cc3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586229
(CHEMBL5089257)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccc(C)c3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586247
(CHEMBL5075514)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3ccc(F)c(F)c3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 3
(Homo sapiens (Human)) | BDBM50586235
(CHEMBL5094939)Show SMILES CC(=O)N1CCc2c(C1)sc1nc(SCC(=O)Nc3cccc(Cl)c3)n(Cc3ccco3)c(=O)c21 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF method |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c02168
BindingDB Entry DOI: 10.7270/Q20Z7752 |
More data for this
Ligand-Target Pair | |
Bromodomain-containing protein 4
(Homo sapiens (Human)) | BDBM50465536
(CHEMBL4282793)Show SMILES CCn1cnc2n(Cc3ccc(CNS(=O)(=O)c4cccc(c4)-c4ccccc4)cc3)c(=O)[nH]c(=O)c12 Show InChI InChI=1S/C27H25N5O4S/c1-2-31-18-28-25-24(31)26(33)30-27(34)32(25)17-20-13-11-19(12-14-20)16-29-37(35,36)23-10-6-9-22(15-23)21-7-4-3-5-8-21/h3-15,18,29H,2,16-17H2,1H3,(H,30,33,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille University
Curated by ChEMBL
| Assay Description
Inhibition of TEV cleavage site-fused-GST tagged BRD4(BD1) (unknown origin) using SGRGK(Ac)CGK(Ac)-GLGK(Ac)GGAK(Ac)RHRKVG-peptide after 3 hrs by HTRF... |
J Med Chem 61: 5719-5732 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00653
BindingDB Entry DOI: 10.7270/Q2Q52S95 |
More data for this
Ligand-Target Pair | |
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