Compile Data Set for Download or QSAR

Found 17137 hits with Last Name = 'aronow' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10112942 (2018) BindingDB Entry DOI: 10.7270/Q2S75JB5
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10137124 (2018) BindingDB Entry DOI: 10.7270/Q28S4RZ6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296817 (US10112942, Example 552 | US10137124, Example 552 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...				US Patent US10953005 (2021) BindingDB Entry DOI: 10.7270/Q2668H9T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10112942 (2018) BindingDB Entry DOI: 10.7270/Q2S75JB5
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10137124 (2018) BindingDB Entry DOI: 10.7270/Q28S4RZ6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296818 (US10112942, Example 553 | US10137124, Example 553 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OCC3(F)CNC3)cn3ncc(C#N)c23)cn1 Show InChI InChI=1S/C28H28FN9O2/c1-39-26-3-2-18(7-34-26)11-37-20-4-21(37)13-36(12-20)25-10-32-24(9-33-25)23-5-22(40-17-28(29)15-31-16-28)14-38-27(23)19(6-30)8-35-38/h2-3,5,7-10,14,20-21,31H,4,11-13,15-17H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...				US Patent US10953005 (2021) BindingDB Entry DOI: 10.7270/Q2668H9T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305704 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-19-10-20(26-17(11-30)13-32-35(26)14-19)16-3-6-25(31-12-16)34-8-7-23(24(36)15-34)33-27(37)21-9-18(29)4-5-22(21)28/h3-6,9-10,12-14,23-24,36H,2,7-8,15H2,1H3,(H,33,37)/t23-,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10137124 (2018) BindingDB Entry DOI: 10.7270/Q28S4RZ6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...				US Patent US10953005 (2021) BindingDB Entry DOI: 10.7270/Q2668H9T
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...				US Patent US10112942 (2018) BindingDB Entry DOI: 10.7270/Q2S75JB5
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296816 (US10112942, Example 551 | US10137124, Example 551 ...) Show SMILES COc1ccc(CN2C3CC2CN(C3)c2cnc(cn2)-c2cc(OC[C@@H]3CNCCO3)cn3ncc(C#N)c23)cn1 |r| Show InChI InChI=1S/C29H31N9O3/c1-39-28-3-2-19(9-34-28)14-37-21-6-22(37)16-36(15-21)27-13-32-26(12-33-27)25-7-23(41-18-24-11-31-4-5-40-24)17-38-29(25)20(8-30)10-35-38/h2-3,7,9-10,12-13,17,21-22,24,31H,4-6,11,14-16,18H2,1H3/t21?,22?,24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305705 (2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...) Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3c(F)cccc3Cl)[C@@H](O)C2)c2c(cnn2c1)C#N |r| Show InChI InChI=1S/C27H24ClFN6O3/c1-2-38-18-10-19(26-17(11-30)13-32-35(26)14-18)16-6-7-24(31-12-16)34-9-8-22(23(36)15-34)33-27(37)25-20(28)4-3-5-21(25)29/h3-7,10,12-14,22-23,36H,2,8-9,15H2,1H3,(H,33,37)/t22-,23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305757 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C26H24ClFN8O2/c1-3-38-18-9-19(24-16(10-29)11-33-36(24)15-18)21-13-31-22(14-30-21)35-6-4-26(2,5-7-35)34-25(37)23-20(27)8-17(28)12-32-23/h8-9,11-15H,3-7H2,1-2H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305759 (3-chloro-N-(1-(5-(3- cyano-6- ethoxypyrazolo[1,5- ...) Show SMILES CCOc1cc(-c2cnc(cn2)N2CCC(C)(CC2)NC(=O)c2nc(C)ccc2Cl)c2c(cnn2c1)C#N Show InChI InChI=1S/C27H27ClN8O2/c1-4-38-19-11-20(25-18(12-29)13-32-36(25)16-19)22-14-31-23(15-30-22)35-9-7-27(3,8-10-35)34-26(37)24-21(28)6-5-17(2)33-24/h5-6,11,13-16H,4,7-10H2,1-3H3,(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305765 (2-chloro-N-(1-(5-(3- cyano-6- hydroxypyrazolo [1,5...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C26H24ClN7O2/c1-16-4-3-5-20(27)23(16)25(36)32-26(2)6-8-33(9-7-26)22-14-29-21(13-30-22)19-10-18(35)15-34-24(19)17(11-28)12-31-34/h3-5,10,12-15,35H,6-9H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...				US Patent US10172845 (2019) BindingDB Entry DOI: 10.7270/Q2M90BR9
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305468 (US10144734, Example 485 | US10172845, Example 485 ...) Show SMILES Cc1ccc(F)cc1C(=O)NC1(C)CCN(CC1)c1ccc(cn1)-c1cc(O)cn2ncc(C#N)c12 Show InChI InChI=1S/C27H25FN6O2/c1-17-3-5-20(28)11-22(17)26(36)32-27(2)7-9-33(10-8-27)24-6-4-18(14-30-24)23-12-21(35)16-34-25(23)19(13-29)15-31-34/h3-6,11-12,14-16,35H,7-10H2,1-2H3,(H,32,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (aa658-end) (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q21G0R6J
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114,V804M] (Homo sapiens (Human))	BDBM305672 (US10144734, Example 690 | US10172845, Example 690 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@@H]2CNCCO2)cn2ncc(C#N)c12 |r| Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10441581 (2019) BindingDB Entry DOI: 10.7270/Q2DZ0BP3
					More data for this Ligand-Target Pair

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