Compile Data Set for Download or QSAR

Found 819 hits with Last Name = 'prajapati' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acetylcholinesterase (Homo sapiens (Human))	BDBM50563378 (CHEMBL4790766) Show SMILES CCOC(=O)c1c(C)nc(nc1-c1ccc(OC)c(OC)c1)N1CCN(CC1)S(=O)(=O)c1ccc(NC(C)=O)c(Cl)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Non-competitive inhibition of AChE in human erythrocytes measured at 2 mins interval for 10 mins by Dixon plot analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113224 BindingDB Entry DOI: 10.7270/Q2HM5D5K
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50546170 (CHEMBL4759108) Show SMILES Fc1ccc(-c2nnc(o2)N2CCN(CC2)c2ccccn2)c(F)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Mixed type inhibition of human erythrocytes AChE using varying levels of acetylthiocholine iodide substrate by Dixon plot analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2019.111707 BindingDB Entry DOI: 10.7270/Q2833WM3
					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50535287 (CHEMBL4583534) Show SMILES FC(F)(F)c1ccc(CNC2CCN(Cc3ccccc3)CC2)cc1 Show InChI InChI=1S/C20H23F3N2/c21-20(22,23)18-8-6-16(7-9-18)14-24-19-10-12-25(13-11-19)15-17-4-2-1-3-5-17/h1-9,19,24H,10-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Indian Institute of Technology (Banaras Hindu University) Curated by ChEMBL					Assay Description Non-competitive inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addit...				Eur J Med Chem 167: 510-524 (2019) Article DOI: 10.1016/j.ejmech.2019.02.030 BindingDB Entry DOI: 10.7270/Q2JD5192
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249396 (US10537571, Compound 108 | US10562888, Compound 10...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<0.100	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...				US Patent US10912774 (2021) BindingDB Entry DOI: 10.7270/Q2PN98QH
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249396 (US10537571, Compound 108 | US10562888, Compound 10...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249396 (US10537571, Compound 108 | US10562888, Compound 10...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<0.200	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249423 (US10537571, Compound 142 | US10912774, Compound 14...) Show SMILES COCCOc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C26H28Cl2N6O6/c1-6-22(35)32-17-11-15(40-10-9-37-3)7-8-16(17)31-20-13-21(30-14-29-20)34(2)26(36)33-25-23(27)18(38-4)12-19(39-5)24(25)28/h6-8,11-14H,1,9-10H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249425 (US10537571, Compound 144 | US10912774, Compound 14...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(F)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34ClFN8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249426 (US10537571, Compound 145 | US10912774, Compound 14...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CO)cc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C24H24Cl2N6O5/c1-5-20(34)30-15-8-13(11-33)6-7-14(15)29-18-10-19(28-12-27-18)32(2)24(35)31-23-21(25)16(36-3)9-17(37-4)22(23)26/h5-10,12,33H,1,11H2,2-4H3,(H,30,34)(H,31,35)(H,27,28,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249427 (US10537571, Compound 147 | US10912774, Compound 14...) Show SMILES COCc1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(34)31-16-9-14(12-36-3)7-8-15(16)30-19-11-20(29-13-28-19)33(2)25(35)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-11,13H,1,12H2,2-5H3,(H,31,34)(H,32,35)(H,28,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249428 (US10537571, Compound 148 | US10912774, Compound 14...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N3CCN(C)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-24(40)35-19-13-17(28(41)39-11-9-37(2)10-12-39)7-8-18(19)34-22-15-23(33-16-32-22)38(3)29(42)36-27-25(30)20(43-4)14-21(44-5)26(27)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,40)(H,36,42)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249429 (US10537571, Compound 149 | US10912774, Compound 14...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(=O)N(C)C)ncn2)c1Cl Show InChI InChI=1S/C26H27Cl2N7O5/c1-7-21(36)32-16-10-14(25(37)34(2)3)8-9-15(16)31-19-12-20(30-13-29-19)35(4)26(38)33-24-22(27)17(39-5)11-18(40-6)23(24)28/h7-13H,1H2,2-6H3,(H,32,36)(H,33,38)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249430 (US10537571, Compound 150 | US10912774, Compound 15...) Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C30H34Cl2N8O5/c1-6-25(41)36-20-14-18(29(42)40-12-10-39(7-2)11-13-40)8-9-19(20)35-23-16-24(34-17-33-23)38(3)30(43)37-28-26(31)21(44-4)15-22(45-5)27(28)32/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,36,41)(H,37,43)(H,33,34,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249431 (US10537571, Compound 151 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)C)ncn2)c1Cl Show InChI InChI=1S/C30H36Cl2N8O4/c1-7-26(41)36-21-14-19(40-12-10-39(11-13-40)18(2)3)8-9-20(21)35-24-16-25(34-17-33-24)38(4)30(42)37-29-27(31)22(43-5)15-23(44-6)28(29)32/h7-9,14-18H,1,10-13H2,2-6H3,(H,36,41)(H,37,42)(H,33,34,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249433 (US10537571, Compound 154 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)ncn2)c1Cl Show InChI InChI=1S/C29H32Cl2N8O5/c1-6-25(41)35-20-13-18(39-11-9-38(10-12-39)17(2)40)7-8-19(20)34-23-15-24(33-16-32-23)37(3)29(42)36-28-26(30)21(43-4)14-22(44-5)27(28)31/h6-8,13-16H,1,9-12H2,2-5H3,(H,35,41)(H,36,42)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249434 (US10537571, Compound 155 | US10912774, Compound 15...) Show SMILES COC(C)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C26H28Cl2N6O5/c1-7-22(35)32-17-10-15(14(2)37-4)8-9-16(17)31-20-12-21(30-13-29-20)34(3)26(36)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-14H,1H2,2-6H3,(H,32,35)(H,33,36)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249435 (US10537571, Compound 156 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)O)ncn2)c1Cl Show InChI InChI=1S/C25H26Cl2N6O5/c1-6-21(35)31-16-9-14(13(2)34)7-8-15(16)30-19-11-20(29-12-28-19)33(3)25(36)32-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13,34H,1H2,2-5H3,(H,31,35)(H,32,36)(H,28,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249436 (US10537571, Compound 157 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCNCC3)ncn2)c1Cl Show InChI InChI=1S/C27H30Cl2N8O4/c1-5-23(38)34-18-12-16(37-10-8-30-9-11-37)6-7-17(18)33-21-14-22(32-15-31-21)36(2)27(39)35-26-24(28)19(40-3)13-20(41-4)25(26)29/h5-7,12-15,30H,1,8-11H2,2-4H3,(H,34,38)(H,35,39)(H,31,32,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249437 (US10537571, Compound 158 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N(C)CCO)ncn2)c1Cl Show InChI InChI=1S/C26H29Cl2N7O5/c1-6-22(37)32-17-11-15(34(2)9-10-36)7-8-16(17)31-20-13-21(30-14-29-20)35(3)26(38)33-25-23(27)18(39-4)12-19(40-5)24(25)28/h6-8,11-14,36H,1,9-10H2,2-5H3,(H,32,37)(H,33,38)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249438 (US10537571, Compound 159 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249439 (US10537571, Compound 160 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249440 (US10537571, Compound 161 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249441 (US10537571, Compound 162 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249442 (US10537571, Compound 163 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249443 (US10537571, Compound 164 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(OCCO)cc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C25H26Cl2N6O6/c1-5-21(35)31-16-10-14(39-9-8-34)6-7-15(16)30-19-12-20(29-13-28-19)33(2)25(36)32-24-22(26)17(37-3)11-18(38-4)23(24)27/h5-7,10-13,34H,1,8-9H2,2-4H3,(H,31,35)(H,32,36)(H,28,29,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249444 (US10537571, Compound 165 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249445 (US10537571, Compound 166 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249446 (US10537571, Compound 167 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249447 (US10537571, Compound 168 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249452 (US10537571, Compound 181 | US10912774, Compound 18...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1 Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249438 (US10537571, Compound 159 | US10912774, Compound 15...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)ncn2)c1Cl Show InChI InChI=1S/C28H32Cl2N8O4/c1-6-24(39)34-19-13-17(38-11-9-36(2)10-12-38)7-8-18(19)33-22-15-23(32-16-31-22)37(3)28(40)35-27-25(29)20(41-4)14-21(42-5)26(27)30/h6-8,13-16H,1,9-12H2,2-5H3,(H,34,39)(H,35,40)(H,31,32,33)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249439 (US10537571, Compound 160 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C(C)N)ncn2)c1Cl Show InChI InChI=1S/C25H27Cl2N7O4/c1-6-21(35)32-16-9-14(13(2)28)7-8-15(16)31-19-11-20(30-12-29-19)34(3)25(36)33-24-22(26)17(37-4)10-18(38-5)23(24)27/h6-13H,1,28H2,2-5H3,(H,32,35)(H,33,36)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249440 (US10537571, Compound 161 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCN)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H35Cl2N9O4/c1-5-25(41)36-20-14-18(40-12-10-39(9-8-32)11-13-40)6-7-19(20)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17H,1,8-13,32H2,2-4H3,(H,36,41)(H,37,42)(H,33,34,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249441 (US10537571, Compound 162 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(F)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H21Cl2FN6O4/c1-5-18(33)29-13-8-6-7-12(26)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(24)14(35-3)9-15(36-4)20(22)25/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249442 (US10537571, Compound 163 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CCN(C)C)cc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C27H31Cl2N7O4/c1-7-23(37)33-18-12-16(10-11-35(2)3)8-9-17(18)32-21-14-22(31-15-30-21)36(4)27(38)34-26-24(28)19(39-5)13-20(40-6)25(26)29/h7-9,12-15H,1,10-11H2,2-6H3,(H,33,37)(H,34,38)(H,30,31,32)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249444 (US10537571, Compound 165 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(C)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C24H24Cl2N6O4/c1-6-19(33)29-14-9-7-8-13(2)22(14)30-17-11-18(28-12-27-17)32(3)24(34)31-23-20(25)15(35-4)10-16(36-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249445 (US10537571, Compound 166 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(NC(=O)C=C)cccc3OC)ncn2)c1Cl Show InChI InChI=1S/C24H24Cl2N6O5/c1-6-19(33)29-13-8-7-9-14(35-3)22(13)30-17-11-18(28-12-27-17)32(2)24(34)31-23-20(25)15(36-4)10-16(37-5)21(23)26/h6-12H,1H2,2-5H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249446 (US10537571, Compound 167 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3c(Cl)cccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H21Cl3N6O4/c1-5-18(33)29-13-8-6-7-12(24)21(13)30-16-10-17(28-11-27-16)32(2)23(34)31-22-19(25)14(35-3)9-15(36-4)20(22)26/h5-11H,1H2,2-4H3,(H,29,33)(H,31,34)(H,27,28,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249447 (US10537571, Compound 168 | US10912774, Compound 16...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CCO)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H34Cl2N8O5/c1-5-25(41)35-20-14-18(39-10-8-38(9-11-39)12-13-40)6-7-19(20)34-23-16-24(33-17-32-23)37(2)29(42)36-28-26(30)21(43-3)15-22(44-4)27(28)31/h5-7,14-17,40H,1,8-13H2,2-4H3,(H,35,41)(H,36,42)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249452 (US10537571, Compound 181 | US10912774, Compound 18...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)\C=C/Cl)c1 Show InChI InChI=1S/C29H33Cl3N8O4/c1-5-39-10-12-40(13-11-39)18-6-7-19(20(14-18)36-25(41)8-9-30)35-23-16-24(34-17-33-23)38(2)29(42)37-28-26(31)21(43-3)15-22(44-4)27(28)32/h6-9,14-17H,5,10-13H2,1-4H3,(H,36,41)(H,37,42)(H,33,34,35)/b9-8-	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249391 (US10537571, Compound 100 | US10912774, Compound 10...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249396 (US10537571, Compound 108 | US10562888, Compound 10...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50355393 (BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
EISAI R&D MANAGEMENT CO., LTD. US Patent					Assay Description Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...				US Patent US9434697 (2016) BindingDB Entry DOI: 10.7270/Q2K07351
					More data for this Ligand-Target Pair				3D Structure (crystal)
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249391 (US10537571, Compound 100 | US10912774, Compound 10...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C23H22Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h5-12H,1H2,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249395 (US10537571, Compound 107 | US10912774, Compound 10...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(Cc2cccnc2)c2cc(Nc3ccccc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C28H25Cl2N7O4/c1-4-24(38)35-19-10-6-5-9-18(19)34-22-13-23(33-16-32-22)37(15-17-8-7-11-31-14-17)28(39)36-27-25(29)20(40-2)12-21(41-3)26(27)30/h4-14,16H,1,15H2,2-3H3,(H,35,38)(H,36,39)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249396 (US10537571, Compound 108 | US10562888, Compound 10...) Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249398 (US10537571, Compound 111 | US10912774, Compound 11...) Show SMILES CCN1CCC(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1 Show InChI InChI=1S/C30H35Cl2N7O4/c1-6-26(40)36-21-14-19(18-10-12-39(7-2)13-11-18)8-9-20(21)35-24-16-25(34-17-33-24)38(3)30(41)37-29-27(31)22(42-4)15-23(43-5)28(29)32/h6,8-9,14-18H,1,7,10-13H2,2-5H3,(H,36,40)(H,37,41)(H,33,34,35)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249399 (US10537571, Compound 112 | US10912774, Compound 11...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(cc3NC(=O)C=C)C3CCN(C)CC3)ncn2)c1Cl Show InChI InChI=1S/C29H33Cl2N7O4/c1-6-25(39)35-20-13-18(17-9-11-37(2)12-10-17)7-8-19(20)34-23-15-24(33-16-32-23)38(3)29(40)36-28-26(30)21(41-4)14-22(42-5)27(28)31/h6-8,13-17H,1,9-12H2,2-5H3,(H,35,39)(H,36,40)(H,32,33,34)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249400 (US10537571, Compound 113 | US10912774, Compound 11...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccc(CN(C)C)cc3NC(=O)C=C)ncn2)c1Cl Show InChI InChI=1S/C26H29Cl2N7O4/c1-7-22(36)32-17-10-15(13-34(2)3)8-9-16(17)31-20-12-21(30-14-29-20)35(4)26(37)33-25-23(27)18(38-5)11-19(39-6)24(25)28/h7-12,14H,1,13H2,2-6H3,(H,32,36)(H,33,37)(H,29,30,31)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM249401 (US10537571, Compound 114 | US10912774, Compound 11...) Show SMILES COc1cc(OC)c(Cl)c(NC(=O)N(C)c2cc(Nc3ccccc3NC(=O)C#C)ncn2)c1Cl Show InChI InChI=1S/C23H20Cl2N6O4/c1-5-19(32)29-14-9-7-6-8-13(14)28-17-11-18(27-12-26-17)31(2)23(33)30-22-20(24)15(34-3)10-16(35-4)21(22)25/h1,6-12H,2-4H3,(H,29,32)(H,30,33)(H,26,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
EISAI R&D Management Co., Ltd. US Patent					Assay Description Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...				US Patent US9730931 (2017) BindingDB Entry DOI: 10.7270/Q2542QPZ
					More data for this Ligand-Target Pair

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