Found 301 hits with Last Name = 'deng' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574637
(CHEMBL4862351)Show SMILES CCOC(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.245 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574628
(CHEMBL4869024)Show SMILES CN1CCN(CCOc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NO)n3)cc2)CC1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.763 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574633
(CHEMBL4870265)Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCC(CC3)C(=O)NO)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574627
(CHEMBL4875985)Show SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(OCCN3CCOCC3)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625594
(US20230322822, Compound 6)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574629
(CHEMBL4870560)Show SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(OCCCN3CCOCC3)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625593
(US20230322822, Compound 5)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625596
(US20230322822, Compound 11)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(F)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574638
(CHEMBL4862976)Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CN3CCOCC3)c(C)c2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625592
(US20230322822, Compound 2)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625591
(US20230322822, Compound 1)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625592
(US20230322822, Compound 2)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625596
(US20230322822, Compound 11)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(F)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574626
(CHEMBL4858714)Show SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCOCC3)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,C797S]
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625592
(US20230322822, Compound 2)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574625
(CHEMBL4861707)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3C(=O)NO)n2)cc1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of wild type EGFR (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625594
(US20230322822, Compound 6)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574628
(CHEMBL4869024)Show SMILES CN1CCN(CCOc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NO)n3)cc2)CC1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625597
(US20230322822, Compound 12)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625593
(US20230322822, Compound 5)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625597
(US20230322822, Compound 12)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625597
(US20230322822, Compound 12)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,C797S]
(Homo sapiens (Human)) | BDBM625597
(US20230322822, Compound 12)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,C797S]
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625594
(US20230322822, Compound 6)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,C797S]
(Homo sapiens (Human)) | BDBM625596
(US20230322822, Compound 11)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(F)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625591
(US20230322822, Compound 1)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 10.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625595
(US20230322822, Compound 9)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2cc(C)ccc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM625596
(US20230322822, Compound 11)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(F)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625597
(US20230322822, Compound 12)Show SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc(C)cc3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,C797S]
(Homo sapiens (Human)) | BDBM625592
(US20230322822, Compound 2)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [T790M,L858R]
(Homo sapiens (Human)) | BDBM625591
(US20230322822, Compound 1)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4
(Homo sapiens (Human)) | BDBM625594
(US20230322822, Compound 6)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M]
(Homo sapiens (Human)) | BDBM625591
(US20230322822, Compound 1)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 14.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4
(Homo sapiens (Human)) | BDBM625591
(US20230322822, Compound 1)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 14.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [L858R,T790M,C797S]
(Homo sapiens (Human)) | BDBM625600
(US20230322822, Compound 32)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Br)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 15.9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50574630
(CHEMBL4858409)Show SMILES ONC(=O)c1ccccc1Nc1nc(Nc2ccc(OCC(=O)N3CCOCC3)cc2)ncc1Cl | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of EGFR L858R/T790M double mutant (unknown origin) measured after 60 mins by ADP-Glo kinase based luminescence assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113626
BindingDB Entry DOI: 10.7270/Q2SN0DR4 |
More data for this
Ligand-Target Pair | |
ALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4
(Homo sapiens (Human)) | BDBM625593
(US20230322822, Compound 5)Show SMILES COc1cc(N2CCC(CC2)N(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 16.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
egfr-c797s/ t790m/del19
(Homo sapiens (Human)) | BDBM625592
(US20230322822, Compound 2)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(C)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210]
(Homo sapiens (Human)) | BDBM625598
(US20230322822, Compound 14)Show SMILES COc1cc(N2CCC(CC2)N2CCN(C)CC2)c(Cl)cc1Nc1ncc(Br)c(Nc2ccc(C)cc2P(C)(C)=O)n1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 16.6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Search and Browse
