Found 24 hits with Last Name = 'matsumura' and Initial = 't' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50512479
(CHEMBL4456440)Show SMILES Cl.CN(C1CCOCC1)c1cc(nc2cc(nn12)-c1nc2ccccc2nc1C)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C25H28FN7O.ClH/c1-16-25(28-20-6-4-3-5-19(20)27-16)21-13-23-29-22(32-10-7-17(26)15-32)14-24(33(23)30-21)31(2)18-8-11-34-12-9-18;/h3-6,13-14,17-18H,7-12,15H2,1-2H3;1H/t17-;/m1./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.0610 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as... |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as... |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50275347
(4-(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-2-(2-(py...)Show SMILES Oc1ccc(Nc2nc(NCCc3ccncc3)ncc2-c2nnc(o2)C2CC2)cc1 Show InChI InChI=1S/C22H21N7O2/c30-17-5-3-16(4-6-17)26-19-18(21-29-28-20(31-21)15-1-2-15)13-25-22(27-19)24-12-9-14-7-10-23-11-8-14/h3-8,10-11,13,15,30H,1-2,9,12H2,(H2,24,25,26,27) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276003
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N4-propyl-N...)Show InChI InChI=1S/C19H23N7O/c1-2-8-21-16-15(18-26-25-17(27-18)14-3-4-14)12-23-19(24-16)22-11-7-13-5-9-20-10-6-13/h5-6,9-10,12,14H,2-4,7-8,11H2,1H3,(H2,21,22,23,24) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50275348
(3-(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-2-(2-(py...)Show SMILES Oc1cccc(Nc2nc(NCCc3ccncc3)ncc2-c2nnc(o2)C2CC2)c1 Show InChI InChI=1S/C22H21N7O2/c30-17-3-1-2-16(12-17)26-19-18(21-29-28-20(31-21)15-4-5-15)13-25-22(27-19)24-11-8-14-6-9-23-10-7-14/h1-3,6-7,9-10,12-13,15,30H,4-5,8,11H2,(H2,24,25,26,27) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276053
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N4-methyl-N...)Show InChI InChI=1S/C17H19N7O/c1-18-14-13(16-24-23-15(25-16)12-2-3-12)10-21-17(22-14)20-9-6-11-4-7-19-8-5-11/h4-5,7-8,10,12H,2-3,6,9H2,1H3,(H2,18,20,21,22) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM14754
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE10A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276056
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N4-phenyl-N...)Show SMILES C(Cc1ccncc1)Nc1ncc(-c2nnc(o2)C2CC2)c(Nc2ccccc2)n1 Show InChI InChI=1S/C22H21N7O/c1-2-4-17(5-3-1)26-19-18(21-29-28-20(30-21)16-6-7-16)14-25-22(27-19)24-13-10-15-8-11-23-12-9-15/h1-5,8-9,11-12,14,16H,6-7,10,13H2,(H2,24,25,26,27) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276054
(2-(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-2-(2-(py...)Show InChI InChI=1S/C18H21N7O2/c26-10-9-20-15-14(17-25-24-16(27-17)13-1-2-13)11-22-18(23-15)21-8-5-12-3-6-19-7-4-12/h3-4,6-7,11,13,26H,1-2,5,8-10H2,(H2,20,21,22,23) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50275349
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-4-ethoxy-N-...)Show InChI InChI=1S/C18H20N6O2/c1-2-25-16-14(17-24-23-15(26-17)13-3-4-13)11-21-18(22-16)20-10-7-12-5-8-19-9-6-12/h5-6,8-9,11,13H,2-4,7,10H2,1H3,(H,20,21,22) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50275346
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N2-(2-(pyri...)Show SMILES Cc1ccc(Nc2nc(NCCc3ccncc3)ncc2-c2nnc(o2)C2CC2)cc1 Show InChI InChI=1S/C23H23N7O/c1-15-2-6-18(7-3-15)27-20-19(22-30-29-21(31-22)17-4-5-17)14-26-23(28-20)25-13-10-16-8-11-24-12-9-16/h2-3,6-9,11-12,14,17H,4-5,10,13H2,1H3,(H2,25,26,27,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 106 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276057
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N2-(2-(pyri...)Show SMILES Cc1ccccc1Nc1nc(NCCc2ccncc2)ncc1-c1nnc(o1)C1CC1 Show InChI InChI=1S/C23H23N7O/c1-15-4-2-3-5-19(15)27-20-18(22-30-29-21(31-22)17-6-7-17)14-26-23(28-20)25-13-10-16-8-11-24-12-9-16/h2-5,8-9,11-12,14,17H,6-7,10,13H2,1H3,(H2,25,26,27,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 289 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE4 (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50275746
(5-(5-methyl-1,3,4-oxadiazol-2-yl)-N4-propyl-N2-(2-...)Show InChI InChI=1S/C16H20N6OS/c1-3-7-17-14-13(15-22-21-11(2)23-15)10-19-16(20-14)18-8-6-12-5-4-9-24-12/h4-5,9-10H,3,6-8H2,1-2H3,(H2,17,18,19,20) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 373 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 437 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE5A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50276055
(5-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)-N4-(2-(meth...)Show SMILES CS(=O)(=O)CCNc1nc(NCCc2ccncc2)ncc1-c1nnc(o1)C1CC1 Show InChI InChI=1S/C19H23N7O3S/c1-30(27,28)11-10-21-16-15(18-26-25-17(29-18)14-2-3-14)12-23-19(24-16)22-9-6-13-4-7-20-8-5-13/h4-5,7-8,12,14H,2-3,6,9-11H2,1H3,(H2,21,22,23,24) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 515 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged FLT3 (unknown origin) by ELISA |
Bioorg Med Chem Lett 18: 5472-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.031 BindingDB Entry DOI: 10.7270/Q2WD40DQ |
More data for this Ligand-Target Pair | |
O43924/P16499/P18545/P35913/P51160/Q13956
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 561 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE6 (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM14754
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE11A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE9A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE8A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE2A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE3A (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM144390
(US8969376, 1.006)Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1 |r| Show InChI InChI=1S/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mitsubishi Tanabe Pharma Corporation
Curated by ChEMBL
| Assay Description Inhibition of PDE7B (unknown origin) |
Bioorg Med Chem 27: 3440-3450 (2019)
Article DOI: 10.1016/j.bmc.2019.06.021 BindingDB Entry DOI: 10.7270/Q2SB492B |
More data for this Ligand-Target Pair | |