Found 10 hits with Last Name = 'jørgensen' and Initial = 'tn' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM25870
(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 | PDB
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CHEMBL
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MCE
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Similars
| DrugBank
PDB
Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50428499
(CHEMBL2336611)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCN3[C@@H]4CC[C@@H]3[C@H]([C@H](C4)c3ccc(Cl)c(Cl)c3)C(=O)OC)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:35.35,38.39,39.53,40.44,TLB:50:39:34:36.37,THB:33:34:40.41.39:36.37,42:40:34:36.37,(30.38,-12.98,;30.41,-14.51,;29.1,-15.31,;29.13,-16.85,;27.81,-17.65,;27.75,-14.57,;26.42,-15.37,;25.06,-14.63,;25.03,-13.08,;23.7,-12.33,;22.38,-13.12,;22.4,-14.66,;21.07,-15.45,;19.74,-14.7,;19.71,-13.15,;21.03,-12.36,;21.01,-10.82,;19.66,-10.08,;21.4,-9.33,;22.52,-11.21,;18.41,-15.49,;19.19,-16.82,;17.65,-16.84,;17.07,-14.74,;15.75,-15.53,;14.4,-14.78,;13.08,-15.57,;11.73,-14.82,;10.41,-15.61,;9.07,-14.86,;9.04,-13.32,;7.75,-15.64,;7.73,-17.17,;6.42,-17.97,;6.46,-19.51,;6.72,-21.05,;5.73,-22.4,;6.91,-21.68,;7.52,-20.34,;9.27,-20.31,;9.54,-21.86,;8.56,-21.05,;10.31,-23.19,;11.84,-23.18,;12.62,-24.5,;11.85,-25.85,;12.62,-27.18,;10.31,-25.85,;9.54,-27.19,;9.54,-24.52,;10.09,-19.01,;9.38,-17.65,;11.63,-19.07,;12.35,-20.44,;23.67,-10.79,;22.33,-10.05,;22.29,-8.52,;23.61,-7.72,;24.96,-8.46,;24.98,-10,;26.33,-10.74,;26.36,-12.28,;27.71,-13.02,;23.58,-6.18,;22.23,-5.44,;20.91,-6.24,;24.89,-5.38,;26.23,-6.13,)| Show InChI InChI=1S/C50H61Cl2N5O9S2/c1-6-55(7-2)33-15-19-37-44(29-33)66-45-30-34(56(8-3)9-4)16-20-38(45)48(37)39-21-18-36(31-46(39)68(62,63)64)67(60,61)54-24-12-10-11-13-47(58)53-25-26-57-35-17-23-43(57)49(50(59)65-5)40(28-35)32-14-22-41(51)42(52)27-32/h14-16,18-22,27,29-31,35,40,43,49,54H,6-13,17,23-26,28H2,1-5H3,(H-,53,58,62,63,64)/t35-,40-,43-,49+/m1/s1 | NCI pathway
Reactome pathway
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| 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human DAT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50428499
(CHEMBL2336611)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCN3[C@@H]4CC[C@@H]3[C@H]([C@H](C4)c3ccc(Cl)c(Cl)c3)C(=O)OC)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:35.35,38.39,39.53,40.44,TLB:50:39:34:36.37,THB:33:34:40.41.39:36.37,42:40:34:36.37,(30.38,-12.98,;30.41,-14.51,;29.1,-15.31,;29.13,-16.85,;27.81,-17.65,;27.75,-14.57,;26.42,-15.37,;25.06,-14.63,;25.03,-13.08,;23.7,-12.33,;22.38,-13.12,;22.4,-14.66,;21.07,-15.45,;19.74,-14.7,;19.71,-13.15,;21.03,-12.36,;21.01,-10.82,;19.66,-10.08,;21.4,-9.33,;22.52,-11.21,;18.41,-15.49,;19.19,-16.82,;17.65,-16.84,;17.07,-14.74,;15.75,-15.53,;14.4,-14.78,;13.08,-15.57,;11.73,-14.82,;10.41,-15.61,;9.07,-14.86,;9.04,-13.32,;7.75,-15.64,;7.73,-17.17,;6.42,-17.97,;6.46,-19.51,;6.72,-21.05,;5.73,-22.4,;6.91,-21.68,;7.52,-20.34,;9.27,-20.31,;9.54,-21.86,;8.56,-21.05,;10.31,-23.19,;11.84,-23.18,;12.62,-24.5,;11.85,-25.85,;12.62,-27.18,;10.31,-25.85,;9.54,-27.19,;9.54,-24.52,;10.09,-19.01,;9.38,-17.65,;11.63,-19.07,;12.35,-20.44,;23.67,-10.79,;22.33,-10.05,;22.29,-8.52,;23.61,-7.72,;24.96,-8.46,;24.98,-10,;26.33,-10.74,;26.36,-12.28,;27.71,-13.02,;23.58,-6.18,;22.23,-5.44,;20.91,-6.24,;24.89,-5.38,;26.23,-6.13,)| Show InChI InChI=1S/C50H61Cl2N5O9S2/c1-6-55(7-2)33-15-19-37-44(29-33)66-45-30-34(56(8-3)9-4)16-20-38(45)48(37)39-21-18-36(31-46(39)68(62,63)64)67(60,61)54-24-12-10-11-13-47(58)53-25-26-57-35-17-23-43(57)49(50(59)65-5)40(28-35)32-14-22-41(51)42(52)27-32/h14-16,18-22,27,29-31,35,40,43,49,54H,6-13,17,23-26,28H2,1-5H3,(H-,53,58,62,63,64)/t35-,40-,43-,49+/m1/s1 | PDB
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| 194 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human NET expressed in COS7 cells after 5 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50428498
(CHEMBL2336610)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCC(=O)Nc3cccc(c3)-c3ccc4c(COC4(CCCN(C)C)c4ccc(F)cc4)c3)c3ccc(cc3oc2c1)=[N+](CC)CC |(19.16,-47.15,;19.13,-48.69,;20.44,-49.49,;20.41,-51.03,;21.72,-51.83,;21.79,-48.75,;23.12,-49.55,;24.48,-48.8,;24.5,-47.26,;25.84,-46.5,;27.16,-47.29,;27.14,-48.84,;28.46,-49.62,;29.8,-48.87,;29.83,-47.33,;28.51,-46.54,;28.53,-45,;29.88,-44.25,;28.13,-43.51,;27.02,-45.39,;31.12,-49.66,;30.34,-51,;31.88,-51.02,;32.47,-48.91,;33.79,-49.7,;35.14,-48.95,;36.46,-49.74,;37.8,-48.99,;39.12,-49.78,;40.47,-49.03,;40.49,-47.49,;41.79,-49.82,;43.14,-49.07,;44.46,-49.86,;45.8,-49.11,;45.83,-47.57,;47.13,-49.92,;48.46,-49.15,;48.46,-47.6,;49.79,-46.83,;51.12,-47.6,;51.12,-49.15,;49.79,-49.91,;52.45,-49.91,;53.78,-49.15,;55.12,-49.92,;55.11,-51.46,;53.78,-52.23,;54.1,-53.73,;55.63,-53.89,;56.26,-52.49,;57.02,-51.15,;58.56,-51.14,;59.32,-49.8,;60.87,-49.79,;61.63,-48.46,;61.64,-51.12,;57.59,-53.26,;58.93,-52.49,;60.26,-53.26,;60.25,-54.8,;61.59,-55.57,;58.92,-55.57,;57.59,-54.8,;52.45,-51.45,;25.87,-44.97,;27.21,-44.23,;27.25,-42.69,;25.93,-41.9,;24.58,-42.64,;24.55,-44.17,;23.2,-44.92,;23.18,-46.45,;21.83,-47.2,;25.96,-40.36,;27.31,-39.61,;28.63,-40.41,;24.65,-39.56,;23.3,-40.31,)| Show InChI InChI=1S/C61H71FN6O9S2/c1-7-67(8-2)48-24-27-51-55(38-48)77-56-39-49(68(9-3)10-4)25-28-52(56)60(51)53-29-26-50(40-57(53)79(73,74)75)78(71,72)64-33-13-11-12-18-58(69)63-34-31-59(70)65-47-17-14-16-42(37-47)43-19-30-54-44(36-43)41-76-61(54,32-15-35-66(5)6)45-20-22-46(62)23-21-45/h14,16-17,19-30,36-40,64H,7-13,15,18,31-35,41H2,1-6H3,(H2-,63,65,69,70,73,74,75) | PDB
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| 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50324231
(3-(5-(3-Amino-phenyl)-1-(4-fluorophenyl)-1,3-dihyd...)Show SMILES CN(C)CCCC1(OCc2cc(ccc12)-c1cccc(N)c1)c1ccc(F)cc1 Show InChI InChI=1S/C25H27FN2O/c1-28(2)14-4-13-25(21-8-10-22(26)11-9-21)24-12-7-19(15-20(24)17-29-25)18-5-3-6-23(27)16-18/h3,5-12,15-16H,4,13-14,17,27H2,1-2H3 | PDB
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PubMed
| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50428499
(CHEMBL2336611)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCN3[C@@H]4CC[C@@H]3[C@H]([C@H](C4)c3ccc(Cl)c(Cl)c3)C(=O)OC)c3ccc(cc3oc2c1)=[N+](CC)CC |r,wU:35.35,38.39,39.53,40.44,TLB:50:39:34:36.37,THB:33:34:40.41.39:36.37,42:40:34:36.37,(30.38,-12.98,;30.41,-14.51,;29.1,-15.31,;29.13,-16.85,;27.81,-17.65,;27.75,-14.57,;26.42,-15.37,;25.06,-14.63,;25.03,-13.08,;23.7,-12.33,;22.38,-13.12,;22.4,-14.66,;21.07,-15.45,;19.74,-14.7,;19.71,-13.15,;21.03,-12.36,;21.01,-10.82,;19.66,-10.08,;21.4,-9.33,;22.52,-11.21,;18.41,-15.49,;19.19,-16.82,;17.65,-16.84,;17.07,-14.74,;15.75,-15.53,;14.4,-14.78,;13.08,-15.57,;11.73,-14.82,;10.41,-15.61,;9.07,-14.86,;9.04,-13.32,;7.75,-15.64,;7.73,-17.17,;6.42,-17.97,;6.46,-19.51,;6.72,-21.05,;5.73,-22.4,;6.91,-21.68,;7.52,-20.34,;9.27,-20.31,;9.54,-21.86,;8.56,-21.05,;10.31,-23.19,;11.84,-23.18,;12.62,-24.5,;11.85,-25.85,;12.62,-27.18,;10.31,-25.85,;9.54,-27.19,;9.54,-24.52,;10.09,-19.01,;9.38,-17.65,;11.63,-19.07,;12.35,-20.44,;23.67,-10.79,;22.33,-10.05,;22.29,-8.52,;23.61,-7.72,;24.96,-8.46,;24.98,-10,;26.33,-10.74,;26.36,-12.28,;27.71,-13.02,;23.58,-6.18,;22.23,-5.44,;20.91,-6.24,;24.89,-5.38,;26.23,-6.13,)| Show InChI InChI=1S/C50H61Cl2N5O9S2/c1-6-55(7-2)33-15-19-37-44(29-33)66-45-30-34(56(8-3)9-4)16-20-38(45)48(37)39-21-18-36(31-46(39)68(62,63)64)67(60,61)54-24-12-10-11-13-47(58)53-25-26-57-35-17-23-43(57)49(50(59)65-5)40(28-35)32-14-22-41(51)42(52)27-32/h14-16,18-22,27,29-31,35,40,43,49,54H,6-13,17,23-26,28H2,1-5H3,(H-,53,58,62,63,64)/t35-,40-,43-,49+/m1/s1 | PDB
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PubMed
| 392 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50428498
(CHEMBL2336610)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCC(=O)Nc3cccc(c3)-c3ccc4c(COC4(CCCN(C)C)c4ccc(F)cc4)c3)c3ccc(cc3oc2c1)=[N+](CC)CC |(19.16,-47.15,;19.13,-48.69,;20.44,-49.49,;20.41,-51.03,;21.72,-51.83,;21.79,-48.75,;23.12,-49.55,;24.48,-48.8,;24.5,-47.26,;25.84,-46.5,;27.16,-47.29,;27.14,-48.84,;28.46,-49.62,;29.8,-48.87,;29.83,-47.33,;28.51,-46.54,;28.53,-45,;29.88,-44.25,;28.13,-43.51,;27.02,-45.39,;31.12,-49.66,;30.34,-51,;31.88,-51.02,;32.47,-48.91,;33.79,-49.7,;35.14,-48.95,;36.46,-49.74,;37.8,-48.99,;39.12,-49.78,;40.47,-49.03,;40.49,-47.49,;41.79,-49.82,;43.14,-49.07,;44.46,-49.86,;45.8,-49.11,;45.83,-47.57,;47.13,-49.92,;48.46,-49.15,;48.46,-47.6,;49.79,-46.83,;51.12,-47.6,;51.12,-49.15,;49.79,-49.91,;52.45,-49.91,;53.78,-49.15,;55.12,-49.92,;55.11,-51.46,;53.78,-52.23,;54.1,-53.73,;55.63,-53.89,;56.26,-52.49,;57.02,-51.15,;58.56,-51.14,;59.32,-49.8,;60.87,-49.79,;61.63,-48.46,;61.64,-51.12,;57.59,-53.26,;58.93,-52.49,;60.26,-53.26,;60.25,-54.8,;61.59,-55.57,;58.92,-55.57,;57.59,-54.8,;52.45,-51.45,;25.87,-44.97,;27.21,-44.23,;27.25,-42.69,;25.93,-41.9,;24.58,-42.64,;24.55,-44.17,;23.2,-44.92,;23.18,-46.45,;21.83,-47.2,;25.96,-40.36,;27.31,-39.61,;28.63,-40.41,;24.65,-39.56,;23.3,-40.31,)| Show InChI InChI=1S/C61H71FN6O9S2/c1-7-67(8-2)48-24-27-51-55(38-48)77-56-39-49(68(9-3)10-4)25-28-52(56)60(51)53-29-26-50(40-57(53)79(73,74)75)78(71,72)64-33-13-11-12-18-58(69)63-34-31-59(70)65-47-17-14-16-42(37-47)43-19-30-54-44(36-43)41-76-61(54,32-15-35-66(5)6)45-20-22-46(62)23-21-45/h14,16-17,19-30,36-40,64H,7-13,15,18,31-35,41H2,1-6H3,(H2-,63,65,69,70,73,74,75) | NCI pathway
Reactome pathway
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PubMed
| 1.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human DAT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50428498
(CHEMBL2336610)Show SMILES CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NCCCCCC(=O)NCCC(=O)Nc3cccc(c3)-c3ccc4c(COC4(CCCN(C)C)c4ccc(F)cc4)c3)c3ccc(cc3oc2c1)=[N+](CC)CC |(19.16,-47.15,;19.13,-48.69,;20.44,-49.49,;20.41,-51.03,;21.72,-51.83,;21.79,-48.75,;23.12,-49.55,;24.48,-48.8,;24.5,-47.26,;25.84,-46.5,;27.16,-47.29,;27.14,-48.84,;28.46,-49.62,;29.8,-48.87,;29.83,-47.33,;28.51,-46.54,;28.53,-45,;29.88,-44.25,;28.13,-43.51,;27.02,-45.39,;31.12,-49.66,;30.34,-51,;31.88,-51.02,;32.47,-48.91,;33.79,-49.7,;35.14,-48.95,;36.46,-49.74,;37.8,-48.99,;39.12,-49.78,;40.47,-49.03,;40.49,-47.49,;41.79,-49.82,;43.14,-49.07,;44.46,-49.86,;45.8,-49.11,;45.83,-47.57,;47.13,-49.92,;48.46,-49.15,;48.46,-47.6,;49.79,-46.83,;51.12,-47.6,;51.12,-49.15,;49.79,-49.91,;52.45,-49.91,;53.78,-49.15,;55.12,-49.92,;55.11,-51.46,;53.78,-52.23,;54.1,-53.73,;55.63,-53.89,;56.26,-52.49,;57.02,-51.15,;58.56,-51.14,;59.32,-49.8,;60.87,-49.79,;61.63,-48.46,;61.64,-51.12,;57.59,-53.26,;58.93,-52.49,;60.26,-53.26,;60.25,-54.8,;61.59,-55.57,;58.92,-55.57,;57.59,-54.8,;52.45,-51.45,;25.87,-44.97,;27.21,-44.23,;27.25,-42.69,;25.93,-41.9,;24.58,-42.64,;24.55,-44.17,;23.2,-44.92,;23.18,-46.45,;21.83,-47.2,;25.96,-40.36,;27.31,-39.61,;28.63,-40.41,;24.65,-39.56,;23.3,-40.31,)| Show InChI InChI=1S/C61H71FN6O9S2/c1-7-67(8-2)48-24-27-51-55(38-48)77-56-39-49(68(9-3)10-4)25-28-52(56)60(51)53-29-26-50(40-57(53)79(73,74)75)78(71,72)64-33-13-11-12-18-58(69)63-34-31-59(70)65-47-17-14-16-42(37-47)43-19-30-54-44(36-43)41-76-61(54,32-15-35-66(5)6)45-20-22-46(62)23-21-45/h14,16-17,19-30,36-40,64H,7-13,15,18,31-35,41H2,1-6H3,(H2-,63,65,69,70,73,74,75) | PDB
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| 1.18E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human NET expressed in COS7 cells after 5 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM25870
(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 | PDB
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CHEMBL
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MCE
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PC cid
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| DrugBank
Article
PubMed
| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human NET expressed in COS7 cells after 5 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM25870
(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute on Drug Abuse-Intramural Research Program
Curated by ChEMBL
| Assay Description
Inhibition of [3H]dopamine uptake at human DAT expressed in COS7 cells after 3 mins by beta-counting |
Bioorg Med Chem Lett 23: 323-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.089
BindingDB Entry DOI: 10.7270/Q23J3F85 |
More data for this
Ligand-Target Pair | |
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