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Compile Data Set for Download or QSAR

Found 11 hits with Last Name = 'elserwy' and Initial = 'ws'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5445
PNG
(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Show SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
Show InChI InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of EGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50566726
PNG
(CHEMBL4868909)
Show SMILES COc1cccc(c1)-c1cc(nc(N)c1C#N)-c1c(O)c2ccccc2oc1=O
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n/an/a 20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGFRbeta (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM50566726
PNG
(CHEMBL4868909)
Show SMILES COc1cccc(c1)-c1cc(nc(N)c1C#N)-c1c(O)c2ccccc2oc1=O
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n/an/a 21n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1/2/3/4


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of FGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50566726
PNG
(CHEMBL4868909)
Show SMILES COc1cccc(c1)-c1cc(nc(N)c1C#N)-c1c(O)c2ccccc2oc1=O
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n/an/a 33n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of EGFR (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50566726
PNG
(CHEMBL4868909)
Show SMILES COc1cccc(c1)-c1cc(nc(N)c1C#N)-c1c(O)c2ccccc2oc1=O
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n/an/a 42n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of VEGFR2 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 55n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGFRbeta (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM21
PNG
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 69n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of VEGFR2 (unknown origin)


Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128258
BindingDB Entry DOI: 10.7270/Q2930XXQ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



National Research Centre

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in human MCF7 cells by horseradish peroxidase-coupled TMB substrate based ELISA


Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115328
BindingDB Entry DOI: 10.7270/Q2N01B4T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50544829
PNG
(CHEMBL4642069)
Show SMILES Cc1cc(=O)oc2cc(OCC(=O)NNCc3ccccc3)ccc12
Show InChI InChI=1S/C19H18N2O4/c1-13-9-19(23)25-17-10-15(7-8-16(13)17)24-12-18(22)21-20-11-14-5-3-2-4-6-14/h2-10,20H,11-12H2,1H3,(H,21,22)
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n/an/a 360n/an/an/an/an/an/a



National Research Centre

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in human MCF7 cells by horseradish peroxidase-coupled TMB substrate based ELISA


Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115328
BindingDB Entry DOI: 10.7270/Q2N01B4T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50544828
PNG
(CHEMBL4649124)
Show SMILES Cc1cc(=O)oc2cc(OCC(=O)Nn3c(=O)[nH]c4ccccc4c3=O)ccc12
Show InChI InChI=1S/C20H15N3O6/c1-11-8-18(25)29-16-9-12(6-7-13(11)16)28-10-17(24)22-23-19(26)14-4-2-3-5-15(14)21-20(23)27/h2-9H,10H2,1H3,(H,21,27)(H,22,24)
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n/an/a 660n/an/an/an/an/an/a



National Research Centre

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in human MCF7 cells by horseradish peroxidase-coupled TMB substrate based ELISA


Bioorg Med Chem 28: (2020)


Article DOI: 10.1016/j.bmc.2020.115328
BindingDB Entry DOI: 10.7270/Q2N01B4T
More data for this
Ligand-Target Pair