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Compile Data Set for Download or QSAR

Found 29 hits with Last Name = 'kogure' and Initial = 'y'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/a 440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced inward current at -60 mV holding poten...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/a 750n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced current response by whole cell patch clamp method


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50140144
PNG
(CHEMBL2387060)
Show SMILES Oc1ccccc1\C=C\c1ccccc1
Show InChI InChI=1S/C14H12O/c15-14-9-5-4-8-13(14)11-10-12-6-2-1-3-7-12/h1-11,15H/b11-10+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of TRPA1 (unknown origin)


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50140156
PNG
(CHEMBL2387062)
Show SMILES COc1ccccc1\C=C\c1ccccc1
Show InChI InChI=1S/C15H14O/c1-16-15-10-6-5-9-14(15)12-11-13-7-3-2-4-8-13/h2-12H,1H3/b12-11+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of TRPA1 (unknown origin)


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243347
PNG
(CHEMBL4064244)
Show SMILES Oc1ccc(\C=C\c2cc(Br)c(O)c(Br)c2)cc1
Show InChI InChI=1S/C14H10Br2O2/c15-12-7-10(8-13(16)14(12)18)2-1-9-3-5-11(17)6-4-9/h1-8,17-18H/b2-1+
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n/an/a 1.61E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50045922
PNG
(5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol | ...)
Show SMILES Oc1cccc(\C=C\c2cc(O)cc(O)c2)c1
Show InChI InChI=1S/C14H12O3/c15-12-3-1-2-10(6-12)4-5-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b5-4+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM23929
PNG
(1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...)
Show SMILES Clc1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C14H9Cl3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9H/b2-1+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243349
PNG
(CHEMBL4090371)
Show SMILES COc1ccc(NC(=O)c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H13NO4/c1-19-13-4-2-10(3-5-13)15-14(18)9-6-11(16)8-12(17)7-9/h2-8,16-17H,1H3,(H,15,18)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243350
PNG
(CHEMBL4088443)
Show SMILES Clc1cc(Cl)cc(\C=C\c2ccccc2)c1
Show InChI InChI=1S/C14H10Cl2/c15-13-8-12(9-14(16)10-13)7-6-11-4-2-1-3-5-11/h1-10H/b7-6+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50140144
PNG
(CHEMBL2387060)
Show SMILES Oc1ccccc1\C=C\c1ccccc1
Show InChI InChI=1S/C14H12O/c15-14-9-5-4-8-13(14)11-10-12-6-2-1-3-7-12/h1-11,15H/b11-10+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243348
PNG
(CHEMBL3827411)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C14H11ClO2/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,16-17H/b2-1+
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50085531
PNG
(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H14O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h3-9,15-17H,1-2H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243347
PNG
(CHEMBL4064244)
Show SMILES Oc1ccc(\C=C\c2cc(Br)c(O)c(Br)c2)cc1
Show InChI InChI=1S/C14H10Br2O2/c15-12-7-10(8-13(16)14(12)18)2-1-9-3-5-11(17)6-4-9/h1-8,17-18H/b2-1+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50140144
PNG
(CHEMBL2387060)
Show SMILES Oc1ccccc1\C=C\c1ccccc1
Show InChI InChI=1S/C14H12O/c15-14-9-5-4-8-13(14)11-10-12-6-2-1-3-7-12/h1-11,15H/b11-10+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50045922
PNG
(5-[2-(3-Hydroxy-phenyl)-vinyl]-benzene-1,3-diol | ...)
Show SMILES Oc1cccc(\C=C\c2cc(O)cc(O)c2)c1
Show InChI InChI=1S/C14H12O3/c15-12-3-1-2-10(6-12)4-5-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b5-4+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM23929
PNG
(1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benz...)
Show SMILES Clc1ccc(\C=C\c2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C14H9Cl3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9H/b2-1+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243350
PNG
(CHEMBL4088443)
Show SMILES Clc1cc(Cl)cc(\C=C\c2ccccc2)c1
Show InChI InChI=1S/C14H10Cl2/c15-13-8-12(9-14(16)10-13)7-6-11-4-2-1-3-5-11/h1-10H/b7-6+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50085531
PNG
(3,4',5-trihydroxybibenzyl | 5-(4-hydroxyphenethyl)...)
Show SMILES Oc1ccc(CCc2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H14O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h3-9,15-17H,1-2H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243349
PNG
(CHEMBL4090371)
Show SMILES COc1ccc(NC(=O)c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H13NO4/c1-19-13-4-2-10(3-5-13)15-14(18)9-6-11(16)8-12(17)7-9/h2-8,16-17H,1H3,(H,15,18)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assay


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 860n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPV1 expressed in CHO cells assessed as induction of 45Ca2+ uptake measured after 5 mins by scintillation counting method


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 2.38E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 10 uM at -60 mV hol...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 180n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 0.6 uM at -60 mV ho...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50131046
PNG
(8,13-Dihydro-7H-indolo[2',3':3,4]pyrido[2,1-b]quin...)
Show SMILES O=c1n2CCc3c([nH]c4ccccc34)-c2nc2ccccc12
Show InChI InChI=1S/C18H13N3O/c22-18-13-6-2-4-8-15(13)20-17-16-12(9-10-21(17)18)11-5-1-3-7-14(11)19-16/h1-8,19H,9-10H2
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n/an/an/an/a 2.06E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPV1 channel expressed in HEK293 cells assessed as induction of channel current at -60 mV holding potential by whole-cell pa...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 100n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Partial antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as capsaicin EC50 for induction of channel current at 0.1 uM at -60 mV ho...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily A member 1


(Homo sapiens (Human))
BDBM50243348
PNG
(CHEMBL3827411)
Show SMILES Oc1cc(O)cc(\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C14H11ClO2/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,16-17H/b2-1+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Hyogo University of Health Sciences

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


Bioorg Med Chem Lett 27: 3167-3172 (2017)


Article DOI: 10.1016/j.bmcl.2017.05.025
BindingDB Entry DOI: 10.7270/Q2TH8Q4R
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 600n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPV1 channel expressed in HEK293 cells assessed as induction of channel current at -60 mV holding potential by whole-cell pa...


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))
BDBM50016250
PNG
(CHEMBL81925)
Show SMILES CN1C2N(CCc3c2[nH]c2ccccc32)C(=O)c2ccccc12
Show InChI InChI=1S/C19H17N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9,18,20H,10-11H2,1H3
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n/an/an/an/a 860n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPV1 expressed in CHO cells assessed as induction of 45Ca2+ uptake measured after 5 mins by scintillation counting method


J Nat Prod 79: 1225-30 (2016)


Article DOI: 10.1021/acs.jnatprod.5b00599
BindingDB Entry DOI: 10.7270/Q2M047D0
More data for this
Ligand-Target Pair