Compile Data Set for Download or QSAR

Found 111 hits with Last Name = '?lusarczyk' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50457943 (CHEMBL4213295) Show SMILES COc1ccc(cc1Cl)C1=NN(C2CCCC2)C(=O)C2CC=CCC12 |c:23,t:10| Show InChI InChI=1S/C20H23ClN2O2/c1-25-18-11-10-13(12-17(18)21)19-15-8-4-5-9-16(15)20(24)23(22-19)14-6-2-3-7-14/h4-5,10-12,14-16H,2-3,6-9H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.780	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of PDE4D3 (unknown origin) using [3H]cAMP as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457965 (CHEMBL4211493) Show SMILES COc1ccc(cc1C)-c1cc2CC(CCc2n1-c1ccc(cc1)S(=O)(=O)Nc1nc(C)cc(C)n1)N1CCN(C)CC1 Show InChI InChI=1S/C33H40N6O3S/c1-22-18-25(6-13-32(22)42-5)31-21-26-20-28(38-16-14-37(4)15-17-38)9-12-30(26)39(31)27-7-10-29(11-8-27)43(40,41)36-33-34-23(2)19-24(3)35-33/h6-8,10-11,13,18-19,21,28H,9,12,14-17,20H2,1-5H3,(H,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human C-terminal FLAG-tagged PDE7A expressed in baculovirus infected Sf9 cells using [3H]-cAMP as substrate after 15 mins by by scintil...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457943 (CHEMBL4213295) Show SMILES COc1ccc(cc1Cl)C1=NN(C2CCCC2)C(=O)C2CC=CCC12 |c:23,t:10| Show InChI InChI=1S/C20H23ClN2O2/c1-25-18-11-10-13(12-17(18)21)19-15-8-4-5-9-16(15)20(24)23(22-19)14-6-2-3-7-14/h4-5,10-12,14-16H,2-3,6-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of PDE7A1 (unknown origin) expressed in baculovirus infected insect cells using [3H]cAMP as substrate preincubated for 5 mins followed by ...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457951 (CHEMBL4209680) Show SMILES Cn1c2nc(NCCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C26H29N7O6/c1-31-23-20(24(38)32(2)26(31)39)33(25(29-23)27-13-12-16-7-4-3-5-8-16)14-6-9-19(35)30-28-15-17-10-11-18(34)22(37)21(17)36/h3-5,7-8,10-11,15,34,36-37H,6,9,12-14H2,1-2H3,(H,27,29)(H,30,35)/b28-15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50074893 (2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...) Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC Show InChI InChI=1S/C34H30N4O5/c1-3-42-29-15-23-14-24(19-39)28(20-40)32(27(23)17-30(29)43-4-2)21-11-13-36-31(16-21)38-34(41)26-10-6-5-9-25(26)33(37-38)22-8-7-12-35-18-22/h5-18,39-40H,3-4,19-20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human recombinant FLAG-tagged PDE7A expressed in African green monkey COS7 cells using [3H]cAMP as substrate after 30 mins by scintilla...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457961 (CHEMBL4207233) Show SMILES Cn1c2nc(NCc3ccccn3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C24H26N8O6/c1-30-21-18(22(37)31(2)24(30)38)32(23(28-21)26-13-15-6-3-4-10-25-15)11-5-7-17(34)29-27-12-14-8-9-16(33)20(36)19(14)35/h3-4,6,8-10,12,33,35-36H,5,7,11,13H2,1-2H3,(H,26,28)(H,29,34)/b27-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457949 (CHEMBL4205843) Show SMILES Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C25H27N7O6/c1-30-22-19(23(37)31(2)25(30)38)32(24(28-22)26-13-15-7-4-3-5-8-15)12-6-9-18(34)29-27-14-16-10-11-17(33)21(36)20(16)35/h3-5,7-8,10-11,14,33,35-36H,6,9,12-13H2,1-2H3,(H,26,28)(H,29,34)/b27-14+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50277784 (CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...) Show SMILES CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50277784 (CHEMBL484928 | N,N,2-trimethyl-5-nitrobenzenesulfo...) Show SMILES CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O Show InChI InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457951 (CHEMBL4209680) Show SMILES Cn1c2nc(NCCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C26H29N7O6/c1-31-23-20(24(38)32(2)26(31)39)33(25(29-23)27-13-12-16-7-4-3-5-8-16)14-6-9-19(35)30-28-15-17-10-11-18(34)22(37)21(17)36/h3-5,7-8,10-11,15,34,36-37H,6,9,12-14H2,1-2H3,(H,27,29)(H,30,35)/b28-15+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457953 (CHEMBL4215783) Show SMILES Cn1c2nc(NCc3ccco3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H25N7O7/c1-28-20-17(21(35)29(2)23(28)36)30(22(26-20)24-12-14-5-4-10-37-14)9-3-6-16(32)27-25-11-13-7-8-15(31)19(34)18(13)33/h4-5,7-8,10-11,31,33-34H,3,6,9,12H2,1-2H3,(H,24,26)(H,27,32)/b25-11+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457952 (CHEMBL4211991) Show SMILES Cn1c2nc(NCc3ccco3)n(CCCC(=O)N\N=C\c3ccc(O)cc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H25N7O6/c1-28-20-19(21(34)29(2)23(28)35)30(22(26-20)24-13-16-5-4-10-36-16)9-3-6-18(33)27-25-12-14-7-8-15(31)11-17(14)32/h4-5,7-8,10-12,31-32H,3,6,9,13H2,1-2H3,(H,24,26)(H,27,33)/b25-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467427 (CHEMBL4289050) Show SMILES CCCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1cc(ccc1O)C(C)(C)C Show InChI InChI=1S/C25H35N5O5/c1-7-8-14-35-23-27-21-20(22(33)29(6)24(34)28(21)5)30(23)13-9-10-19(32)26-17-15-16(25(2,3)4)11-12-18(17)31/h11-12,15,31H,7-10,13-14H2,1-6H3,(H,26,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467427 (CHEMBL4289050) Show SMILES CCCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1cc(ccc1O)C(C)(C)C Show InChI InChI=1S/C25H35N5O5/c1-7-8-14-35-23-27-21-20(22(33)29(6)24(34)28(21)5)30(23)13-9-10-19(32)26-17-15-16(25(2,3)4)11-12-18(17)31/h11-12,15,31H,7-10,13-14H2,1-6H3,(H,26,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.43E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457942 (CHEMBL4217546) Show SMILES Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)cc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C25H27N7O5/c1-30-22-21(23(36)31(2)25(30)37)32(24(28-22)26-14-16-7-4-3-5-8-16)12-6-9-20(35)29-27-15-17-10-11-18(33)13-19(17)34/h3-5,7-8,10-11,13,15,33-34H,6,9,12,14H2,1-2H3,(H,26,28)(H,29,35)/b27-15+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457958 (CHEMBL4218055) Show SMILES Cn1c2nc(NCCc3ccccc3)n(CCCC(=O)N\N=C\c3ccccc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C26H29N7O4/c1-31-23-22(24(36)32(2)26(31)37)33(25(29-23)27-15-14-18-9-4-3-5-10-18)16-8-13-21(35)30-28-17-19-11-6-7-12-20(19)34/h3-7,9-12,17,34H,8,13-16H2,1-2H3,(H,27,29)(H,30,35)/b28-17+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457953 (CHEMBL4215783) Show SMILES Cn1c2nc(NCc3ccco3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H25N7O7/c1-28-20-17(21(35)29(2)23(28)36)30(22(26-20)24-12-14-5-4-10-37-14)9-3-6-16(32)27-25-11-13-7-8-15(31)19(34)18(13)33/h4-5,7-8,10-11,31,33-34H,3,6,9,12H2,1-2H3,(H,24,26)(H,27,32)/b25-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457960 (CHEMBL4214541) Show SMILES Cn1c2nc(NCc3ccccn3)n(CCCC(=O)N\N=C\c3ccccc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C24H26N8O4/c1-30-21-20(22(35)31(2)24(30)36)32(23(28-21)26-15-17-9-5-6-12-25-17)13-7-11-19(34)29-27-14-16-8-3-4-10-18(16)33/h3-6,8-10,12,14,33H,7,11,13,15H2,1-2H3,(H,26,28)(H,29,34)/b27-14+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467436 (CHEMBL4284497) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H33N5O4/c1-7-15-33-22-26-20-19(21(31)28(6)23(32)27(20)5)29(22)14-8-9-18(30)25-17-12-10-16(11-13-17)24(2,3)4/h10-13H,7-9,14-15H2,1-6H3,(H,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457945 (CHEMBL4203371) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1O Show InChI InChI=1S/C20H24N6O5/c1-4-31-19-22-17-16(18(29)25(3)20(30)24(17)2)26(19)11-7-10-15(28)23-21-12-13-8-5-6-9-14(13)27/h5-6,8-9,12,27H,4,7,10-11H2,1-3H3,(H,23,28)/b21-12+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457949 (CHEMBL4205843) Show SMILES Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C25H27N7O6/c1-30-22-19(23(37)31(2)25(30)38)32(24(28-22)26-13-15-7-4-3-5-8-15)12-6-9-18(34)29-27-14-16-10-11-17(33)21(36)20(16)35/h3-5,7-8,10-11,14,33,35-36H,6,9,12-13H2,1-2H3,(H,26,28)(H,29,34)/b27-14+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467423 (CHEMBL4282582) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)CC Show InChI InChI=1S/C24H33N5O4/c1-6-15-33-23-26-21-20(22(31)28(5)24(32)27(21)4)29(23)14-8-9-19(30)25-18-12-10-17(11-13-18)16(3)7-2/h10-13,16H,6-9,14-15H2,1-5H3,(H,25,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457961 (CHEMBL4207233) Show SMILES Cn1c2nc(NCc3ccccn3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C24H26N8O6/c1-30-21-18(22(37)31(2)24(30)38)32(23(28-21)26-13-15-6-3-4-10-25-15)11-5-7-17(34)29-27-12-14-8-9-16(33)20(36)19(14)35/h3-4,6,8-10,12,33,35-36H,5,7,11,13H2,1-2H3,(H,26,28)(H,29,34)/b27-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457952 (CHEMBL4211991) Show SMILES Cn1c2nc(NCc3ccco3)n(CCCC(=O)N\N=C\c3ccc(O)cc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H25N7O6/c1-28-20-19(21(34)29(2)23(28)35)30(22(26-20)24-13-16-5-4-10-36-16)9-3-6-18(33)27-25-12-14-7-8-15(31)11-17(14)32/h4-5,7-8,10-12,31-32H,3,6,9,13H2,1-2H3,(H,24,26)(H,27,33)/b25-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457947 (CHEMBL4207258) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1O Show InChI InChI=1S/C21H26N6O5/c1-4-12-32-20-23-18-17(19(30)26(3)21(31)25(18)2)27(20)11-7-10-16(29)24-22-13-14-8-5-6-9-15(14)28/h5-6,8-9,13,28H,4,7,10-12H2,1-3H3,(H,24,29)/b22-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457959 (CHEMBL4214592) Show SMILES Cn1c2nc(NCc3ccco3)n(CCCC(=O)N\N=C\c3ccccc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C23H25N7O5/c1-28-20-19(21(33)29(2)23(28)34)30(22(26-20)24-14-16-8-6-12-35-16)11-5-10-18(32)27-25-13-15-7-3-4-9-17(15)31/h3-4,6-9,12-13,31H,5,10-11,14H2,1-2H3,(H,24,26)(H,27,32)/b25-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467439 (CHEMBL4290956) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1cc(ccc1O)C(C)(C)C Show InChI InChI=1S/C24H33N5O5/c1-7-13-34-22-26-20-19(21(32)28(6)23(33)27(20)5)29(22)12-8-9-18(31)25-16-14-15(24(2,3)4)10-11-17(16)30/h10-11,14,30H,7-9,12-13H2,1-6H3,(H,25,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457966 (CHEMBL4214256) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccc(O)cc1O Show InChI InChI=1S/C20H24N6O6/c1-4-32-19-22-17-16(18(30)25(3)20(31)24(17)2)26(19)9-5-6-15(29)23-21-11-12-7-8-13(27)10-14(12)28/h7-8,10-11,27-28H,4-6,9H2,1-3H3,(H,23,29)/b21-11+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.62E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467423 (CHEMBL4282582) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)CC Show InChI InChI=1S/C24H33N5O4/c1-6-15-33-23-26-21-20(22(31)28(5)24(32)27(21)4)29(23)14-8-9-19(30)25-18-12-10-17(11-13-18)16(3)7-2/h10-13,16H,6-9,14-15H2,1-5H3,(H,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467435 (CHEMBL4291934) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)C Show InChI InChI=1S/C23H31N5O4/c1-6-14-32-22-25-20-19(21(30)27(5)23(31)26(20)4)28(22)13-7-8-18(29)24-17-11-9-16(10-12-17)15(2)3/h9-12,15H,6-8,13-14H2,1-5H3,(H,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467432 (CHEMBL4280337) Show SMILES COc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C22H29N5O4/c1-22(2,3)14-9-11-15(12-10-14)23-16(28)8-7-13-27-17-18(24-20(27)31-6)25(4)21(30)26(5)19(17)29/h9-12H,7-8,13H2,1-6H3,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.98E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467421 (CHEMBL4292772) Show SMILES CCCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)CC Show InChI InChI=1S/C25H35N5O4/c1-6-8-16-34-24-27-22-21(23(32)29(5)25(33)28(22)4)30(24)15-9-10-20(31)26-19-13-11-18(12-14-19)17(3)7-2/h11-14,17H,6-10,15-16H2,1-5H3,(H,26,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467436 (CHEMBL4284497) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C24H33N5O4/c1-7-15-33-22-26-20-19(21(31)28(6)23(32)27(20)5)29(22)14-8-9-18(30)25-17-12-10-16(11-13-17)24(2,3)4/h10-13H,7-9,14-15H2,1-6H3,(H,25,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457958 (CHEMBL4218055) Show SMILES Cn1c2nc(NCCc3ccccc3)n(CCCC(=O)N\N=C\c3ccccc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C26H29N7O4/c1-31-23-22(24(36)32(2)26(31)37)33(25(29-23)27-15-14-18-9-4-3-5-10-18)16-8-13-21(35)30-28-17-19-11-6-7-12-20(19)34/h3-7,9-12,17,34H,8,13-16H2,1-2H3,(H,27,29)(H,30,35)/b28-17+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457945 (CHEMBL4203371) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1O Show InChI InChI=1S/C20H24N6O5/c1-4-31-19-22-17-16(18(29)25(3)20(30)24(17)2)26(19)11-7-10-15(28)23-21-12-13-8-5-6-9-14(13)27/h5-6,8-9,12,27H,4,7,10-11H2,1-3H3,(H,23,28)/b21-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50027176 (2-Acetoxy-Benzoic Acid | 3-Isobutyl-Methylxanthine...) Show SMILES CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50027176 (2-Acetoxy-Benzoic Acid | 3-Isobutyl-Methylxanthine...) Show SMILES CC(C)Cn1c2[nH]cnc2c(=O)n(C)c1=O Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457947 (CHEMBL4207258) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1O Show InChI InChI=1S/C21H26N6O5/c1-4-12-32-20-23-18-17(19(30)26(3)21(31)25(18)2)27(20)11-7-10-16(29)24-22-13-14-8-5-6-9-15(14)28/h5-6,8-9,13,28H,4,7,10-12H2,1-3H3,(H,24,29)/b22-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.11E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467428 (CHEMBL4288977) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)C Show InChI InChI=1S/C22H29N5O4/c1-6-31-21-24-19-18(20(29)26(5)22(30)25(19)4)27(21)13-7-8-17(28)23-16-11-9-15(10-12-16)14(2)3/h9-12,14H,6-8,13H2,1-5H3,(H,23,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.23E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457957 (CHEMBL4210386) Show SMILES Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccccc3O)c2c(=O)n(C)c1=O Show InChI InChI=1S/C25H27N7O4/c1-30-22-21(23(35)31(2)25(30)36)32(24(28-22)26-15-17-9-4-3-5-10-17)14-8-13-20(34)29-27-16-18-11-6-7-12-19(18)33/h3-7,9-12,16,33H,8,13-15H2,1-2H3,(H,26,28)(H,29,34)/b27-16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457955 (CHEMBL4213966) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1 Show InChI InChI=1S/C20H24N6O4/c1-4-30-19-22-17-16(18(28)25(3)20(29)24(17)2)26(19)12-8-11-15(27)23-21-13-14-9-6-5-7-10-14/h5-7,9-10,13H,4,8,11-12H2,1-3H3,(H,23,27)/b21-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467435 (CHEMBL4291934) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)C Show InChI InChI=1S/C23H31N5O4/c1-6-14-32-22-25-20-19(21(30)27(5)23(31)26(20)4)28(22)13-7-8-18(29)24-17-11-9-16(10-12-17)15(2)3/h9-12,15H,6-8,13-14H2,1-5H3,(H,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50467439 (CHEMBL4290956) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1cc(ccc1O)C(C)(C)C Show InChI InChI=1S/C24H33N5O5/c1-7-13-34-22-26-20-19(21(32)28(6)23(33)27(20)5)29(22)12-8-9-18(31)25-16-14-15(24(2,3)4)10-11-17(16)30/h10-11,14,30H,7-9,12-13H2,1-6H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.12E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE7A using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50467437 (CHEMBL4290996) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)Nc1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C23H31N5O4/c1-7-32-21-25-19-18(20(30)27(6)22(31)26(19)5)28(21)14-8-9-17(29)24-16-12-10-15(11-13-16)23(2,3)4/h10-13H,7-9,14H2,1-6H3,(H,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Inhibition of recombinant human PDE4B using cAMP as substrate after 10 mins by PDE-Glo Phosphodiesterase Assay				Eur J Med Chem 158: 517-533 (2018) Article DOI: 10.1016/j.ejmech.2018.09.021 BindingDB Entry DOI: 10.7270/Q2TB19K7
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457950 (CHEMBL4217007) Show SMILES COc1ccc(\C=N\NC(=O)CCCn2c(NCc3ccccc3)nc3n(C)c(=O)n(C)c(=O)c23)c(O)c1 Show InChI InChI=1S/C26H29N7O5/c1-31-23-22(24(36)32(2)26(31)37)33(25(29-23)27-15-17-8-5-4-6-9-17)13-7-10-21(35)30-28-16-18-11-12-19(38-3)14-20(18)34/h4-6,8-9,11-12,14,16,34H,7,10,13,15H2,1-3H3,(H,27,29)(H,30,35)/b28-16+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457948 (CHEMBL4204397) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccc(OC)cc1O Show InChI InChI=1S/C22H28N6O6/c1-5-11-34-21-24-19-18(20(31)27(3)22(32)26(19)2)28(21)10-6-7-17(30)25-23-13-14-8-9-15(33-4)12-16(14)29/h8-9,12-13,29H,5-7,10-11H2,1-4H3,(H,25,30)/b23-13+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.78E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (Homo sapiens (Human))	BDBM50457955 (CHEMBL4213966) Show SMILES CCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1 Show InChI InChI=1S/C20H24N6O4/c1-4-30-19-22-17-16(18(28)25(3)20(29)24(17)2)26(19)12-8-11-15(27)23-21-13-14-9-6-5-7-10-14/h5-7,9-10,13H,4,8,11-12H2,1-3H3,(H,23,27)/b21-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.89E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50457962 (CHEMBL4209377) Show SMILES CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCC(=O)N\N=C\c1ccccc1 Show InChI InChI=1S/C21H26N6O4/c1-4-13-31-20-23-18-17(19(29)26(3)21(30)25(18)2)27(20)12-8-11-16(28)24-22-14-15-9-6-5-7-10-15/h5-7,9-10,14H,4,8,11-13H2,1-3H3,(H,24,28)/b22-14+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insect cells using cAMP as substrate after 10 mins by PDE-Glo Phosphodiest...				Eur J Med Chem 146: 381-394 (2018) Article DOI: 10.1016/j.ejmech.2018.01.068 BindingDB Entry DOI: 10.7270/Q2XD1496
					More data for this Ligand-Target Pair

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