Compile Data Set for Download or QSAR

Found 853 hits with Last Name = 'abeywardane' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Collagenase 3 (Mus musculus (Mouse))	BDBM126722 (US8785489, 4-{[({1-methyl-5-[2-(3-methyl-1,2,4-oxa...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1cc(nn1C)C(=O)NCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H20N6O4/c1-13-26-23(34-29-13)20-10-17-9-16(7-8-18(17)27-20)21-11-19(28-30(21)2)22(31)25-12-14-3-5-15(6-4-14)24(32)33/h3-11,27H,12H2,1-2H3,(H,25,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126723 (US8785489, 4-{[({4-[2-(3-methyl-1,2,4-oxadiazol-5-...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1ccnc(c1)C(=O)NCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C25H19N5O4/c1-14-28-24(34-30-14)22-12-19-10-17(6-7-20(19)29-22)18-8-9-26-21(11-18)23(31)27-13-15-2-4-16(5-3-15)25(32)33/h2-12,29H,13H2,1H3,(H,27,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126726 (US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1ccc(=O)[nH]c1 Show InChI InChI=1S/C22H19N7O3/c1-11-19(28-20(25-11)21(31)24-10-13-3-6-18(30)23-9-13)14-4-5-16-15(7-14)8-17(27-16)22-26-12(2)29-32-22/h3-9,27H,10H2,1-2H3,(H,23,30)(H,24,31)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126725 (US8785489, 4-{[({5-methyl-4-[2-(3-methyl-1,2,4-oxa...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H20N6O4/c1-12-20(16-7-8-18-17(9-16)10-19(28-18)23-27-13(2)30-34-23)29-21(26-12)22(31)25-11-14-3-5-15(6-4-14)24(32)33/h3-10,28H,11H2,1-2H3,(H,25,31)(H,26,29)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126724 (US8785489, 4-{[({5-methyl-4-[2-(3-methyl-1,2,4-oxa...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1cc(ncc1C)C(=O)NCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C26H21N5O4/c1-14-12-27-22(24(32)28-13-16-3-5-17(6-4-16)26(33)34)11-20(14)18-7-8-21-19(9-18)10-23(30-21)25-29-15(2)31-35-25/h3-12,30H,13H2,1-2H3,(H,28,32)(H,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289984 (2-Methyl-8-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-ylox...) Show SMILES CN1CCC2(CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O Show InChI InChI=1S/C26H27N5O3/c1-30-11-7-26(25(30)32)8-12-31(13-9-26)16-19-17-33-23-14-20(3-4-21(19)23)34-24-5-2-18(15-27-24)22-6-10-28-29-22/h2-6,10,14-15,17H,7-9,11-13,16H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289920 (2-Methoxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin-2-y...) Show SMILES COCC(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289869 (N-((R)-1-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...) Show SMILES CC(=O)N[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289983 ((S)-3-Hydroxy-1-(1-{6-[5-(2H- pyrazol-3-yl)-pyridi...) Show SMILES O[C@H]1CCN(C2CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)CC2)C1=O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289980 (N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...) Show SMILES CC(=O)NCC1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1 Show InChI InChI=1S/C25H27N5O3/c1-17(31)26-13-18-7-10-30(11-8-18)15-20-16-32-24-12-21(3-4-22(20)24)33-25-5-2-19(14-27-25)23-6-9-28-29-23/h2-6,9,12,14,16,18H,7-8,10-11,13,15H2,1H3,(H,26,31)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.380	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
C-C chemokine receptor type 10 (Homo sapiens (Human))	BDBM50198921 (CHEMBL3889627) Show SMILES CC1CCN(CC1)C(=O)C(CCn1cccc1C#N)NS(=O)(=O)c1cccc2[nH]ccc12 Show InChI InChI=1S/C23H27N5O3S/c1-17-8-13-28(14-9-17)23(29)21(10-15-27-12-3-4-18(27)16-24)26-32(30,31)22-6-2-5-20-19(22)7-11-25-20/h2-7,11-12,17,21,25-26H,8-10,13-15H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.398	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in p...				Bioorg Med Chem Lett 26: 5277-5283 (2016) Article DOI: 10.1016/j.bmcl.2016.09.047 BindingDB Entry DOI: 10.7270/Q2KD20WF
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126727 (US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1cnn(C)c1 Show InChI InChI=1S/C21H20N8O2/c1-11-18(27-19(24-11)20(30)22-8-13-9-23-29(3)10-13)14-4-5-16-15(6-14)7-17(26-16)21-25-12(2)28-31-21/h4-7,9-10,26H,8H2,1-3H3,(H,22,30)(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289864 (2-Hydroxy-1-(4-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-...) Show SMILES OCC(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C25H25N5O3/c31-17-25(32)30-11-9-29(10-12-30)16-18-1-2-20-14-22(5-3-19(20)13-18)33-24-6-4-21(15-26-24)23-7-8-27-28-23/h1-8,13-15,31H,9-12,16-17H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126728 (US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1ccncc1 Show InChI InChI=1S/C22H19N7O2/c1-12-19(28-20(25-12)21(30)24-11-14-5-7-23-8-6-14)15-3-4-17-16(9-15)10-18(27-17)22-26-13(2)29-31-22/h3-10,27H,11H2,1-2H3,(H,24,30)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289987 (2-Hydroxy-N-methyl-N-((R)-1-{6- [5-(2H-pyrazol-3-y...) Show SMILES CN([C@@H]1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)C1)C(=O)CO |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.420	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289989 (2-Hydroxy-1-(7-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...) Show SMILES OCC(=O)N1CCC2(CCN(Cc3coc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc34)C2)C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289917 ((S)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin...) Show SMILES C[C@H](O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289897 (1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyrimidin- 2-yloxy]-n...) Show SMILES CCC(=O)N1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C25H26N6O2/c1-2-24(32)31-11-9-30(10-12-31)17-18-3-4-20-14-22(6-5-19(20)13-18)33-25-26-15-21(16-27-25)23-7-8-28-29-23/h3-8,13-16H,2,9-12,17H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289858 (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphtha...) Show SMILES OC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 Show InChI InChI=1S/C22H20N4O2/c27-19-13-26(14-19)12-15-1-2-17-10-20(5-3-16(17)9-15)28-22-6-4-18(11-23-22)21-7-8-24-25-21/h1-11,19,27H,12-14H2,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM217341 (US9303018, 14) Show SMILES CCC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C25H26N6O2/c1-2-25(32)31-11-9-30(10-12-31)17-18-13-19-3-5-21(14-23(19)26-15-18)33-24-6-4-20(16-27-24)22-7-8-28-29-22/h3-8,13-16H,2,9-12,17H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.440	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9303018 (2016) BindingDB Entry DOI: 10.7270/Q2CR5S6Q
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289918 (2-Hydroxy-2-methyl-1-(8-{6-[5-(2H- pyrazol-3-yl)-p...) Show SMILES CC(C)(O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289859 (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2- yloxy]-naphth...) Show SMILES NC(=O)C1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 Show InChI InChI=1S/C23H21N5O2/c24-23(29)19-13-28(14-19)12-15-1-2-17-10-20(5-3-16(17)9-15)30-22-6-4-18(11-25-22)21-7-8-26-27-21/h1-11,19H,12-14H2,(H2,24,29)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289932 (1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]-...) Show SMILES O=C1CCCN1C1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1 Show InChI InChI=1S/C27H29N5O3/c33-27-2-1-12-32(27)21-9-14-31(15-10-21)13-8-20-18-34-25-16-22(4-5-23(20)25)35-26-6-3-19(17-28-26)24-7-11-29-30-24/h3-7,11,16-18,21H,1-2,8-10,12-15H2,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM290023 (2-Methyl-3-oxo-3-(4-{6-[5-(2H-pyrazol- 3-yl)-pyrid...) Show SMILES CC(C#N)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.470	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289867 (2-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-naphtha...) Show SMILES OC1CC2(C1)CN(Cc1ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c1)C2 Show InChI InChI=1S/C25H24N4O2/c30-21-11-25(12-21)15-29(16-25)14-17-1-2-19-10-22(5-3-18(19)9-17)31-24-6-4-20(13-26-24)23-7-8-27-28-23/h1-10,13,21,30H,11-12,14-16H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289861 ((1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-napht...) Show SMILES OCC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 Show InChI InChI=1S/C23H22N4O2/c28-15-17-13-27(14-17)12-16-1-2-19-10-21(5-3-18(19)9-16)29-23-6-4-20(11-24-23)22-7-8-25-26-22/h1-11,17,28H,12-15H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.480	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289976 (1-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2- yloxy]-benzof...) Show SMILES CNC(=O)C1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1 Show InChI InChI=1S/C24H25N5O3/c1-25-24(30)16-7-10-29(11-8-16)14-18-15-31-22-12-19(3-4-20(18)22)32-23-5-2-17(13-26-23)21-6-9-27-28-21/h2-6,9,12-13,15-16H,7-8,10-11,14H2,1H3,(H,25,30)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289866 (2-Hydroxy-N-(1-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-...) Show SMILES OCC(=O)NC1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C26H27N5O3/c32-17-25(33)29-22-8-11-31(12-9-22)16-18-1-2-20-14-23(5-3-19(20)13-18)34-26-6-4-21(15-27-26)24-7-10-28-30-24/h1-7,10,13-15,22,32H,8-9,11-12,16-17H2,(H,28,30)(H,29,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289860 (N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-nap...) Show SMILES CC(=O)NC1CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 Show InChI InChI=1S/C24H23N5O2/c1-16(30)27-21-14-29(15-21)13-17-2-3-19-11-22(6-4-18(19)10-17)31-24-7-5-20(12-25-24)23-8-9-26-28-23/h2-12,21H,13-15H2,1H3,(H,26,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289916 ((1-Hydroxy-cyclopropyl)-(8-{6-[5- (2H-pyrazol-3-yl...) Show SMILES OC1(CC1)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289868 (3-Methyl-1-{6-[5-(2H-pyrazol-3- yl)-pyridin-2-ylox...) Show SMILES CC1(O)CN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 Show InChI InChI=1S/C23H22N4O2/c1-23(28)14-27(15-23)13-16-2-3-18-11-20(6-4-17(18)10-16)29-22-7-5-19(12-24-22)21-8-9-25-26-21/h2-12,28H,13-15H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.530	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289919 ((R)-2-Hydroxy-1-(8-{6-[5-(2H-pyrazol-3-yl)-pyridin...) Show SMILES C[C@@H](O)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM217350 (US9303018, 23) Show SMILES CC(C)C(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C26H28N6O2/c1-18(2)26(33)32-11-9-31(10-12-32)17-19-13-20-3-5-22(14-24(20)27-15-19)34-25-6-4-21(16-28-25)23-7-8-29-30-23/h3-8,13-16,18H,9-12,17H2,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9303018 (2016) BindingDB Entry DOI: 10.7270/Q2CR5S6Q
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289977 (N-(1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-ben...) Show SMILES CC(=O)NC1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1 Show InChI InChI=1S/C24H25N5O3/c1-16(30)27-19-7-10-29(11-8-19)14-18-15-31-23-12-20(3-4-21(18)23)32-24-5-2-17(13-25-24)22-6-9-26-28-22/h2-6,9,12-13,15,19H,7-8,10-11,14H2,1H3,(H,26,28)(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM290002 (2-Methoxy-2-methyl-1-(4-{6- [5-(2H-pyrazol-3-yl)-p...) Show SMILES COC(C)(C)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1 Show InChI InChI=1S/C27H30N6O3/c1-27(2,35-3)26(34)33-14-12-32(13-15-33)18-21-6-4-19-16-22(7-8-23(19)30-21)36-25-9-5-20(17-28-25)24-10-11-29-31-24/h4-11,16-17H,12-15,18H2,1-3H3,(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289988 (2-Hydroxy-N-methyl-N-((S)-1-{6- [5-(2H-pyrazol-3-y...) Show SMILES CN([C@H]1CCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)C1)C(=O)CO |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289863 ((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...) Show SMILES O[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM290014 ((R)-2-Methoxy-1-(4-{6-[5-(2H-pyrazol- 3-yl)-pyridi...) Show SMILES CO[C@H](C)C(=O)N1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3n2)CC1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289970 (1-(4-{6-[5-(2H-Pyrazol-3-yl)-pyridin-2-yloxy]-benz...) Show SMILES CC(=O)N1CCCN(Cc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1 Show InChI InChI=1S/C24H25N5O3/c1-17(30)29-10-2-9-28(11-12-29)15-19-16-31-23-13-20(4-5-21(19)23)32-24-6-3-18(14-25-24)22-7-8-26-27-22/h3-8,13-14,16H,2,9-12,15H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289968 (1-(4-{6-[4-(2H-Pyrazol-3-yl)- phenoxy]-imidazo[1,2...) Show SMILES CC(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1 Show InChI InChI=1S/C23H24N6O2/c1-17(30)28-12-10-27(11-13-28)14-19-15-29-16-21(6-7-23(29)25-19)31-20-4-2-18(3-5-20)22-8-9-24-26-22/h2-9,15-16H,10-14H2,1H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126729 (US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1ccncn1 Show InChI InChI=1S/C21H18N8O2/c1-11-18(28-19(25-11)20(30)23-9-15-5-6-22-10-24-15)13-3-4-16-14(7-13)8-17(27-16)21-26-12(2)29-31-21/h3-8,10,27H,9H2,1-2H3,(H,23,30)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289862 ((S)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-na...) Show SMILES O[C@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM217329 (US9303018, 2) Show SMILES CC(=O)N1CCN(Cc2cnc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)CC1 Show InChI InChI=1S/C24H24N6O2/c1-17(31)30-10-8-29(9-11-30)16-18-12-19-2-4-21(13-23(19)25-14-18)32-24-5-3-20(15-26-24)22-6-7-27-28-22/h2-7,12-15H,8-11,16H2,1H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9303018 (2016) BindingDB Entry DOI: 10.7270/Q2CR5S6Q
					More data for this Ligand-Target Pair
Collagenase 3 (Mus musculus (Mouse))	BDBM126730 (US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...) Show SMILES Cc1noc(n1)-c1cc2cc(ccc2[nH]1)-c1nc([nH]c1C)C(=O)NCc1cccnc1 Show InChI InChI=1S/C22H19N7O2/c1-12-19(28-20(25-12)21(30)24-11-14-4-3-7-23-10-14)15-5-6-17-16(8-15)9-18(27-17)22-26-13(2)29-31-22/h3-10,27H,11H2,1-2H3,(H,24,30)(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...				US Patent US8785489 (2014) BindingDB Entry DOI: 10.7270/Q24B300F
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289878 (2-Hydroxy-1-[(R)-3-(methyl-{6-[5-(2H-pyrazol-3-yl)...) Show SMILES OCC(=O)N1CC[C@H](C1)NCc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289881 (((R)-1-{6-[5-(2H-Pyrazol-3-yl)-pyridin- 2-yloxy]-n...) Show SMILES OC[C@@H]1CCN(Cc2ccc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289956 (2-Methoxy-1-(4-{6-[4-(2H-pyrazol- 3-yl)-phenoxy]-i...) Show SMILES COCC(=O)N1CCN(Cc2cn3cc(Oc4ccc(cc4)-c4ccn[nH]4)ccc3n2)CC1 Show InChI InChI=1S/C24H26N6O3/c1-32-17-24(31)29-12-10-28(11-13-29)14-19-15-30-16-21(6-7-23(30)26-19)33-20-4-2-18(3-5-20)22-8-9-25-27-22/h2-9,15-16H,10-14,17H2,1H3,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289923 (1-(1-{(R)-6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]...) Show SMILES O=C1CCCN1C1CCN(C[C@H]2Cc3ccc(Oc4ccc(cn4)-c4ccn[nH]4)cc3O2)CC1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289913 ((S)-2-Methoxy-1-(8-{6-[5-(2H-pyrazol- 3-yl)-pyridi...) Show SMILES CO[C@@H](C)C(=O)N1CC2CCC(C1)N2Cc1ccc2cc(Oc3ccc(cn3)-c3ccn[nH]3)ccc2n1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair
Leukotriene A-4 hydrolase (Homo sapiens (Human))	BDBM289975 (2-Hydroxy-1-(7-{6-[5-(2H-pyrazol- 3-yl)-pyridin-2-...) Show SMILES OCC(=O)N1CCC2(CCN(Cc3ccc4cc(Oc5ccc(cn5)-c5ccn[nH]5)ccc4n3)C2)C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	7.5	25
Boehringer Ingelheim International GmbH US Patent					Assay Description The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...				US Patent US9573957 (2017) BindingDB Entry DOI: 10.7270/Q27S7QTT
					More data for this Ligand-Target Pair

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