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Compile Data Set for Download or QSAR

Found 2834 hits with Last Name = 'bone' and Initial = 'w'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478724
PNG
(US10894784, Example 117.02 | cyclopropyl(4-{(1R or...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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UniChem
US Patent
n/an/a 0.330n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478844
PNG
(US10894784, Example 117.05)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 |w:11.11|
PDB

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n/an/a 0.473n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478804
PNG
(US10894784, Example 152.02)
Show SMILES FC(F)(F)CC(=O)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cc(NC4CCC4)ncn3)c2)CC1
Show InChI InChI=1S/C28H30F3N9O/c29-28(30,31)15-26(41)40-10-8-39(9-11-40)16-18-6-7-32-24(12-18)38-27-36-21-5-4-19(13-23(21)37-27)22-14-25(34-17-33-22)35-20-2-1-3-20/h4-7,12-14,17,20H,1-3,8-11,15-16H2,(H,33,34,35)(H2,32,36,37,38)
PDB

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n/an/a 0.480n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478725
PNG
(3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(pyrr...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1
PDB

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UniProtKB/SwissProt

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n/an/a 0.490n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478853
PNG
(US10894784, Example 164.03)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1
PDB

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n/an/a 0.558n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478542
PNG
(US10894784, Example 55.03 | cyclopropyl{4-[(1R or ...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 |w:33.36|
PDB

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n/an/a 0.564n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478855
PNG
(US10894784, Example 164.05)
Show SMILES CC(N1CCN(CC1)C(=O)[C@@H]1CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1 |r|
PDB

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n/an/a 0.566n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478573
PNG
(US10894784, Example 55.03.01 | US10894784, Example...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1
PDB

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n/an/a 0.610n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478719
PNG
((4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimidi...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCC2)c1
PDB

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n/an/a 0.620n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478581
PNG
(1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-chlorocyclopropyl...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3(Cl)CC3)c2)c1
PDB

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n/an/a 0.640n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478573
PNG
(US10894784, Example 55.03.01 | US10894784, Example...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1
PDB

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n/an/a 0.660n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478614
PNG
(3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(meth...)
Show SMILES COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1
PDB

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n/an/a 0.700n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478571
PNG
(1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1R or IS)-2,2-difl...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1
PDB

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n/an/a 0.720n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478583
PNG
(US10894784, Example 70.02 | {4-[(1R or 1S)-1-(2-{[...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5(F)F)c4)c(Cl)c3[nH]2)c1 |w:29.31|
PDB

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n/an/a 0.730n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478720
PNG
(US10894784, Example 116.02 | cyclopropyl(4-{(1R or...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(F)(F)C2)c1
PDB

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n/an/a 0.760n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478718
PNG
(1-(4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)pyrimi...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCC2)c1
PDB

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n/an/a 0.760n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478843
PNG
(US10894784, Example 117.04)
Show SMILES CC(N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1
PDB

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n/an/a 0.819n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478854
PNG
(US10894784, Example 164.04)
Show SMILES CC(N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1
PDB

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n/an/a 0.832n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478845
PNG
(US10894784, Example 117.06)
Show SMILES CC(N1CCN(CC1)C(=O)C1(C)CC1(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCCC2)c1 |w:10.11|
PDB

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n/an/a 0.860n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478582
PNG
(1-{4-[(1R or 1S)-1-(2-{[7-chloro-6-(1-{[(1RS)-2,2-...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5(F)F)c4)c(Cl)c3[nH]2)c1 |w:31.32|
PDB

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n/an/a 0.880n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478594
PNG
((4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylmet...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)c(Cl)c3[nH]2)c1
PDB

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n/an/a 0.880n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478852
PNG
(US10894784, Example 164.02)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(C2)C(F)(F)F)c1
PDB

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n/an/a 0.943n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478805
PNG
(US10894784, Example 152.03)
Show SMILES O=C(C1CC1)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cc(NC4CCC4)ncn3)c2)CC1
Show InChI InChI=1S/C29H33N9O/c39-28(20-4-5-20)38-12-10-37(11-13-38)17-19-8-9-30-26(14-19)36-29-34-23-7-6-21(15-25(23)35-29)24-16-27(32-18-31-24)33-22-2-1-3-22/h6-9,14-16,18,20,22H,1-5,10-13,17H2,(H,31,32,33)(H2,30,34,35,36)
PDB

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n/an/a 0.960n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478722
PNG
((4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin-1...)
Show SMILES CC(N1CCN(CC1)C(=O)C1(CC1)C(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(F)(F)C2)c1
PDB

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n/an/a 1n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478803
PNG
(US10894784, Example 151.03)
Show SMILES O=C(C1CC1)N1CCN(Cc2ccnc(Nc3nc4ccc(cc4[nH]3)-c3cc(NC4CC4)ncn3)c2)CC1
Show InChI InChI=1S/C28H31N9O/c38-27(19-1-2-19)37-11-9-36(10-12-37)16-18-7-8-29-25(13-18)35-28-33-22-6-3-20(14-24(22)34-28)23-15-26(31-17-30-23)32-21-4-5-21/h3,6-8,13-15,17,19,21H,1-2,4-5,9-12,16H2,(H,30,31,32)(H2,29,33,34,35)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478708
PNG
((4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-metho...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1)N1CCC1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478541
PNG
(1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1RS)-2,2-difluoroc...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1 |w:35.37|
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478715
PNG
(US10894784, Example 113.03 | cyclopropyl(4-{(1R or...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1)N1CC(F)(F)C1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478736
PNG
((4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclopropylme...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)c(Cl)c3[nH]2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478613
PNG
(US10894784, Example 84.01 | tert-butyl 4-{(1R or 1...)
Show SMILES COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)OC(C)(C)C)[nH]c2c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478735
PNG
(1-(4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclopropyl...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)c(Cl)c3[nH]2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478721
PNG
(1-(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CC(F)(F)C2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478711
PNG
(US10894784, Example 112.02 | cyclopropyl(4-{(1R or...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1)N1CCCC1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478571
PNG
(1-{4-[(1R or 1S)-1-(2-{[6-(1-{[(1R or IS)-2,2-difl...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3(F)F)c2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478811
PNG
(US10894784, Example 154.03)
Show SMILES CC(C)Nc1cc(ncn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)C4CC4)ccn3)[nH]c2c1
Show InChI InChI=1S/C28H33N9O/c1-18(2)32-26-15-23(30-17-31-26)21-5-6-22-24(14-21)34-28(33-22)35-25-13-19(7-8-29-25)16-36-9-11-37(12-10-36)27(38)20-3-4-20/h5-8,13-15,17-18,20H,3-4,9-12,16H2,1-2H3,(H,30,31,32)(H2,29,33,34,35)
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478712
PNG
(3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[5-metho...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1)N1CCCC1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478717
PNG
(US10894784, Example 115.01 | tert-butyl 4-{(1R or ...)
Show SMILES CC(N1CCN(CC1)C(=O)OC(C)(C)C)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCC2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478728
PNG
(3,3,3-trifluoro-1-(4-{(1R or 1S)-1-[2-({6-[6-(morp...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N2CCOCC2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478593
PNG
(1-(4-{(1R or 1S)-1-[2-({7-chloro-6-[1-(cyclobutylm...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)c(Cl)c3[nH]2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478709
PNG
(1-(4-{(1R or 1S)-1-[2-({6-[6-(azetidin-1-yl)-5-met...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1)N1CCC1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478611
PNG
(US10894784, Example 83.04 | cyclopropyl{4-[(1R or ...)
Show SMILES COc1c(C)ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478621
PNG
(US10894784, Example 86.03 | cyclopropyl{4-[(1R or ...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5(F)F)c4)c(F)c3[nH]2)c1 |w:29.31|
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478579
PNG
(3,3,3-trifluoro-1-{4-[(1R or 1S)-1-{2-[(6-{1-[(1-m...)
Show SMILES CC(N1CCN(CC1)C(=O)OC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3(C)CC3)c2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478652
PNG
(1-(4-{(1R or 1S)-1-[2-({6-[6-(dimethylamino)pyrimi...)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(ncn2)N(C)C)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478714
PNG
(1-(4-{(1R or 1S)-1-[2-({6-[6-(3,3-difluoroazetidin...)
Show SMILES COc1c(ncnc1-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)CC(F)(F)F)[nH]c2c1)N1CC(F)(F)C1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478733
PNG
(US10894784, Example 121.03 | cyclopropyl(4-{(1R or...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)c(F)c3[nH]2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478495
PNG
(US10894784, Example 39.02.03 | cyclopropyl(4-{(1R ...)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cnn(CC3CC3)c2)c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478615
PNG
(US10894784, Example 84.03 | cyclopropyl(4-{(1R or ...)
Show SMILES COCc1cc(ncn1)-c1ccc2nc(Nc3cc(ccn3)C(C)N3CCN(CC3)C(=O)C3CC3)[nH]c2c1
PDB

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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478856
PNG
(US10894784, Example 165.02)
Show SMILES CC(N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(OCC(C)(F)F)ncn2)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.71n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase TBK1


(Homo sapiens (Human))
BDBM478857
PNG
(US10894784, Example 165.03)
Show SMILES CC(N1CCN(CC1)C(=O)C1CC1)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(OCC(C)(F)F)ncn2)c1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.79n/an/an/an/an/an/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...


US Patent US10894784 (2021)


BindingDB Entry DOI: 10.7270/Q2PV6PFT
More data for this
Ligand-Target Pair
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