Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM26658 (2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 5.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells by competitive inhibition assay | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50158460 ((3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM26658 (2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Rattus norvegicus) | BDBM26658 (2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in rat renal brush border membrane vesicles | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM35440 (ALLOPURINOL | MLS000069453 | SMR000059083 | cid_20...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase (unknown origin) by spectrophotometry | J Nat Prod 62: 1053-5 (1999) Article DOI: 10.1021/np990009i BindingDB Entry DOI: 10.7270/Q2MP531P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM50242286 (2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,6-dimethox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase (unknown origin) by spectrophotometry | J Nat Prod 62: 1053-5 (1999) Article DOI: 10.1021/np990009i BindingDB Entry DOI: 10.7270/Q2MP531P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase/oxidase (Homo sapiens (Human)) | BDBM50240898 (5,7-Dihydroxy-3,6-dimethoxy-2-(4-methoxy-phenyl)-c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing University Curated by ChEMBL | Assay Description Inhibition of xanthine oxidase (unknown origin) by spectrophotometry | J Nat Prod 62: 1053-5 (1999) Article DOI: 10.1021/np990009i BindingDB Entry DOI: 10.7270/Q2MP531P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50206509 (4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 22 member 12 (Homo sapiens (Human)) | BDBM50026604 (1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)py...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Chinese University of Hong Kong Curated by ChEMBL | Assay Description Inhibition of human URAT1-mediated urate uptake in HEK293 cells | Drug Metab Dispos 35: 981-6 (2007) Article DOI: 10.1124/dmd.106.012187 BindingDB Entry DOI: 10.7270/Q2KK9CPP | |||||||||||
More data for this Ligand-Target Pair |