Found 17 hits with Last Name = 'fairman' and Initial = 'e' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50350947
(CHEMBL1818218)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1 Show InChI InChI=1S/C26H38N6O2/c1-20(2)15-27-24-23(25(33)28-16-21-7-4-3-5-8-21)17-29-26(30-24)32-12-10-31(11-13-32)18-22-9-6-14-34-19-22/h3-5,7-8,17,20,22H,6,9-16,18-19H2,1-2H3,(H,28,33)(H,27,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human ERG expressed in human HEK293 cells by patch-clamp electrophysiology |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350947
(CHEMBL1818218)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1 Show InChI InChI=1S/C26H38N6O2/c1-20(2)15-27-24-23(25(33)28-16-21-7-4-3-5-8-21)17-29-26(30-24)32-12-10-31(11-13-32)18-22-9-6-14-34-19-22/h3-5,7-8,17,20,22H,6,9-16,18-19H2,1-2H3,(H,28,33)(H,27,29,30) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 97 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50350948
(CHEMBL1818217)Show SMILES O=C(NCc1ccccc1)c1cnc(nc1NC1CC1)N1CCN(CC2CCCOC2)CC1 Show InChI InChI=1S/C25H34N6O2/c32-24(26-15-19-5-2-1-3-6-19)22-16-27-25(29-23(22)28-21-8-9-21)31-12-10-30(11-13-31)17-20-7-4-14-33-18-20/h1-3,5-6,16,20-21H,4,7-15,17-18H2,(H,26,32)(H,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 109 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50350947
(CHEMBL1818218)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(CC2CCCOC2)CC1 Show InChI InChI=1S/C26H38N6O2/c1-20(2)15-27-24-23(25(33)28-16-21-7-4-3-5-8-21)17-29-26(30-24)32-12-10-31(11-13-32)18-22-9-6-14-34-19-22/h3-5,7-8,17,20,22H,6,9-16,18-19H2,1-2H3,(H,28,33)(H,27,29,30) | PDB
KEGG
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50350951
(CHEMBL1818209)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C27H34N6O/c1-21(2)17-28-25-24(26(34)29-18-22-9-5-3-6-10-22)19-30-27(31-25)33-15-13-32(14-16-33)20-23-11-7-4-8-12-23/h3-12,19,21H,13-18,20H2,1-2H3,(H,29,34)(H,28,30,31) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50350950
(CHEMBL1818210)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1cccnc1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C26H33N7O/c1-20(2)15-28-24-23(25(34)29-17-22-9-6-10-27-16-22)18-30-26(31-24)33-13-11-32(12-14-33)19-21-7-4-3-5-8-21/h3-10,16,18,20H,11-15,17,19H2,1-2H3,(H,29,34)(H,28,30,31) | PDB
KEGG
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350948
(CHEMBL1818217)Show SMILES O=C(NCc1ccccc1)c1cnc(nc1NC1CC1)N1CCN(CC2CCCOC2)CC1 Show InChI InChI=1S/C25H34N6O2/c32-24(26-15-19-5-2-1-3-6-19)22-16-27-25(29-23(22)28-21-8-9-21)31-12-10-30(11-13-31)17-20-7-4-14-33-18-20/h1-3,5-6,16,20-21H,4,7-15,17-18H2,(H,26,32)(H,27,28,29) | PDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 848 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350952
(CHEMBL1818215)Show SMILES O=C(NCc1ccccc1)c1cnc(nc1NC1CC1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C26H30N6O/c33-25(27-17-20-7-3-1-4-8-20)23-18-28-26(30-24(23)29-22-11-12-22)32-15-13-31(14-16-32)19-21-9-5-2-6-10-21/h1-10,18,22H,11-17,19H2,(H,27,33)(H,28,29,30) | PDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 468 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350949
(CHEMBL1818214)Show SMILES Fc1cccc(F)c1C(=O)N1CCN(CC1)c1ncc(C(=O)NCc2ccccc2)c(NC2CC2)n1 Show InChI InChI=1S/C26H26F2N6O2/c27-20-7-4-8-21(28)22(20)25(36)33-11-13-34(14-12-33)26-30-16-19(23(32-26)31-18-9-10-18)24(35)29-15-17-5-2-1-3-6-17/h1-8,16,18H,9-15H2,(H,29,35)(H,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 186 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350953
(CHEMBL1818213)Show SMILES O=C(NCc1ccccc1)c1cnc(nc1NC1CC1)N1CCN(CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C26H28N6O2/c33-24(27-17-19-7-3-1-4-8-19)22-18-28-26(30-23(22)29-21-11-12-21)32-15-13-31(14-16-32)25(34)20-9-5-2-6-10-20/h1-10,18,21H,11-17H2,(H,27,33)(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350954
(CHEMBL1818212)Show SMILES COCCNC(=O)c1cnc(nc1NCC(C)C)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C23H34N6O2/c1-18(2)15-25-21-20(22(30)24-9-14-31-3)16-26-23(27-21)29-12-10-28(11-13-29)17-19-7-5-4-6-8-19/h4-8,16,18H,9-15,17H2,1-3H3,(H,24,30)(H,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 581 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350955
(CHEMBL1818211)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccn1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C26H33N7O/c1-20(2)16-28-24-23(25(34)29-17-22-10-6-7-11-27-22)18-30-26(31-24)33-14-12-32(13-15-33)19-21-8-4-3-5-9-21/h3-11,18,20H,12-17,19H2,1-2H3,(H,29,34)(H,28,30,31) | PDB
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350950
(CHEMBL1818210)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1cccnc1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C26H33N7O/c1-20(2)15-28-24-23(25(34)29-17-22-9-6-10-27-16-22)18-30-26(31-24)33-13-11-32(12-14-33)19-21-7-4-3-5-8-21/h3-10,16,18,20H,11-15,17,19H2,1-2H3,(H,29,34)(H,28,30,31) | PDB
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 215 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50350951
(CHEMBL1818209)Show SMILES CC(C)CNc1nc(ncc1C(=O)NCc1ccccc1)N1CCN(Cc2ccccc2)CC1 Show InChI InChI=1S/C27H34N6O/c1-21(2)17-28-25-24(26(34)29-18-22-9-5-3-6-10-22)19-30-27(31-25)33-15-13-32(14-16-33)20-23-11-7-4-8-12-23/h3-12,19,21H,13-18,20H2,1-2H3,(H,29,34)(H,28,30,31) | PDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 175 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Rattus norvegicus) | BDBM50203072
(3-isothiocyanatoprop-1-ene | Allyl isothiocyanate ...) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.81E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescence ... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50203072
(3-isothiocyanatoprop-1-ene | Allyl isothiocyanate ...) | PDB
KEGG
UniProtKB/SwissProt
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CHEMBL
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PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50350949
(CHEMBL1818214)Show SMILES Fc1cccc(F)c1C(=O)N1CCN(CC1)c1ncc(C(=O)NCc2ccccc2)c(NC2CC2)n1 Show InChI InChI=1S/C26H26F2N6O2/c27-20-7-4-8-21(28)22(20)25(36)33-11-13-34(14-12-33)26-30-16-19(23(32-26)31-18-9-10-18)24(35)29-15-17-5-2-1-3-6-17/h1-8,16,18H,9-15H2,(H,29,35)(H,30,31,32) | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as calcium influx measured at every 1 second for 60 seconds by fluorescenc... |
Bioorg Med Chem Lett 21: 4857-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.035
BindingDB Entry DOI: 10.7270/Q21Z44S2 |
More data for this
Ligand-Target Pair | |
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