Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2Y purinoceptor 12 (Homo sapiens (Human)) | BDBM50318031 (CHEMBL1097279 | cangrelor) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at P2Y12 receptor by [35S]GTPgammaS binding assay | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318031 (CHEMBL1097279 | cangrelor) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50475205 (CHEMBL190899) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50169045 ((R)-2-(4-isobutylphenyl)-N-(methylsulfonyl)propana...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50169048 ((R)-2-(3-Benzoyl-phenyl)-propionic acid | (R)-2-(3...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50088570 ((S)-2-(3-Benzoyl-phenyl)-propionic acid | (S)-2-(3...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50475204 (CHEMBL192943) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50169047 ((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1/2 (Homo sapiens (Human)) | BDBM50169044 ((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Domp£ S.p.A. Curated by ChEMBL | Assay Description Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear cells | J Med Chem 48: 4312-31 (2005) Article DOI: 10.1021/jm049082i BindingDB Entry DOI: 10.7270/Q2Z89G5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318030 (((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Homo sapiens (Human)) | BDBM50318029 (CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 508 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at P2Y1 receptor by [35S]GTPgammaS binding assay | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318029 (CHEMBL1096400 | diammonium (2R,3S,5R)-2-[(hydrogen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 508 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318028 (CHEMBL1094760 | diammonium (2R,3S,5R)-5-(6-amino-2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 582 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Antagonist activity at human GPR17 expressed in human 1321N1 cells assessed as inhibition of UDP-glucose-induced [35S]GTPgammaS binding after 30 mins... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318022 (CHEMBL1096401 | uridine diphosphate trisodium salt) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50306710 (((2R,3S,4R,5R)-3,4-dihydroxy-5-(5-iodo-2,4-dioxo-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 945 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318027 (((2R,3S,4R,5R)-5-(6-amino-2-(phenylethynyl)-9H-pur...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0360 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318025 (((2R,3S,4R,5R)-5-(6-chloro-4-(methylamino)-1H-imid...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318026 (((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Uracil nucleotide/cysteinyl leukotriene receptor (Homo sapiens (Human)) | BDBM50318024 (((2R,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-puri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
University of Pavia Curated by ChEMBL | Assay Description Agonist activity at human GPR17 expressed in human 1321N1 cells assessed as induction of [35S]GTPgammaS binding after 30 mins by rapid filtration ass... | J Med Chem 53: 3489-501 (2010) Article DOI: 10.1021/jm901691y BindingDB Entry DOI: 10.7270/Q28C9WFW | |||||||||||
More data for this Ligand-Target Pair |