Found 1533 hits with Last Name = 'fenster' and Initial = 'e' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475646
(US10851102, Example 39 | US11339160, Ex No. 39)Show SMILES C[C@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475648
(US10851102, Example 41 | US11339160, Ex No. 41)Show SMILES C[C@H]1CN(CC[C@H]1Oc1cc(cn2cncc12)-c1ccc(O)cc1)C(=O)C=C |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)24-9-8-20(15(2)12-24)28-21-10-17(13-25-14-23-11-19(21)25)16-4-6-18(26)7-5-16/h3-7,10-11,13-15,20,26H,1,8-9,12H2,2H3/t15-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475655
(US10851102, Example 48 | US11339160, Ex No. 48)Show SMILES CCc1cc(O)c(F)cc1-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:22:21:18.17:14.20.15| Show InChI InChI=1S/C25H26FN3O3/c1-3-15-7-23(30)21(26)11-20(15)16-8-24(22-12-27-14-28(22)13-16)32-19-9-17-5-6-18(10-19)29(17)25(31)4-2/h4,7-8,11-14,17-19,30H,2-3,5-6,9-10H2,1H3/t17-,18+,19- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608555
(US11697648, Example 124)Show SMILES CN(C)C(=O)N1CCN(CC1)c1cccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608556
(US11697648, Example 125)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4cccc(CN5CCN(CC5)S(=O)(=O)CC#N)c4)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608557
(US11697648, Example 126)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4cccc(CN5CCN(CC5)S(=O)(=O)C5COC5)c4)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608558
(US11697648, Example 127)Show SMILES CS(=O)(=O)N1CCN(CC1)c1cccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608559
(US11697648, Example 128)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4cccc(c4)N4CCN(CC4)S(=O)(=O)CC#N)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608560
(US11697648, Example 129)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4cccc(c4)N4CCN(CC4)S(=O)(=O)C4COC4)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608563
(US11697648, Example 132)Show SMILES COCCS(=O)(=O)N1CCN(Cc2cccc(Nc3ncc4ccc(=O)n(CCC5CN(C5)C(=O)C=C)c4n3)c2)CC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608564
(US11697648, Example 133)Show SMILES CC(=O)N1CCN(Cc2cccc(Nc3ncc4ccc(=O)n(CCC5CN(C5)C(=O)C=C)c4n3)c2)CC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608565
(US11697648, Example 134)Show SMILES CSCC(=O)N1CCN(Cc2cccc(Nc3ncc4ccc(=O)n(CCC5CN(C5)C(=O)C=C)c4n3)c2)CC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608569
(US11697648, Example 138)Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608570
(US11697648, Example 139)Show SMILES CS(=O)CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608571
(US11697648, Example 140)Show SMILES CS(=O)(=O)CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608573
(US11697648, Example 142)Show SMILES CC1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608574
(US11697648, Example 143)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4ccc(cc4)N4CCCCC4)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608575
(US11697648, Example 144)Show SMILES COCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCN4CCN(CC4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608581
(US11697648, Example 150)Show SMILES CSCC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCN4CCN(CC4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475613
(US10851102, Example 8 | US11339160, Ex No. 8)Show SMILES Oc1ccc(c(F)c1F)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17F2N3O3/c1-2-18(27)24-7-12(8-24)10-28-17-5-13(9-25-11-23-6-15(17)25)14-3-4-16(26)20(22)19(14)21/h2-6,9,11-12,26H,1,7-8,10H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475615
(US10851102, Example 10 | US11339160, Ex No. 10)Show SMILES Oc1ccc(cc1)-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,THB:19:18:15.14:11.17.12| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475620
(US10851102, Example 15 | US11339160, Ex No. 15)Show SMILES C[C@@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475631
(US10851102, Example 24 | US11339160, Ex No. 24)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OCC2CN(C2)C(=O)\C=C\CN(C)C)c2cncn2c1 Show InChI InChI=1S/C25H29FN4O3/c1-4-18-8-23(31)21(26)10-20(18)19-9-24(22-11-27-16-30(22)14-19)33-15-17-12-29(13-17)25(32)6-5-7-28(2)3/h5-6,8-11,14,16-17,31H,4,7,12-13,15H2,1-3H3/b6-5+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475635
(US10851102, Example 28 | US11339160, Ex No. 28)Show SMILES CC(C)(Oc1cc(cn2cncc12)-c1ccc(O)cc1)C1CN(C1)C(=O)C=C Show InChI InChI=1S/C22H23N3O3/c1-4-21(27)24-12-17(13-24)22(2,3)28-20-9-16(11-25-14-23-10-19(20)25)15-5-7-18(26)8-6-15/h4-11,14,17,26H,1,12-13H2,2-3H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475637
(US10851102, Example 30 | US11339160, Ex No. 30)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H21N3O3/c1-2-21(26)23-9-7-18(8-10-23)27-20-11-16(13-24-14-22-12-19(20)24)15-3-5-17(25)6-4-15/h2-6,11-14,18,25H,1,7-10H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475638
(US10851102, Example 31 | US11339160, Ex No. 31)Show SMILES Oc1c(F)cc(cc1Cl)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17ClFN3O3/c1-2-19(26)24-7-12(8-24)10-28-18-5-14(9-25-11-23-6-17(18)25)13-3-15(21)20(27)16(22)4-13/h2-6,9,11-12,27H,1,7-8,10H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475640
(US10851102, Example 33 | US11339160, Ex No. 33)Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17Cl2N3O3/c1-2-19(26)24-7-12(8-24)10-28-18-5-14(9-25-11-23-6-17(18)25)13-3-15(21)20(27)16(22)4-13/h2-6,9,11-12,27H,1,7-8,10H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475643
(US10851102, Example 36 | US11339160, Ex No. 36)Show SMILES Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:10:11:15.14:18| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475646
(US10851102, Example 39 | US11339160, Ex No. 39)Show SMILES C[C@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475648
(US10851102, Example 41 | US11339160, Ex No. 41)Show SMILES C[C@H]1CN(CC[C@H]1Oc1cc(cn2cncc12)-c1ccc(O)cc1)C(=O)C=C |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)24-9-8-20(15(2)12-24)28-21-10-17(13-25-14-23-11-19(21)25)16-4-6-18(26)7-5-16/h3-7,10-11,13-15,20,26H,1,8-9,12H2,2H3/t15-,20+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475654
(US10851102, Example 47 | US11339160, Ex No. 47)Show SMILES CCc1cc(O)c(F)cc1-c1cc(OC2CCN(CC2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C23H24FN3O3/c1-3-15-9-21(28)19(24)11-18(15)16-10-22(20-12-25-14-27(20)13-16)30-17-5-7-26(8-6-17)23(29)4-2/h4,9-14,17,28H,2-3,5-8H2,1H3 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475655
(US10851102, Example 48 | US11339160, Ex No. 48)Show SMILES CCc1cc(O)c(F)cc1-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,TLB:22:21:18.17:14.20.15| Show InChI InChI=1S/C25H26FN3O3/c1-3-15-7-23(30)21(26)11-20(15)16-8-24(22-12-27-14-28(22)13-16)32-19-9-17-5-6-18(10-19)29(17)25(31)4-2/h4,7-8,11-14,17-19,30H,2-3,5-6,9-10H2,1H3/t17-,18+,19- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Theravance Biopharma R&D IP, LLC
US Patent
| |
US Patent US10851102 (2020)
BindingDB Entry DOI: 10.7270/Q2N87DV3 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475610
(US10851102, Example 5 | US11339160, Ex No. 5)Show SMILES Oc1ccc(cc1)-c1cc(OCC2CN(C2)C(=O)C=C)c2nncn2c1 Show InChI InChI=1S/C19H18N4O3/c1-2-18(25)22-8-13(9-22)11-26-17-7-15(10-23-12-20-21-19(17)23)14-3-5-16(24)6-4-14/h2-7,10,12-13,24H,1,8-9,11H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475613
(US10851102, Example 8 | US11339160, Ex No. 8)Show SMILES Oc1ccc(c(F)c1F)-c1cc(OCC2CN(C2)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C20H17F2N3O3/c1-2-18(27)24-7-12(8-24)10-28-17-5-13(9-25-11-23-6-15(17)25)14-3-4-16(26)20(22)19(14)21/h2-6,9,11-12,26H,1,7-8,10H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475615
(US10851102, Example 10 | US11339160, Ex No. 10)Show SMILES Oc1ccc(cc1)-c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C(=O)C=C)c2cncn2c1 |r,THB:19:18:15.14:11.17.12| Show InChI InChI=1S/C23H23N3O3/c1-2-23(28)26-17-5-6-18(26)11-20(10-17)29-22-9-16(13-25-14-24-12-21(22)25)15-3-7-19(27)8-4-15/h2-4,7-9,12-14,17-18,20,27H,1,5-6,10-11H2/t17-,18+,20- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475619
(US10851102, Example 14 | US11339160, Ex No. 14)Show SMILES Oc1ccc(cc1)-c1cc(OC2CCN(CC2(F)F)C(=O)C=C)c2cncn2c1 Show InChI InChI=1S/C21H19F2N3O3/c1-2-20(28)25-8-7-19(21(22,23)12-25)29-18-9-15(11-26-13-24-10-17(18)26)14-3-5-16(27)6-4-14/h2-6,9-11,13,19,27H,1,7-8,12H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM475620
(US10851102, Example 15 | US11339160, Ex No. 15)Show SMILES C[C@@H]1C[C@@H](CCN1C(=O)C=C)Oc1cc(cn2cncc12)-c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H23N3O3/c1-3-22(27)25-9-8-19(10-15(25)2)28-21-11-17(13-24-14-23-12-20(21)24)16-4-6-18(26)7-5-16/h3-7,11-15,19,26H,1,8-10H2,2H3/t15-,19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2CF9T9W |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608506
(US11697648, Example 88)Show SMILES CCN(CC)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608509
(US11697648, Example 91)Show SMILES CN(C)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608511
(US11697648, Example 93)Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608525
(US11697648, Example 94)Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608526
(US11697648, Example 95)Show SMILES CN(C)C(=S)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608527
(US11697648, Example 96)Show SMILES CNS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608529
(US11697648, Example 98)Show SMILES CC(C)(C)SC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608530
(US11697648, Example 99)Show SMILES COCCOC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608531
(US11697648, Example 100)Show SMILES CC(C)OC(=O)N1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(CCC4CN(C4)C(=O)C=C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM608532
(US11697648, Example 101)Show SMILES C=CC(=O)N1CC(CCn2c3nc(Nc4ccc(cc4)N4CCN(CC4)S(=O)(=O)CC#N)ncc3ccc2=O)C1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25H7MDT |
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