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Compile Data Set for Download or QSAR

Found 108 hits with Last Name = 'ferritto' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157059
PNG
((S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-phenyl}-2...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)C(=O)c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H26O6/c1-30-24(26(28)29)18-19-8-12-22(13-9-19)31-16-5-17-32-23-14-10-21(11-15-23)25(27)20-6-3-2-4-7-20/h2-4,6-15,24H,5,16-18H2,1H3,(H,28,29)/t24-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157055
PNG
((S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-3-chloro-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)C(=O)c2ccccc2)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C26H25ClO6/c1-31-24(26(29)30)17-18-8-13-23(22(27)16-18)33-15-5-14-32-21-11-9-20(10-12-21)25(28)19-6-3-2-4-7-19/h2-4,6-13,16,24H,5,14-15,17H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157057
PNG
((S)-2-Methoxy-3-{4-[5-(4-phenoxy-phenoxy)-pent-1-y...)
Show SMILES CO[C@@H](Cc1ccc(cc1)C#CCCCOc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C27H26O5/c1-30-26(27(28)29)20-22-13-11-21(12-14-22)8-4-3-7-19-31-23-15-17-25(18-16-23)32-24-9-5-2-6-10-24/h2,5-6,9-18,26H,3,7,19-20H2,1H3,(H,28,29)/t26-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157058
PNG
((S)-2-Methoxy-3-{3-methoxy-4-[3-(4-phenoxy-phenoxy...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)c(OC)c1)C(O)=O
Show InChI InChI=1S/C26H28O7/c1-29-24-17-19(18-25(30-2)26(27)28)9-14-23(24)32-16-6-15-31-20-10-12-22(13-11-20)33-21-7-4-3-5-8-21/h3-5,7-14,17,25H,6,15-16,18H2,1-2H3,(H,27,28)/t25-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157060
PNG
((S)-2-Methoxy-3-{4-[4-(4-phenoxy-phenoxy)-but-1-yn...)
Show SMILES CO[C@@H](Cc1ccc(cc1)C#CCCOc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H24O5/c1-29-25(26(27)28)19-21-12-10-20(11-13-21)7-5-6-18-30-22-14-16-24(17-15-22)31-23-8-3-2-4-9-23/h2-4,8-17,25H,6,18-19H2,1H3,(H,27,28)/t25-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157061
PNG
((S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-phenyl}-2-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C25H26O5/c1-28-24(25(26)27)18-19-8-12-22(13-9-19)29-16-5-17-30-23-14-10-21(11-15-23)20-6-3-2-4-7-20/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157056
PNG
((S)-2-Methoxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)cc1)C(O)=O
Show InChI InChI=1S/C25H26O6/c1-28-24(25(26)27)18-19-8-10-20(11-9-19)29-16-5-17-30-21-12-14-23(15-13-21)31-22-6-3-2-4-7-22/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM50157054
PNG
((S)-2-Ethoxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]-...)
Show SMILES CCO[C@@H](Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)cc1)C(O)=O
Show InChI InChI=1S/C26H28O6/c1-2-29-25(26(27)28)19-20-9-11-21(12-10-20)30-17-6-18-31-22-13-15-24(16-14-22)32-23-7-4-3-5-8-23/h3-5,7-16,25H,2,6,17-19H2,1H3,(H,27,28)/t25-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor gamma


(Homo sapiens (Human))
BDBM28681
PNG
(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Show SMILES CN(CCOc1ccc(Cc2sc(=O)[nH]c2O)cc1)c1ccccn1
Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,22H,10-12H2,1H3,(H,20,23)
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n/an/a 70n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor gamma


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475107
PNG
(CHEMBL179928)
Show SMILES Clc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H8Cl3NO3S/c14-8-1-4-10(5-2-8)21(19,20)17-13(18)11-6-3-9(15)7-12(11)16/h1-7H,(H,17,18)
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n/an/a 170n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475105
PNG
(CHEMBL189605)
Show SMILES Clc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Br)cc1Cl
Show InChI InChI=1S/C13H8BrCl2NO3S/c14-8-1-6-11(12(16)7-8)13(18)17-21(19,20)10-4-2-9(15)3-5-10/h1-7H,(H,17,18)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475147
PNG
(CHEMBL185804)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H11Cl2NO3S/c1-9-2-5-11(6-3-9)21(19,20)17-14(18)12-7-4-10(15)8-13(12)16/h2-8H,1H3,(H,17,18)
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n/an/a 210n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475104
PNG
(CHEMBL362085)
Show SMILES Clc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Br
Show InChI InChI=1S/C13H8BrCl2NO3S/c14-12-7-9(16)3-6-11(12)13(18)17-21(19,20)10-4-1-8(15)2-5-10/h1-7H,(H,17,18)
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n/an/a 240n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475152
PNG
(CHEMBL188975)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2ccc(Br)cc2)c(Cl)c1
Show InChI InChI=1S/C13H8BrCl2NO3S/c14-8-1-4-10(5-2-8)21(19,20)17-13(18)11-6-3-9(15)7-12(11)16/h1-7H,(H,17,18)
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n/an/a 240n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475145
PNG
(CHEMBL187453)
Show SMILES Clc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Br)cc1Br
Show InChI InChI=1S/C13H8Br2ClNO3S/c14-8-1-6-11(12(15)7-8)13(18)17-21(19,20)10-4-2-9(16)3-5-10/h1-7H,(H,17,18)
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n/an/a 250n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475139
PNG
(CHEMBL187192)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2cccc(Br)c2)c(Cl)c1
Show InChI InChI=1S/C13H8BrCl2NO3S/c14-8-2-1-3-10(6-8)21(19,20)17-13(18)11-5-4-9(15)7-12(11)16/h1-7H,(H,17,18)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475159
PNG
(CHEMBL189864)
Show SMILES Cc1cc(Cl)ccc1C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11Cl2NO3S/c1-9-8-11(16)4-7-13(9)14(18)17-21(19,20)12-5-2-10(15)3-6-12/h2-8H,1H3,(H,17,18)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157055
PNG
((S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-3-chloro-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)C(=O)c2ccccc2)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C26H25ClO6/c1-31-24(26(29)30)17-18-8-13-23(22(27)16-18)33-15-5-14-32-21-11-9-20(10-12-21)25(28)19-6-3-2-4-7-19/h2-4,6-13,16,24H,5,14-15,17H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/a 309n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475146
PNG
(CHEMBL189138)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H17Cl2NO3S/c1-17(2,3)11-4-7-13(8-5-11)24(22,23)20-16(21)14-9-6-12(18)10-15(14)19/h4-10H,1-3H3,(H,20,21)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475122
PNG
(CHEMBL188715)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H11Cl2NO4S/c1-21-10-3-5-11(6-4-10)22(19,20)17-14(18)12-7-2-9(15)8-13(12)16/h2-8H,1H3,(H,17,18)
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n/an/a 350n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475124
PNG
(CHEMBL188687)
Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H10Cl3NO3S/c1-8-2-4-10(7-12(8)16)22(20,21)18-14(19)11-5-3-9(15)6-13(11)17/h2-7H,1H3,(H,18,19)
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n/an/a 360n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475109
PNG
(CHEMBL185679)
Show SMILES Fc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H8Cl2FNO3S/c14-8-1-6-11(12(15)7-8)13(18)17-21(19,20)10-4-2-9(16)3-5-10/h1-7H,(H,17,18)
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n/an/a 410n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475121
PNG
(CHEMBL363735)
Show SMILES Fc1ccc(cc1Cl)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H7Cl3FNO3S/c14-7-1-3-9(10(15)5-7)13(19)18-22(20,21)8-2-4-12(17)11(16)6-8/h1-6H,(H,18,19)
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n/an/a 410n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475154
PNG
(CHEMBL187967)
Show SMILES Clc1cccc(c1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H8Cl3NO3S/c14-8-2-1-3-10(6-8)21(19,20)17-13(18)11-5-4-9(15)7-12(11)16/h1-7H,(H,17,18)
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n/an/a 440n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475108
PNG
(CHEMBL180882)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO3S/c14-7-1-3-9(11(16)5-7)13(19)18-22(20,21)8-2-4-10(15)12(17)6-8/h1-6H,(H,18,19)
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n/an/a 460n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157059
PNG
((S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-phenyl}-2...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)C(=O)c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H26O6/c1-30-24(26(28)29)18-19-8-12-22(13-9-19)31-16-5-17-32-23-14-10-21(11-15-23)25(27)20-6-3-2-4-7-20/h2-4,6-15,24H,5,16-18H2,1H3,(H,28,29)/t24-/m0/s1
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n/an/a 470n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475134
PNG
(CHEMBL181855)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C13H9Cl2NO3S/c14-9-6-7-11(12(15)8-9)13(17)16-20(18,19)10-4-2-1-3-5-10/h1-8H,(H,16,17)
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n/an/a 530n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475131
PNG
(CHEMBL364656)
Show SMILES CSc1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H11Cl2NO3S2/c1-21-10-3-5-11(6-4-10)22(19,20)17-14(18)12-7-2-9(15)8-13(12)16/h2-8H,1H3,(H,17,18)
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n/an/a 530n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475111
PNG
(CHEMBL186038)
Show SMILES CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C15H11Cl2NO4S/c1-9(19)10-2-5-12(6-3-10)23(21,22)18-15(20)13-7-4-11(16)8-14(13)17/h2-8H,1H3,(H,18,20)
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n/an/a 560n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157061
PNG
((S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-phenyl}-2-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C25H26O5/c1-28-24(25(26)27)18-19-8-12-22(13-9-19)29-16-5-17-30-23-14-10-21(11-15-23)20-6-3-2-4-7-20/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1
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n/an/a 568n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475123
PNG
(CHEMBL189072)
Show SMILES Cc1cc(Br)ccc1C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H11BrClNO3S/c1-9-8-10(15)2-7-13(9)14(18)17-21(19,20)12-5-3-11(16)4-6-12/h2-8H,1H3,(H,17,18)
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n/an/a 610n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475120
PNG
(CHEMBL187388)
Show SMILES [O-][N+](=O)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c(Cl)c1
Show InChI InChI=1S/C13H8Cl2N2O5S/c14-8-1-4-10(5-2-8)23(21,22)16-13(18)11-6-3-9(17(19)20)7-12(11)15/h1-7H,(H,16,18)
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n/an/a 620n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475151
PNG
(CHEMBL186218)
Show SMILES CCc1cc(Cl)ccc1C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H13Cl2NO3S/c1-2-10-9-12(17)5-8-14(10)15(19)18-22(20,21)13-6-3-11(16)4-7-13/h3-9H,2H2,1H3,(H,18,19)
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n/an/a 630n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475136
PNG
(CHEMBL186516)
Show SMILES Cc1cccc(c1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H11Cl2NO3S/c1-9-3-2-4-11(7-9)21(19,20)17-14(18)12-6-5-10(15)8-13(12)16/h2-8H,1H3,(H,17,18)
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n/an/a 750n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157057
PNG
((S)-2-Methoxy-3-{4-[5-(4-phenoxy-phenoxy)-pent-1-y...)
Show SMILES CO[C@@H](Cc1ccc(cc1)C#CCCCOc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C27H26O5/c1-30-26(27(28)29)20-22-13-11-21(12-14-22)8-4-3-7-19-31-23-15-17-25(18-16-23)32-24-9-5-2-6-10-24/h2,5-6,9-18,26H,3,7,19-20H2,1H3,(H,28,29)/t26-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475153
PNG
(CHEMBL365095)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H8Cl2N2O5S/c14-8-4-5-11(12(15)6-8)13(18)16-23(21,22)10-3-1-2-9(7-10)17(19)20/h1-7H,(H,16,18)
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n/an/a 910n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475140
PNG
(CHEMBL426981)
Show SMILES COc1cccc(c1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C14H11Cl2NO4S/c1-21-10-3-2-4-11(8-10)22(19,20)17-14(18)12-6-5-9(15)7-13(12)16/h2-8H,1H3,(H,17,18)
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n/an/a 910n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475150
PNG
(CHEMBL365284)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2ccc(Br)c(Br)c2)c(Cl)c1
Show InChI InChI=1S/C13H7Br2Cl2NO3S/c14-10-4-2-8(6-11(10)15)22(20,21)18-13(19)9-3-1-7(16)5-12(9)17/h1-6H,(H,18,19)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475119
PNG
(CHEMBL187977)
Show SMILES CN(C)c1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C15H14Cl2N2O3S/c1-19(2)11-4-6-12(7-5-11)23(21,22)18-15(20)13-8-3-10(16)9-14(13)17/h3-9H,1-2H3,(H,18,20)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475103
PNG
(CHEMBL360177)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2cccc(c2)-c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2NO3S/c20-15-9-10-17(18(21)12-15)19(23)22-26(24,25)16-8-4-7-14(11-16)13-5-2-1-3-6-13/h1-12H,(H,22,23)
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Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157060
PNG
((S)-2-Methoxy-3-{4-[4-(4-phenoxy-phenoxy)-but-1-yn...)
Show SMILES CO[C@@H](Cc1ccc(cc1)C#CCCOc1ccc(Oc2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C26H24O5/c1-29-25(26(27)28)19-21-12-10-20(11-13-21)7-5-6-18-30-22-14-16-24(17-15-22)31-23-8-3-2-4-9-23/h2-4,8-17,25H,6,18-19H2,1H3,(H,27,28)/t25-/m0/s1
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n/an/a 1.15E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475161
PNG
(CHEMBL186419)
Show SMILES COC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C15H11Cl2NO5S/c1-23-15(20)9-2-5-11(6-3-9)24(21,22)18-14(19)12-7-4-10(16)8-13(12)17/h2-8H,1H3,(H,18,19)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475133
PNG
(CHEMBL186420)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)NC(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H8Cl2N2O5S/c14-8-1-6-11(12(15)7-8)13(18)16-23(21,22)10-4-2-9(3-5-10)17(19)20/h1-7H,(H,16,18)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475155
PNG
(CHEMBL189671)
Show SMILES CCCc1cc(Cl)ccc1C(=O)NS(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15Cl2NO3S/c1-2-3-11-10-13(18)6-9-15(11)16(20)19-23(21,22)14-7-4-12(17)5-8-14/h4-10H,2-3H2,1H3,(H,19,20)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha


(Homo sapiens (Human))
BDBM50157058
PNG
((S)-2-Methoxy-3-{3-methoxy-4-[3-(4-phenoxy-phenoxy...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(Oc3ccccc3)cc2)c(OC)c1)C(O)=O
Show InChI InChI=1S/C26H28O7/c1-29-24-17-19(18-25(30-2)26(27)28)9-14-23(24)32-16-6-15-31-20-10-12-22(13-11-20)33-21-7-4-3-5-8-21/h3-5,7-14,17,25H,6,15-16,18H2,1-2H3,(H,27,28)/t25-/m0/s1
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n/an/a 1.35E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator activated receptor alpha


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50157061
PNG
((S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-phenyl}-2-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)-c2ccccc2)cc1)C(O)=O
Show InChI InChI=1S/C25H26O5/c1-28-24(25(26)27)18-19-8-12-22(13-9-19)29-16-5-17-30-23-14-10-21(11-15-23)20-6-3-2-4-7-20/h2-4,6-15,24H,5,16-18H2,1H3,(H,26,27)/t24-/m0/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor delta


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475143
PNG
(CHEMBL364873)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2ccc(cc2)-c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H13Cl2NO3S/c20-15-8-11-17(18(21)12-15)19(23)22-26(24,25)16-9-6-14(7-10-16)13-4-2-1-3-5-13/h1-12H,(H,22,23)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475115
PNG
(CHEMBL186217)
Show SMILES Clc1ccc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c(Cl)c1
Show InChI InChI=1S/C13H7Cl4NO3S/c14-7-1-2-11(12(17)6-7)13(19)18-22(20,21)10-4-8(15)3-9(16)5-10/h1-6H,(H,18,19)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1/2/3


(Homo sapiens (Human))
BDBM50475114
PNG
(CHEMBL188382)
Show SMILES FC(F)(F)c1ccc(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H8ClF6NO3S/c16-9-2-4-10(5-3-9)27(25,26)23-13(24)11-6-1-8(14(17,18)19)7-12(11)15(20,21)22/h1-7H,(H,23,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibition of vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cell proliferation


J Med Chem 47: 5367-80 (2004)


Article DOI: 10.1021/jm030594r
BindingDB Entry DOI: 10.7270/Q2QR50W8
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50157055
PNG
((S)-3-{4-[3-(4-Benzoyl-phenoxy)-propoxy]-3-chloro-...)
Show SMILES CO[C@@H](Cc1ccc(OCCCOc2ccc(cc2)C(=O)c2ccccc2)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C26H25ClO6/c1-31-24(26(29)30)17-18-8-13-23(22(27)16-18)33-15-5-14-32-21-11-9-20(10-12-21)25(28)19-6-3-2-4-7-19/h2-4,6-13,16,24H,5,14-15,17H2,1H3,(H,29,30)/t24-/m0/s1
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n/an/a 1.51E+3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Mean inhibitory concentration against human peroxisome proliferator-activated receptor delta


Bioorg Med Chem Lett 15: 51-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.042
BindingDB Entry DOI: 10.7270/Q24B30T6
More data for this
Ligand-Target Pair
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