Compile Data Set for Download or QSAR

Found 150 hits with Last Name = 'fetter' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204883 ((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204865 (CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204868 (CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204882 (CHEMBL375615 | [4-(4-chloro-phenoxy)-piperidin-1-y...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(Cl)cc1 Show InChI InChI=1S/C19H18ClN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204899 ((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204887 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204861 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204864 (CHEMBL220474 | [4-(4-fluoro-phenoxy)-piperidin-1-y...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204861 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methoxy-ben...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O4/c1-28-15-4-2-3-14(10-15)9-13-5-7-24(8-6-13)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,10-13,25-26H,5-9H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189380 (CHEMBL215372 | N-(2-(4-benzylpiperidine-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H24N4O3S/c1-29(27,28)24-17-7-8-18-19(14-17)23-20(22-18)21(26)25-11-9-16(10-12-25)13-15-5-3-2-4-6-15/h2-8,14,16,24H,9-13H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189391 ((5-hydroxy-1H-benzo[d]imidazol-2-yl)(4-(p-tolyloxy...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O3/c1-13-2-5-15(6-3-13)26-16-8-10-23(11-9-16)20(25)19-21-17-7-4-14(24)12-18(17)22-19/h2-7,12,16,24H,8-11H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204863 ((4-benzyl-piperidin-1-yl)-[4(7)-hydroxy-1H-benzimi...) Show SMILES Oc1ccc(O)c2[nH]c(nc12)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-15-6-7-16(25)18-17(15)21-19(22-18)20(26)23-10-8-14(9-11-23)12-13-4-2-1-3-5-13/h1-7,14,24-25H,8-12H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204868 (CHEMBL424752 | N-[2-(4-benzyl-piperidin-1-carbonyl...) Show SMILES CS(=O)(=O)Nc1cc2nc([nH]c2cc1NS(C)(=O)=O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H27N5O5S2/c1-33(29,30)25-19-13-17-18(14-20(19)26-34(2,31)32)24-21(23-17)22(28)27-10-8-16(9-11-27)12-15-6-4-3-5-7-15/h3-7,13-14,16,25-26H,8-12H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204883 ((6-hydroxy-1H-benzimidazol-2-yl)-(4-p-tolyloxy-pip...) Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)cc1 Show InChI InChI=1S/C20H21N3O4/c1-12-2-4-13(5-3-12)27-14-6-8-23(9-7-14)20(26)19-21-15-10-17(24)18(25)11-16(15)22-19/h2-5,10-11,14,24-25H,6-9H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189383 ((4-(3-methoxybenzyl)piperidin-1-yl)(5-hydroxy-1H-b...) Show SMILES COc1cccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-27-17-4-2-3-15(12-17)11-14-7-9-24(10-8-14)21(26)20-22-18-6-5-16(25)13-19(18)23-20/h2-6,12-14,25H,7-11H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204862 (CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...) Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1 Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204862 (CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...) Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1 Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204865 (CHEMBL220611 | [4-(4-fluoro-benzyl)-piperidin-1-yl...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O3/c21-14-3-1-12(2-4-14)9-13-5-7-24(8-6-13)20(27)19-22-15-10-17(25)18(26)11-16(15)23-19/h1-4,10-11,13,25-26H,5-9H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241126 ((4-benzylpiperidin-1-yl)(5-hydroxy-1H-benzo[d]imid...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O2/c24-16-6-7-17-18(13-16)22-19(21-17)20(25)23-10-8-15(9-11-23)12-14-4-2-1-3-5-14/h1-7,13,15,24H,8-12H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189385 ((4-(4-fluorobenzyl)piperidin-1-yl)(5-hydroxy-1H-be...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C20H20FN3O2/c21-15-3-1-13(2-4-15)11-14-7-9-24(10-8-14)20(26)19-22-17-6-5-16(25)12-18(17)23-19/h1-6,12,14,25H,7-11H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204884 (6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...) Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1 Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204899 ((4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimi...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O3/c24-17-11-15-16(12-18(17)25)22-19(21-15)20(26)23-8-6-14(7-9-23)10-13-4-2-1-3-5-13/h1-5,11-12,14,24-25H,6-10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204884 (6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...) Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1 Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204895 ((4-amino-1H-indol-2-yl)-(4-benzyl-piperidin-1-yl)-...) Show SMILES Nc1cccc2[nH]c(cc12)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H23N3O/c22-18-7-4-8-19-17(18)14-20(23-19)21(25)24-11-9-16(10-12-24)13-15-5-2-1-3-6-15/h1-8,14,16,23H,9-13,22H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241129 ((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(4-methyl-ben...) Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)cc1 Show InChI InChI=1S/C21H23N3O2/c1-14-2-4-15(5-3-14)12-16-8-10-24(11-9-16)21(26)20-22-18-7-6-17(25)13-19(18)23-20/h2-7,13,16,25H,8-12H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241127 ((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(3-methyl-ben...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3ccc(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O2/c1-14-3-2-4-16(11-14)12-15-7-9-24(10-8-15)21(26)20-22-18-6-5-17(25)13-19(18)23-20/h2-6,11,13,15,25H,7-10,12H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204887 ((6-hydroxy-1H-benzimidazol-2-yl)-[4-(3-methyl-benz...) Show SMILES Cc1cccc(CC2CCN(CC2)C(=O)c2nc3cc(O)c(O)cc3[nH]2)c1 Show InChI InChI=1S/C21H23N3O3/c1-13-3-2-4-15(9-13)10-14-5-7-24(8-6-14)21(27)20-22-16-11-18(25)19(26)12-17(16)23-20/h2-4,9,11-12,14,25-26H,5-8,10H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204873 ((4-benzylpiperidin-1-yl)-(3,6-dihydro-pirrolo[3,2-...) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]ncc23)[nH]1 Show InChI InChI=1S/C22H22N4O/c27-22(21-13-17-18-14-23-25-20(18)7-6-19(17)24-21)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,24H,8-12H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50241128 ((4-(3-fluorobenzyl)piperidin-1-yl)(5-hydroxy-1H-be...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(Cc2cccc(F)c2)CC1 Show InChI InChI=1S/C20H20FN3O2/c21-15-3-1-2-14(11-15)10-13-6-8-24(9-7-13)20(26)19-22-17-5-4-16(25)12-18(17)23-19/h1-5,11-13,25H,6-10H2,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204891 ((4-benzylpiperidin-1-yl)-(3,6-dihydro-imidazo[4,5-...) Show SMILES O=C(N1CCC(Cc2ccccc2)CC1)c1cc2c(ccc3[nH]cnc23)[nH]1 Show InChI InChI=1S/C22H22N4O/c27-22(20-13-17-18(25-20)6-7-19-21(17)24-14-23-19)26-10-8-16(9-11-26)12-15-4-2-1-3-5-15/h1-7,13-14,16,25H,8-12H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50080029 (4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...) Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50484545 (CHEMBL1933935) Show SMILES CC1(C)CNC(=O)c2sc(Nc3ccc(I)cc3F)c(C(=O)NOC[C@H](O)CO)c2C1 |r| Show InChI InChI=1S/C20H23FIN3O5S/c1-20(2)6-12-15(17(28)25-30-8-11(27)7-26)19(31-16(12)18(29)23-9-20)24-14-4-3-10(22)5-13(14)21/h3-5,11,24,26-27H,6-9H2,1-2H3,(H,23,29)(H,25,28)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assay				Bioorg Med Chem Lett 22: 472-5 (2012) Article DOI: 10.1016/j.bmcl.2011.10.105 BindingDB Entry DOI: 10.7270/Q28G8PJD
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204864 (CHEMBL220474 | [4-(4-fluoro-phenoxy)-piperidin-1-y...) Show SMILES Oc1cc2nc([nH]c2cc1O)C(=O)N1CCC(CC1)Oc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O4/c20-11-1-3-12(4-2-11)27-13-5-7-23(8-6-13)19(26)18-21-14-9-16(24)17(25)10-15(14)22-18/h1-4,9-10,13,24-25H,5-8H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134652 ((4-Benzyl-piperidin-1-yl)-(4,6-dihydroxy-1H-indol-...) Show SMILES Oc1cc(O)c2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-16-11-18-17(20(25)12-16)13-19(22-18)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189388 ((4-(4-fluorophenoxy)piperidin-1-yl)(5-hydroxy-1H-b...) Show SMILES Oc1ccc2nc([nH]c2c1)C(=O)N1CCC(CC1)Oc1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O3/c20-12-1-4-14(5-2-12)26-15-7-9-23(10-8-15)19(25)18-21-16-6-3-13(24)11-17(16)22-18/h1-6,11,15,24H,7-10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50080029 (4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-...) Show SMILES C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 |r| Show InChI InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134652 ((4-Benzyl-piperidin-1-yl)-(4,6-dihydroxy-1H-indol-...) Show SMILES Oc1cc(O)c2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-16-11-18-17(20(25)12-16)13-19(22-18)21(26)23-8-6-15(7-9-23)10-14-4-2-1-3-5-14/h1-5,11-13,15,22,24-25H,6-10H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204884 (6-(2-(4-(4-fluorobenzyl)piperidin-1-yl)ethylsulfin...) Show SMILES Fc1ccc(CC2CCN(CCS(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc1 Show InChI InChI=1S/C21H23FN2O3S/c22-17-3-1-15(2-4-17)13-16-7-9-24(10-8-16)11-12-28(26)18-5-6-19-20(14-18)27-21(25)23-19/h1-6,14,16H,7-13H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50134648 ((6-Hydroxy-1H-indol-2-yl)-(4-phenoxymethyl-piperid...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=O)N1CCC(COc2ccccc2)CC1 Show InChI InChI=1S/C21H22N2O3/c24-17-7-6-16-12-20(22-19(16)13-17)21(25)23-10-8-15(9-11-23)14-26-18-4-2-1-3-5-18/h1-7,12-13,15,22,24H,8-11,14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50032651 (1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...) Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1 Show InChI InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50484549 (CHEMBL1933934) Show SMILES CC1(C)CNC(=O)c2sc(Nc3ccc(I)cc3F)c(C(=O)NOCCO)c2C1 Show InChI InChI=1S/C19H21FIN3O4S/c1-19(2)8-11-14(16(26)24-28-6-5-25)18(29-15(11)17(27)22-9-19)23-13-4-3-10(21)7-12(13)20/h3-4,7,23,25H,5-6,8-9H2,1-2H3,(H,22,27)(H,24,26)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assay				Bioorg Med Chem Lett 22: 472-5 (2012) Article DOI: 10.1016/j.bmcl.2011.10.105 BindingDB Entry DOI: 10.7270/Q28G8PJD
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50484550 (CHEMBL1933937) Show SMILES CC1(C)CNC(=O)c2sc(Nc3ccc(I)cc3F)c(C(=O)N[C@@H]3CCNC3)c2C1 |r| Show InChI InChI=1S/C21H24FIN4O2S/c1-21(2)8-13-16(18(28)26-12-5-6-24-9-12)20(30-17(13)19(29)25-10-21)27-15-4-3-11(23)7-14(15)22/h3-4,7,12,24,27H,5-6,8-10H2,1-2H3,(H,25,29)(H,26,28)/t12-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assay				Bioorg Med Chem Lett 22: 472-5 (2012) Article DOI: 10.1016/j.bmcl.2011.10.105 BindingDB Entry DOI: 10.7270/Q28G8PJD
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189384 ((5-hydroxy-1H-benzoimidazol-2-yl)-[4-(2-methyl-ben...) Show SMILES Cc1ccccc1CC1CCN(CC1)C(=O)c1nc2ccc(O)cc2[nH]1 Show InChI InChI=1S/C21H23N3O2/c1-14-4-2-3-5-16(14)12-15-8-10-24(11-9-15)21(26)20-22-18-7-6-17(25)13-19(18)23-20/h2-7,13,15,25H,8-12H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204870 (2-[(4-benzyl-piperidin-1-yl)-imino-methyl]-1H-indo...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=N)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H23N3O/c22-21(20-13-17-6-7-18(25)14-19(17)23-20)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,22-23,25H,8-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204862 (CHEMBL436521 | N-(2-((4-benzylpiperidin-1-yl)methy...) Show SMILES CS(=O)(=O)Nc1ccc2nc(CN3CCC(Cc4ccccc4)CC3)[nH]c2c1 Show InChI InChI=1S/C21H26N4O2S/c1-28(26,27)24-18-7-8-19-20(14-18)23-21(22-19)15-25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14,17,24H,9-13,15H2,1H3,(H,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium co...				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204885 (CHEMBL222197 | N-[2-(4-benzyl-piperidine-1-carbony...) Show SMILES CS(=O)(=O)Nc1ccc2cc([nH]c2c1)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C22H25N3O3S/c1-29(27,28)24-19-8-7-18-14-21(23-20(18)15-19)22(26)25-11-9-17(10-12-25)13-16-5-3-2-4-6-16/h2-8,14-15,17,23-24H,9-13H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50484543 (CHEMBL1933932) Show SMILES CC1(C)CNC(=O)c2sc(Nc3ccc(I)cc3F)c(C(N)=O)c2C1 Show InChI InChI=1S/C17H17FIN3O2S/c1-17(2)6-9-12(14(20)23)16(25-13(9)15(24)21-7-17)22-11-4-3-8(19)5-10(11)18/h3-5,22H,6-7H2,1-2H3,(H2,20,23)(H,21,24)	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assay				Bioorg Med Chem Lett 22: 472-5 (2012) Article DOI: 10.1016/j.bmcl.2011.10.105 BindingDB Entry DOI: 10.7270/Q28G8PJD
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/2 (Homo sapiens (Human))	BDBM50484551 (CHEMBL1933928) Show SMILES CC1(C)CNC(=O)c2sc(Nc3ccc(I)cc3Cl)c(C(=O)NOC[C@H](O)CO)c2C1 |r| Show InChI InChI=1S/C20H23ClIN3O5S/c1-20(2)6-12-15(17(28)25-30-8-11(27)7-26)19(31-16(12)18(29)23-9-20)24-14-4-3-10(22)5-13(14)21/h3-5,11,24,26-27H,6-9H2,1-2H3,(H,23,29)(H,25,28)/t11-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Inhibition of human MEK using fluorescein-labelled Erk-tide as substrate after 20 mins by IMAP assay				Bioorg Med Chem Lett 22: 472-5 (2012) Article DOI: 10.1016/j.bmcl.2011.10.105 BindingDB Entry DOI: 10.7270/Q28G8PJD
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50204870 (2-[(4-benzyl-piperidin-1-yl)-imino-methyl]-1H-indo...) Show SMILES Oc1ccc2cc([nH]c2c1)C(=N)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C21H23N3O/c22-21(20-13-17-6-7-18(25)14-19(17)23-20)24-10-8-16(9-11-24)12-15-4-2-1-3-5-15/h1-7,13-14,16,22-23,25H,8-12H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain				J Med Chem 50: 901-14 (2007) Article DOI: 10.1021/jm060420k BindingDB Entry DOI: 10.7270/Q2DV1JJ4
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50189389 ((4-benzylpiperidin-1-yl)(4-hydroxy-1H-benzo[d]imid...) Show SMILES Oc1cccc2[nH]c(nc12)C(=O)N1CCC(Cc2ccccc2)CC1 Show InChI InChI=1S/C20H21N3O2/c24-17-8-4-7-16-18(17)22-19(21-16)20(25)23-11-9-15(10-12-23)13-14-5-2-1-3-6-14/h1-8,15,24H,9-13H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Gedeon Richter Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]Ro25-6981 from NR2B NMDA receptor in rat forebrain membrane				Bioorg Med Chem Lett 16: 4638-40 (2006) Article DOI: 10.1016/j.bmcl.2006.06.002 BindingDB Entry DOI: 10.7270/Q2V69J7M
					More data for this Ligand-Target Pair

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