Found 11 hits with Last Name = 'figg' and Initial = 'wd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190657
(CHEMBL1194747)Show SMILES [H][C@@]12C[C@@]34[C@@H](O)[C@@]([H])(C(=O)C=C3S1)[N+]1=C3c5c(CC1)c[nH]c5C(=O)C(N2)=C43 |r,c:10,t:15,30,TLB:5:4:13.26.14:11.8.10| Show InChI InChI=1S/C18H13N3O3S/c22-7-3-8-18-4-9(25-8)20-13-11(18)15-10-6(5-19-12(10)16(13)23)1-2-21(15)14(7)17(18)24/h3,5,9,14,17,24H,1-2,4H2,(H,19,20,23)/p+1/t9-,14+,17-,18+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190661
(CHEMBL3901938)Show SMILES [H][C@]12Nc3ccccc3[C@]1(C[C@]13SS[C@@](CO)(N(C)C1=O)C(=O)N23)n1cc(C[C@]23SS[C@@](CO)(N(C)C2=O)C(=O)N3C)c2ccccc12 |r| Show InChI InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30-,31-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190659
(CHEMBL3912024)Show SMILES [H][C@@]12C[C@@]34C(S1)=CC(=O)[C@@]([H])([N+]1=C5c6c(CC1)c[nH]c6C(=O)C(N2)=C35)[C@]4([H])Sc1ncc(C[C@H](N)C(O)=O)n1C |r,c:6,t:12,27,TLB:6:4:2:22.24.23,THB:8:7:25:24.12.11| Show InChI InChI=1S/C25H22N6O4S2/c1-30-10(4-11(26)23(34)35)8-28-24(30)37-22-19-12(32)5-13-25(22)6-14(36-13)29-18-16(25)20-15-9(2-3-31(19)20)7-27-17(15)21(18)33/h5,7-8,11,14,19,22H,2-4,6,26H2,1H3,(H2,27,29,33,34,35)/p+1/t11-,14-,19+,22-,25+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190656
(CHEMBL3910426)Show SMILES [H][C@@]12C[C@@]34C(S1)=CC(=O)[C@@]([H])([N+]1=C5c6c(CC1)c[nH]c6C(=O)C(N2)=C35)[C@]4([H])SC1=CC(=O)C(Br)=C[C@]11CCNC2=C1C1=NCCc3c[nH]c(c13)C2=O |r,c:6,40,47,t:12,27,35,50,TLB:6:4:2:22.24.23,THB:8:7:25:24.12.11| Show InChI InChI=1S/C36H25BrN6O4S2/c37-15-9-35(3-5-39-28-23(35)25-21-13(1-4-38-25)11-40-26(21)32(28)46)18(7-16(15)44)49-34-30-17(45)8-19-36(34)10-20(48-19)42-29-24(36)31-22-14(2-6-43(30)31)12-41-27(22)33(29)47/h7-9,11-12,20,30,34H,1-6,10H2,(H3,38,39,40,41,42,46,47)/p+1/t20-,30+,34-,35+,36+/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50269764
((+)-Discorhabdin B | CHEMBL459120 | Discorhabdin A...)Show SMILES BrC1=C[C@]23C[C@H](SC2=CC1=O)N=C1C3C2=NCCc3c[nH]c(c23)C1=O |r,c:8,13,t:1,17| Show InChI InChI=1S/C18H12BrN3O2S/c19-8-4-18-5-11(25-10(18)3-9(8)23)22-16-13(18)14-12-7(1-2-20-14)6-21-15(12)17(16)24/h3-4,6,11,13,21H,1-2,5H2/t11?,13?,18-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50312636
((-)-Makaluvamine F | CHEMBL509890 | Makaluvamine F)Show SMILES Oc1cc2SC(Cc2cc1Br)NC1=CC2=NCCc3c[nH]c(c23)C1=O |t:14,16| Show InChI InChI=1S/C18H14BrN3O2S/c19-10-3-9-4-15(25-14(9)6-13(10)23)22-12-5-11-16-8(1-2-20-11)7-21-17(16)18(12)24/h3,5-7,15,21-23H,1-2,4H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190660
(CHEMBL3920971)Show SMILES O[C@H]1C(Br)=C[C@@]2(CCNC3=C2C2=NCCc4c[nH]c(c24)C3=O)C=C1Br |r,wU:5.4,wD:1.0,c:3,9,26,t:12,(13.65,-19.56,;13.66,-18.02,;15,-17.26,;16.39,-18.07,;15.01,-15.71,;13.68,-14.94,;15.02,-14.18,;15.03,-12.65,;13.7,-11.71,;12.36,-12.63,;12.36,-14.17,;11.05,-14.94,;11.05,-16.46,;9.72,-17.22,;8.25,-16.33,;8.24,-14.65,;7.33,-13.4,;8.2,-12.02,;9.71,-12.62,;9.71,-14.17,;11.05,-11.85,;11.05,-10.31,;12.34,-15.7,;12.34,-17.23,;11.01,-17.99,)| Show InChI InChI=1S/C18H15Br2N3O2/c19-9-5-18(6-10(20)16(9)24)2-4-22-15-12(18)13-11-8(1-3-21-13)7-23-14(11)17(15)25/h5-7,16,22-24H,1-4H2/t16-,18- | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.52E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50190658
(CHEMBL3938903)Show SMILES BrC1=C[C@]2(CCNC3=C2C2=NCCc4c[nH]c(c24)C3=O)C(SSC2=CC(=O)C(Br)=C[C@]22CCNC3=C2C2=NCCc4c[nH]c(c24)C3=O)=CC1=O |r,c:7,32,39,55,t:1,10,27,42| Show InChI InChI=1S/C36H26Br2N6O4S2/c37-17-11-35(3-7-41-31-25(35)27-23-15(1-5-39-27)13-43-29(23)33(31)47)21(9-19(17)45)49-50-22-10-20(46)18(38)12-36(22)4-8-42-32-26(36)28-24-16(2-6-40-28)14-44-30(24)34(32)48/h9-14,41-44H,1-8H2/t35-,36-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Displacement of GST-tagged p300-CH1 domain (323 to 423 residues) from synthetic biotinylated HIF-1alpha C-TAD domain (786 to 826 residues) (unknown o... |
J Nat Prod 79: 1267-75 (2016)
Article DOI: 10.1021/acs.jnatprod.5b00846 BindingDB Entry DOI: 10.7270/Q2H9975X |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50601267
(CHEBI:72441 | ENGLERIN A | Englerin A)Show SMILES [H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)\C=C\c1ccccc1)[C@@]1(C[C@@H](OC(=O)CO)[C@@]2(C)O1)C(C)C |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00258 BindingDB Entry DOI: 10.7270/Q2MW2N6G |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50601265
(CHEMBL5177160)Show SMILES [H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)\C=C\c1ccccc1)[C@@]1(C[C@@H](OC(=O)COC(C)=O)[C@@]2(C)O1)C(C)C |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 480 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00258 BindingDB Entry DOI: 10.7270/Q2MW2N6G |
More data for this Ligand-Target Pair | |
Short transient receptor potential channel 5
(Homo sapiens (Human)) | BDBM50601266
(CHEMBL5173479)Show SMILES [H][C@@]12[#6]-[#6]-[#6@@H](-[#6])[C@@]1([H])[#6@H](-[#8]-[#6](=O)\[#6]=[#6]\c1ccccc1)[C@@]1([#6]-[#6@@H](-[#8]-[#6](=O)-[#6]-[#8]-[#6](=O)\[#6]=[#6](\[#6])-[#6])[C@@]2([#6])[#8]1)[#6](-[#6])-[#6] |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00258 BindingDB Entry DOI: 10.7270/Q2MW2N6G |
More data for this Ligand-Target Pair | |