Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM17051 (BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Berlex Biosciences | Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub... | J Biol Chem 280: 19867-74 (2005) Article DOI: 10.1074/jbc.M501367200 BindingDB Entry DOI: 10.7270/Q21Z42PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM17052 (BX-912 | N-{3-[(5-bromo-4-{[2-(1H-imidazol-4-yl)et...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Berlex Biosciences | Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub... | J Biol Chem 280: 19867-74 (2005) Article DOI: 10.1074/jbc.M501367200 BindingDB Entry DOI: 10.7270/Q21Z42PW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-phosphoinositide-dependent protein kinase 1 (Homo sapiens (Human)) | BDBM17053 (BX-320 | N-(3-{[5-bromo-2-({3-[(pyrrolidin-1-ylcar...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Berlex Biosciences | Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub... | J Biol Chem 280: 19867-74 (2005) Article DOI: 10.1074/jbc.M501367200 BindingDB Entry DOI: 10.7270/Q21Z42PW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |