BindingDB PrimarySearch

Found 14 hits with Last Name = 'fowler' and Initial = 'js'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251] (Staphylococcus aureus)	BDBM97445 (PT119) Show SMILES CCCCCCc1ccc(Oc2ccccc2C#N)c(O)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Stony Brook University Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus enoyl ACP reductase				Eur J Med Chem 88: 66-73 (2014) Article DOI: 10.1016/j.ejmech.2014.09.008 BindingDB Entry DOI: 10.7270/Q25T3N3S
Stony Brook University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50401014 (CHEMBL2206307) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Binding affinity to DAT				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.93	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]WIN35,428 from human DAT expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Brookhaven National Laboratory Curated by ChEMBL					Assay Description Inhibition of human dopamine transporter				Bioorg Med Chem Lett 19: 4343-5 (2009) Article DOI: 10.1016/j.bmcl.2009.05.090 BindingDB Entry DOI: 10.7270/Q27081HZ
Brookhaven National Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.26	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]DA from human DAT expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50114826 (8-(4-Methoxy-phenyl)-8-oxo-octanoic acid hydroxyam...) Show SMILES COc1ccc(cc1)C(=O)CCCCCCC(=O)NO Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Chonbuk National University Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin)				Bioorg Med Chem Lett 23: 6700-5 (2013) Article DOI: 10.1016/j.bmcl.2013.10.038 BindingDB Entry DOI: 10.7270/Q2P2722W
Chonbuk National University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22.5	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31.0	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]NE from human NET expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] A/B (Homo sapiens (Human))	BDBM50228339 (CHEMBL58177) Show SMILES C[C@H](Cc1ccc(F)cc1)N(C)CC#C Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Brookhaven National Laboratory Curated by ChEMBL					Assay Description In vitro inhibitory activity against Monoamine oxidase in baboon brain was determined				J Med Chem 33: 2015-9 (1990) BindingDB Entry DOI: 10.7270/Q29K4DFK
Brookhaven National Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]citalopram from human SERT expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50296249 ((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Displacement of [3H]5-HT from human SERT expressed in HEK293 cells				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50006543 (3-(2-Iodo-benzoyloxy)-8-methyl-8-aza-bicyclo[3.2.1...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Brookhaven National Laboratory Curated by ChEMBL					Assay Description Concentration of the compound inhibiting [3H]-Cocaine binding site to rat striatal membranes.				J Med Chem 35: 2178-83 (1992) BindingDB Entry DOI: 10.7270/Q2FT8K00
Brookhaven National Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50296782 ((1R,2S,3S,5S)-methyl 8-((E)-3-iodoallyl)-3-p-tolyl...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Binding affinity to rat DAT				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50401015 (CHEMBL1947086) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
Johannes Gutenberg University Curated by ChEMBL					Assay Description Binding affinity to rat DAT				Bioorg Med Chem Lett 22: 679-82 (2011) Article DOI: 10.1016/j.bmcl.2011.10.053 BindingDB Entry DOI: 10.7270/Q2ZW1N2D
Johannes Gutenberg University Curated by ChEMBL					More data for this Ligand-Target Pair