BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 102 hits with Last Name = 'fravolini' and Initial = 'a'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 1.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040072
PNG
(4-Chloro-benzene-1,3-disulfonic acid 3-amide 1-({2...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)S(=O)(=O)NCCNCC(O)COc1cccc2NC(=O)CCc12
Show InChI InChI=1S/C20H25ClN4O7S2/c21-16-6-4-14(10-19(16)33(22,28)29)34(30,31)24-9-8-23-11-13(26)12-32-18-3-1-2-17-15(18)5-7-20(27)25-17/h1-4,6,10,13,23-24,26H,5,7-9,11-12H2,(H,25,27)(H2,22,28,29)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 1.40n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040065
PNG
(5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihyd...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12
Show InChI InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
DrugBank
PubMed
 1.90n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
KEGG
PC cid
PC sid
PDB
UniChem

Patents

Similars
DrugBank
PubMed
 2.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 2.70n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040076
PNG
(4-Chloro-benzene-1,3-disulfonic acid 3-amide 1-({2...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)S(=O)(=O)NCCNCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C19H23ClN4O7S3/c20-14-5-4-13(8-17(14)33(21,27)28)34(29,30)23-7-6-22-9-12(25)10-31-16-3-1-2-15-19(16)32-11-18(26)24-15/h1-5,8,12,22-23,25H,6-7,9-11H2,(H,24,26)(H2,21,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 5.20n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 5.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040073
PNG
(4-Chloro-N-{2-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-b...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)C(=O)NCCNCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C20H23ClN4O6S2/c21-14-5-4-12(8-17(14)33(22,29)30)20(28)24-7-6-23-9-13(26)10-31-16-3-1-2-15-19(16)32-11-18(27)25-15/h1-5,8,13,23,26H,6-7,9-11H2,(H,24,28)(H,25,27)(H2,22,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 7.40n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040069
PNG
(2-Chloro-5-{2-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-b...)
Show SMILES NS(=O)(=O)c1cc(NCCNCC(O)COc2cccc3NC(=O)CSc23)ccc1Cl
Show InChI InChI=1S/C19H23ClN4O5S2/c20-14-5-4-12(8-17(14)31(21,27)28)23-7-6-22-9-13(25)10-29-16-3-1-2-15-19(16)30-11-18(26)24-15/h1-5,8,13,22-23,25H,6-7,9-11H2,(H,24,26)(H2,21,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 7.80n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086668
PNG
(7-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-18-21(12-17)30-15-22(27)23-18/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 8.30n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218566
PNG
(CHEMBL140477)
Show SMILES COc1ccccc1N1CCN(CCCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-19-8-3-2-7-18(19)25-13-11-24(12-14-25)10-5-15-28-20-9-4-6-17-22(20)29-16-21(26)23-17/h2-4,6-9H,5,10-16H2,1H3,(H,23,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 14n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040074
PNG
(2-Chloro-5-{2-[2-hydroxy-3-(naphthalen-1-yloxy)-pr...)
Show SMILES NS(=O)(=O)c1cc(NCCNCC(O)COc2cccc3ccccc23)ccc1Cl
Show InChI InChI=1S/C21H24ClN3O4S/c22-19-9-8-16(12-21(19)30(23,27)28)25-11-10-24-13-17(26)14-29-20-7-3-5-15-4-1-2-6-18(15)20/h1-9,12,17,24-26H,10-11,13-14H2,(H2,23,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 15n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218562
PNG
(CHEMBL141194)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-21-18(15-17)23-22(26)16-29-21/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 15n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 16n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 20n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086665
PNG
(7-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-19-20(11-18)29-14-21(27)23-19/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 20n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086673
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)NCC(O)COc1cccc2NC(=O)CSc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218565
PNG
(CHEMBL143288)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-18-21(15-17)29-16-22(26)23-18/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218563
PNG
(CHEMBL341723)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-17-20(14-16)28-15-21(25)22-17/h2-7,14H,8-13,15H2,1H3,(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 23n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040070
PNG
(8-tert-Butylamino-2-(3-hydroxy-propoxy)-4H-benzo[1...)
Show SMILES CC(C)(C)Nc1cccc2NC(=O)C(OCCCO)Sc12
Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)17-11-7-4-6-10-12(11)21-14(13(19)16-10)20-9-5-8-18/h4,6-7,14,17-18H,5,8-9H2,1-3H3,(H,16,19)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 24n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 27n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040071
PNG
(2-Chloro-5-{4-[2-hydroxy-3-(naphthalen-1-yloxy)-pr...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C23H26ClN3O4S/c24-21-9-8-18(14-23(21)32(25,29)30)27-12-10-26(11-13-27)15-19(28)16-31-22-7-3-5-17-4-1-2-6-20(17)22/h1-9,14,19,28H,10-13,15-16H2,(H2,25,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 31n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218563
PNG
(CHEMBL341723)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3NC(=O)CSc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-17-20(14-16)28-15-21(25)22-17/h2-7,14H,8-13,15H2,1H3,(H,22,25)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 32n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 38n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
PubMed
 39n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 60n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218567
PNG
(CHEMBL142859)
Show SMILES COc1ccccc1N1CCN(CCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-18-7-3-2-6-17(18)24-11-9-23(10-12-24)13-14-27-19-8-4-5-16-21(19)28-15-20(25)22-16/h2-8H,9-15H2,1H3,(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 73n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 88n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086663
PNG
(6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-1-3-16(4-2-15)25-9-7-24(8-10-25)12-17(26)13-28-18-5-6-20-19(11-18)23-21(27)14-29-20/h1-6,11,17,26H,7-10,12-14H2,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 90n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218566
PNG
(CHEMBL140477)
Show SMILES COc1ccccc1N1CCN(CCCOc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-19-8-3-2-7-18(19)25-13-11-24(12-14-25)10-5-15-28-20-9-4-6-17-22(20)29-16-21(26)23-17/h2-4,6-9H,5,10-16H2,1H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 99n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 100n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040066
PNG
(2-Chloro-5-{4-[2-hydroxy-3-(3-oxo-3,4-dihydro-2H-b...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C21H25ClN4O5S2/c22-16-5-4-14(10-19(16)33(23,29)30)26-8-6-25(7-9-26)11-15(27)12-31-18-3-1-2-17-21(18)32-13-20(28)24-17/h1-5,10,15,27H,6-9,11-13H2,(H,24,28)(H2,23,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 140n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040068
PNG
(4-Chloro-benzene-1,3-disulfonic acid 3-amide 1-({2...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)S(=O)(=O)NCCNCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C21H24ClN3O6S2/c22-19-9-8-17(12-21(19)32(23,27)28)33(29,30)25-11-10-24-13-16(26)14-31-20-7-3-5-15-4-1-2-6-18(15)20/h1-9,12,16,24-26H,10-11,13-14H2,(H2,23,27,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 160n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040075
PNG
(4-Chloro-N-{2-[2-hydroxy-3-(2-oxo-1,2,3,4-tetrahyd...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)C(=O)NCCNCC(O)COc1cccc2NC(=O)CCc12
Show InChI InChI=1S/C21H25ClN4O6S/c22-16-6-4-13(10-19(16)33(23,30)31)21(29)25-9-8-24-11-14(27)12-32-18-3-1-2-17-15(18)5-7-20(28)26-17/h1-4,6,10,14,24,27H,5,7-9,11-12H2,(H,25,29)(H,26,28)(H2,23,30,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 300n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086670
PNG
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 330n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50218562
PNG
(CHEMBL141194)
Show SMILES COc1ccccc1N1CCN(CCCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O3S/c1-27-20-6-3-2-5-19(20)25-12-10-24(11-13-25)9-4-14-28-17-7-8-21-18(15-17)23-22(26)16-29-21/h2-3,5-8,15H,4,9-14,16H2,1H3,(H,23,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 370n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 440n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50086666
PNG
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1
Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 530n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50218564
PNG
(CHEMBL143923)
Show SMILES COc1ccccc1N1CCN(CCOc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C21H25N3O3S/c1-26-19-5-3-2-4-18(19)24-10-8-23(9-11-24)12-13-27-16-6-7-20-17(14-16)22-21(25)15-28-20/h2-7,14H,8-13,15H2,1H3,(H,22,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 540n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50040067
PNG
(4-Chloro-N-{2-[2-hydroxy-3-(naphthalen-1-yloxy)-pr...)
Show SMILES NS(=O)(=O)c1cc(ccc1Cl)C(=O)NCCNCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C22H24ClN3O5S/c23-19-9-8-16(12-21(19)32(24,29)30)22(28)26-11-10-25-13-17(27)14-31-20-7-3-5-15-4-1-2-6-18(15)20/h1-9,12,17,25,27H,10-11,13-14H2,(H,26,28)(H2,24,29,30)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
 820n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.

J Med Chem 36: 157-61 (1993)


BindingDB Entry DOI: 10.7270/Q2ZK5FQV
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50773
PNG
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1
Show InChI InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086672
PNG
(7-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-16-18(10-15)29-13-19(25)21-16)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086677
PNG
(6-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ccc3SCC(=O)Nc3c2)CC1
Show InChI InChI=1S/C22H27N3O4S/c1-28-20-5-3-2-4-19(20)25-10-8-24(9-11-25)13-16(26)14-29-17-6-7-21-18(12-17)23-22(27)15-30-21/h2-7,12,16,26H,8-11,13-15H2,1H3,(H,23,27)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-prazosin binding in rat brain; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086678
PNG
(7-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2NC(=O)CSc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-19-20(11-18)31-14-21(28)24-19/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086674
PNG
(6-{3-[4-(Furan-2-carbonyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C20H23N3O5S/c24-14(12-28-15-3-4-18-16(10-15)21-19(25)13-29-18)11-22-5-7-23(8-6-22)20(26)17-2-1-9-27-17/h1-4,9-10,14,24H,5-8,11-13H2,(H,21,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086662
PNG
(4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3ccccc23)CC1
Show InChI InChI=1S/C22H27N3O2S/c1-27-20-9-4-2-7-18(20)24-15-13-23(14-16-24)11-6-12-25-19-8-3-5-10-21(19)28-17-22(25)26/h2-5,7-10H,6,11-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)		BDBM50086679
PNG
(8-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-hydrox...)
Show SMILES OC(COc1cccc2NC(=O)CSc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN3O3S/c22-15-4-6-16(7-5-15)25-10-8-24(9-11-25)12-17(26)13-28-19-3-1-2-18-21(19)29-14-20(27)23-18/h1-7,17,26H,8-14H2,(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung; Not Active means Ki >1000 nM

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50086660
PNG
(6-{3-[4-(4-Fluoro-benzoyl)-piperazin-1-yl]-2-hydro...)
Show SMILES OC(COc1ccc2SCC(=O)Nc2c1)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O4S/c23-16-3-1-15(2-4-16)22(29)26-9-7-25(8-10-26)12-17(27)13-30-18-5-6-20-19(11-18)24-21(28)14-31-20/h1-6,11,17,27H,7-10,12-14H2,(H,24,28)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat heart ; Not Active means Ki >1000 ...

Bioorg Med Chem Lett 10: 465-8 (2000)


BindingDB Entry DOI: 10.7270/Q2SJ1JVG
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 102 total )  |  Next  |  Last  >>
Jump to: