Compile Data Set for Download or QSAR

Found 47 hits with Last Name = 'freeman' and Initial = 'ea'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CYP2C8 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Cytochrome P450 1A2 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP1A2 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CYP2D6 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Cytochrome P450 2C9 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP2C9 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CYP2C19 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of gamma secretase (unknown origin) assessed as reduction in notch cleavage				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human ERG				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human ERG by patch clamp assay				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 2C19 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP2C19 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 2C8 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP2C8 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
FORUM Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin)				J Med Chem 60: 2383-2400 (2017) Article DOI: 10.1021/acs.jmedchem.6b01620 BindingDB Entry DOI: 10.7270/Q2WD42TX
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577496 (CHEMBL4859045) Show SMILES COc1ccc(cc1)C1CON=C(N1)c1ccc(c(OC)n1)-n1cnc(C)c1 |c:12| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577495 (CHEMBL4866858) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(cc1)C#N |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577498 (CHEMBL4846662) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(C)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	74	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577499 (CHEMBL4872582) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(cc1)C1CC1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577500 (CHEMBL4848262) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(cc1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577501 (CHEMBL4851690) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(cc1)C(C)(C)C |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577502 (CHEMBL4865043) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cccc(c1)C#N |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	214	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577503 (CHEMBL4878673) Show SMILES COc1cccc(c1)C1CON=C(N1)c1ccc(c(OC)n1)-n1cnc(C)c1 |c:12| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	197	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577504 (CHEMBL4849643) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cccc(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577505 (CHEMBL4863683) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cccc(c1)C1CC1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577506 (CHEMBL4849519) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cccc(c1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577507 (CHEMBL4871709) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)c(F)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577508 (CHEMBL4848661) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)c(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577509 (CHEMBL4850647) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)c(C)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577510 (CHEMBL4858970) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)c(c1)C1CC1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577511 (CHEMBL4864477) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)c(c1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577512 (CHEMBL4873343) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(C)c(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577513 (CHEMBL4865396) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(C2CC2)c(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577514 (CHEMBL4868749) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(c(Cl)c1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577515 (CHEMBL4872778) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(c(F)c1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577516 (CHEMBL4855162) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(F)c(c1)C(F)(F)F |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577517 (CHEMBL4878938) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(F)c(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577518 (CHEMBL4855120) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1cc(Cl)cc(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577519 (CHEMBL4849599) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)(C)C(N1)c1ccccc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	75	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577520 (CHEMBL4868827) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)(C)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577521 (CHEMBL4851284) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577522 (CHEMBL4848087) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)C(N1)c1ccc(Cl)c(F)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577523 (CHEMBL4869387) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)C(N1)c1cccc(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577524 (CHEMBL4862666) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C)C(N1)c1ccc(Cl)c(Cl)c1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577525 (CHEMBL4848062) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577494 (CHEMBL4855113) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(F)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577493 (CHEMBL4865935) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccccc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577493 (CHEMBL4865935) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccccc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50236004 (CHEMBL4101809) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC[C@@H](N1)c1cc2ccccc2o1 |r,t:16| Show InChI InChI=1S/C21H19N5O3/c1-13-10-26(12-22-13)17-8-7-15(24-21(17)27-2)20-23-16(11-28-25-20)19-9-14-5-3-4-6-18(14)29-19/h3-10,12,16H,11H2,1-2H3,(H,23,25)/t16-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50577497 (CHEMBL4855802) Show SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOCC(N1)c1ccc(Cl)cc1 |t:16| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a
TBA					Assay Description Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00904 BindingDB Entry DOI: 10.7270/Q2RV0SJR
					More data for this Ligand-Target Pair