Found 1856 hits with Last Name = 'fretz' and Initial = 'h' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50064333
(CHEMBL49860 | Phosphoric acid mono-(2-amino-4-{2-a...)Show SMILES NC(Cc1ccc(OP(O)(O)=O)c(N)c1)C(=O)NC1(CCCCC1)C(=O)NC(CC(N)=O)C(N)=O Show InChI InChI=1S/C20H31N6O8P/c21-12-8-11(4-5-15(12)34-35(31,32)33)9-13(22)18(29)26-20(6-2-1-3-7-20)19(30)25-14(17(24)28)10-16(23)27/h4-5,8,13-14H,1-3,6-7,9-10,21-22H2,(H2,23,27)(H2,24,28)(H,25,30)(H,26,29)(H2,31,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of binding to Growth factor receptor bound protein 2 (Grb2) SH2 domain |
J Med Chem 41: 1741-4 (1998)
Article DOI: 10.1021/jm970856n
BindingDB Entry DOI: 10.7270/Q2M32TWK |
More data for this
Ligand-Target Pair | 
3D Structure (docked) |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50073913
(CHEMBL73003 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCn1ccc2cc(O)ccc12 Show InChI InChI=1S/C34H45N6O9P/c1-22(41)37-27(18-23-6-8-24(9-7-23)21-50(47,48)49)32(45)39-34(13-3-2-4-14-34)33(46)38-28(20-30(35)43)31(44)36-15-5-16-40-17-12-25-19-26(42)10-11-29(25)40/h6-12,17,19,27-28,42H,2-5,13-16,18,20-21H2,1H3,(H2,35,43)(H,36,44)(H,37,41)(H,38,46)(H,39,45)(H2,47,48,49)/t27-,28-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor |
Bioorg Med Chem Lett 9: 221-6 (1999)
BindingDB Entry DOI: 10.7270/Q2N58KJG |
More data for this
Ligand-Target Pair | |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50073909
(CHEMBL72036 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCn1ccc2cc(C)ccc12 Show InChI InChI=1S/C35H47N6O8P/c1-23-7-12-30-27(19-23)13-18-41(30)17-6-16-37-32(44)29(21-31(36)43)39-34(46)35(14-4-3-5-15-35)40-33(45)28(38-24(2)42)20-25-8-10-26(11-9-25)22-50(47,48)49/h7-13,18-19,28-29H,3-6,14-17,20-22H2,1-2H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,47,48,49)/t28-,29-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor |
Bioorg Med Chem Lett 9: 221-6 (1999)
BindingDB Entry DOI: 10.7270/Q2N58KJG |
More data for this
Ligand-Target Pair | |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50073917
(CHEMBL72694 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)Show SMILES COc1ccc2n(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(C)=O)ccc2c1 Show InChI InChI=1S/C35H47N6O9P/c1-23(42)38-28(19-24-7-9-25(10-8-24)22-51(47,48)49)33(45)40-35(14-4-3-5-15-35)34(46)39-29(21-31(36)43)32(44)37-16-6-17-41-18-13-26-20-27(50-2)11-12-30(26)41/h7-13,18,20,28-29H,3-6,14-17,19,21-22H2,1-2H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,47,48,49)/t28-,29-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor |
Bioorg Med Chem Lett 9: 221-6 (1999)
BindingDB Entry DOI: 10.7270/Q2N58KJG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639880
(3-Ethoxy-5-{6-[2-(3-methoxy-1-methyl-naphthalen-2-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccccc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639881
(5-{6-[2-(3-Cyano-1-methyl-naphthalen-2-yl)-ethylam...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccccc3cc2C#N)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639887
(3-Ethoxy-5-{6-[2-(6-methoxy-4-methyl-benzofuran-5-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640273
(2-Cyclobutoxy-4-{6-[2-(7-methoxy-5-methyl-2,3-dihy...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(OC2CCC2)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM640239
(3-Ethoxy-5-{6-[2-(7-fluoro-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc(F)c3sccc3c2)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM640244
(3-Ethoxy-5-{6-[2-(4-fluoro-benzo[b]thiophen-5-yl)-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2F)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50064333
(CHEMBL49860 | Phosphoric acid mono-(2-amino-4-{2-a...)Show SMILES NC(Cc1ccc(OP(O)(O)=O)c(N)c1)C(=O)NC1(CCCCC1)C(=O)NC(CC(N)=O)C(N)=O Show InChI InChI=1S/C20H31N6O8P/c21-12-8-11(4-5-15(12)34-35(31,32)33)9-13(22)18(29)26-20(6-2-1-3-7-20)19(30)25-14(17(24)28)10-16(23)27/h4-5,8,13-14H,1-3,6-7,9-10,21-22H2,(H2,23,27)(H2,24,28)(H,25,30)(H,26,29)(H2,31,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of binding to Grb2 SH2 domain |
J Med Chem 41: 1741-4 (1998)
Article DOI: 10.1021/jm970856n
BindingDB Entry DOI: 10.7270/Q2M32TWK |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50073918
(CHEMBL431982 | [4-((S)-2-Acetylamino-2-{1-[(S)-2-c...)Show SMILES CC(=O)N[C@@H](Cc1ccc(CP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCn1ccc2ccccc12 Show InChI InChI=1S/C34H45N6O8P/c1-23(41)37-27(20-24-10-12-25(13-11-24)22-49(46,47)48)32(44)39-34(15-5-2-6-16-34)33(45)38-28(21-30(35)42)31(43)36-17-7-18-40-19-14-26-8-3-4-9-29(26)40/h3-4,8-14,19,27-28H,2,5-7,15-18,20-22H2,1H3,(H2,35,42)(H,36,43)(H,37,41)(H,38,45)(H,39,44)(H2,46,47,48)/t27-,28-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor |
Bioorg Med Chem Lett 9: 221-6 (1999)
BindingDB Entry DOI: 10.7270/Q2N58KJG |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120045
(US8697869, 38)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1nc2ccc(F)cc2s1 Show InChI InChI=1S/C22H19F2N3O2S/c1-26(22-25-17-5-2-13(24)9-20(17)30-22)14-4-7-19-16(10-14)15-8-12(23)3-6-18(15)27(19)11-21(28)29/h2-3,5-6,8-9,14H,4,7,10-11H2,1H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120025
(US8697869, 18)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1nc2cc(Cl)ccc2o1 Show InChI InChI=1S/C22H19ClFN3O3/c1-26(22-25-17-8-12(23)2-7-20(17)30-22)14-4-6-19-16(10-14)15-9-13(24)3-5-18(15)27(19)11-21(28)29/h2-3,5,7-9,14H,4,6,10-11H2,1H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120031
(US8697869, 24)Show SMILES CCN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(Cl)cn1 Show InChI InChI=1S/C20H20ClFN4O2/c1-2-25(20-23-9-12(21)10-24-20)14-4-6-18-16(8-14)15-7-13(22)3-5-17(15)26(18)11-19(27)28/h3,5,7,9-10,14H,2,4,6,8,11H2,1H3,(H,27,28)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120034
(US8697869, 27)Show SMILES OC(=O)Cn1c2CC[C@@H](Cc2c2cc(F)ccc12)N(CC1CC1)c1ncc(Cl)cn1 Show InChI InChI=1S/C22H22ClFN4O2/c23-14-9-25-22(26-10-14)27(11-13-1-2-13)16-4-6-20-18(8-16)17-7-15(24)3-5-19(17)28(20)12-21(29)30/h3,5,7,9-10,13,16H,1-2,4,6,8,11-12H2,(H,29,30)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387199
(CHEMBL2048197)Show SMILES COc1ccc(cc1CSc1nc2cc(F)ccc2n1CC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C24H19FN2O4S/c1-31-21-10-7-16(23(30)15-5-3-2-4-6-15)11-17(21)14-32-24-26-19-12-18(25)8-9-20(19)27(24)13-22(28)29/h2-12H,13-14H2,1H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639918
(3-Ethoxy-5-{6-[2-(7-ethoxy-2,3-dihydro-benzo[1,4]d...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCCOc3cc2OCC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120060
(US8697869, 54)Show SMILES CN(C1CCc2c(C1)c1cc(Cl)ccc1n2CC(O)=O)c1ncc(Cl)cn1 Show InChI InChI=1S/C19H18Cl2N4O2/c1-24(19-22-8-12(21)9-23-19)13-3-5-17-15(7-13)14-6-11(20)2-4-16(14)25(17)10-18(26)27/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639882
(3-Ethoxy-5-{6-[2-(1-fluoro-3-methoxy-naphthalen-2-...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(F)c3ccccc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639883
(3-Ethoxy-5-{6-[2-(6-methoxy-benzo[b]thiophen-5-yl)...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640277
(4-{6-[2-(7-Methoxy-5-methyl-2,3-dihydro-benzo[1,4]...)Show SMILES COc1cc2OCCOc2c(C)c1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
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More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM640236
(5-{6-[2-(7-Chloro-benzo[b]thiophen-5-yl)-ethylamin...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc(Cl)c3sccc3c2)ncn1 | PDB
Reactome pathway
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More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387187
(CHEMBL2048183)Show InChI InChI=1S/C19H18N2O4S/c1-12(22)13-7-8-17(25-2)14(9-13)11-26-19-20-15-5-3-4-6-16(15)21(19)10-18(23)24/h3-9H,10-11H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
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UniChem
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Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells in presence of 0.5% human serum albumin |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387205
(CHEMBL2048189)Show SMILES COc1ccc(cc1CSc1nc2cc(ccc2n1CC(O)=O)[N+]([O-])=O)C(C)=O Show InChI InChI=1S/C19H17N3O6S/c1-11(23)12-3-6-17(28-2)13(7-12)10-29-19-20-15-8-14(22(26)27)4-5-16(15)21(19)9-18(24)25/h3-8H,9-10H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
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Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387184
(CHEMBL2048187)Show SMILES COc1ccc(cc1CSc1nc2cc(F)ccc2n1CC(O)=O)C(C)=O Show InChI InChI=1S/C19H17FN2O4S/c1-11(23)12-3-6-17(26-2)13(7-12)10-27-19-21-15-8-14(20)4-5-16(15)22(19)9-18(24)25/h3-8H,9-10H2,1-2H3,(H,24,25) | PDB
Reactome pathway
KEGG
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Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640100
(2-Ethoxy-4-{6-[2-(6-methoxy-4-methyl-benzofuran-5-...)Show SMILES CCOc1cc(ccc1C(O)=O)-c1cc(NCCc2c(C)c3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
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More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120047
(US8697869, 40)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1nc2ccc(Cl)cc2o1 Show InChI InChI=1S/C22H19ClFN3O3/c1-26(22-25-17-5-2-12(23)8-20(17)30-22)14-4-7-19-16(10-14)15-9-13(24)3-6-18(15)27(19)11-21(28)29/h2-3,5-6,8-9,14H,4,7,10-11H2,1H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
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| US Patent
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Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120018
(US8697869, 11)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(cn1)C(F)(F)F Show InChI InChI=1S/C20H18F4N4O2/c1-27(19-25-8-11(9-26-19)20(22,23)24)13-3-5-17-15(7-13)14-6-12(21)2-4-16(14)28(17)10-18(29)30/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,29,30)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
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Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120016
(US8697869, 42 | US8697869, 9)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(Cl)cn1 Show InChI InChI=1S/C19H18ClFN4O2/c1-24(19-22-8-11(20)9-23-19)13-3-5-17-15(7-13)14-6-12(21)2-4-16(14)25(17)10-18(26)27/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,26,27)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120014
(US8697869, 7)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(F)cn1 Show InChI InChI=1S/C19H18F2N4O2/c1-24(19-22-8-12(21)9-23-19)13-3-5-17-15(7-13)14-6-11(20)2-4-16(14)25(17)10-18(26)27/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,26,27)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120016
(US8697869, 42 | US8697869, 9)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(Cl)cn1 Show InChI InChI=1S/C19H18ClFN4O2/c1-24(19-22-8-11(20)9-23-19)13-3-5-17-15(7-13)14-6-12(21)2-4-16(14)25(17)10-18(26)27/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,26,27)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639883
(3-Ethoxy-5-{6-[2-(6-methoxy-benzo[b]thiophen-5-yl)...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccsc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
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UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639884
(5-[6-(2-Benzo[b]thiophen-5-yl-ethylamino)-pyrimidi...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2ccc3sccc3c2)ncn1 | PDB
Reactome pathway
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More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639891
(3-Ethoxy-5-{6-[2-(6-methoxy-benzofuran-5-yl)-ethyl...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3ccoc3cc2OC)ncn1 | PDB
Reactome pathway
KEGG
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UniChem
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More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM640213
(5-{6-[2-(1,3-Difluoro-naphthalen-2-yl)-ethylamino]...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(F)cc3ccccc3c2F)ncn1 | PDB
Reactome pathway
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UniChem
| | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
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More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387205
(CHEMBL2048189)Show SMILES COc1ccc(cc1CSc1nc2cc(ccc2n1CC(O)=O)[N+]([O-])=O)C(C)=O Show InChI InChI=1S/C19H17N3O6S/c1-11(23)12-3-6-17(28-2)13(7-12)10-29-19-20-15-8-14(22(26)27)4-5-16(15)21(19)9-18(24)25/h3-8H,9-10H2,1-2H3,(H,24,25) | PDB
Reactome pathway
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRTh2 receptor expressed in HEK293 cells assessed as inhibition of PGD2-induced calcium flux by FLIPR assay |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387204
(CHEMBL2048190)Show SMILES COc1ccc(cc1CSc1nc2cc(ccc2n1CC(O)=O)C(F)(F)F)C(C)=O Show InChI InChI=1S/C20H17F3N2O4S/c1-11(26)12-3-6-17(29-2)13(7-12)10-30-19-24-15-8-14(20(21,22)23)4-5-16(15)25(19)9-18(27)28/h3-8H,9-10H2,1-2H3,(H,27,28) | PDB
Reactome pathway
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387189
(CHEMBL2048204)Show SMILES COc1ccc(cc1CSc1nc2cc(F)ccc2n1CC(O)=O)C(=O)N1CCc2ccccc12 Show InChI InChI=1S/C26H22FN3O4S/c1-34-23-9-6-17(25(33)29-11-10-16-4-2-3-5-21(16)29)12-18(23)15-35-26-28-20-13-19(27)7-8-22(20)30(26)14-24(31)32/h2-9,12-13H,10-11,14-15H2,1H3,(H,31,32) | PDB
Reactome pathway
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Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120046
(US8697869, 39)Show SMILES CN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1nc2cc(F)ccc2s1 Show InChI InChI=1S/C22H19F2N3O2S/c1-26(22-25-17-9-13(24)3-7-20(17)30-22)14-4-6-19-16(10-14)15-8-12(23)2-5-18(15)27(19)11-21(28)29/h2-3,5,7-9,14H,4,6,10-11H2,1H3,(H,28,29)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
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| PC cid
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UniChem
Similars
| US Patent
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Growth factor receptor-bound protein 2
(Homo sapiens (Human)) | BDBM50073911
(CHEMBL72525 | {4-[(S)-2-Acetylamino-2-(1-{(S)-2-ca...)Show SMILES CN(C)c1ccc2n(CCCNC(=O)[C@H](CC(N)=O)NC(=O)C3(CCCCC3)NC(=O)[C@H](Cc3ccc(CP(O)(O)=O)cc3)NC(C)=O)ccc2c1 Show InChI InChI=1S/C36H50N7O8P/c1-24(44)39-29(20-25-8-10-26(11-9-25)23-52(49,50)51)34(47)41-36(15-5-4-6-16-36)35(48)40-30(22-32(37)45)33(46)38-17-7-18-43-19-14-27-21-28(42(2)3)12-13-31(27)43/h8-14,19,21,29-30H,4-7,15-18,20,22-23H2,1-3H3,(H2,37,45)(H,38,46)(H,39,44)(H,40,48)(H,41,47)(H2,49,50,51)/t29-,30-/m0/s1 | PDB
MMDB
KEGG
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| CHEMBL
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UniChem
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Grb-SH2 domain binding to phosphorylated carboxy-terminal intracellular domain of epidermal growth factor receptor |
Bioorg Med Chem Lett 9: 221-6 (1999)
BindingDB Entry DOI: 10.7270/Q2N58KJG |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120064
(US8697869, 58)Show SMILES CN(C1CCc2c(C1)c1cc(ccc1n2CC(O)=O)C(F)(F)F)c1ncc(Cl)cn1 Show InChI InChI=1S/C20H18ClF3N4O2/c1-27(19-25-8-12(21)9-26-19)13-3-5-17-15(7-13)14-6-11(20(22,23)24)2-4-16(14)28(17)10-18(29)30/h2,4,6,8-9,13H,3,5,7,10H2,1H3,(H,29,30) | PDB
Reactome pathway
KEGG
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| PC cid
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UniChem
Similars
| US Patent
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM120032
(US8697869, 25)Show SMILES CCCN([C@H]1CCc2c(C1)c1cc(F)ccc1n2CC(O)=O)c1ncc(Cl)cn1 Show InChI InChI=1S/C21H22ClFN4O2/c1-2-7-26(21-24-10-13(22)11-25-21)15-4-6-19-17(9-15)16-8-14(23)3-5-18(16)27(19)12-20(28)29/h3,5,8,10-11,15H,2,4,6-7,9,12H2,1H3,(H,28,29)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
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| PC cid
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UniChem
Similars
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| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Actelion Pharmaceuticals Ltd.
US Patent
| Assay Description
Binding assay was performed in a final assay volume of 250 μl. First, 25 μl of test compound, previously diluted in Binding-Buffer (Binding... |
US Patent US8697869 (2014)
BindingDB Entry DOI: 10.7270/Q2251GVB |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM639885
(5-{6-[2-(7-Cyano-2,3-dihydro-benzo[1,4]dioxin-6-yl...)Show SMILES CCOc1cc(sc1C(O)=O)-c1cc(NCCc2cc3OCCOc3cc2C#N)ncn1 | PDB
Reactome pathway
KEGG
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| PC cid
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UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
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More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM639897
(4-{6-[2-(6-Methoxy-benzo[b]thiophen-5-yl)-ethylami...)Show SMILES COc1cc2sccc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387201
(CHEMBL2048193)Show SMILES COc1ccc(cc1CSc1nc2cc(C=O)ccc2n1CC(O)=O)C(C)=O Show InChI InChI=1S/C20H18N2O5S/c1-12(24)14-4-6-18(27-2)15(8-14)11-28-20-21-16-7-13(10-23)3-5-17(16)22(20)9-19(25)26/h3-8,10H,9,11H2,1-2H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387200
(CHEMBL2048194)Show SMILES CCOc1ccc(cc1CSc1nc2cc(F)ccc2n1CC(O)=O)C(C)=O Show InChI InChI=1S/C20H19FN2O4S/c1-3-27-18-7-4-13(12(2)24)8-14(18)11-28-20-22-16-9-15(21)5-6-17(16)23(20)10-19(25)26/h4-9H,3,10-11H2,1-2H3,(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGD2 from human CRTh2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50387199
(CHEMBL2048197)Show SMILES COc1ccc(cc1CSc1nc2cc(F)ccc2n1CC(O)=O)C(=O)c1ccccc1 Show InChI InChI=1S/C24H19FN2O4S/c1-31-21-10-7-16(23(30)15-5-3-2-4-6-15)11-17(21)14-32-24-26-19-12-18(25)8-9-20(19)27(24)13-22(28)29/h2-12H,13-14H2,1H3,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human CRTh2 receptor expressed in HEK293 cells assessed as inhibition of PGD2-induced calcium flux by FLIPR assay |
Bioorg Med Chem Lett 22: 4660-4 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.087
BindingDB Entry DOI: 10.7270/Q2M32WTH |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM640016
(4-{6-[2-(7-Ethoxy-2,3-dihydro-benzo[1,4]dioxin-6-y...)Show SMILES CCOc1cc2OCCOc2cc1CCNc1cc(ncn1)-c1ccc(C(O)=O)c(SC)c1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Prostaglandin D2 receptor 2
(Homo sapiens (Human)) | BDBM50434995
(CHEMBL2386080)Show SMILES OC(=O)Cn1c2CCN(Cc2c2cc(Cl)ccc12)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C24H19ClN2O3/c25-16-8-9-21-19(12-16)20-13-26(11-10-22(20)27(21)14-23(28)29)24(30)18-7-3-5-15-4-1-2-6-17(15)18/h1-9,12H,10-11,13-14H2,(H,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Actelion Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGD2 from recombinant human CRTH2 receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting analysis |
J Med Chem 56: 4899-911 (2013)
Article DOI: 10.1021/jm400122f
BindingDB Entry DOI: 10.7270/Q2ZP47HB |
More data for this
Ligand-Target Pair | |
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