Compile Data Set for Download or QSAR

Found 36 hits with Last Name = 'frysova' and Initial = 'i'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.35E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.60E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12028 (4-Arylazo-3,5-diamino-1H-pyrazole 31b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 |w:8.9| Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	6.90E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.70E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.70E+4	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.20E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12025 (4-Arylazo-3,5-diamino-1H-pyrazole 26b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair				3D Structure (docked)
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12027 (3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 Show InChI InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.2	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12029 (4-Arylazo-3,5-diamino-1H-pyrazole 35b | {2-[(E)-2-...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1CO Show InChI InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12024 (4-Arylazo-3,5-diamino-1H-pyrazole 1b | 4-[(E)-2-ph...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1ccccc1 Show InChI InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair
Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM12026 (4-Arylazo-3,5-diamino-1H-pyrazole 27b | 4-[(E)-2-(...) Show SMILES Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	30
Palacky University					Assay Description In vitro CDK assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of ATP/ [gamma-32P] ATP. 32P...				J Med Chem 49: 6500-9 (2006) Article DOI: 10.1021/jm0605740 BindingDB Entry DOI: 10.7270/Q2M61HHK
					More data for this Ligand-Target Pair