Compile Data Set for Download or QSAR

Found 84 hits with Last Name = 'gregory' and Initial = 'jp'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50213867 (CHEMBL329303) Show SMILES COC(=O)c1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O4/c1-28-19(26)14-8-5-9-15(10-14)24-17-16(21-12-22-17)18(25)23(20(24)27)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214164 (CHEMBL100011) Show SMILES COc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C19H16N4O3/c1-26-15-9-5-8-14(10-15)23-17-16(20-12-21-17)18(24)22(19(23)25)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Relative inhibition of phosphodiesterase 4 activity and Rolipram binding to PDE4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of Rolipram binding to PDE4 at 1 uM				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214288 (CHEMBL98483) Show SMILES Clc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C18H13ClN4O2/c19-13-7-4-8-14(9-13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214284 (CHEMBL420265) Show SMILES O=c1n(Cc2ccccc2)c(=O)c2[nH]cnc2n1-c1ccccc1 Show InChI InChI=1S/C18H14N4O2/c23-17-15-16(20-12-19-15)22(14-9-5-2-6-10-14)18(24)21(17)11-13-7-3-1-4-8-13/h1-10,12H,11H2,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214287 (CHEMBL316499) Show SMILES Fc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O |(7.14,-7.47,;5.84,-8.29,;5.88,-9.83,;4.58,-10.64,;3.23,-9.92,;3.17,-8.38,;4.49,-7.58,;4.43,-6.04,;5.74,-5.21,;7.21,-5.64,;8.07,-4.37,;7.14,-3.17,;5.69,-3.68,;4.32,-2.96,;4.28,-1.42,;3.03,-3.79,;1.66,-3.06,;1.61,-1.52,;2.91,-.71,;2.85,.82,;1.49,1.54,;.19,.72,;.24,-.82,;3.09,-5.32,;1.78,-6.14,)| Show InChI InChI=1S/C18H13FN4O2/c19-13-8-4-5-9-14(13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-6-2-1-3-7-12/h1-9,11H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214509 (CHEMBL101301) Show SMILES Nc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C18H15N5O2/c19-13-7-4-8-14(9-13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-5-2-1-3-6-12/h1-9,11H,10,19H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216236 (CHEMBL89860) Show SMILES CCn1cc(C(=O)NCCc2ccncc2)c(=S)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C20H18F3N3OS/c1-2-26-12-16(19(27)25-10-7-13-5-8-24-9-6-13)18(28)15-11-14(20(21,22)23)3-4-17(15)26/h3-6,8-9,11-12H,2,7,10H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216262 (CHEMBL90278) Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1ccc2ccccc2c1=O Show InChI InChI=1S/C17H15NO5S/c1-22-15-8-7-13(11-16(15)23-2)24(20,21)18-10-9-12-5-3-4-6-14(12)17(18)19/h3-11H,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216272 (CHEMBL415474) Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1c2ccccc2c(cc1=O)-c1ccccc1 Show InChI InChI=1S/C23H19NO5S/c1-28-21-13-12-17(14-22(21)29-2)30(26,27)24-20-11-7-6-10-18(20)19(15-23(24)25)16-8-4-3-5-9-16/h3-15H,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216269 (CHEMBL410340) Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1c(cc2ccccc2c1=O)-c1ccccc1 Show InChI InChI=1S/C23H19NO5S/c1-28-21-13-12-18(15-22(21)29-2)30(26,27)24-20(16-8-4-3-5-9-16)14-17-10-6-7-11-19(17)23(24)25/h3-15H,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216235 (CHEMBL89569) Show SMILES CCn1cc(C(=O)NCCc2ccccc2)c(=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C21H19F3N2O2/c1-2-26-13-17(20(28)25-11-10-14-6-4-3-5-7-14)19(27)16-12-15(21(22,23)24)8-9-18(16)26/h3-9,12-13H,2,10-11H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214286 (CHEMBL317172) Show SMILES Cc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O |(7.14,-7.47,;5.84,-8.29,;5.89,-9.83,;4.58,-10.64,;3.23,-9.92,;3.17,-8.38,;4.49,-7.58,;4.43,-6.04,;5.75,-5.21,;7.21,-5.64,;8.07,-4.37,;7.14,-3.17,;5.69,-3.68,;4.32,-2.96,;4.28,-1.42,;3.03,-3.79,;1.66,-3.06,;1.61,-1.52,;2.92,-.71,;2.85,.82,;1.49,1.54,;.19,.72,;.24,-.82,;3.09,-5.33,;1.78,-6.14,)| Show InChI InChI=1S/C19H16N4O2/c1-13-7-5-6-10-15(13)23-17-16(20-12-21-17)18(24)22(19(23)25)11-14-8-3-2-4-9-14/h2-10,12H,11H2,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216237 (CHEMBL90054) Show SMILES CCn1cc(C(=O)NC2CCc3cc(OC)c(OC)cc23)c(=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C24H23F3N2O4/c1-4-29-12-17(22(30)16-10-14(24(25,26)27)6-8-19(16)29)23(31)28-18-7-5-13-9-20(32-2)21(33-3)11-15(13)18/h6,8-12,18H,4-5,7H2,1-3H3,(H,28,31)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50213843 (CHEMBL99494) Show SMILES Cc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2cccs2)c1=O |(27.78,-27.15,;26.42,-27.87,;26.37,-29.41,;25.01,-30.14,;23.71,-29.32,;23.76,-27.79,;25.12,-27.07,;25.17,-25.53,;26.53,-24.8,;27.97,-25.33,;28.92,-24.11,;28.05,-22.84,;26.57,-23.27,;25.27,-22.45,;25.31,-20.91,;23.91,-23.18,;22.6,-22.36,;21.24,-23.09,;21.03,-24.62,;19.51,-24.89,;18.79,-23.53,;19.85,-22.42,;23.86,-24.72,;22.5,-25.44,)| Show InChI InChI=1S/C17H14N4O2S/c1-11-5-2-3-7-13(11)21-15-14(18-10-19-15)16(22)20(17(21)23)9-12-6-4-8-24-12/h2-8,10H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216225 (CHEMBL89127) Show SMILES CCn1cc(C(=O)N\N=C\c2ccccc2Cl)c(=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C20H15ClF3N3O2/c1-2-27-11-15(19(29)26-25-10-12-5-3-4-6-16(12)21)18(28)14-9-13(20(22,23)24)7-8-17(14)27/h3-11H,2H2,1H3,(H,26,29)/b25-10+	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214507 (CHEMBL318727) Show SMILES Cc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2ccco2)c1=O |(7.14,-7.47,;5.84,-8.29,;5.89,-9.83,;4.58,-10.65,;3.23,-9.92,;3.17,-8.38,;4.49,-7.58,;4.43,-6.04,;5.75,-5.21,;7.22,-5.65,;8.07,-4.37,;7.14,-3.17,;5.69,-3.69,;4.32,-2.96,;4.28,-1.42,;3.03,-3.79,;1.66,-3.06,;1.61,-1.52,;.33,-.66,;.73,.79,;2.29,.86,;2.83,-.57,;3.09,-5.33,;1.78,-6.14,)| Show InChI InChI=1S/C17H14N4O3/c1-11-5-2-3-7-13(11)21-15-14(18-10-19-15)16(22)20(17(21)23)9-12-6-4-8-24-12/h2-8,10H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216240 (CHEMBL89510) Show SMILES CCn1cc(C(=O)NCCc2ccncc2)c(=O)c2cnc(nc12)N1CCCC1 Show InChI InChI=1S/C21H24N6O2/c1-2-26-14-17(20(29)23-10-7-15-5-8-22-9-6-15)18(28)16-13-24-21(25-19(16)26)27-11-3-4-12-27/h5-6,8-9,13-14H,2-4,7,10-12H2,1H3,(H,23,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216291 (CHEMBL88948) Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1c(cc2ncccc2c1=O)-c1ccccc1 Show InChI InChI=1S/C22H18N2O5S/c1-28-20-11-10-16(13-21(20)29-2)30(26,27)24-19(15-7-4-3-5-8-15)14-18-17(22(24)25)9-6-12-23-18/h3-14H,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216223 (CHEMBL89708) Show SMILES CCn1cc(C(=O)NCCc2ccncc2)c(=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O2/c1-2-26-12-16(19(28)25-10-7-13-5-8-24-9-6-13)18(27)15-11-14(20(21,22)23)3-4-17(15)26/h3-6,8-9,11-12H,2,7,10H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216284 (CHEMBL420805) Show SMILES COc1ccc(cc1OCCCCCc1ccccc1)S(=O)(=O)N(Cc1cccnc1)S(C)(=O)=O Show InChI InChI=1S/C25H30N2O6S2/c1-32-24-15-14-23(18-25(24)33-17-8-4-7-12-21-10-5-3-6-11-21)35(30,31)27(34(2,28)29)20-22-13-9-16-26-19-22/h3,5-6,9-11,13-16,18-19H,4,7-8,12,17,20H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50071804 (CHEMBL314962 | N-Furan-2-ylmethyl-3,4-dimethoxy-N-...) Show SMILES CCCN(Cc1ccco1)S(=O)(=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C16H21NO5S/c1-4-9-17(12-13-6-5-10-22-13)23(18,19)14-7-8-15(20-2)16(11-14)21-3/h5-8,10-11H,4,9,12H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50213840 (CHEMBL98654) Show SMILES C[S+]([O-])c1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C19H16N4O3S/c1-27(26)15-9-5-8-14(10-15)23-17-16(20-12-21-17)18(24)22(19(23)25)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216258 (CHEMBL542902) Show SMILES Cl.CCCn1cc(C(=O)NCCc2ccncc2)c(=O)c2cc(ccc12)C(F)(F)F Show InChI InChI=1S/C21H20F3N3O2/c1-2-11-27-13-17(20(29)26-10-7-14-5-8-25-9-6-14)19(28)16-12-15(21(22,23)24)3-4-18(16)27/h3-6,8-9,12-13H,2,7,10-11H2,1H3,(H,26,29)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216239 (CHEMBL262644) Show SMILES CCn1cc(C(=O)NC2CCc3cc(NC(C)=O)ccc23)c(=O)c2cnc(nc12)N1CCCC1 Show InChI InChI=1S/C25H28N6O3/c1-3-30-14-20(22(33)19-13-26-25(29-23(19)30)31-10-4-5-11-31)24(34)28-21-9-6-16-12-17(27-15(2)32)7-8-18(16)21/h7-8,12-14,21H,3-6,9-11H2,1-2H3,(H,27,32)(H,28,34)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216265 (CHEMBL91526) Show SMILES CCCN(Cc1ccc(cc1)C(=O)NC)S(=O)(=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C20H26N2O5S/c1-5-12-22(14-15-6-8-16(9-7-15)20(23)21-2)28(24,25)17-10-11-18(26-3)19(13-17)27-4/h6-11,13H,5,12,14H2,1-4H3,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216275 (CHEMBL315963) Show SMILES COc1ccc(cc1OC1CCCC1)S(=O)(=O)N(Cc1cccnc1)S(C)(=O)=O Show InChI InChI=1S/C19H24N2O6S2/c1-26-18-10-9-17(12-19(18)27-16-7-3-4-8-16)29(24,25)21(28(2,22)23)14-15-6-5-11-20-13-15/h5-6,9-13,16H,3-4,7-8,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214287 (CHEMBL316499) Show SMILES Fc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O |(7.14,-7.47,;5.84,-8.29,;5.88,-9.83,;4.58,-10.64,;3.23,-9.92,;3.17,-8.38,;4.49,-7.58,;4.43,-6.04,;5.74,-5.21,;7.21,-5.64,;8.07,-4.37,;7.14,-3.17,;5.69,-3.68,;4.32,-2.96,;4.28,-1.42,;3.03,-3.79,;1.66,-3.06,;1.61,-1.52,;2.91,-.71,;2.85,.82,;1.49,1.54,;.19,.72,;.24,-.82,;3.09,-5.32,;1.78,-6.14,)| Show InChI InChI=1S/C18H13FN4O2/c19-13-8-4-5-9-14(13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-6-2-1-3-7-12/h1-9,11H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216273 (CHEMBL88399) Show SMILES COc1ccc2CCC(NS(=O)(=O)c3ccc(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C18H21NO5S/c1-22-13-6-4-12-5-8-16(15(12)10-13)19-25(20,21)14-7-9-17(23-2)18(11-14)24-3/h4,6-7,9-11,16,19H,5,8H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216274 (CHEMBL88524) Show SMILES COc1ccc(cc1OC)C(=O)NC1CCc2ccccc12 Show InChI InChI=1S/C18H19NO3/c1-21-16-10-8-13(11-17(16)22-2)18(20)19-15-9-7-12-5-3-4-6-14(12)15/h3-6,8,10-11,15H,7,9H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Binding activity towards Rolipram binding site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216292 (CHEMBL89478) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(Cc1cccnc1)S(=O)(=O)CCNS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C22H25N3O8S3/c1-32-21-11-10-20(15-22(21)33-2)36(30,31)25(17-18-7-6-12-23-16-18)34(26,27)14-13-24-35(28,29)19-8-4-3-5-9-19/h3-12,15-16,24H,13-14,17H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2629-34 (1998) BindingDB Entry DOI: 10.7270/Q2M32XZQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216262 (CHEMBL90278) Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1ccc2ccccc2c1=O Show InChI InChI=1S/C17H15NO5S/c1-22-15-8-7-13(11-16(15)23-2)24(20,21)18-10-9-12-5-3-4-6-14(12)17(18)19/h3-11H,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of Rolipram binding to phosphodiesterase 4 at 20 uM				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50213867 (CHEMBL329303) Show SMILES COC(=O)c1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O4/c1-28-19(26)14-8-5-9-15(10-14)24-17-16(21-12-22-17)18(25)23(20(24)27)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216289 (CHEMBL88384) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(CCC#N)C1CCc2ccccc12 Show InChI InChI=1S/C20H22N2O4S/c1-25-19-11-9-16(14-20(19)26-2)27(23,24)22(13-5-12-21)18-10-8-15-6-3-4-7-17(15)18/h3-4,6-7,9,11,14,18H,5,8,10,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50213843 (CHEMBL99494) Show SMILES Cc1ccccc1-n1c2nc[nH]c2c(=O)n(Cc2cccs2)c1=O |(27.78,-27.15,;26.42,-27.87,;26.37,-29.41,;25.01,-30.14,;23.71,-29.32,;23.76,-27.79,;25.12,-27.07,;25.17,-25.53,;26.53,-24.8,;27.97,-25.33,;28.92,-24.11,;28.05,-22.84,;26.57,-23.27,;25.27,-22.45,;25.31,-20.91,;23.91,-23.18,;22.6,-22.36,;21.24,-23.09,;21.03,-24.62,;19.51,-24.89,;18.79,-23.53,;19.85,-22.42,;23.86,-24.72,;22.5,-25.44,)| Show InChI InChI=1S/C17H14N4O2S/c1-11-5-2-3-7-13(11)21-15-14(18-10-19-15)16(22)20(17(21)23)9-12-6-4-8-24-12/h2-8,10H,9H2,1H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216287 (CHEMBL313600) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N1CCc2ccccc12 Show InChI InChI=1S/C16H17NO4S/c1-20-15-8-7-13(11-16(15)21-2)22(18,19)17-10-9-12-5-3-4-6-14(12)17/h3-8,11H,9-10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216265 (CHEMBL91526) Show SMILES CCCN(Cc1ccc(cc1)C(=O)NC)S(=O)(=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C20H26N2O5S/c1-5-12-22(14-15-6-8-16(9-7-15)20(23)21-2)28(24,25)17-10-11-18(26-3)19(13-17)27-4/h6-11,13H,5,12,14H2,1-4H3,(H,21,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Binding activity towards Rolipram binding site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216275 (CHEMBL315963) Show SMILES COc1ccc(cc1OC1CCCC1)S(=O)(=O)N(Cc1cccnc1)S(C)(=O)=O Show InChI InChI=1S/C19H24N2O6S2/c1-26-18-10-9-17(12-19(18)27-16-7-3-4-8-16)29(24,25)21(28(2,22)23)14-15-6-5-11-20-13-15/h5-6,9-13,16H,3-4,7-8,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Binding activity towards Rolipram binding site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214284 (CHEMBL420265) Show SMILES O=c1n(Cc2ccccc2)c(=O)c2[nH]cnc2n1-c1ccccc1 Show InChI InChI=1S/C18H14N4O2/c23-17-15-16(20-12-19-15)22(14-9-5-2-6-10-14)18(24)21(17)11-13-7-3-1-4-8-13/h1-10,12H,11H2,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216260 (CHEMBL313397) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(Cc1ccccc1)Cc1cccnc1 Show InChI InChI=1S/C21H22N2O4S/c1-26-20-11-10-19(13-21(20)27-2)28(24,25)23(15-17-7-4-3-5-8-17)16-18-9-6-12-22-14-18/h3-14H,15-16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216283 (CHEMBL328733) Show SMILES COc1ccc(cc1OC)S(=O)(=O)NC1CCc2cc(Cl)ccc12 Show InChI InChI=1S/C17H18ClNO4S/c1-22-16-8-5-13(10-17(16)23-2)24(20,21)19-15-7-3-11-9-12(18)4-6-14(11)15/h4-6,8-10,15,19H,3,7H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216263 (CHEMBL313096) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(Cc1ccccn1)C1CCc2ccccc12 Show InChI InChI=1S/C23H24N2O4S/c1-28-22-13-11-19(15-23(22)29-2)30(26,27)25(16-18-8-5-6-14-24-18)21-12-10-17-7-3-4-9-20(17)21/h3-9,11,13-15,21H,10,12,16H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216271 (CHEMBL92362) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(Cc1cccnc1)S(C)(=O)=O Show InChI InChI=1S/C15H18N2O6S2/c1-22-14-7-6-13(9-15(14)23-2)25(20,21)17(24(3,18)19)11-12-5-4-8-16-10-12/h4-10H,11H2,1-3H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216270 (CHEMBL315779) Show SMILES COc1ccc(cc1OC)S(=O)(=O)NC1CCc2ccccc12 Show InChI InChI=1S/C17H19NO4S/c1-21-16-10-8-13(11-17(16)22-2)23(19,20)18-15-9-7-12-5-3-4-6-14(12)15/h3-6,8,10-11,15,18H,7,9H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214164 (CHEMBL100011) Show SMILES COc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C19H16N4O3/c1-26-15-9-5-8-14(10-15)23-17-16(20-12-21-17)18(24)22(19(23)25)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50216285 (CHEMBL328945) Show SMILES COc1ccc(cc1OC)S(=O)(=O)N(CCC#N)C1CCCc2ccccc12 Show InChI InChI=1S/C21H24N2O4S/c1-26-20-12-11-17(15-21(20)27-2)28(24,25)23(14-6-13-22)19-10-5-8-16-7-3-4-9-18(16)19/h3-4,7,9,11-12,15,19H,5-6,8,10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description In vitro binding activity towards catalytic site of phosphodiesterase 4				Bioorg Med Chem Lett 8: 2635-40 (1999) BindingDB Entry DOI: 10.7270/Q2MP52FN
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50214288 (CHEMBL98483) Show SMILES Clc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C18H13ClN4O2/c19-13-7-4-8-14(9-13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiroscience Ltd Curated by ChEMBL					Assay Description Inhibition of PDE4				Bioorg Med Chem Lett 8: 2925-30 (1998) BindingDB Entry DOI: 10.7270/Q2Z89FKG
					More data for this Ligand-Target Pair

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